1,808,776 results match your criteria normal tissues


The outcome of intra-cytoplasmic sperm injection (ICSI): do the sperm concentration and motility matter?

Horm Mol Biol Clin Investig 2021 Jun 14. Epub 2021 Jun 14.

Advanced Reproductive Centre (ARC), Hospital Canselor Tuanku Muhriz (HCTM), Kuala Lumpur, Malaysia.

Objectives: The male-factor subfertility was reported to be 30% globally; thus, the intracytoplasmic sperm injection (ICSI) procedure was implemented to improve the overall fertilization (IVF) rates. Nevertheless, at least 10% of fertilization failure still occurs. Concerning this issue, we explored the association of sperm concentration and motility with the quality of embryo development and pregnancy outcome in IVF-ICSI cycles. Read More

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Dermatomyositis: Patterns of MRI findings in muscles, fascia and skin of pelvis and thigh.

Eur J Radiol 2021 Jun 6;141:109812. Epub 2021 Jun 6.

Department of Radiodiagnosis, Post Graduate Institute of Medical Education & Research, Chandigarh, 160012, India.

Purpose: This review discusses characteristic, subtle, and florid changes in muscle, fascia, skin, and subcutaneous tissue of the lower limbs in MR imaging in patients with dermatomyositis.

Material And Methods: This review is based on the analysis of 43 patients with dermatomyositis who were imaged from January 2014 to March 2021 in our institute as well a critical review of literature of MRI in dermatomyositis.

Results: Muscle involvement is predominantly bilaterally symmetric and involves anterior, posterior as well as medial compartments of the thigh. Read More

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Postexercise hypotension due to resistance exercise is not mediated by autonomic control: A systematic review and meta-analysis.

Auton Neurosci 2021 May 27;234:102825. Epub 2021 May 27.

Department of Kinesiology, University of Connecticut, Storrs, CT, USA.

Changes in autonomic control have been suggested to mediate postexercise hypotension (PEH). We investigated through meta-analysis the after-effects of acute resistance exercise (RE) on blood pressure (BP) and autonomic activity in individuals with normal and elevated BP. Electronic databases were searched for trials including: adults; exclusive RE interventions; and BP and autonomic outcomes measured pre- and postintervention for at least 30 min. Read More

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A computational pipeline for data augmentation towards the improvement of disease classification and risk stratification models: A case study in two clinical domains.

Comput Biol Med 2021 Jun 6;134:104520. Epub 2021 Jun 6.

Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, Ioannina, GR45110, Greece; Department of Biomedical Research, FORTH-IMBB, Ioannina, GR45110, Greece. Electronic address:

Virtual population generation is an emerging field in data science with numerous applications in healthcare towards the augmentation of clinical research databases with significant lack of population size. However, the impact of data augmentation on the development of AI (artificial intelligence) models to address clinical unmet needs has not yet been investigated. In this work, we assess whether the aggregation of real with virtual patient data can improve the performance of the existing risk stratification and disease classification models in two rare clinical domains, namely the primary Sjögren's Syndrome (pSS) and the hypertrophic cardiomyopathy (HCM), for the first time in the literature. Read More

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HOXB5 promotes the progression of breast cancer through wnt/beta-catenin pathway.

Pathol Res Pract 2020 Jul 13;224:153117. Epub 2020 Jul 13.

National Clinical Research Center for Normal Aging and Geriatric & The Key Lab of Normal Aging and Geriatric, Institute of Geriatric, PLA General Hospital, Beijing, China. Electronic address:

Objective: The present study was designed to explore the function of HOXB5 in breast cancer and related signaling pathway.

Methods: Breast cancer tissues and non-cancerous tissues were collected from 82 cases who were pathologically diagnosed with breast cancer. The mRNA level of HOXB5 was detected via quantitative real-time polymerase chain reaction (qRT-PCR). Read More

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High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma.

Transl Oncol 2021 Jun 9;14(8):101146. Epub 2021 Jun 9.

Department of Otolaryngology Head & Neck Surgery, The Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, No. 639, Zhi-Zao-Ju Road, Shanghai 200011, China; Ear Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China. Electronic address:

Head and neck paragangliomas (HNPGLs) are rare neoplasms that represent difficult treatment paradigms in neurotology. Germline mutations in genes encoding succinate dehydrogenase (SDH) are the cause of nearly all familial HNPGLs. However, the molecular mechanisms underlying tumorigenesis remain unclear. Read More

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Metagenomic insights into the effect of thermal hydrolysis pre-treatment on microbial community of an anaerobic digestion system.

