1,796,379 results match your criteria normal pregnancy


Hyperspectral image-based analysis of thermal damage for ex-vivo bovine liver utilizing radiofrequency ablation.

Surg Oncol 2021 Apr 7;38:101564. Epub 2021 Apr 7.

Biomedical Engineering Department, Military Technical College, Cairo, Egypt.

Background & Objective: Thermal ablation is the predominant methodology to treat liver tumors for segregating patients who are not permitted to have surgical intervention. However, noticing or predicting the size of the thermal strategies is a challenging endeavor. We aim to analyze the effects of ablation district volume following radiofrequency ablation (RFA) of ex-vivo liver exploiting a custom Hyperspectral Imaging (HSI) system. Read More

View Article and Full-Text PDF

Disentangling Cognitive Heterogeneity in Psychotic Spectrum Disorders.

Asian J Psychiatr 2021 Apr 6;60:102651. Epub 2021 Apr 6.

Department of Clinical Neurosciences, IRCCS San Raffaele Scientific Institute, Milan, Italy.

Neuropsychological impairments represent a central feature of psychosis-spectrum disorders. It is characterized by a great both within- and between-subjects variability (i.e. Read More

View Article and Full-Text PDF

Seeking sustainable development policies at the municipal level based on the triad of city, economy and environment: evidence from Hunan province, China.

J Environ Manage 2021 Apr 14;290:112554. Epub 2021 Apr 14.

State Key Laboratory of Remote Sensing Science, Jointly Sponsored by Beijing Normal University and Institute of Remote Sensing and Digital Earth of Chinese Academy of Sciences, Beijing, 100875, China; Beijing Engineering Research Center for Global Land Remote Sensing Products, Institute of Remote Sensing Science and Engineering, Faculty of Geographical Science, Beijing Normal University, Beijing, 100875, China.

Keeping urbanization, economy and eco-environment in harmony is a core issue for attaining Sustainable Development Goals (SDGs) in any complex geographical regions. Previous studies mainly focused on seeking the balance between urban expansion levels, eco-environment quality and socioeconomic degree. But the challenges still exist in solving the negative influence of urban expansion that affects eco-environmental and economic development. Read More

View Article and Full-Text PDF

Visible-light induced activation of persulfate by self-assembled EHPDI/TiO photocatalyst toward efficient degradation of carbamazepine.

Sci Total Environ 2021 Apr 9;783:146996. Epub 2021 Apr 9.

State Key Laboratory of Hydraulics and Mountain River Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, China; Sino-German Centre for Water and Health Research, Sichuan University, Chengdu 610065, China. Electronic address:

Removal of pharmaceutical and personal care products from wastewater is very important in water treatment process. Combining photocatalysis with persulfate (PS) could be a good solvent for this problem. Novel perylene diimide derivative (EHPDI) was designed and synthesized. Read More

View Article and Full-Text PDF

Hydrologic and nutrient-driven regime shifts of cyanobacterial and eukaryotic algal communities in a large shallow lake: Evidence from empirical state indicator and ecological network analyses.

Sci Total Environ 2021 Apr 12;783:147059. Epub 2021 Apr 12.

State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.

The detection and prediction of lake ecosystem responses to environmental changes are pressing scientific challenge of major global relevance. Specifically, an understanding of lake ecosystem stability over long-term scales is urgently needed to identify impending ecosystem regime shifts induced by human activities and improve lake ecosystem protection. This study investigated regime shifts in cyanobacterial and eukaryotic algal communities in a large shallow lake over a century in response to nutrient enrichment and hydrologic regulation using evidence from empirical state indicators and ecological network analyses of sedimentary-inferred communities. Read More

View Article and Full-Text PDF

An induced pluripotent stem cell line (CSUi004-A) from skin fibroblasts of a healthy individual.

Stem Cell Res 2021 Apr 8;53:102336. Epub 2021 Apr 8.

Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China; Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; Key Laboratory of Hunan Province in Neurodegenerative Disorders, Central South University, Changsha, Hunan 410008, China. Electronic address:

We established an induced pluripotent stem cell (iPSC) reprogrammed from dermal fibroblasts of a 53-year-old healthy man. Retroviruses expressing Yamanaka factors (OCT4, SOX2, KLF4 and c-MYC) were employed to initiate the reprogramming and were silenced in iPSCs. The generated iPSCs were pluripotent as determined by immunostaining and expression of pluripotency markers. Read More

View Article and Full-Text PDF

A de novo mutation of the SOX10 gene associated with inner ear malformation in a Guangxi family with Waardenburg syndrome type II.

