21,677 results match your criteria normal-weight obese

Life-course trajectories of weight and their impact on the incidence of type 2 diabetes.

Sci Rep 2021 Jun 14;11(1):12494. Epub 2021 Jun 14.

Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden.

Although exposure to overweight and obesity at different ages is associated to a higher risk of type 2 diabetes, the effect of different patterns of exposure through life remains unclear. We aimed to characterize life-course trajectories of weight categories and estimate their impact on the incidence of type 2 diabetes. We categorized the weight of 7203 participants as lean, normal or overweight at five time-points from ages 7-55 using retrospective data. Read More

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The Timing of Obesity Matters: Associations Between Current Versus Chronic Obesity since Adolescence and Romantic Relationship Satisfaction Among Young Adult Women.

Womens Health Issues 2021 Jun 11. Epub 2021 Jun 11.

PolicyLab, Children's Hospital of Philadelphia Research Institute, Philadelphia, Pennsylvania.

Background: Although the social consequences of obesity for women are well-documented, its stigmatizing effect on romantic relationships across the life course has seldom been explored. We examined whether having current or chronic obesity since adolescence is associated with romantic relationship satisfaction among women in early adulthood.

Methods: This is a secondary analysis of data from the National Longitudinal Study of Adolescent Health. Read More

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Roux-en-Y gastric bypass-induced bacterial perturbation contributes to altered host-bacterial co-metabolic phenotype.

Microbiome 2021 Jun 14;9(1):139. Epub 2021 Jun 14.

Division of Digestive Disease, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, SW7 2AZ, UK.

Background: Bariatric surgery, used to achieve effective weight loss in individuals with severe obesity, modifies the gut microbiota and systemic metabolism in both humans and animal models. The aim of the current study was to understand better the metabolic functions of the altered gut microbiome by conducting deep phenotyping of bariatric surgery patients and bacterial culturing to investigate causality of the metabolic observations.

Methods: Three bariatric cohorts (n = 84, n = 14 and n = 9) with patients who had undergone Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG) or laparoscopic gastric banding (LGB), respectively, were enrolled. Read More

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Impact of a prenatal education intervention in pregnant women to prevent overweight in infants.

Gac Med Mex 2021 ;157(1):3-9

Faculty of Nursing, Universidad Autónoma de Nuevo León, Nuevo León. Mexico.

Introduction: During the first 1000 days of life is the basis for a child's future health established.

Objective: To evaluate the impact of a prenatal educational intervention in pregnant women on the nutritional status of the child from birth to 4 months of age.

Methods: Quasi-experimental intervention design in women with at least 12 weeks of gestation, who were randomly assigned to an intervention group (IG) to participate in five group and three individual sessions on feeding practices and maternal perception of the child's weight and signals of hunger-satiety; the control group (CG) received routine care that included at least three prenatal consultations. Read More

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January 2021

Factors associated with stroke among patients with type 2 diabetes mellitus in China: a propensity score matched study.

Acta Diabetol 2021 Jun 14. Epub 2021 Jun 14.

School of Public Health, Xuzhou Medical University, Xuzhou, 221004, Jiangsu, China.

Objective: This study aimed to examine the prevalence of stroke and associated factors of stroke in patients with type 2 diabetes(T2DM) in China.

Methods: Participants were 18,013 T2DM patients recruited with stratified random cluster sampling method from December 2013 to January 2014 in China. Propensity score matching was used to eliminate confounding effects between groups and logistic regression analysis was used to examine factors associated with stroke among T2DM patients. Read More

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MelLec Exacerbates the Pathogenesis of -Induced Allergic Inflammation in Mice.

Front Immunol 2021 28;12:675702. Epub 2021 May 28.

Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, Aberdeen, United Kingdom.

Environmental factors, particularly fungi, influence the pathogenesis of allergic airway inflammation, but the mechanisms underlying these effects are still unclear. Melanin is one fungal component which is thought to modulate pulmonary inflammation. We recently identified a novel C-type lectin receptor, MelLec (Clec1a), which recognizes fungal 1,8-dihydroxynaphthalene (DHN)-melanin and is able to regulate inflammatory responses. Read More

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Associations of the pre-pregnancy weight status with anemia and the erythropoiesis-related micronutrient status.

