15,345 results match your criteria normal cox


Defining the risk profile of women with stage 1 hypertension: A time to event analysis.

Am J Obstet Gynecol MFM 2021 Apr 17:100376. Epub 2021 Apr 17.

Department of Obstetrics and Gynecology, Washington University in St. Louis School of Medicine, St. Louis, MO.

Background: Chronic hypertension complicates up to 5% of pregnancies and is increasing in prevalence. Women with hypertension have increased risks of serious maternal morbidity and mortality in pregnancy including the development of preeclampsia. In 2017, new guidelines reclassified blood pressure into four categories: normal (<120/<80 mmHg), elevated (120-129/<80 mmHg), stage 1 hypertension (130-139/80-89 mmHg), and stage 2 hypertension (>140/>90 mmHg). Read More

View Article and Full-Text PDF

Body mass index and absolute lymphocyte count predict disease-free survival in Korean breast cancer patients.

Br J Cancer 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: Our study evaluated the association between body mass index (BMI) and absolute lymphocyte count (ALC) in breast cancer patients and healthy females. Additionally, we determined the prognostic value of these factors in breast cancer.

Methods: We retrospectively identified 1225 primary invasive breast cancer patients and 35,991 healthy females. Read More

View Article and Full-Text PDF

Autonomic Imbalance and Risk of Dementia and Stroke: The Framingham Study.

Stroke 2021 Apr 20:STROKEAHA120030601. Epub 2021 Apr 20.

The Framingham Study, MA (K.D.-P., A.S.B., S.S.).

Background And Purpose: The autonomic nervous system has been implicated in stroke and dementia pathophysiology. High resting heart rate and low heart rate variability indicate the effect of autonomic imbalance on the heart. We examined the associations of resting heart rate and heart rate variability with incident stroke and dementia in a community-based cohort of middle- and old-aged adults. Read More

View Article and Full-Text PDF

Association of Skeletal Maturity and Injury Risk in Elite Youth Soccer Players: A 4-Season Prospective Study With Survival Analysis.

Orthop J Sports Med 2021 Mar 31;9(3):2325967121999113. Epub 2021 Mar 31.

Department of Sport and Physical Activity, Edge Hill University, Ormskirk, UK.

Background: The association between injury risk and skeletal maturity in youth soccer has received little attention.

Purpose: To prospectively investigate injury patterns and incidence in relation to skeletal maturity in elite youth academy soccer players and to determine the injury risks associated with the skeletal maturity status, both overall and to the lower limb apophysis.

Study Design: Descriptive epidemiology study. Read More

View Article and Full-Text PDF

Identification of a Gene Prognostic Signature for Oral Squamous Cell Carcinoma by RNA Sequencing and Bioinformatics.

Biomed Res Int 2021 1;2021:6657767. Epub 2021 Apr 1.

Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China.

Objectives: Oral squamous cell carcinoma (OSCC) is the most common oral cancer and has a poor prognosis. We aimed to identify new biomarkers or potential therapeutic targets for OSCC.

Materials And Methods: Four pairs of tumor and adjacent normal tissues were collected from OSCC patients, and differentially expressed genes (DEGs) were screened via high-throughput RNA sequencing (RNA-seq). Read More

View Article and Full-Text PDF

A Novel Defined Risk Signature of the Ferroptosis-Related Genes for Predicting the Prognosis of Ovarian Cancer.

Front Mol Biosci 2021 1;8:645845. Epub 2021 Apr 1.

The Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Ferroptosis is an iron-dependent, regulated form of cell death, and the process is complex, consisting of a variety of metabolites and biological molecules. Ovarian cancer (OC) is a highly malignant gynecologic tumor with a poor survival rate. However, the predictive role of ferroptosis-related genes in ovarian cancer prognosis remains unknown. Read More

View Article and Full-Text PDF

Three Immune-Related Prognostic mRNAs as Therapeutic Targets for Pancreatic Cancer.

Front Med (Lausanne) 2021 1;8:649326. Epub 2021 Apr 1.

