85,549 results match your criteria normal immunoglobulin

Elevated RBP-Jκ and CXCL11 Expression in Colon Cancer is Associated with an Unfavorable Clinical Outcome.

Cancer Manag Res 2021 5;13:3651-3661. Epub 2021 May 5.

Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, 710061, People's Republic of China.

Introduction: This study aims at exploring the expression and significance of recombination signal-binding protein for immunoglobulin kappa J region (RBP-Jκ) and C-X-C motif chemokine 11 (CXCL11) in human colon cancer tissues.

Methods: The RBP-Jκ and CXCL11 expression levels were assessed by immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) in patients with colon cancer, and their prognostic significance was evaluated.

Results: Through analyzing 342 samples of colon cancer patients treated at our institution, increased expression of RBP-Jκ and CXCL11 was found in human colon cancer specimens compared with matched paratumorous normal specimens (<0. Read More

View Article and Full-Text PDF

Delayed-Onset ADA1 (ADA) Deficiency Not Detected by TREC Screen.

Pediatrics 2021 May 11. Epub 2021 May 11.

Division of Allergy and Immunology, Department of Otolaryngology, College of Medicine, The Ohio State University, Columbus, Ohio; and.

A 9-month-old boy presented to a community pediatrician with a recent history of failure to thrive. Workup revealed neutropenia and lymphopenia. Subsequent admission for fever and pneumonia revealed an absolute neutrophil count of 860 and absolute lymphocyte count of 214. Read More

View Article and Full-Text PDF

Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum.

Gut 2021 May 7. Epub 2021 May 7.

Department of Immunology, Medical Research Institute, TMDU, Bunkyo-ku, Tokyo, Japan

Objective: Although immunoglobulin A (IgA) is abundantly expressed in the gut and known to be an important component of mucosal barriers against luminal pathogens, its precise function remains unclear. Therefore, we tried to elucidate the effect of IgA on gut homeostasis maintenance and its mechanism.

Design: We generated various IgA mutant mouse lines using the CRISPR/Cas9 genome editing system. Read More

View Article and Full-Text PDF

Advanced isolated light chain amyloid cardiomyopathy with negative immunofixation and normal free light chain ratio.

ESC Heart Fail 2021 May 7. Epub 2021 May 7.

Division of Cardiology, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, Graz, A-8036, Austria.

Amyloid light chain (AL) cardiomyopathy is the most malignant specific cardiomyopathy. According to international recommendations, it should be ruled out non-invasively using the serum free light chain (FLC) ratio and immunofixation electrophoresis in both serum and urine. Here, we report on a 69-year-old female patient with new-onset heart failure with mid-range ejection fraction. Read More

View Article and Full-Text PDF

Spontaneous reactivation of hepatitis B virus with a frameshift mutation in the precore region in an elderly hepatitis B virus carrier with lifestyle-related diseases.

Clin J Gastroenterol 2021 May 6. Epub 2021 May 6.

Division of Virology, Department of Infection and Immunity, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, 329-0498, Japan.

A 76-year-old woman with spontaneous reactivation of hepatitis B virus (HBV) without any immunosuppressants who had been successfully treated with tenofovir alafenamide fumarate (TAF) was reported. The patient was admitted to our hospital because of acute exacerbation of the liver function and jaundice. She had been found to have chronic HBV infection with a normal liver function and had been treated for lifestyle-related diseases, such as diabetes mellitus, dyslipidemia and hypertension, for over 10 years at a local clinic. Read More

View Article and Full-Text PDF

Cardiac Troponin T: The Impact of Posttranslational Modifications on Analytical Immunoreactivity in Blood up to the Excretion in Urine.

Adv Exp Med Biol 2021 ;1306:41-59

Unit of Clinical Chemistry, Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.

Cardiac troponin T (cTnT) is a sensitive and specific biomarker for detecting cardiac muscle injury. Its concentration in blood can be significantly elevated outside the normal reference range under several pathophysiological conditions. The classical analytical method in routine clinical analysis to detect cTnT in serum or plasma is a single commercial immunoassay, which is designed to quantify the intact cTnT molecule. Read More

View Article and Full-Text PDF

Immunomodulatory effects of standardized extract of val. on cytokines, antibody and delayed-type hypersensitivity response in Wistar rats.