Int J Pediatr Otorhinolaryngol 2021 Apr 14;145:110711. Epub 2021 Apr 14.

Department of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China; Regional Key Laboratory of Early Prevention and Treatment of High-Rise Tumors, Nanning, 530021, China. Electronic address:

Objective: Waardenburg syndrome type 2 (WS2) is a rare neural-crest disorder, characterized by heterochromic irides or blue eyes and sensorineural hearing loss. The aim of this study was to analyze the clinical features and investigate the genetic cause of WS2 in a small family from Guangxi Zhuang Autonomous region.

Methods: Whole-exome sequencing and mutational analysis were used to identify disease-causing genes in this family. Read More

View Article and Full-Text PDF

Exploring the quorum sensing inhibition of isolated chrysin from Penicillium chrysogenum DXY-1.

Bioorg Chem 2021 Apr 8;111:104894. Epub 2021 Apr 8.

Engineering Research Center of Industrial Biocatalysis, Fujian Province University, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Provincial Key Laboratory of Polymer Materials, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education, College of Chemistry and Materials Science, Fujian Normal University, 32 Shangsan Road, Fuzhou 350007, People's Republic of China. Electronic address:

We recently and for the first time reported that ethyl acetate extracts isolated from Penicillium chrysogenum DXY-1 exhibited anti-quorum sensing (anti-QS) activity. Herein, another active molecule in the extracts was identified as chrysin by NMR and MS. A 20 μg/mL dose of chrysin inhibited violacein production regulated by QS in C. Read More

View Article and Full-Text PDF

An improved nightlight threshold method for revealing the spatiotemporal dynamics and driving forces of urban expansion in China.

J Environ Manage 2021 Apr 14;289:112574. Epub 2021 Apr 14.

Shanghai Key Laboratory for Urban Ecological Processes and Eco-Restoration, School of Ecological and Environmental Sciences, East China Normal University, Shanghai, 200041, China; Institute of Eco-Chongming, 3663 N. Zhongshan Rd., Shanghai, 200062, China. Electronic address:

An accurate and efficient extraction of urban extent is important for understanding the dynamics of urban expansion process and for sustainable planning and management of cities. We proposed an improved dynamic nightlight threshold method to model urban extent and to reveal the spatiotemporal dynamics and driving forces of urban expansion. Differing from previous studies, we correct the blooming and over-saturation problems of nighttime light (NTL), and highlight a combination of NTL with urban population data for determining a yearly-continued and city-class-wide threshold for urban mapping. Read More

View Article and Full-Text PDF

High-mobility group box 1 serves as an inflammation driver of cardiovascular disease.

Biomed Pharmacother 2021 Apr 14;139:111555. Epub 2021 Apr 14.

Department of Cardiology, the Third Xiangya Hospital of Central South University, Changsha, Hunan, China. Electronic address:

Cardiovascular disease (CVD) is the most deadly disease, which can cause sudden death, in which inflammation is a key factor in its occurrence and development. High-mobility group box 1 (HMGB1) is a novel nuclear DNA-binding protein that activates innate immunity to induce inflammation in CVD. HMGB1 exists in the cytoplasm and nucleus of different cell types, including those in the heart. Read More

View Article and Full-Text PDF

Indacaterol/glycopyrronium affects lung function and cardiovascular events in patients with chronic obstructive pulmonary diseases: A meta-analysis.

Heart Lung 2021 Apr 13;50(4):532-541. Epub 2021 Apr 13.

Division of Respiratory Medicine, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China. Electronic address:

Background: Bronchodilators are the cornerstone for treating patients with chronic obstructive pulmonary diseases (COPD), although some studies have shown that dual bronchodilators may exacerbate incidence of adverse cardiovascular events. Here, we evaluated the cardiopulmonary safety of indacaterol/glycopyrronium (IND/GLY) using a meta-analysis.

Methods: We searched PubMed, OVID, Cochrane Library and Web of Science databases, using "indacaterol/glycopyrronium", "indacaterol/glycopyrrolate", "IND/GLY", "QVA149", "chronic obstructive pulmonary diseases", "COPD", "chronic obstructive airway disease", "chronic obstructive lung disease" as key words. Read More

View Article and Full-Text PDF

Estimated Glomerular Filtration Rate (eGFR) based on cystatin C was associated with increased risk of hip and proximal humerus fractures in women and decreased risk of hip fracture in men, whereas eGFR based on creatinine was not associated with fracture risk in both sexes: The Tromsø Study.

