78,791 results match your criteria normal lung


C5aR inhibition of non-immune cells suppresses inflammation and maintains epithelial integrity in SARS-CoV-2-infected primary human airway epithelia.

J Allergy Clin Immunol 2021 Apr 11. Epub 2021 Apr 11.

Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Austria. Electronic address:

Background: Excessive inflammation triggered by a hitherto undescribed mechanism is a hallmark of severe SARS-CoV-2 infections and is associated with enhanced pathogenicity and mortality.

Objective: Complement hyper activation promotes lung injury and was observed in patients suffering from MERS-CoV, SARS-CoV-1 and SARS-CoV-2 infections. Therefore, we investigated the very first interactions of primary human airway epithelial cells upon exposure to SARS-CoV-2 in terms of complement C3-mediated effects. Read More

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Micro-costing diagnostics in oncology: from single-gene testing to whole genome sequencing.

Expert Rev Pharmacoecon Outcomes Res 2021 Apr 14. Epub 2021 Apr 14.

Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, GA Utrecht, The Netherlands.

: Predictive diagnostics play an increasingly important role in personalized medicine for cancer treatment. Whole genome sequencing (WGS) based treatment selection is expected to rapidly increase worldwide. This study aimed to calculate and compare the total cost of currently used diagnostic techniques and of WGS in treatment of non-small cell lung carcinoma (NSCLC), melanoma, colorectal cancer (CRC) and gastrointestinal stromal tumor (GIST) in the Netherlands. Read More

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Legacy and Emerging Poly- and Perfluoroalkyl Substances in Finless Porpoises from East China Sea: Temporal Trends and Tissue-Specific Accumulation.

Environ Sci Technol 2021 Apr 14. Epub 2021 Apr 14.

School of Environmental Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China.

Perfluoroalkyl sulfonates (PFSAs), perfluoroalkyl carboxylates (PFCAs), and emerging alternatives and precursors of these compounds were determined in tissues of finless porpoise () collected from East China Sea in 2009-2010 and 2018-2019. The median hepatic concentrations of emerging poly- and perfluoroalkyl substances (PFASs), including 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA), 8:2 chlorinated polyfluorinated ether sulfonate (8:2 Cl-PFESA), 2,3,3,3-tetrafluoro-2-propanoate (HFPO-DA), and 4,8-dioxa-3-perfluorononanoate (ADONA) were 16.2, 2. Read More

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PINK1 Mediates the Protective Effects of Thyroid Hormone T3 in Hyperoxia-induced Lung Injury.

Am J Physiol Lung Cell Mol Physiol 2021 Apr 14. Epub 2021 Apr 14.

Medicine, Duke University School of Medicine, United States.

Introduction: Hyperoxia can lead to respiratory failure and death. Our previous work demonstrates that oxidant and mitochondrial injury plays a critical role in hyperoxia-induced acute lung injury (HALI). Recently, thyroid hormone has been demonstrated to promote mitochondrial survival in other models of lung injury, but its role in hyperoxia is unknown. Read More

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Comprehensive analyses of in multiple cancer types and its association with clinical response to immunotherapy and immune infiltrates.

Ann Transl Med 2021 Mar;9(6):465

Thoracic Surgery Department, The Affiliated Hospital of Qingdao University, Qingdao, China.

Background: The prognostic value of polybromo 1 () gene mutations in clear cell renal carcinoma (CCRCC) with anti-programmed death-ligand 1 (PD-L1) therapy remains controversial, and few studies have reported the impact of mutations in other cancer types.

Methods: The patient information was obtained from cBioPortal and the Tumor Immune Estimation Resource (TIMER) databases. Mann-Whitney U test were used for correlation analysis. Read More

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Bicarbonate Ringer's solution for early resuscitation in hemorrhagic shock rabbits.

Ann Transl Med 2021 Mar;9(6):462

Department of Anesthesiology, the First Medical Center of the Chinese People's Liberation Army (PLA) General Hospital, Beijing, China.

Background: Fluid resuscitation is important for correcting hypovolemia. Isotonic crystalloids are the preferred solution for the initial clinical management of patients with multiple traumas. Bicarbonated Ringer's solution (BRS), offering physiological levels of bicarbonate ions and electrolyte ions, can be used for supplementing missing extracellular fluid and correcting metabolic acidosis. Read More

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COL1A1 is a prognostic biomarker and correlated with immune infiltrates in lung cancer.