Sci Total Environ 2021 Jun 1;791:148096. Epub 2021 Jun 1.

Advanced Environmental Biotechnology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, Singapore 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, Singapore 639798, Singapore. Electronic address:

Thermal hydrolysis process (THP) is an effective pre-treatment method to reduce solids volume and improve biogas production during anaerobic digestion (AD) via increasing the biodegradability of waste activated sludge (WAS). However, the effects of THP pre-treated sludge on microbial diversity, interspecies interactions, and metabolism in AD systems remain largely unknown. We therefore setup and operated an anaerobic digester during a long-term period to shed light on the effect of THP pre-treatment on AD microbial ecology in comparison to conventional AD via Illumina based 16S rRNA gene amplicon sequencing and genome-centric metagenomics analysis. Read More

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OXTR moderates adverse childhood experiences on depressive symptoms among incarcerated males.

J Psychiatr Res 2021 May 23;140:221-227. Epub 2021 May 23.

Psychology Program, School of Social Sciences, Nanyang Technological University, Singapore, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Department of Psychology and Cognitive Science, University of Trento, Rovereto, Italy.

Objectives: This study examined the moderation of an oxytocin receptor (OXTR) gene in the link between childhood adversity and depressive symptoms among incarcerated males.

Methods: Questionnaires about adverse childhood experiences and depressive symptoms, as well as genomic DNA from blood were collected among 608 incarcerated males (M = 32.4 years, SD = 9. Read More

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Generation of IBMS-iPSC-021, -022, -023 human induced pluripotent stem cells (IBMSi016-A, IBMSi017-A, and IBMSi018-A) derived from patients with the ALDH2 rs671 polymorphism.

Stem Cell Res 2021 Jun 9;54:102416. Epub 2021 Jun 9.

Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Heart Rhythm Center, Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan.

ALDH2 gene is coded for the aldehyde dehydrogenase (ALDH), which is an enzyme involved in alcohol metabolism. Compared to normal aldehyde dehydrogenases, a homozygous point mutation on exon 12 from G to A significantly reduces its efficiency. In this study, we have reported the generation of IBMS-iPSC-021-04, IBMS-iPSC-022-01, and IBMS-iPSC-023-03 as induced pluripotent stem cell (iPSC) lines carrying the homozygous form of ALDH2 with the rs671 genetic polymorphism (E487K mutation). Read More

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Generation of a homozygous knock-in human embryonic stem cell line expressing SNAP-tagged SOD1.

Stem Cell Res 2021 Jun 6;54:102415. Epub 2021 Jun 6.

Department of Chemistry, University of Houston, Houston, TX 77204, USA. Electronic address:

Superoxide Dismutase 1 (SOD1) is an antioxidant enzyme that protects the cells from radical oxygen species. To study the behavior of endogenous SOD1 under a microscope, we genetically modified H1 human embryonic stem cells (hESCs) to express SOD1 fused with a SNAP-tag, a protein tag that can be covalently labeled with a variety of synthetic probes. The engineered homozygous clone expressing SOD1-SNAP fusion proteins has normal stem cell morphology and karyotype, expresses pluripotency markers, and can be differentiated into all three germ layers in vitro, providing a versatile platform for imaging-based studies of SOD1. Read More

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Corrigendum to "Facile construction of ratiometric electrochemical immunosensor using hierarchical PtCoIr nanowires and porous [email protected] nanoparticles for accurate detection of septicemia biomarker" [Bioelectrochemistry 140 (2021) 107802].

Bioelectrochemistry 2021 Jun 9;141:107866. Epub 2021 Jun 9.

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, College of Chemistry and Life Sciences, College of Geography and Environmental Sciences, Zhejiang Normal University, Jinhua 321004, China. Electronic address:

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Biodegradable plastics in the air and soil environment: Low degradation rate and high microplastics formation.

J Hazard Mater 2021 Jun 5;418:126329. Epub 2021 Jun 5.

State Key Laboratory of Estuarine and Coastal Research, East China Normal University, 500 Dongchuan Road, Minhang District, Shanghai 200241, China. Electronic address:

In recent years, the promotion and use of biodegradable plastics (BPs) are growing into a general trend. Here the degradation performance of different types of BPs was investigated in the natural environment. Their degradation levels followed the order of pure BPs> BP blends> claimed "BP"≈ non-biodegradable plastic after 6-month incubation. Read More

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Co-benefits of biochar-supported nanoscale zero-valent iron in simultaneously stabilizing soil heavy metals and reducing their bioaccessibility.