Public Health Nutr 2021 Jun 14:1-31. Epub 2021 Jun 14.

School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan.

Objective: The coexistence of underweight (UW) and overweight (OW)/obese (OB) at the population level is known to affect iron-deficiency anemia (IDA), but how the weight status affects erythropoiesis during pregnancy is less clear at a population scale. This study investigated associations between the pre-pregnancy body mass index (pBMI) and erythropoiesis-related nutritional deficiencies.

Design: Anthropometry, blood biochemistry, and 24-h dietary recall data were collected during prenatal care visits. Read More

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The use of simple muscle strength tests to reflect body compositions among individuals with spinal cord injury.

Spinal Cord 2021 Jun 12. Epub 2021 Jun 12.

School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand.

Study Design: A cross-sectional study.

Objectives: To investigate the correlation between simple muscle strength tests (including handgrip test and upper limb loading during a seated push-up test [ULL-SPUT]) and body compositions among individuals with spinal cord injury (SCI).

Setting: A tertiary rehabilitation center. Read More

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Association between patients' body mass index and emergency department wait times: A multicenter observational cohort investigation by the reducing disparities increasing equity in emergency medicine (REDEEM) study group.

Am J Emerg Med 2021 Jun 8;49:178-184. Epub 2021 Jun 8.

Department of Emergency Medicine, Mayo Clinic, Rochester, MN, United States.

Objective: Numerous studies have demonstrated evidence of obesity bias in healthcare settings, however, little is known about obesity bias in the Emergency Department (ED). The objective of this study was to investigate obesity bias in an ED setting by assessing the association between body mass index (BMI) and door-to-room (DTR) or door-to-provider (DTP) times among ED patients.

Methods: We conducted an observational cohort study of all adult patient (age ≥ 18 years of age) visits to 21 Mayo Clinic and Mayo Clinic Health System EDs between November 1, 2018 and March 31, 2020. Read More

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Prevalence and Impact of Obesity on Disease-Specific Outcomes in a Population-Based Cohort of Patients with Ulcerative Colitis.

J Crohns Colitis 2021 Jun 12. Epub 2021 Jun 12.

Division of Gastroenterology and Hepatology, Mayo Clinic, Southwest Rochester, MN, USA.

Background And Aims: There remains a historical misconception that inflammatory bowel disease (IBD) patients are underweight. However, recent data suggests rates of obesity in IBD parallel those of the general population. The impact obesity has on the natural history of IBD is unclear. Read More

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Chronobiological evaluation and an intervention study on timing of food intake in the treatment of obesity.

Int J Clin Pract 2021 Jun 12:e14502. Epub 2021 Jun 12.

Department of Family Medicine, Düzce University Medical Faculty, Duzce, Turkey.

Background: The chronotype of patients who cannot reach their ideal weight despite diet and exercise may play a role in this resistance. In this study, the relationship between BMI and chronobiological preferences was examined and a weight loss program was applied to refractory obese patients with evening type (ET).

Method: The study included 50 obese (BMI≥30 kg/m ), 50 overweight (BMI=25-29 kg/m ), and 50 normal normal-weight (BMI<25 kg/m ). Read More

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Oral health of overweight and obese children and adolescents: a comparative study with a multivariate analysis of risk indicators.

Eur Arch Paediatr Dent 2021 Jun 11. Epub 2021 Jun 11.

First Department of Pediatrics, Medical School, Aghia Sophia Children's Hospital, National and Kapodistrian University of Athens, 1 Thivon Str, Goudi, 11527, Athens, Greece.

Purpose: The aim of this study was to investigate the oral health status of overweight and obese children compared to normal weight children and to explore the effect of risk indicators, including stress, on the oral health of the children.

Methods: For this cross-sectional study, 7-15-year-old children were enrolled: divided into a group of overweight and obese and a group of normal weight children. Parent-reported questionnaires were used to for data collection demographic data, children's medical and developmental history, brushing frequency and dietary habits. Read More

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Overweight and Obesity and Progression of ADPKD.

Clin J Am Soc Nephrol 2021 Jun 11;16(6):908-915. Epub 2021 Jun 11.