Bone 2021 Apr 14:115960. Epub 2021 Apr 14.

Women's Health and Perinatalogy Research Group, Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway; Department of Gynecology and Obstetrics, University Hospital of North Norway, Tromsø, Norway; Norwegian Research Centre for Women's Health, Oslo University Hospital, Oslo, Norway. Electronic address:

Purpose: Patients with end-stage kidney disease have an increased fracture risk. Whether mild to moderate reductions in kidney function is associated with increased fracture risk is uncertain. Results from previous studies may be confounded by muscle mass because of the use of creatinine-based estimates of the glomerular filtration rate (eGFRcre). Read More

View Article and Full-Text PDF

Differences in growth of Trypanoplasma borreli in carp serum is dependent on transferrin genotype.

Fish Shellfish Immunol 2021 Apr 14. Epub 2021 Apr 14.

Polish Academy of Sciences, Institute of Ichthyobiology and Aquaculture in Gołysz, Zaborze, 43-520, Chybie, Poland. Electronic address:

Kinetoplastid parasites require transferrin (Tf), being the main source of iron, for growth and multiplication. This group of parasites developed a unique receptor-mediated system for acquiring host Tf which bears no structural homology with the host transferrin receptor. Trypanoplasma borreli, a blood parasite of common carp, probably uses a similar mechanism to sequester iron from host transferrin. Read More

View Article and Full-Text PDF

THE EFFECT OF ERYTHROPOIETIN AND UMBILICAL CORD-DERIVED MESENCHYMAL STEM CELLS ON NERVE REGENERATION IN RATS WITH SCIATIC NERVE INJURY.

J Chem Neuroanat 2021 Apr 14:101958. Epub 2021 Apr 14.

Department of Histology and Embryology, Erciyes University, Faculty of Medicine, 38039, Kayseri, Turkey. Electronic address:

Objective: We aimed to investigate the effects of umbilical cord-derived mesenchymal stem cells and erythropoietin on nerve regeneration in the sciatic nerve 'crush injury' in a rat model.

Methods: Experimental animals were randomly divided into 5 groups: Crush Injury, Sham, Crush Injury + Erythropoietin, Crush Injury + Mesenchymal Stem Cell, Crush Injury + Erythropoietin + Mesenchymal Stem Cell groups. Crush injury made with bulldog clamp. Read More

View Article and Full-Text PDF

Abnormal Development of Cerebral Arteries and Veins in Offspring of Experimentally Preeclamptic Rats: Potential Role in Perinatal Stroke.

Mech Ageing Dev 2021 Apr 14:111491. Epub 2021 Apr 14.

Department of Pediatrics, University of Vermont Larner College of Medicine, Burlington, VT, 05405, USA; Department of Obstetrics, Gynecology & Reproductive Sciences, University of Vermont Larner College of Medicine, Burlington, VT, 05405, USA; Department of Pharmacology, University of Vermont Larner College of Medicine, Burlington, VT, 05405, USA.

Preeclampsia, a hypertensive disorder of pregnancy, complicates up to 10% of all pregnancies and increases the risk for perinatal stroke in offspring. The mechanism of this increase is unknown, but may involve vascular dysfunction. The goal of this study was to evaluate the effect of experimental preeclampsia (ePE) on cerebrovascular function in offspring to eludciate a possible mechanism for this association. Read More

View Article and Full-Text PDF

Deproteinization of caries-affected dentin with chemo-mechanical caries removal agents and its effect on dentin bonding with self-etch adhesives.

J Dent 2021 Apr 14:103665. Epub 2021 Apr 14.

Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Objectives: To evaluate the micro-tensile bond strength (µTBS) of self-etch adhesives (SEA) to normal and caries-affected dentin after smear layer deproteinization with papain enzyme-based and NaOCl-based chemo-mechanical caries removal agents (CRAs) and to compare their efficacy to a 6% NaOCl solution.

Methods: Forty extracted human molars with occlusal carious lesions were randomly divided into four pretreatment groups: no treatment (control), Papacarie for 60 s, Carisolv for 60 s, and 6% NaOCl for 15 s. After pretreatment, Universal Bond Quick ER (UBQ, one-step, 1-SEA) or Clearfil SE Bond 2 (CSE, two-step, 2-SEA) was applied to the pre-treated surface, and built-up with resin composite (Clearfil AP-X). Read More

View Article and Full-Text PDF

The anti-obesity effects exerted by different fractions of Artemisia sphaerocephala Krasch polysaccharide in diet-induced obese mice.