J Hazard Mater 2021 Jun 6;418:126292. Epub 2021 Jun 6.

College of Environmental & Resource Sciences, Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, Zhejiang University, Hangzhou 310058, China. Electronic address:

We investigated the performance and encapsulation mechanisms of novel biochar-supported nanoscale zero-valent iron (nZVI-BC) used for the remediation of soil co-contaminated with arsenic (As), cadmium (Cd), and lead (Pb) via incubation and column experiments. Compared with the control, 0.50% of nZVI-BC significantly decreased the leakage of As, Cd, and Pb by 97. Read More

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Toxic mechanism on phenanthrene-induced cytotoxicity, oxidative stress and activity changes of superoxide dismutase and catalase in earthworm (Eisenia foetida): A combined molecular and cellular study.

J Hazard Mater 2021 Jun 9;418:126302. Epub 2021 Jun 9.

School of Environmental Science and Engineering, Shandong University, China-America CRC for Environment & Health, Shandong Province, 72# Jimo Binhai Road, Qingdao, Shandong 266237, PR China. Electronic address:

Phenanthrene (PHE) is an important organic compound, which is widespread in the soil environment and exhibits potential threats to soil organisms. Toxic effects of PHE to earthworms have been extensively studied, but toxic mechanisms on PHE-induced cytotoxicity and oxidative stress at the molecular and cellular levels have not been reported yet. Therefore, we explored the cytotoxicity and oxidative stress caused by PHE in earthworm coelomocytes and the interaction mechanism between PHE and the major antioxidant enzymes SOD/CAT. Read More

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Impending cauda equina syndrome due to Kummell disease; A case report and literature review.

Int J Surg Case Rep 2021 May 26;83:106041. Epub 2021 May 26.

The School of Medicine, University of Central Lancashire, Preston, Lancashire, United Kingdom. Electronic address:

Introduction: Kummell disease (KD) is a rare cause of vertebral fracture due to osteonecrosis. The natural history of the disease is characterized by a previous minor trauma, a subclinical window period, and then a symptomatic period presenting with disabling pain, kyphosis, or neurologic deficit.

Importance: As an important but rare cause of non-discogenic cauda equina syndrome. Read More

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Analysis of prolactin and sexual side effects in patients with schizophrenia who switched from paliperidone palmitate to aripiprazole lauroxil.

Psychiatry Res 2021 May 27;302:114030. Epub 2021 May 27.

Alkermes, Inc., Waltham, MA, USA.

One strategy to address hyperprolactinemia and associated sexual side effects in patients receiving antipsychotics is switching to an antipsychotic not associated with prolactin elevation (eg, aripiprazole). This post hoc analysis assessed prolactin concentrations and sexual side effects in an open-label prospective study of switching long-acting injectable antipsychotics from paliperidone palmitate (PP) to aripiprazole lauroxil (AL). Serum prolactin was measured throughout the study. Read More

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K channel blockers control glucagon secretion by distinct mechanisms: a direct stimulation of α-cells involving a [Ca] rise and an indirect inhibition mediated by somatostatin.

Mol Metab 2021 Jun 9:101268. Epub 2021 Jun 9.

Université Catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pôle d'Endocrinologie, Diabète et Nutrition, Brussels, Belgium. Electronic address:

Objective: Glucagon is secreted by pancreatic α-cells in response to hypoglycemia and its hyperglycemic effect helps to restore normal blood glucose. Insulin and somatostatin (SST) secretions from β- and δ-cells, respectively, are stimulated by glucose by mechanisms implicating an inhibition of their ATP-sensitive K (K) channels, leading to an increase in [Ca] that triggers exocytosis. Drugs that close K channels, such as sulfonylureas, are used to stimulate insulin release in type 2 diabetic patients. Read More

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Enhanced immune reconstitution of γδ T cells after allograft overcomes negative impact of pre-transplant MRD positive status in AML patients.: γδ T cells and MRD+ AML.

Transplant Cell Ther 2021 Jun 9. Epub 2021 Jun 9.

Department of Stem Cell Transplantation, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address:

Background: Minimal residual disease (MRD) prior to allogeneic stem cell transplantation (allo-SCT) in AML is a poor risk factor for outcome. The γδ T cells represents a unique minority lymphocyte population which is preferentially located in peripheral tissues, can recognize antigens in non-MHC restricted manner and plays a "bridging" role between innate and adaptive immune system.