Department of Hematology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Pancreatic cancer is a highly lethal malignancy globally. This study aimed to probe and validate immune-related prognostic mRNAs as therapeutic targets for pancreatic cancer. Gene transcriptome data of pancreatic cancer and normal pancreas were retrieved from TCGA-GTEx projects. Read More

View Article and Full-Text PDF

Construction of a Prognostic Immune-Related LncRNA Risk Model for Lung Adenocarcinoma.

Front Cell Dev Biol 2021 18;9:648806. Epub 2021 Mar 18.

Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China.

Background: Lung adenocarcinoma (LUAD) originates mainly from the mucous epithelium and glandular epithelium of the bronchi. It is the most common pathologic subtype of non-small cell lung cancer (NSCLC). At present, there is still a lack of clear criteria to predict the efficacy of immunotherapy. Read More

View Article and Full-Text PDF

Identification of IFN-Induced Transmembrane Protein 1 With Prognostic Value in Pancreatic Cancer Using Network Module-Based Analysis.

Front Oncol 2021 22;11:626883. Epub 2021 Mar 22.

Department of Radiation Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Despite improvements reported in diagnosis and treatments in recent decades, pancreatic cancer is still characterized by poor prognosis and low survival rate among solid tumors. Intensive interests have grown in exploring novel predictive biomarkers, aiming to enhance the efficiency in early detection and treatment prognosis. In this study, we identified the differentially expressed genes (DEGs) in pancreatic cancer by analyzing five gene expression profiles and established the functional modules according to the functional interaction (FI) network between the DEGs. Read More

View Article and Full-Text PDF

The Gene Family Serves as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma.

Front Oncol 2021 31;11:620126. Epub 2021 Mar 31.

The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.

The cysteine-serine-rich nuclear protein () family has prognostic value for various cancers. However, the association between this proteins and prognosis of clear cell renal cell carcinoma (ccRCC) remains unclear. This study aimed to determine the prognostic value of the family for patients with ccRCC. Read More

View Article and Full-Text PDF

Incidence and risk factors of anti-tuberculosis drug induced liver injury (DILI): Large cohort study involving 4652 Chinese adult tuberculosis patients.

Liver Int 2021 Apr 18. Epub 2021 Apr 18.

NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK.

Background And Aims: Anti-tuberculosis drugs remain important causes of drug-induced liver injury (DILI) worldwide. Adverse drug reactions reduce the effectiveness of treatment. We aimed to determine the incidence and risk factors associated with anti-tuberculosis DILI (ATDILI). Read More

View Article and Full-Text PDF

Survival and oncologic outcomes of complete transurethral resection of bladder tumor prior to neoadjuvant chemotherapy for muscle-invasive bladder cancer.

Urol Oncol 2021 Apr 14. Epub 2021 Apr 14.

Department of Urology, Columbia University Irving Medical Center,NY.

Objectives: Prior studies have shown that pathologic complete response at radical cystectomy, a significant prognostic factor, can be attributed to both neoadjuvant chemotherapy (NAC) and high-quality transurethral resections (TURBT) prior to NAC. It remains unclear whether the visual completeness of TURBT prior to NAC plays an important role in subsequent outcomes. We sought to assess the association of completeness of TURBT prior to NAC with response and survival outcomes. Read More

View Article and Full-Text PDF

Prognostic Significance of Red Cell Distribution Width in Advanced Non-Small Cell Lung Cancer Patients.

Clin Lab 2021 Apr;67(4)

Background: Red blood cell distribution width (RDW) is a parameter reported in blood routine examination, and has been reported as an inflammatory biomarker. The objective of this study was to investigate the significance of RDW in NSCLC patients with EGFR mutations.

Methods: The clinical data of 102 patients with NSCLC who underwent radical resection surgery in the First Affiliated Hospital of Wenzhou Medical University from December 2012 to November 2017 were collected. Read More

View Article and Full-Text PDF

Establishment of a Novel Risk Score System of Immune Genes Associated With Prognosis in Esophageal Carcinoma.