Int J Biol Macromol 2021 Apr 14. Epub 2021 Apr 14.

Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, Shaanxi, People's Republic of China. Electronic address:

Artemisia sphaerocephala Krasch polysaccharide (ASKP) consists of two main fractions, 60P (molecular weight at 551 kDa) and 60S (molecular weight at 39 kDa). The anti-obesity effects of ASKP and its two fractions were investigated in high-fat-diet-fed mice and showed similar capability in efficiently preventing the development of obesity. The final body weight and body weight gain of obesity mice model were reduced by 12. Read More

View Article and Full-Text PDF

Polychlorinated Biphenyl Congener 180 (PCB 180) Regulates Mitotic Clonal Expansion and Enhances Adipogenesis through Modulation of C/EBPβ SUMOylation in Preadipocytes.

Food Chem Toxicol 2021 Apr 14:112205. Epub 2021 Apr 14.

State Key Laboratory of Environmental Chemistry and Eco-Toxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address:

PCB 180 is a typical non-dioxin-like polychlorinated biphenyl (NDL-PCB). It is one of the most prevalent PCB-congeners found in human adipose tissue. However, the role of PCB 180 in obesity remains poorly understood. Read More

View Article and Full-Text PDF

Modeling of Tumor Control Probability in Stereotactic Body Radiation Therapy for Adrenal Tumors.

Int J Radiat Oncol Biol Phys 2021 May;110(1):217-226

Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York.

Purpose: Stereotactic body radiation therapy (SBRT) in the management of adrenal metastases is emerging as a well-tolerated, effective method of treatment for patients with limited metastatic disease. SBRT planning and treatment utilization are widely variable, and publications report heterogeneous radiation dose fractionation schemes and treatment outcomes. The objective of this analysis was to review the current literature on SBRT for adrenal metastases and to develop treatment guidelines and a model for tumor control probability of SBRT for adrenal metastases based on these publications. Read More

View Article and Full-Text PDF

Temporal evolution of the biological response to laser-induced refractive index change (LIRIC) in rabbit corneas.

Exp Eye Res 2021 Apr 14:108579. Epub 2021 Apr 14.

The Institute of Optics, University of Rochester, Rochester, NY, 14627, USA; The Center for Visual Science, University of Rochester, Rochester, NY, 14627, USA; The Flaum Eye Institute, University of Rochester, Rochester, NY, 14642, USA. Electronic address:

Laser induced refractive index change (LIRIC) is a new, non-incisional, non-ablative, femtosecond photo-modification technique being developed for vision correction in humans. Prior, ex-vivo studies showed intra-tissue refractive index change to induce minimal cell death, restricted to the laser focal zone in the corneal stroma, and with no observable damage to the epithelium or endothelium. Here, we used live rabbits to ascertain longer-term consequences of LIRIC in vivo. Read More

View Article and Full-Text PDF

[Congenital coagulation disorders in neurosurgical patients. Literature review and case series].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):91-98

Burdenko Neurosurgical Center, Moscow, Russia.

Congenital coagulation disorders account about 1-2% and can pose a serious risk for neurosurgical patients. Indeed, coagulation management in these patients is essential to ensure normal hemostasis. Analysis of available literature devoted to this issue and case series of neurosurgical patients with congenital coagulation disorders. Read More

View Article and Full-Text PDF
January 2021

[Central neurocytomas: long-term treatment outcomes].

Zh Vopr Neirokhir Im N N Burdenko 2021 ;85(2):5-16

Burdenko Neurosurgical Center, Moscow, Russia.

Central neurocytoma is a rare benign brain tumor. These tumors may be giant and accompanied by compression of ventricular system and surrounding structures. Modern treatment of brain neurocytoma includes extended resection and restoration of normal CSF circulation. Read More

View Article and Full-Text PDF
January 2021

Knockdown of PNO1 inhibits esophageal cancer progression.

Oncol Rep 2021 May 13;45(5). Epub 2021 Apr 13.

Department of Thoracic Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.