Objectives: In this study, we investigated a potential graft-vs-leukaemia effect of γδ T cells reconstitution post-transplant in AML patients with pre-transplant positive minimal/measurable disease status (MRD+). Read More

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Short-term and Long-term Psychological Impact and Quality of Life of Patients Undergoing Orthognathic Surgery.

Biomed J 2021 Jun 9. Epub 2021 Jun 9.

Department of Craniofacial Research Center, Chang Gung Memorial Hospital and College of Medicine, Taoyuan, Taiwan.

Background: Orthognathic Surgery (OGS) is a surgery for patients with dento-facial deformity but not all patients are satisfied with its outcome. The purpose of this study is to find out the short-term and long-term psychological impact and quality-of-life of OGS.

Methods: 77 participants receiving OGS and 32 age and gender-matched controls were enrolled. Read More

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Consistent Alterations of Human Fecal Microbes after Transplantation into Germ-free Mice.

Genomics Proteomics Bioinformatics 2021 Jun 9. Epub 2021 Jun 9.

MOE Key Laboratory of Molecular Biophysics, Hubei Key Laboratory of Bioinformatics and Molecular-imaging, Department of Bioinformatics and Systems Biology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; College of Life Science, Henan Normal University, Xinxiang 453007, China. Electronic address:

Fecal microbiota transplantation (FMT) of human fecal samples into germ-free (GF) mice is useful for establishing causal relationships between the gut microbiota and human phenotypes. However, due to the intrinsic differences between human and mouse intestines and the different diets of the two organisms, it may not be possible to replicate human phenotypes in mice through FMT; similarly, treatments that are effective in mouse models may not be effective in humans. In this study, we aimed to identify human gut microbes that undergo significant and consistent changes (i. Read More

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Circadian clock genes as promising therapeutic targets for autoimmune diseases.

Autoimmun Rev 2021 Jun 9:102866. Epub 2021 Jun 9.

Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. Electronic address:

Circadian rhythm is a natural, endogenous process whose physiological functions are controlled by a set of clock genes. Disturbance of the clock genes have detrimental effects on both innate and adaptive immunity, which significantly enhance pro-inflammatory responses and susceptibility to autoimmune diseases via strictly controlling the individual cellular components of the immune system that initiate and perpetuate the inflammation pathways. Autoimmune diseases, especially rheumatoid arthritis (RA), often exhibit substantial circadian oscillations, and circadian rhythm is involved in the onset and progression of autoimmune diseases. Read More

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The miRNA expression profile directly reflects the energy metabolic differences between slow and fast muscle with nutritional regulation of the Chinese perch (Siniperca chuatsi).

Comp Biochem Physiol A Mol Integr Physiol 2021 Jun 9:111003. Epub 2021 Jun 9.

Hunan Provincial Key Laboratory of Nutrition and Quality Control of Aquatic Animals, Department of Biological and Environmental Engineering, Changsha University, Changsha 410022, China. Electronic address:

Fish skeletal muscles are composed of two distinct types, slow and fast muscles, and they play important roles in maintaining the body's movement and energy metabolism. The two types of muscle are easy to separate, so they are often used as the model system for studies on their physiological and functional characteristics. In this study, we revealed that the carbohydrate and lipid metabolic KEGG pathways are different between slow and fast muscles of Chinese perch with transcriptome analysis. Read More

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Prediction and interpretation of rare missense variant in OTOG associated with hearing loss.

Genomics 2021 Jun 9. Epub 2021 Jun 9.

Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. Electronic address:

OTOG encodes for otogelin, a component of the tectorial membrane. This gene is associated with nonprogressive mild-to-moderate hearing loss. However, no studies have yet identified the association between OTOG variation and severe-to-profound hearing loss. Read More

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Revealing transcriptional and post-transcriptional regulatory mechanisms of γ-glutamyl transferase and keratin isoforms as novel cooperative biomarkers in low-grade glioma and glioblastoma multiforme.

Genomics 2021 Jun 9. Epub 2021 Jun 9.

Laboratory of Systems Biology and Bioinformatics (LBB), Department of Bioinformatics, University of Tehran, Kish International Campus, Kish, Iran; Laboratory of Systems Biology and Bioinformatics (LBB), Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. Electronic address:

Gamma-glutamyltransferase (GGT) and keratins (KRT) are key factors in regulating tumor progression rely on emerging evidence. However, the prognostic values of GGT and KRT isoforms and their regulation patterns at transcriptional and post-transcriptional levels have been rarely studied. In this study, we aimed to identify cooperative prognostic biomarker signature conducted by GGT and KRT genes for overall survival prediction and discrimination in patients with low-grade glioma (LGG) and glioblastoma multiforme (GBM). Read More

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HAART exacerbates testicular damage and impaired spermatogenesis in anti-Koch-treated rats via dysregulation of lactate transport and glutathione content.