PeerJ 2021 30;9:e11145. Epub 2021 Mar 30.

Engineering Laboratory for Digital Telemedicine Service, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Objective: Lung cancer (LC) is one of the top ten malignant tumors and the first leading cause of cancer-related death among both men and women worldwide. It is imperative to identify immune-related biomarkers for early LC diagnosis and treatment.

Methods: Three Gene Expression Omnibus (GEO) datasets were selected to acquire the differentially expressed genes(DEGs) between LC and normal lung samples through GEO2R tools of NCBI. Read More

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[LIM-domain binding protein 2 regulated by mA modification inhibits lung adenocarcinoma cell proliferation ].

Nan Fang Yi Ke Da Xue Xue Bao 2021 Mar;41(3):329-335

Cancer Research Institute, Affiliated Cancer Hospital of Guangzhou Medical University//Guangzhou Key Laboratory of Translational Medicine on Cancer Treatment, Guangzhou 510095, China.

Objective: To investigate the role and expression pattern of LIM-domain binding protein 2 (LDB2) in lung adenocarcinoma.

Objective: We studied the expression pattern of LDB2 in lung adenocarcinoma based on data from the online databases TCGA, GEO and CPTAC, and the results were verified in lung adenocarcinoma tissues and cells using immunohistochemistry, qRT-PCR and Western blotting. The relationship between LDB2 and the prognosis of patients with lung adenocarcinoma was analyzed using GEPIA and GEO databases. Read More

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Early single-stage surgical revascularization of pulmonary artery in unilateral absence of a pulmonary artery.

J Cardiothorac Surg 2021 Apr 13;16(1):80. Epub 2021 Apr 13.

Heart Center, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, 9# Jinsui Road, Guangzhou, 510623, China.

Background: This research aims to summarize the findings of the early single-stage revascularization of remnant pulmonary artery in unilateral absent intrapericardial pulmonary artery.

Methods: We retrospectively analyzed the medical records of 10 patients with unilateral absent pulmonary artery, in which 7 were right and 3 were left, the median age and mean weight at surgery was 4 months and 5.6 kg, respectively. Read More

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Association between elevated serum bilirubin levels with preserved lung function under conditions of exposure to air pollution.

BMC Pulm Med 2021 Apr 13;21(1):119. Epub 2021 Apr 13.

Laboratory of Pulmonary and Allergic Diseases, Tel-Aviv Sourasky Medical Center, Affiliated to the Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, 6423906, Tel-Aviv, Israel.

Background: High serum bilirubin levels have been shown to be associated with an improved pulmonary function test results. Their potential ability to similarly benefit pulmonary function in an environment of polluted air has not been tested. We retrospectively analyzed data of 15,605 apparently healthy individuals in order to evaluate the effect of serum bilirubin levels on forced expiratory volume in 1 s (FEV1). Read More

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Thoracic endometriosis: a case report and review of the literature.

Ann Palliat Med 2021 Mar;10(3):3500-3503

Department of Thoracic Surgery, The Affiliated Hospital of Zunyi Medical University, Guizhou, China.

Thoracic endometriosis is characterized by the presence of normal functioning endometrial tissues in normal pleural, diaphragm, or lung parenchyma, and main clinical symptoms include pneumothorax, menstrual hemothorax, menstrual hemoptysis, and pulmonary nodules. Chest X-ray (CXR), computed tomography (CT), magnetic resonance imaging (MRI), bronchoscopy, and surgical biopsy could be applied to the diagnosis of TE. Both drug therapy and surgical treatment were widely used to treat this disease, but no theory was used to guide the choice of treatment options. Read More

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A Before-and-After Study of Evidence-Based Recommendations for On-Call Bronchoscopy.

Respiration 2021 Apr 13:1-11. Epub 2021 Apr 13.

Department of Respiratory Medicine, Hannover Medical School, Hannover, Germany.

Background: Bronchoscopy is widely used and regarded as standard of care in most intensive care units (ICUs). Data concerning recommendations for on-call bronchoscopy are lacking.

Objectives: Evaluation of recommendations, complications, and outcome of on-call bronchoscopies. Read More

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Investigation on potential biomarkers of hyperprogressive disease (HPD) triggered by immune checkpoint inhibitors (ICIs).

Authors:
J Liu Q Wu S Wu X Xie

Clin Transl Oncol 2021 Apr 13. Epub 2021 Apr 13.

