113,019 results match your criteria normal abnormal

Myristic acid defends against testicular oxidative stress, inflammation, apoptosis: Restoration of spermatogenesis, steroidogenesis in diabetic rats.

Life Sci 2021 May 11:119605. Epub 2021 May 11.

Department of Physiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. Electronic address:

Diabetes mellitus (DM) may lead to testicular infertility while Myristic acid (MA) is beneficial to lower hyperglycaemia. Thus, we hypothesized that MA could protect testes against hyperglycaemia-induced damage in DM. DM was induced in adult male rats by high-fat diet consumption for 12 weeks, accompanied by a single dose streptozotocin injection. Read More

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MCDCD: Multi-Source Unsupervised Domain Adaptation for Abnormal Human Gait Detection.

IEEE J Biomed Health Inform 2021 May 14;PP. Epub 2021 May 14.

For gait analysis, especially for the detection of subtle gait abnormalities, the collected datasets involve high variability across subjects due to inherent biometric traits and movement behaviors, leading to limited detection accuracy and poor generalizability. To address this, we propose a novel deep multi-source Unsupervised Domain Adaptation (UDA) approach, namely Maximum Cross-Domain Classifier Discrepancy (MCDCD), which aims to improve the classification performance on the test subject (target domain) by leveraging the information from multiple labelled training subjects (source domains). Specifically, the proposed model consists of a feature extractor and a domain-specific category classifier per source domain. Read More

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Ultrasonography Findings of the Carpal Tunnel after Endoscopic Carpal Tunnel Release for Carpal Tunnel Syndrome.

Korean J Radiol 2021 May 4. Epub 2021 May 4.

Department of Orthopaedics and Traumatology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong.

Objective: To investigate changes in the median nerve, retinaculum, and carpal tunnel on ultrasound after successful endoscopic carpal tunnel release (ECTR).

Materials And Methods: This prospective study involved 37 wrists in 35 patients (5 male, 30 female; mean age ± standard deviation [SD], 56.9 ± 6. Read More

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IBSP, a potential recurrence biomarker, promotes the progression of colorectal cancer via Fyn/β-catenin signaling pathway.

Cancer Med 2021 May 13. Epub 2021 May 13.

State Key Laboratory of Chemical Oncogenomics, Key Laboratory of Chemical Biology, Tsinghua Shenzhen International Graduate School, Shenzhen, Guangdong, China.

Colorectal cancer (CRC) is a frequently occurring digestive system cancer and postoperative tumor metastasis and recurrence are the main reasons for the failure of CRC treatment. The aim of this study was to identifying and validating key genes associated with metastatic recurrence of CRC. RNA expression of three datasets (GSE17538, GSE32323, and GSE29623) was used for biomarker discovery. Read More

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Ventilation heterogeneity in children with severe asthma.

Eur J Pediatr 2021 May 13. Epub 2021 May 13.

Department of Respiratory Sciences and Institute for Lung Health, Leicester NIHR Biomedical Research Centre - Respiratory Theme, Leicester Royal Infirmary, University of Leicester, PO Box 65, Robert Kilpatrick Clinical Sciences Building, Leicester, LE2 7LX, UK.

Small airway disease, characterised by ventilation heterogeneity (VH), is present in a subgroup of patients with asthma. Ventilation heterogeneity can be measured using multiple breath washout testing. Few studies have been reported in children. Read More

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Impact of abnormal climate events on the production of Italian ryegrass as a season in Korea.

J Anim Sci Technol 2021 Jan 31;63(1):77-90. Epub 2021 Jan 31.

Department of Animal Industry Convergence, Kangwon National University, Chuncheon 24341, Korea.

This study aimed to assess the impact of abnormal climate events on the production of Italian ryegrass (IRG), such as autumn low-temperature, severe winter cold and spring droughts in the central inland, southern inland and southern coastal regions. Seasonal climatic variables, including temperature, precipitation, wind speed, relative humidity, and sunshine duration, were used to set the abnormal climate events using principal component analysis, and the abnormal climate events were distinguished from normal using Euclidean-distance cluster analysis. Furthermore, to estimate the impact caused by abnormal climate events, the dry matter yield (DMY) of IRG between abnormal and normal climate events was compared using a -test with 5% significance level. Read More

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January 2021

Genome-wide DNA methylome and whole-transcriptome landscapes of spontaneous intraductal papilloma in tree shrews.

Ann Transl Med 2021 Apr;9(8):688

The Center of Tree Shrew Germplasm Resources, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, China.

Background: Breast intraductal papilloma (IP) is mainly caused by the abnormal proliferation of ductal epithelial cells. Tree shrews have potential as an animal model for the study of breast tumours; however, little is known regarding the transcriptome and DNA methylome landscapes of breast IP in tree shrews. In this research, we conducted whole-genome DNA methylation and transcriptome analyses of breast IP and normal mammary glands in tree shrews. Read More

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Comparative transcriptome analysis reveals key insights into male sterility in Bunge.

PeerJ 2021 27;9:e11326. Epub 2021 Apr 27.