Res Pharm Sci 2021 Feb 30;16(1):16-25. Epub 2020 Dec 30.

Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Indonesia.

Background And Purpose: Recently, we have highlighted the immunomodulatory activity of Val. on phagocytosis ability. The current study was conducted to determine the immunomodulatory effects of the standardized extract of rhizomes by and studies. Read More

View Article and Full-Text PDF
February 2021

Lupus acute cardiomyopathy is highly responsive to intravenous immunoglobulin treatment: Case series and literature review.

Medicine (Baltimore) 2021 May;100(18):e25591

Department of Internal Medicine E, Meir Medical Center, Kfar Saba.

Introduction: Intravenous immunoglobulin (IVIg) is currently used with considerable success for the treatment of many autoimmune diseases, including systemic lupus erythematosus (SLE). Among its various indications, IVIg has also been found to be beneficial in myocarditis, whether or not it is associated with an autoimmune disease. Nevertheless, data regarding IVIg treatment for myocarditis/cardiomyopathy in patients with SLE are sparse. Read More

View Article and Full-Text PDF

A case report of atypical Kawasaki disease presented with severe elevated transaminases and literature review.

BMC Infect Dis 2021 May 4;21(1):415. Epub 2021 May 4.

Department of Paediatrics, ShaoXing KeQiao Women And Children's Hospital, ShaoXing, 312030, Zhejiang Province, PR China.

Background: Kawasaki disease (KD) is the most common cause of acquired heart disease among children in developed countries, in which the resulting coronary artery (CA) abnormalities cause myocardial ischemia, infarction, and death. Prompt diagnosis was essential, and supplemental information should be used to assist the diagnosis when classical clinical criteria are incomplete. The elevated levels of serum transaminases in most KD patients are mild. Read More

View Article and Full-Text PDF

Changes in Thyroid Stimulating Hormone Receptor Antibody Levels Following Total Thyroidectomy or Radioiodine Therapy in Patients with Refractory Graves' Disease.

Thyroid 2021 May 5. Epub 2021 May 5.

Samsung Medical Center, 36626, Division of Endocrinology and Metabolism, Department of Medicine, Gangnam-gu, Seoul, Korea (the Republic of).

Background: The actions of thyrotropin-binding inhibitory immunoglobulins (TBIIs) against thyrotropin receptors in thyroid follicular cells have been studied as important etiological factors in Graves' disease (GD). The purpose of this study was to investigate changes in the TBII levels of patients undergoing total thyroidectomy (TTx) or radioactive iodine (RAI) therapy for GD refractory to antithyroid drugs (ATD).

Methods: We enrolled patients who underwent TTx or RAI for GD with previous ATD use between January 2011 and December 2017 at the Samsung Seoul Hospital in Seoul, Korea. Read More

View Article and Full-Text PDF

Aberrant Immunoglobulin G Glycosylation in Multiple Sclerosis.

J Neuroimmune Pharmacol 2021 May 3. Epub 2021 May 3.

Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

A hallmark of the inflammatory response in multiple sclerosis (MS) is the presence of intrathecal Immunoglobulin G (IgG) antibodies and oligoclonal bands (OCBs). The biological activity of IgGs is modulated by changes in glycosylation. Using multiple immunoassays with common lectins for sialylation and galactosylation, we investigated levels of IgG glycosylation in 28 MS and 37 control sera as well as paired CSF and serum. Read More

View Article and Full-Text PDF

Galcanezumab for the prevention of high frequency episodic and chronic migraine in real life in Italy: a multicenter prospective cohort study (the GARLIT study).

J Headache Pain 2021 May 3;22(1):35. Epub 2021 May 3.

Headache and Pain Unit, IRCCS San Raffaele Pisana, Rome, Italy.

Background: The clinical benefit of galcanezumab, demonstrated in randomized clinical trials (RCTs), remains to be quantified in real life. This study aimed at evaluating the effectiveness, safety and tolerability of galcanezumab in the prevention of high-frequency episodic migraine (HFEM) and chronic migraine (CM) in a real-life setting.

Methods: This multicenter prospective observational cohort study was conducted between November 2019 and January 2021 at 13 Italian headache centers. Read More

View Article and Full-Text PDF

LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis.

Scand J Gastroenterol 2021 May 3:1-15. Epub 2021 May 3.

Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, PA, USA.