Front Oncol 2021 30;11:625271. Epub 2021 Mar 30.

Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: Few studies have addressed the role of immune-related genes in the survival and prognosis of different esophageal cancer (EC) sub-types. We established two new prognostic model indexes by bioinformatics analysis to select patients with esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) who may benefit from immunotherapy.

Methods: Based on TCGA and ImmPort data sets, we screened immune genes differentially expressed between tumor and normal tissues in ESCC and EAC and analyzed the relationship between these genes and patient survival outcomes. Read More

View Article and Full-Text PDF

The diagnostic and prognostic value of H2AFY in hepatocellular carcinoma.

BMC Cancer 2021 Apr 15;21(1):418. Epub 2021 Apr 15.

Department of Technology Education Training, Luzhou People's Hospital, Section 2 of JiuGu Avenue, Jiangyang District, Luzhou, 646000, Sichuan, People's Republic of China.

Background: The potential correlation between H2AFY (also known as MacroH2A1) and the clinical characteristics of hepatocellular carcinoma (HCC) patients was analysed through gene expression profiles and clinical data in The Cancer Genome Atlas (TCGA) database, and the diagnostic and prognostic value of H2AFY in HCC was discussed.

Methods: The gene expression data of HCC and the corresponding clinical characteristics of HCC patients were downloaded from the TCGA database. The differences in H2AFY in normal liver tissues and HCC were analysed. Read More

View Article and Full-Text PDF

Survival time prediction by integrating cox proportional hazards network and distribution function network.

BMC Bioinformatics 2021 Apr 15;22(1):192. Epub 2021 Apr 15.

The Institute for Molecular Imaging and Theranostics, Chonnam National University Medical School, Jeonnam, South Korea.

Background: The Cox proportional hazards model is commonly used to predict hazard ratio, which is the risk or probability of occurrence of an event of interest. However, the Cox proportional hazard model cannot directly generate an individual survival time. To do this, the survival analysis in the Cox model converts the hazard ratio to survival times through distributions such as the exponential, Weibull, Gompertz or log-normal distributions. Read More

View Article and Full-Text PDF

Clinical characteristics and prognostic analysis of Lung Cancer patients with Hypercoagulability: A single-center, retrospective, real-world study.

J Cancer 2021 19;12(10):2968-2974. Epub 2021 Mar 19.

Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, 100010, China.

We explored the clinical regularity and prognosis of lung carcinoma (LC) patients with hypercoagulability, which is often associated with the occurrence and development of tumors. This retrospective study analyzed 624 LC patients diagnosed from 2010-2017 in the Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, China. Kaplan-Meier analysis was used to estimate survival and the log-rank test was used to identify differences in survival between groups. Read More

View Article and Full-Text PDF

Construction of miRNA-mRNA Regulatory Network and Prognostic Signature in Endometrial Cancer.

Onco Targets Ther 2021 6;14:2363-2378. Epub 2021 Apr 6.

Department of Gynecology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, People's Republic of China.

Introduction: This bioinformatic study confirmed a new miRNA-mRNA regulatory network and a prognostic signature in endometrial cancer (EC).

Materials And Methods: We downloaded RNA-seq and miRNA-seq data of EC from the TCGA database, then used EdegR package to screen differentially expressed miRNAs and mRNAs (DE-miRNAs and DE-mRNAs). Then, we constructed a regulatory network of EC-associated miRNAs and hub genes by Cytoscape, and determined the expression of unexplored miRNAs in EC tissues and normal adjacent tissues by quantitative Real-Time PCR (qRT-PCR). Read More

View Article and Full-Text PDF

Association Analysis of Hyperlipidemia with the 28-Day All-Cause Mortality of COVID-19 in Hospitalized Patients.

Chin Med Sci J 2021 Mar;36(1):17-26

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430071, China.