University of Colorado Anschutz Medical Campus, Aurora, Colorado.

Background And Objectives: On the basis of earlier observations, we evaluated the association between overweight and obesity and rapid progression of autosomal dominant polycystic kidney disease in participants in the Tolvaptan Efficacy and Safety in Management of Autosomal Dominant Polycystic Kidney Disease and Its Outcomes (TEMPO) 3:4 trial. More importantly, we also determined whether efficacy of tolvaptan was attenuated in individuals with baseline overweight or obesity.

Design, Setting, Participants, & Measurements: A total of 1312 study participants with relatively early-stage autosomal dominant polycystic kidney disease (mean eGFR 78±22 ml/min per 1. Read More

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Activation of Ventral Tegmental Area Neurotensin Receptor-1 Neurons Promotes Weight Loss.

Neuropharmacology 2021 Jun 8:108639. Epub 2021 Jun 8.

Department of Physiology and College of Natural Science, Michigan State University, East Lansing, MI 48114. Electronic address:

Dopamine (DA) neurons in the ventral tegmental area (VTA) modulate physical activity and feeding behaviors that are disrupted in obesity. Yet, the heterogeneity of VTA DA neurons has hindered determination of which ones might be leveraged to support weight loss. We hypothesized that increased activity in the subset of VTA DA neurons expressing neurotensin receptor-1 (NtsR1) might promote weight loss behaviors. Read More

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Association of obesity with diabetic retinopathy in US adults with diabetes in a national survey.

Endocr Connect 2021 Jun 1. Epub 2021 Jun 1.

Z Xie, Clinical and Translational Science Institute, School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, United States.

Objective: There is a lack of consensus on whether a high body mass index (BMI) increases the risk of diabetic retinopathy (DR). We aimed to investigate the association between BMI, overweight, obesity, and DR using the data of diabetes respondents in the 2015 US Behavioral Risk Factor Surveillance System survey.

Methods: Diabetes respondents aged over 18-year-old with complete information as well as undergone fundus examination in the past two years or had been diagnosed with DR were included. Read More

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Puerarin reduces impairment of intestinal and adipose immune responses to influenza virus infection in mice.

Arch Virol 2021 Jun 10. Epub 2021 Jun 10.

Basic Medical College, Guangzhou University of Chinese Medicine, 12 Jichang Rd., San Yuanli St., Bai Yun Dist., Guangzhou, 510405, Guangdong, People's Republic of China.

Influenza is an acute viral respiratory disease that can also cause gastroenteritis-like symptoms, such as abdominal pain, nausea, vomiting, and diarrhea. Immune dysfunction of adipose tissue is involved in the occurrence and prognosis of influenza viral pneumonia. In this study, we analyzed intestinal and adipose immune responses in mice infected with influenza virus and found that the impairment of intestinal and adipose immunity to influenza virus infection could be reversed by treatment with puerarin, a medicinal compound isolated from Pueraria lobata (called "gegen" in Chinese). Read More

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Relationship Between Different Risk Factor Patterns and Follow-Up Outcomes in Patients With ST-Segment Elevation Myocardial Infarction.

Front Cardiovasc Med 2021 25;8:633992. Epub 2021 May 25.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.

Few studies have been concerned with the combined influences of the presence of multiple risk factors on follow-up outcomes in AMI patients. Our study aimed to identify risk factor patterns that may be associated with 1-year survival in male patients with ST-segment elevation myocardial infarction (STEMI). Data were from the China STEMI Care Project Phase 2 (CSCAP-2) collected between 2015 and 2018. Read More

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Obesity and mortality in critically ill COVID-19 patients with respiratory failure.

Int J Obes (Lond) 2021 Jun 10. Epub 2021 Jun 10.

Specialized Obesity Center and Department of Endocrinology, Diabetology, Nutrition, CHRU-Nancy, Brabois Hospital, Université de Lorraine, Nancy, France.

Background: Patients with obesity are at increased risk of severe COVID-19, requiring mechanical ventilation due to acute respiratory failure. However, conflicting data are obtained for intensive care unit (ICU) mortality.