Recovery of damaged mucosal surfaces following inflammatory insult requires diverse regenerative mechanisms that remain poorly defined. Previously, we demonstrated that the reparative actions of Trefoil Factor 3 (TFF3) depend upon the enigmatic receptor, leucine rich repeat and immunoglobulin-like domain containing nogo receptor 2 (LINGO2). This study examined the related orphan receptor LINGO3 in the context of intestinal tissue damage to determine whether LINGO family members are generally important for mucosal wound healing and maintenance of the intestinal stem cell (ISC) compartment needed for turnover of mucosal epithelium. Read More

View Article and Full-Text PDF

SERUM GLP-2 is Increased in Association with Excess Gestational Weight Gain.

Am J Perinatol 2021 May 3. Epub 2021 May 3.

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

Objective:  Obesity in pregnancy bears unique maternal and fetal risks. Obesity has also been associated with chronic inflammation, including elevated serum levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Higher serum lipopolysaccharide (LPS) levels have been implicated in driving this inflammation, a phenomenon called metabolic endotoxemia (ME). Read More

View Article and Full-Text PDF

Clinical relevance of serum immunoglobulin G4 in glucocorticoid therapy of Graves' ophthalmopathy.

Clin Endocrinol (Oxf) 2021 May 3. Epub 2021 May 3.

Department of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, P.R. China.

Objective: Previous studies suggested IgG4 levels were associated with the development of Graves' ophthalmopathy (GO). The present study investigated the role of IgG4 levels in glucocorticoid (GC) treatment in GO patients.

Methods: Sixty-nine GO patients were enrolled. Read More

View Article and Full-Text PDF

A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression.

Biomed Res Int 2021 10;2021:5541780. Epub 2021 Apr 10.

Department of Integrative Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China.

Objective: This study is aimed at investigating the enriched functions of polymeric immunoglobulin receptor (PIGR) and its correlations with liver fibrosis stage.

Methods: PIGR mRNA expression in normal liver, liver fibrosis, hepatic stellate cells (HSCs), and hepatitis virus infection samples was calculated in Gene Expression Omnibus (GEO) and Oncomine databases. Enrichment analysis of PIGR-related genes was conducted in Metascape and Gene Set Enrichment Analysis (GSEA). Read More

View Article and Full-Text PDF

Chronic Exposure to Continuous Brightness or Darkness Modulates Immune Responses and Ameliorates the Antioxidant Enzyme System in Male Rats.

Amira Moustafa

Front Vet Sci 2021 15;8:621188. Epub 2021 Apr 15.

Department of Physiology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt.

Circadian rhythms are considered vital regulators of immune functions. This study aims to elucidate the effects of chronic circadian disruption on immune functions, clock genes expression, and antioxidant enzymes levels in lymphoid tissues. Adult male Sprague-Dawley rats were subjected to a normal light/dark cycle or either continuous light (LL) or continuous dark (DD) for 8 weeks. Read More

View Article and Full-Text PDF

[Intervention mechanism of moxa-cone moxibustion at Shu- and Mu-acupoints on the expression of RORγt/Foxp3 in asthma mice: an analysis based on PI3K signaling pathway].

Zhen Ci Yan Jiu 2021 Apr;46(4):272-7

College of Pharmacy, Guangxi University of Chinese Medicine, Nanning 530200, China.

Objective: To explore the effect of moxa-cone moxibustion at "Feishu" (BL13) and "Zhongfu" (LU1) on the contents of related inflammatory factors in serum and bronchoalveolar lavage fluid (BALF), and the expression of phosphatidy-linositol-3-kinase (PI3K), retinoic acid related orphan receptor γt (RORγt) and fork/wing helix transcription factor 3 (Foxp3) in lung tissue in asthma mice.

Methods: Sixty male Balb/c mice were divided into normal, model, LY294002 (an inhibitor of PI3K, LY), electroacupuncture (EA) and moxa-cone moxibustion (moxibustion) groups (=12 in each group). The asthma model was established by intraperitoneal injection of ovalbumin sensitization. Read More

View Article and Full-Text PDF

Vaccine-induced prothrombotic immune thrombocytopenia (VIPIT): Consider IVIG batch in the treatment.

J Thromb Haemost 2021 May 1. Epub 2021 May 1.