Objective This study aimed to determine the association of hyperlipidemia with clinical endpoints among hospitalized patients with COVID-19, especially those with pre-existing cardiovascular diseases (CVDs) and diabetes. Methods This multicenter retrospective cohort study included all patients who were hospitalized due to COVID-19 from 21 hospitals in Hubei province, China between December 31, 2019 and April 21, 2020. Patients who were aged < 18 or ≥ 85 years old, in pregnancy, with acute lethal organ injury (e. Read More

View Article and Full-Text PDF

Metabolic Syndrome in Obesity: Treatment Success and Adverse Pregnancy Outcomes with Ovulation Induction in Polycystic Ovary Syndrome.

Am J Obstet Gynecol 2021 Apr 11. Epub 2021 Apr 11.

Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK; Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences Center.

Objective: Obesity is common in women with polycystic ovary syndrome (PCOS). PCOS and obesity are associated with reduced fertility. Metabolic syndrome's (MetS) effect on infertility treatment success and pregnancy outcomes in women with PCOS undergoing ovulation induction (OI) has not been investigated. Read More

View Article and Full-Text PDF

Identification and validation of a five apoptosis-related genes signature for prediction of disease-free survival for testicular germ cell tumors.

Transl Androl Urol 2021 Mar;10(3):1250-1272

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

Background: More and more studies have paid attention to the role of apoptosis in tumorigenesis. A variety of apoptosis-related genes (ARGs) are related to tumor progression and resistance to chemotherapy drugs. Therefore, this study aims to establish a prognostic marker for ARG-based testicular germ cell tumors (TCGT). Read More

View Article and Full-Text PDF

C-C motif chemokine ligand 2/C-C receptor 2 is associated with glioma recurrence and poor survival.

Exp Ther Med 2021 Jun 26;21(6):564. Epub 2021 Mar 26.

Department of Radiation Oncology, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China.

Several studies have explored the mechanisms of C-C motif chemokine ligand (CCL)2/CC receptor (R)2 function in tumorigenesis and inflammation. However, little is known about the role of CCL2/CCR2 in tumor recurrence, especially after radiotherapy. The present study aimed to determine the association between CCL2/CCR2 and glioma relapse. Read More

View Article and Full-Text PDF

Characteristics and prognostic value of potential dependency genes in clear cell renal cell carcinoma based on a large-scale CRISPR-Cas9 and RNAi screening database DepMap.

Int J Med Sci 2021 11;18(9):2063-2075. Epub 2021 Mar 11.

Department of Urology, School of Medicine, Xinhua Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200092, P.R. China.

Background: Large-scale loss-of-function screening database such as Cancer Dependency Map (Depmap) provide abundant resources. Investigation of these potential dependency genes from human cancer cell lines in the real-world patients cohort would evaluate their prognostic value thus facilitate their clinical application and guide drug development.

Methods: A few genes were selected from top clear cell renal cell carcinoma (ccRCC) lineage preferential dependency candidates from Depmap. Read More

View Article and Full-Text PDF

Greater variability in lipid measurements associated with kidney diseases in patients with type 2 diabetes mellitus in a 10-year diabetes cohort study.

Sci Rep 2021 Apr 13;11(1):8047. Epub 2021 Apr 13.

Department of Family Medicine and Primary Care, The University of Hong Kong, 3/F Ap Lei Chau Clinic, 161 Main Street, Ap Lei Chau, Hong Kong.

This study aimed to evaluate the associations between variability of lipid parameters and the risk of kidney disease in patients with type 2 diabetes mellitus. Low-density lipoprotein-cholesterol, total cholesterol to high-density lipoprotein-cholesterol ratio and triglyceride were specifically addressed in this study. This retrospective cohort study included 105,552 patients aged 45-84 with type 2 diabetes mellitus and normal kidney function who were managed under Hong Kong public primary care clinics during 2008-2012. Read More

View Article and Full-Text PDF

Association of maternal body mass index with intellectual disability risk.

Arch Dis Child Fetal Neonatal Ed 2021 Apr 13. Epub 2021 Apr 13.