Objective: To analyze the relationship between obesity and in-hospital mortality of ICU patients with COVID-19. Read More

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Continuous glucose monitoring in obese pregnant women with no hyperglycemia on glucose tolerance test.

PLoS One 2021 10;16(6):e0253047. Epub 2021 Jun 10.

Department of Obstetrics and Gynecology, General Hospital of Caxias do Sul, Caxias do Sul University, Caxias do Sul, RS, Brazil.

Objective: The objective of the present study was to compare 24-hour glycemic levels between obese pregnant women with normal glucose tolerance and non-obese pregnant women.

Methods: In the present observational, longitudinal study, continuous glucose monitoring was performed in obese pregnant women with normal oral glucose tolerance test with 75 g of glucose between the 24th and the 28th gestational weeks. The control group (CG) consisted of pregnant women with normal weight who were selected by matching the maternal age and parity with the same characteristics of the obese group (OG). Read More

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Clinical significance of serum gonadotropin and androgen levels among Egyptian overweight/obese pubertal girls.

J Complement Integr Med 2021 Jun 9. Epub 2021 Jun 9.

Biological Anthropology Dept., National Research Centre, Giza, Egypt.

Objectives: Evaluate the association between overweight/obesity with serum gonadotropin and androgen levels in Egyptian pubertal girls.

Subjects And Methods: A case-control study carried out in "Obesity Clinic" of "Diabetes, Endocrine and Metabolism Pediatric Unit (DEMPU)", Pediatric Hospital, Cairo University. It included 40 overweight and obese girls and 40 age-matching normal weight (control) ones, aged 12-18 years. Read More

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Gut microbiota of adults with different metabolic phenotypes.

Nutrition 2021 Apr 28;90:111293. Epub 2021 Apr 28.

Postgraduate Program in Medicine (Cardiology), Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. Electronic address:

Objective: The aim of this study was to investigate the gut microbiota of individuals with different metabolic phenotypes and to compare their characteristics.

Methods: This was a cross-sectional study with 109 adults, classified according to metabolic status, by body mass index, and homeostasis model assessment. Anthropometric and biochemical characteristics and blood pressure were evaluated. Read More

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[The Relationship between Body Mass Index and Adult Acute Myeloid Leukemia].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2021 Jun;29(3):677-684

The First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Objective: To analysis the relationship between different BMI (body mass index) and the clinical characteristics, laboratory examination indexes of newly diagnosed adult patients with acute myeloid leukemia (AML), so as to investigate the effects of BMI to the efficacy of first induction chemotherapy.

Methods: The clinical data of 145 newly diagnosed adult AML patients treated in the First Hospital of Lanzhou University from August 2015 to August 2019 were retrospective analyzed. According to the guidelines for prevention and control of overweight and obesity in Chinese adults, the BMI (kg/m) of the selected AML patients before induction chemotherapy was calculated and the patients were divided into the low body mass group (BMI<18. Read More

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A retrospective cohort study of race/ethnicity, pre-pregnancy weight, and pregnancy complications.

J Matern Fetal Neonatal Med 2021 Jun 8:1-8. Epub 2021 Jun 8.

Department of Health Services, School of Public Health, University of Washington, Seattle, WA, USA.

Objective: To examine the relationship between race/ethnicity, pre-pregnancy overweight/obesity status, and pregnancy complications.

Methods: We conducted a retrospective cohort study among mothers with singleton live births using data from hospitals contributing to the Obstetrical Care Outcomes Assessment Program database ( = 72,697). Race was categorized as Non-Hispanic (NH) White, NH African-American, Hispanic, NH Asian, NH American Indian/Alaskan Native, and NH Native-Hawaiian/Other Pacific Islander. Read More

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The effect of obesity on pain severity and pain interference.

Pain Manag 2021 Jun 9. Epub 2021 Jun 9.

Department of Anesthesiology, Weill Cornell Medicine, New York, NY 10065, USA.

Obesity is one of the most prevalent comorbidities associated with chronic pain, which can severely interfere with daily living and increase utilization of clinical resources. We hypothesized that a higher level of obesity, measured by BMI, would be associated with increased pain severity (intensity) and interference (pain related disability). Participant data was pulled from a multisite chronic pain outpatient database and categorized based on BMI. Read More

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Systematic review and meta-analysis of the association between paediatric obesity and telomere length.