Institut National de la Santé et de la Recherche Médicale, Centre de Recherché des Cordeliers, Sorbonne Université, Université de Paris, 75006, Paris, France.

Various vaccines have been developed recently to protect the population from corona virus disease-19 (COVID-19). Although the beneficial effects of vaccines outweigh the risks associated with vaccination, an unusual but life threatening thrombosis and thrombocytopenia has been observed in certain individuals who received recombinant adenoviral vector encoding spike protein of SARS-CoV-2 ChAdOx1 nCov-19 (AstraZeneca) . Exploration of underlying mechanisms have identified that ChAdOx1 nCov-19 vaccine-induced platelet-activating antibodies against platelet factor 4 (PF4) are responsible for these adverse events . Read More

View Article and Full-Text PDF

Pleuritis associated with immunoglobulin G4-related disease under normal thoracoscopic findings: a case report.

J Med Case Rep 2021 Apr 30;15(1):241. Epub 2021 Apr 30.

Department of Diagnostic Pathology, Kyoto University Hospital, 54 Shougoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Immunoglobulin G4 (IgG4)-related disease is a chronic inflammatory disease that was recognized in 2011. Pleuritis associated with IgG4-related disease is rare and can be difficult to diagnose. Although there have been previous reports on pleuritis associated with IgG4-related disease by thoracoscopic findings, this is the first to observe pleuritis with IgG4-related disease from normal pleural thoracoscopic findings. Read More

View Article and Full-Text PDF

Immune Modulatory Activities of Arginyl-Fructose (AF) and AF-Enriched Natural Products in In-Vitro and In-Vivo Animal Models.

Molecules 2021 Apr 13;26(8). Epub 2021 Apr 13.

Department of Food and Nutrition, Hannam University, Daejeon 34054, Korea.

The immune system plays an important role in maintaining body homeostasis. Recent studies on the immune-enhancing effects of ginseng saponins have revealed more diverse mechanisms of action. Maillard reaction that occurs during the manufacturing processes of red ginseng produces a large amount of Amadori rearrangement compounds (ARCs), such as arginyl-fructose (AF). Read More

View Article and Full-Text PDF

Therapeutic Effects of Decursin and Nakai Root Extract in Gerbil Brain after Transient Ischemia via Protecting BBB Leakage and Astrocyte Endfeet Damage.

Molecules 2021 Apr 9;26(8). Epub 2021 Apr 9.

Department of Biomedical Science and Research Institute for Bioscience and Biotechnology, Hallym University, Chuncheon 24252, Korea.

Nakai root contains decursin which exerts beneficial properties such as anti-amnesic and anti-inflammatory activities. Until now, however, the neuroprotective effects of decursin against transient ischemic injury in the forebrain have been insufficiently investigated. Here, we revealed that post-treatment with decursin and the root extract saved pyramidal neurons in the hippocampus following transient ischemia for 5 min in gerbil forebrain. Read More

View Article and Full-Text PDF

V-Set and Immunoglobulin Domain-Containing 1 (VSIG1), Predominantly Expressed in Testicular Germ Cells, Is Dispensable for Spermatogenesis and Male Fertility in Mice.

Animals (Basel) 2021 Apr 7;11(4). Epub 2021 Apr 7.

College of Pharmacy, Catholic University of Daegu, Gyeongsan-si 38430, Korea.

To elucidate the functional role of V-set and immunoglobulin domain-containing 1 (VSIG1) in spermatogenesis and fertilization, we knocked out (KO) VSIG1 in a mouse embryo using CRISPR/Cas9 (Clustered regularly interspaced short palindromic repeat/CRISPR-associated protein 9) -mediated genome editing. Reverse transcription PCR was performed using cDNA synthesized from VSIG1 KO testis RNA. Although Western blot analysis using a specific antibody to VSIG1 confirmed VSIG1 protein defects in the KO mice, hematoxylin-eosin staining analysis was similar in the KO and wild-type mice. Read More

View Article and Full-Text PDF

Anti-glomerular basement membrane disease mediated by IgG and IgA: a case report.

Ren Fail 2021 Dec;43(1):774-778

Department of Nephrology, China-Japan Friendship Hospital, Beijing, People's Republic of China.

