Am J Pathol 2021 Jun 11. Epub 2021 Jun 11.
Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas; Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI; Cell and Molecular Biology Graduate Program, College of Natural Sciences, Michigan State University, East Lansing, MI. Electronic address:
Male factors, including those of autoimmune origin, contribute to approximately 50% of infertility cases in humans. However, the mechanisms underlying autoimmune male infertility are poorly understood. Deficiency in autoimmune regulator (AIRE) impairs central immune tolerance because of diminished expression of self-antigens in the thymus. Read More