The present study aimed to investigate the role of partner of NOB1 homolog (PNO1) in esophageal cancer (EC). The expression levels of PNO1 in EC were primarily analyzed using data obtained from databases. PNO1 expression was also knocked down in EC cells (Eca‑109 and TE1) to determine the biological effects of PNO1 on tumorigenesis and . Read More

View Article and Full-Text PDF

Estimating the Reference Interval from a Fixed Effects Meta-Analysis.

Res Synth Methods 2021 Apr 17. Epub 2021 Apr 17.

1Division of Biostatistics, University of Minnesota, Minneapolis, Minnesota, USA.

A reference interval provides a basis for physicians to determine whether a measurement is typical of a healthy individual. It can be interpreted as a prediction interval for a new individual from the overall population. However, a reference interval based on a single study may not be representative of the broader population. Read More

View Article and Full-Text PDF

The selective cytotoxicity of silver thiosulfate, a silver complex, on MCF-7 breast cancer cells through ROS-induced cell death.

Pharmacol Rep 2021 Apr 17. Epub 2021 Apr 17.

Division of Pharmacokinetics and Pharmacodynamics, Department of Pharmacology, Toxicology and Therapeutics, School of Pharmacy, Showa University, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, 142-8555, Japan.

Background: Silver is a transition metal that is known to be less toxic than platinum. However, only few studies have reported the anticancer effects of some silver complexes and their possibility as an alternative to platinum complex. This study investigated the anticancer effects of the silver thiosulfate complex (STS), [Ag(SO)], consisting of silver and sodium thiosulfate. Read More

View Article and Full-Text PDF

MYRF: A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases.

Neurosci Bull 2021 Apr 17. Epub 2021 Apr 17.

Institute of Life Sciences, Zhejiang Key Laboratory of Organ Development and Regeneration, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 311121, China.

View Article and Full-Text PDF

Comparison between MGI and Illumina sequencing platforms for whole genome sequencing.

Genes Genomics 2021 Apr 17. Epub 2021 Apr 17.

Personalized Genomic Medicine Research Center, KRIBB, 34141, Daejeon, South Korea.

Background: Illumina next generation sequencing (NGS) systems are the major sequencing platform in worldwide next-generation sequencing market. On the other hand, MGI Tech launched a series of new NGS equipment that promises to deliver high-quality sequencing data faster and at lower prices than Illumina's sequencing instruments.

Objective: In this study, we compared the performance of the two platform's major sequencing instruments-Illumina's NovaSeq 6000 and MGI's MGISEQ-2000 and DNBSEQ-T7-to test whether the MGISEQ-2000 and DNBSEQ-T7 sequencing instruments are also suitable for whole genome sequencing. Read More

View Article and Full-Text PDF

Evaluation of sirtuin 1 (SIRT1) levels in autosomal dominant polycystic kidney disease.

Int Urol Nephrol 2021 Apr 17. Epub 2021 Apr 17.

Division of Nephrology, Department of Internal Medicine, Konya Training and Research Hospital, University of Health Sciences, Konya, Turkey.

Purpose: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease and the majority of patients have a PKD-1 or PKD-2 mutation. Sirtuin 1 (SIRT1) has roles in cellular aging, antioxidant activity, cellular proliferation. In an experimental study, inhibition of SIRT1 was found to delay renal cyst development in ADPKD. Read More

View Article and Full-Text PDF

The role of RST1 and RIPR proteins in plant RNA quality control systems.

Plant Mol Biol 2021 Apr 17. Epub 2021 Apr 17.

Biological Research Centre, Institute of Plant Biology, ELKH, Temesvári krt 62, 6726, Szeged, Hungary.

To keep mRNA homeostasis, the RNA degradation, quality control and silencing systems should act in balance in plants. Degradation of normal mRNA starts with deadenylation, then deadenylated transcripts are degraded by the SKI-exosome 3'-5' and/or XRN4 5'-3' exonucleases. RNA quality control systems identify and decay different aberrant transcripts. Read More

View Article and Full-Text PDF

Human umbilical cord-derived mesenchymal stem cells and their chondroprogenitor derivatives reduced pain and inflammation signaling and promote regeneration in a rat intervertebral disc degeneration model.

Mol Cell Biochem 2021 Apr 17. Epub 2021 Apr 17.

Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.

Intervertebral disc (IVD) degeneration is an asymptomatic pathophysiological condition and a strong causative factor of low back pain. There is no cure available except spinal fusion and pain management. Stem cell-based regenerative medicine is being considered as an alternative approach to treat disc diseases. Read More

View Article and Full-Text PDF