Reprod Toxicol 2021 Jun 9. Epub 2021 Jun 9.

Reproductive Biology and Toxicology Research Laboratories, Oasis of Grace Hospital, Osogbo, Osun State, Nigeria; Department of Morbid Anatomy, Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile-Ife, Osun State, Nigeria.

Highly active anti-retroviral therapy (HAART) is an effective anti-retroviral cocktail. Similarly, anti-Koch is highly potent against Mycobacterium tuberculosis. However, these drugs have been shown to impair male fertility. Read More

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Risk of psoriasis according to body mass index: a retrospective cohort analysis.

J Am Acad Dermatol 2021 Jun 9. Epub 2021 Jun 9.

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra / Northwell, New Hyde Park, NY, USA. Electronic address:

Background: Psoriasis has been linked to obesity, although there is limited data on the incidence of psoriasis according to body mass index.

Objective: To compare incidence of psoriasis among patients stratified by BMI category (normal or underweight, overweight, obese-class 1, obese-class 2/3).

Methods: Retrospective cohort analysis of a demographically heterogeneous sample of over 1. Read More

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Metal salt-modified biochars derived from agro-waste for effective congo red dye removal.

Environ Res 2021 Jun 9:111492. Epub 2021 Jun 9.

Department of Materials Science and Engineering, Korea University, 145, Anam-ro Seongbuk-gu, Seoul, 02841, Republic of Korea. Electronic address:

Anionic Congo red dye (CR) is not effectively removed by conventional adsorbents. Three novel biochars derived from agro-waste (Acacia auriculiformis), modified with metal salts of FeCl, AlCl, and CaCl at 500 °C pyrolysis have been developed to enhance CR treatment. These biochars revealed significant differences in effluents compared to BC, which satisfied initial research expectations (P < 0. Read More

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Effects of somatic tissue cryopreservation on puma (Puma concolor Linnaeus, 1771) tissue integrity and cell preservation after in vitro culture.

Cryobiology 2021 Jun 9. Epub 2021 Jun 9.

Laboratory of Animal Biotechnology, Federal Rural University of Semi-Arid (UFERSA), Mossoro, RN, Brazil. Electronic address:

Somatic resource banks play a crucial role in the conservation of genetic diversity, allowing for the preservation of biological samples from different populations. Puma somatic cells can be recovered from these banks and used in assisted techniques toward enhancing their multiplication and conservation. In response to the population reduction of this ecologically importance species, we aimed to evaluate the capacity of cryopreservation of somatic tissues on the maintenance of the integrity and quality of the cells recovered after culture, with the aim of establishing a somatic tissue bank that will allow for the safeguarding of a wide genetic sampling of pumas. Read More

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Attention modulates repetition effects in a context of low periodicity.

Brain Res 2021 Jun 9:147559. Epub 2021 Jun 9.

Centre National de la Recherche Scientifique (CNRS), Integrative Neuroscience and Cognition Center (INCC), Unité Mixte de Recherche, 8002, 75006 Paris, France; Université de Paris, 75006 Paris, France; Fondation Ophtalmologique Rothschild, Paris, France. Electronic address:

Stimulus repetition can result in a reduction in neural responses (i.e., repetition suppression) in neuroimaging studies. Read More

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Beneficial effect of the methanolic leaf extract of Allium hookeri on stimulating glutathione biosynthesis and preventing impaired glucose metabolism in type 2 diabetes.

Arch Biochem Biophys 2021 Jun 9:108961. Epub 2021 Jun 9.

Chemical Biology Lab, Institute of Advanced Study in Science and Technology (IASST) Paschim Boragaon, Guwahati, 35, India; Assam Down Town University, Panikhaiti, Assam, 781068, India. Electronic address:

Oxidative stress resulting from the depletion of glutathione (GSH) level plays a vital role in generating various degenerative diseases, including type 2 diabetes (T2D). We tested the hypothesis that depleted glutathione levels can be enhanced and the impaired glucose metabolism can be prevented by supplementing Allium hookeri, a herb rich in organosulfur compounds, in a High Fat (HF) diet-induced T2D Male Sprague Dawley rat model. The experimental rats were divided into three groups (n = 6), namely normal diet, high-fat diet, and high-fat diet treated with A. Read More

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