Department of Oncology, Molecular Oncology Research Institute, the First Affiliated Hospital, Fujian Medical University, Chazhong Road No 20, Fuzhou 350005, Fujian, China.

Purpose: This project aimed to survey the clinical characteristics and survivals of hyperprogressive disease (HPD) mediated by immune checkpoint inhibitors (ICIs) in an attempt to explore the potential predictors.

Methods: After searching PubMed, MEDLINE, Google Scholar and Cochrane Library databases, 12 studies incorporating 1766 individuals were enrolled. The data were analyzed with Review manager 5. Read More

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High pretreatment D-dimer level is an independent unfavorable prognostic factor of small cell lung cancer: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25447

Lung Cancer Center, West China Hospital, Sichuan University, Chengdu.

Background: High pretreatment level of D-dimer in small cell lung cancer (SCLC) is commonly encountered, but the impact of high pretreatment D-dimer level on the prognosis of SCLC patients remains undetermined. Therefore, we conducted this meta-analysis focusing specifically on the prognostic value of high pretreatment D-dimer level in SCLC patients comprehensively.

Methods: We searched systematically in PubMed, Embase, and Web of Science for relevant studies published before January 28, 2019. Read More

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Pulmonary Functional Imaging: Part 2-State-of-the-Art Clinical Applications and Opportunities for Improved Patient Care.

Radiology 2021 Apr 13:204033. Epub 2021 Apr 13.

From the Department of Radiology, Penn Medicine, University of Pennsylvania, Philadelphia, Pa (W.B.G.); Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine (SKKU-SOM), Seoul, South Korea (K.S.L.); Department of Radiology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wis (M.L.S.); Departments of Medicine and Medical Biophysics, Robarts Research Institute, Western University, London, Canada (G.P.); Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (J.B.S.); Department of Radiology and Joint Research Laboratory of Advanced Medical Imaging, Fujita Health University School of Medicine, Toyoake, Japan (Y.O.); and Center for Pulmonary Functional Imaging, Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA 02215 (H.H.).

Pulmonary functional imaging may be defined as the regional quantification of lung function by using primarily CT, MRI, and nuclear medicine techniques. The distribution of pulmonary physiologic parameters, including ventilation, perfusion, gas exchange, and biomechanics, can be noninvasively mapped and measured throughout the lungs. This information is not accessible by using conventional pulmonary function tests, which measure total lung function without viewing the regional distribution. Read More

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MicroRNA‑485‑5p suppresses the progression of esophageal squamous cell carcinoma by targeting flotillin‑1 and inhibits the epithelial‑mesenchymal transition.

Oncol Rep 2021 Jun 13;45(6). Epub 2021 Apr 13.

Research Centre, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.

As esophageal squamous cell carcinoma (ESCC) is one of the most frequently diagnosed cancers in Asia, it is crucial to uncover its underlying molecular mechanisms that support its development and progression. Several articles have reported that microRNA (miR)‑485‑5p inhibits the malignant phenotype in a number of cancer types, such as lung, gastric and breast cancer, but to the best of our knowledge, its function in ESCC has not been studied in depth until the present study. It is of great significance to probe the regulatory action and underlying mechanism of miR‑485‑5p in ESCC. Read More

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Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology.

Nat Biotechnol 2021 Apr 12. Epub 2021 Apr 12.

Division of Bioinformatics and Biostatistics, National Center for Toxicological Research, US Food and Drug Administration, Jefferson, AR, USA.

Circulating tumor DNA (ctDNA) sequencing is being rapidly adopted in precision oncology, but the accuracy, sensitivity and reproducibility of ctDNA assays is poorly understood. Here we report the findings of a multi-site, cross-platform evaluation of the analytical performance of five industry-leading ctDNA assays. We evaluated each stage of the ctDNA sequencing workflow with simulations, synthetic DNA spike-in experiments and proficiency testing on standardized, cell-line-derived reference samples. Read More

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Clinical application of a lung cancer organoid (tumoroid) culture system.

NPJ Precis Oncol 2021 Apr 12;5(1):29. Epub 2021 Apr 12.

Department of General Surgery, Kawasaki Medical School, Okayama, Japan.