Department of Clinical Medicine-Department of Clinical Epidemiology, Aarhus Universitet, Aarhus, Midtjylland, Denmark.

Objectives: The study aimed to investigate the association between maternal body mass index (BMI) in early pregnancy and children's intellectual disability (ID) risk in the absence of chromosomal disorders, neurofibromatosis and tuberous sclerosis, taking adverse birth outcomes, maternal hypertension/diabetes and maternal socioeconomic status into consideration.

Methods: We conducted a cohort study of singletons without common genetic defects born in Sweden during 1992-2006, and followed them from birth until 31 December 2014 (n=1 186 836). Cox proportional hazards models were used to analyse the association between maternal BMI in early pregnancy and the risk of offspring's ID. Read More

View Article and Full-Text PDF

BMI, weight change, and incidence of disability among Korean adults: A nationwide retrospective cohort study.

Disabil Health J 2021 Apr 1:101104. Epub 2021 Apr 1.

College of Pharmacy, Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, South Korea. Electronic address:

Background: Little is known about the risk of acquired disability diagnosed by a physician in relation to baseline BMI and weight change, particularly in the Asian population.

Objective: This study assessed the association of baseline BMI and weight change with incidence of disability.

Methods: This study included 331,900 individuals aged ≥40 years who participated in two health-screening programs since 2002 or 2003 and who were followed up until 2013. Read More

View Article and Full-Text PDF

gene as a characteristic prognostic biomarker of colorectal cancer.

J Int Med Res 2021 Apr;49(4):3000605211004386

Dean's Office, The Third Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.

Objective: To investigate the expression and clinical value of the E-selectin gene () in colorectal cancer (CRC).

Methods: Using gene expression profiles and clinicopathological data for patients with CRC from The Cancer Genome Atlas, and tumor and adjacent normal tissues from 31 patients with CRC from Xianyang Central Hospital, we studied the correlation between gene expression and clinical parameters using Kaplan-Meier and Cox proportional hazards regression analyses.

Results: Higher expression of was significantly associated with a poorer prognosis and shorter survival in patients with CRC. Read More

View Article and Full-Text PDF

Upregulation of GNPNAT1 Predicts Poor Prognosis and Correlates With Immune Infiltration in Lung Adenocarcinoma.

Front Mol Biosci 2021 25;8:605754. Epub 2021 Mar 25.

Department of Thoracic Oncology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China.

Background: Glucosamine 6-phosphate -acetyltransferase (GNPNAT1) is a key enzyme in the hexosamine biosynthetic pathway (HBP), which functions as promoting proliferation in some tumors, yet its potential biological function and mechanism in lung adenocarcinoma (LUAD) have not been explored.

Methods: The mRNA differential expression of GNPNAT1 in LUAD and normal tissues was analyzed using the Cancer Genome Atlas (TCGA) database and validated by real-time PCR. The clinical value of GNPNAT1 in LUAD was investigated based on the data from the TCGA database. Read More

View Article and Full-Text PDF

Comprehensive Analysis of the Prognostic Role and Mutational Characteristics of m6A-Related Genes in Lung Squamous Cell Carcinoma.

Front Cell Dev Biol 2021 25;9:661792. Epub 2021 Mar 25.

Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Background: There have been limited treatment therapies for lung squamous cell carcinoma (LUSC). M6A-related genes may be the next therapeutic targets for LUSC. In this study, we explored the prognostic role and mutational characteristics of m6A-related genes in LUSC. Read More

View Article and Full-Text PDF

An immunohistochemical panel of three small ubiquitin-like modifier genes predicts outcomes of patients with triple-negative breast cancer.

Gland Surg 2021 Mar;10(3):1067-1084

Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, China.

Background: Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive disease. Developing new candidate biomarkers for chemotherapy response and possible therapeutic targets has become an urgent clinical need. Small ubiquitin-like modifiers (SUMOs) mediate post-translational modifications (SUMOylation) has been shown to be involved in numerous biological processes. Read More

View Article and Full-Text PDF