Acta Paediatr 2021 Jun 8. Epub 2021 Jun 8.

Department of Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, 510080, China.

Aim: This systematic review and meta-analysis aimed to assess the association between paediatric obesity and telomere length.

Methods: We conducted a comprehensive literature search for original studies assessing the associations between obesity and telomere length in children. Fixed or random effects with inverse-variance meta-analysis were used to estimate the standardised mean difference (SMD) and its 95% confidence interval (95% CI) between overweight or obese and normal-weight children. Read More

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Examining the associations between dietary patterns and obesity indexes: Systematic review of observational studies.

Nutr Health 2021 Jun 8:2601060211020975. Epub 2021 Jun 8.

Department of Nutrition and Dietetics, Harokopio University, School of Health Sciences and Education, Greece.

Background: Few reports on the association of population-derived dietary patterns with excess body weight, using the approach of a systematic review currently exist.

Aim: The aim of the present systematic review was to identify dietary patterns associated with body mass index (BMI), body weight (BW)/BMI change, weight status and weight loss maintenance status.

Methods: Using MEDLINE (via PubMed) and EBSCO Host databases, we systematically reviewed studies from 1980 to 2020, which included men and women, aged ≥18 years. Read More

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Association between body mass index and patient-reported-outcome questionnaire scores (CAT™, ACT™, mMRC dyspnoea scale, IPAQ) in Ukraine, Kazakhstan and Azerbaijan: results of the CORE study.

BMC Pulm Med 2021 Jun 7;21(1):192. Epub 2021 Jun 7.

GlaxoSmithKline, Dubai, UAE.

Background: The overweight/obese population (evaluated by a body mass index, BMI) represents a global health problem and contributes to the development of various chronic diseases. In this epidemiological study we evaluated this relationship by analyzing patient-reported questionnaires related to respiratory function, physical activity and BMI.

Methods: In 2013-2015, adult residents of selected cities were enrolled to this study in: Ukraine (M/F: 403/561), Kazakhstan (M/F = 348/597) and Azerbaijan (M/F: 389/544). Read More

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Obesity, putative biological mediators, and cognitive function in a national sample of children and adolescents.

Prev Med 2021 Jun 5;150:106659. Epub 2021 Jun 5.

Mayo Clinic, 200 First Street SW, Rochster, MN 55901, United States of America.

Childhood obesity has reached epidemic rates nationwide and may be associated with impaired cognitive function. A growing body of evidence suggests that poorer academic performance for children with obesity and overweight is related to declines in executive function skills. This study aimed to identify biological mediators between obesity and overweight and cognitive function among children and adolescents. Read More

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Lifestyle Interventions for Diabetes Prevention in South Asians: Current Evidence and Opportunities.

Curr Diab Rep 2021 Jun 7;21(8):23. Epub 2021 Jun 7.

Department of Family and Preventive Medicine, Emory University School of Medicine, Atlanta, GA, USA.

Purpose Of Review: This review summarizes the burden of diabetes in South Asian populations and reviews recent evidence for diabetes prevention through lifestyle modification among South Asians worldwide. We indicate important gaps in the current literature and point to opportunities for additional research in this area.

Recent Findings: Randomized, controlled, efficacy studies and implementation research show that lifestyle intervention can be an effective, cost-effective, and feasible method for reducing diabetes risk, improving cardiometabolic health, and improving lifestyle behaviors in South Asian populations, a population at high diabetes risk and elevated rates of diabetes risk factors. Read More

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Maternal body-mass-index and neonatal brachial plexus palsy in a California cohort.

J Matern Fetal Neonatal Med 2021 Jun 6:1-8. Epub 2021 Jun 6.

Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.

Objective: To evaluate risk factors and describe the association between maternal pre-pregnancy body-mass-index (BMI) and neonatal brachial plexus palsy (BPP) in vaginal deliveries with and without shoulder dystocia.

Methods: This is a retrospective cohort study of singleton, non-anomalous, term vaginal deliveries in California (2007-2011). Deliveries were classified as with or without shoulder dystocia. Read More

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