Despite high expectations for lung tumoroids, they have not been applied in the clinic due to the difficulty of their long-term culture. Here, however, using AO (airway organoid) media developed by the Clevers laboratory, we succeeded in generating 3 lung tumoroid lines for long-term culture (>13 months) from 41 lung cancer cases (primary or metastatic). Use of nutlin-3a was key to selecting lung tumoroids that harbor mutant p53 in order to eliminate normal lung epithelial organoids. Read More

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Abnormal myocardial work in children with Kawasaki disease.

Sci Rep 2021 Apr 12;11(1):7974. Epub 2021 Apr 12.

Department of Paediatric Cardiology, Royal Brompton Hospital, London, SW36NP, UK.

Kawasaki disease (KD) can be associated with high morbidity and mortality due to coronary artery aneurysms formation and myocardial dysfunction. Aim of this study was to evaluate the diagnostic performance of non-invasive myocardial work in predicting subtle myocardial abnormalities in Kawasaki disease (KD) children with coronary dilatation (CADL). A total of 100 patients (age 8. Read More

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Comparison of diagnostic accuracy of digital chest X-ray images between PACS and WhatsApp Messenger in resource poor setting.

Indian J Tuberc 2021 Apr 6;68(2):186-194. Epub 2020 Aug 6.

Department of Respiratory & Sleep Medicine, Medanta the Medicity, Gurgaon, India.

Purpose: Many underserved remote locations without specialists would benefit from the ability to quickly and easily share images of radiographs with trained radiologists using WhatsApp messenger. However, there is limited evidence on the role of WhatsApp messenger for sharing chest x-ray (CXR) images to aid diagnosis and management. The objective of the study was to determine the diagnostic accuracy and inter-observer agreement of WhatsApp messenger images of digital CXR compared to viewing on Picture Archiving and Communication System (PACS) monitor. Read More

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Mechanism of thorium-nitrate and thorium-dioxide induced cytotoxicity in normal human lung epithelial cells (WI26): Role of oxidative stress, HSPs and DNA damage.

Environ Pollut 2021 Mar 23;281:116969. Epub 2021 Mar 23.

Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085, India; Homi Bhabha National Institute, Anushakti Nagar, Mumbai, 400 094, India. Electronic address:

Inhalation represents the most prevalent route of exposure with Thorium-232 compounds (Th-nitrate/Th-dioxide)/Th-containing dust in real occupational scenario. The present study investigated the mechanism of Th response in normal human alveolar epithelial cells (WI26), exposed to Th-nitrate or colloidal Th-dioxide (1-100 μg/ml, 24-72 h). Assessment in terms of changes in cell morphology, cell proliferation (cell count), plasma membrane integrity (lactate dehydrogenase leakage) and mitochondrial metabolic activity (MTT reduction) showed that Th-dioxide was quantitatively more deleterious than Th-nitrate to WI26 cells. Read More

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Quantitative pleural line characterization outperforms traditional lung texture ultrasound features in detection of COVID-19.

J Am Coll Emerg Physicians Open 2021 Apr 2;2(2):e12418. Epub 2021 Apr 2.

Department of Radiology University of Pennsylvania Philadelphia Pennsylvania USA.

Background And Objective: Lung ultrasound is an inherently user-dependent modality that could benefit from quantitative image analysis. In this pilot study we evaluate the use of computer-based pleural line (p-line) ultrasound features in comparison to traditional lung texture (TLT) features to test the hypothesis that p-line thickening and irregularity are highly suggestive of coronavirus disease 2019 (COVID-19) and can be used to improve the disease diagnosis on lung ultrasound.

Methods: Twenty lung ultrasound images, including normal and COVID-19 cases, were used for quantitative analysis. Read More

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Upregulation of GNPNAT1 Predicts Poor Prognosis and Correlates With Immune Infiltration in Lung Adenocarcinoma.

Front Mol Biosci 2021 25;8:605754. Epub 2021 Mar 25.

Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Background: Glucosamine 6-phosphate -acetyltransferase (GNPNAT1) is a key enzyme in the hexosamine biosynthetic pathway (HBP), which functions as promoting proliferation in some tumors, yet its potential biological function and mechanism in lung adenocarcinoma (LUAD) have not been explored.

Methods: The mRNA differential expression of GNPNAT1 in LUAD and normal tissues was analyzed using the Cancer Genome Atlas (TCGA) database and validated by real-time PCR. The clinical value of GNPNAT1 in LUAD was investigated based on the data from the TCGA database. Read More

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Comprehensive Analysis of the Prognostic Role and Mutational Characteristics of m6A-Related Genes in Lung Squamous Cell Carcinoma.