Background: Anti-glomerular basement membrane (anti-GBM) disease is a rare autoimmune condition responsible for rapidly progressive glomerulonephritis. This disease is usually mediated by IgG autoantibodies against the noncollagenous domain of the α3(IV) collagen chain. In rare cases, IgA or IgM anti-GBM antibodies are involved. Read More

View Article and Full-Text PDF
December 2021

Effect of Weight Reduction on Treatment Outcomes for Patients with Atopic Dermatitis.

Ann Dermatol 2020 Aug 30;32(4):319-326. Epub 2020 Jun 30.

Department of Dermatology, Hallym University Kangnam Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Background: Several epidemiological studies have shown that the atopic tendency increases in the obese population.

Objective: The aim of this study was to confirm the effect of weight reduction on improvement of atopic dermatitis (AD) symptoms and to investigate the relationship between AD severity and the level of serum adipokines.

Methods: Forty subjects who were AD outpatients were recruited for this study. Read More

View Article and Full-Text PDF

Bortezomib-induced glomerular microangiopathy complicated with monoclonal immunoglobulin deposition disease.

CEN Case Rep 2021 Apr 28. Epub 2021 Apr 28.

Department of Nephrology, Japan Community Health Care Organization Sendai Hospital, 3-16-1, Tsutsumimachi, Aoba-Ku, Sendai, Miyagi, 981-8501, Japan.

A 75-year-old man admitted with IgG λ-type myeloma with creatinine level of 2.3 mg/dL. Serum lactate dehydrogenase level and platelet count were normal. Read More

View Article and Full-Text PDF

Immunodeficiency, Centromeric Region Instability, and Facial Anomalies Syndrome (ICF) in a Boy with Variable Clinical and Immunological Presentations.

Iran J Allergy Asthma Immunol 2021 Apr 17;20(2):249-254. Epub 2021 Apr 17.

Department of Allergy and Clinical Immunology, Iran University of Medical Sciences, Tehran, Iran.

Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome is a rare primary immunodeficiency disorder characterized by recurrent infections and low immunoglobulin levels due to variable combined immunodeficiency, and centromeric region instability, and facial dysmorphism. We describe a 12-year-old boy with recurrent respiratory tract infections, facial anomalies, scoliosis, and psychomotor retardation. He had recurrent pneumonia with low serum IgG and IgM levels during infancy and preschool age. Read More

View Article and Full-Text PDF

A case of multisystem inflammatory syndrome in children in a japanese boy: with discussion of cytokine profile.

Mod Rheumatol Case Rep 2021 Apr 27:1-11. Epub 2021 Apr 27.

Department of Pediatrics, Graduate School of Medicine, Yokohama City University, Yokohama, Japan.

The new disease concept of multisystem inflammatory syndrome in children (MIS-C), which is a systemic inflammatory syndrome with multiple organ involvement after SARS-CoV2 infection, was established in 2020. MIS-C is common in Hispanic and black children in Europe and North America, with few reports in East Asians. A significant portion of patients with MIS-C develop Kawasaki disease (KD)-like symptoms. Read More

View Article and Full-Text PDF

Stepwise generation of AID knock-in and conditional knockout mice from single gene-targeting event.

Int Immunol 2021 Apr 27. Epub 2021 Apr 27.

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Activation-induced cytidine deaminase (AID) encoded by the Aicda gene initiates class-switch recombination and somatic hypermutation of immunoglobulin genes. In addition to this function, AID is also implicated in the epigenetic regulation in pluripotent stem cells and in the oncogenesis of lymphoid and non-lymphoid origins. To examine AID's role in specific cell types, we developed mouse strains of conditional knockout (Aicda-FL) and knock-in with red-fluorescent protein gene (RFP) inserted into the Aicda locus (Aicda-RFP). Read More

View Article and Full-Text PDF

A Rare Case of Pembrolizumab-Induced Dermatomyositis in a Patient with Cancer of Unknown Primary Origin.

Am J Case Rep 2021 Apr 27;22:e930286. Epub 2021 Apr 27.

Department of Respiratory Medicine, Hamanomachi Hospital, Fukuoka City, Fukuoka, Japan.

BACKGROUND Pembrolizumab is a humanized monoclonal antibody against programmed cell death-1 protein. Pembrolizumab sometimes causes immune-related adverse events (irAEs). Dermatomyositis is a rare irAE of immune checkpoint inhibitors. Read More

View Article and Full-Text PDF