Front Cell Dev Biol 2021 25;9:661792. Epub 2021 Mar 25.

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: There have been limited treatment therapies for lung squamous cell carcinoma (LUSC). M6A-related genes may be the next therapeutic targets for LUSC. In this study, we explored the prognostic role and mutational characteristics of m6A-related genes in LUSC. Read More

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Investigation of a Novel Deep Learning-Based Computed Tomography Perfusion Mapping Framework for Functional Lung Avoidance Radiotherapy.

Front Oncol 2021 24;11:644703. Epub 2021 Mar 24.

Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, Hong Kong.

Functional lung avoidance radiation therapy aims to minimize dose delivery to the normal lung tissue while favoring dose deposition in the defective lung tissue based on the regional function information. However, the clinical acquisition of pulmonary functional images is resource-demanding, inconvenient, and technically challenging. This study aims to investigate the deep learning-based lung functional image synthesis from the CT domain. Read More

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Prognostic Impact of PCK1 Protein Kinase Activity-Dependent Nuclear SREBP1 Activation in Non-Small-Cell Lung Carcinoma.

Front Oncol 2021 26;11:561247. Epub 2021 Mar 26.

Zhejiang Provincial Key Laboratory of Pancreatic Disease of the First Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.

Metabolic enzymes can perform non-metabolic functions and play critical roles in the regulation of a variety of important cellular activities. Phosphoenolpyruvate carboxykinase 1 (PCK1), a gluconeogenesis enzyme, was recently identified as an AKT-regulated protein kinase that phosphorylates INSIG1/2 to promote nuclear SREBP1-dependent lipogenesis. However, the relationship of this regulation with the progression of non-small-cell lung carcinoma (NSCLC) is unclear. Read More

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Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein.

J Adv Res 2021 Mar 27;29:13-22. Epub 2020 Aug 27.

Department of Clinical Nutrition, Shengjing Hospital of China Medical University, Shenyang 110004, China.

Introduction: Intrinsic vitamin D affects the proliferation, apoptosis, invasion, metastasis, and tumorigenesis of lung cancer by regulating tumor signaling pathways. Histidine-rich calcium-binding protein (HRC) maintains Ca homeostasis, which plays crucial roles in the occurrence and development of cancer.

Objectives: Our study aims to investigate the ability of vitamin D in the regulation of HRC and the role of HRC playing in lung cancer. Read More

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Enhanced expression of FGF19 predicts poor prognosis in patients with non-small cell lung cancer.

J Thorac Dis 2021 Mar;13(3):1769-1784

Changzhou Tumor Hospital Affiliated to Soochow University, Changzhou, China.

Background: Lung cancer is one of the most common cancers and a leading cause of cancer-related death worldwide. Although many treatment options exist for lung cancer, some patients still suffer postoperative recurrence, and a consequent reduction of overall survival (OS). Our study aimed to investigate the correlation of FGF19 expression with the clinicopathological features and survival outcomes of non-small cell lung cancer (NSCLC) patients. Read More

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Computed tomography-based visual assessment of chronic obstructive pulmonary disease: comparison with pulmonary function test and quantitative computed tomography.

J Thorac Dis 2021 Mar;13(3):1495-1506

Department of Internal Medicine and Environmental Health Center, School of Medicine, Kangwon National University, Chuncheon, Republic of Korea.

Background: Chronic obstructive pulmonary disease (COPD) has variable subtypes involving mixture of large airway inflammation, small airway disease, and emphysema. This study evaluated the relationship between visually assessed computed tomography (CT) subtypes and clinical/imaging characteristics.

Methods: In total, 452 participants were enrolled in this study between 2012 and 2017. Read More

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Musashi 2 (MSI2) expression as an independent prognostic biomarker in non-small cell lung cancer (NSCLC).

J Thorac Dis 2021 Mar;13(3):1370-1379

Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, PA, USA.

Background: Musashi-2 (MSI2) is a member of RNA-binding protein family that regulates mRNA translation of numerous intracellular targets and influences maintenance of stem cell identity. This study assessed MSI2 as a potential clinical biomarker in non-small cell lung cancer (NSCLC).

Methods: The current study included 40 patients with NSCLC, of whom one presented with stage 1, 14 presented with stage II, 15 presented with stage III, and 10 patients had stage IV. Read More

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