College of Sciences, Sichuan Agricultural University, Ya'an, Sichuan, China.

Background: Large-scale heterosis breeding depends upon stable, inherited male sterility lines. We accidentally discovered a male sterility line (SW-S) in the Fprogeny of a Bunge from Shandong, China (purple flowers) crossed with a f. alba from Sichuan, China (white flowers). Read More

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Roles of Motor Cortex Neuron Classes in Reach-Related Modulation for Hemiparkinsonian Rats.

Front Neurosci 2021 27;15:645849. Epub 2021 Apr 27.

Key Laboratory of Animal Resistance Biology of Shandong Province, College of Life Science, Shandong Normal University, Jinan, China.

Disruption of the function of the primary motor cortex (M1) is thought to play a critical role in motor dysfunction in Parkinson's disease (PD). Detailed information regarding the specific aspects of M1 circuits that become abnormal is lacking. We recorded single units and local field potentials (LFPs) of M1 neurons in unilateral 6-hydroxydopamine (6-OHDA) lesion rats and control rats to assess the impact of dopamine (DA) cell loss during rest and a forelimb reaching task. Read More

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The Relationship Between the Metabolic Syndrome and the Place of Residence in the Local Community on the Example of the Janów Lubelski District in Eastern Poland: A Population-Based Study.

Diabetes Metab Syndr Obes 2021 6;14:2041-2056. Epub 2021 May 6.

Department of Normal Anatomy, Lviv National Medical University, Lviv, Ukraine.

Purpose: The aim of this study was to estimate the incidence concerning metabolic syndrome (MetS) in a local community with a low socioeconomic status and a medium and high cardiovascular risk on the example of residents of Janów Lubelski district, eastern Poland. The second goal of the research was to analyze the relationship between residence and the occurrence of MetS.

Methods: We conducted a cross-sectional study of 4040 people living in eastern Poland. Read More

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A generative adversarial network-based abnormality detection using only normal images for model training with application to digital breast tomosynthesis.

Sci Rep 2021 May 13;11(1):10276. Epub 2021 May 13.

Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA.

Deep learning has shown tremendous potential in the task of object detection in images. However, a common challenge with this task is when only a limited number of images containing the object of interest are available. This is a particular issue in cancer screening, such as digital breast tomosynthesis (DBT), where less than 1% of cases contain cancer. Read More

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[Association between glucose and blood lipid among adolescents in eastern China].

Wei Sheng Yan Jiu 2021 Mar;50(2):205-209

Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.

Objective: To analyze the relationship between glucose and blood lipid among adolescents aged 12-17 years in eastern China during 2016-2017.

Methods: The data comes from the "Chinese Children and Nursing Mothers Nutrition and Health Monitoring" during 2016-2017. The detection of blood glucose and blood lipids were conducted among 8873 subjects(4405 boys, 4468 girls) from 8 provinces and 3 municipality of eastern China by multi-stage stratified cluster sampling method. Read More

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A dual autoencoder and singular value decomposition based feature optimization for the segmentation of brain tumor from MRI images.

K Aswani D Menaka

BMC Med Imaging 2021 May 13;21(1):82. Epub 2021 May 13.

Department of Applied Electronics, Noorul Islam Center for Higher Education, Kumrancoil, Tamil Nadu, India.

Background: The brain tumor is the growth of abnormal cells inside the brain. These cells can be grown into malignant or benign tumors. Segmentation of tumor from MRI images using image processing techniques started decades back. Read More

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Cephalic Index of Korean Children With Normal Brain Development During the First 7 Years of Life Based on Computed Tomography.

Ann Rehabil Med 2021 Apr 30;45(2):141-149. Epub 2021 Apr 30.

Department of Physical Medicine and Rehabilitation, Inje University Busan Paik Hospital, Inje University College of Medicine, Busan, Korea.

Objective: To identify the normal range, distribution, and age-dependent differences in the cephalic index (CI) of Korean children with normal brain development and develop a classification of the current CI for Korean children up to 7 years of age.

Methods: We retrospectively analyzed 1,389 children who visited our hospital in the emergency room between October 2015 and September 2020 because of suspected head injuries. Finally, 1,248 children (741 male and 507 female) were enrolled after excluding abnormal medical or familial history and divided into 10 groups by age. Read More

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An interictal measurement of cerebral oxygen extraction fraction in MRI-negative refractory epilepsy using quantitative susceptibility mapping.

Phys Med 2021 May 10;85:87-97. Epub 2021 May 10.

Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Neuroimaging and Analysis, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran; Research Center for Molecular and Cellular Imaging, Tehran University of Medical Science, Tehran, Iran. Electronic address:

Purpose: Oxygen extraction fraction (OEF) can be a factor to identify brain tissue's disability in epileptic patients. This study aimed to assess the OEF's level measurement in refractory epileptic patients (REPs) using a quantitative susceptibility mapping (QSM) method and to determine whether the OEF parameters change.

Methods: QSM-OEF maps of 26 REPs and 16 healthy subjects were acquired using 3T MRI with a 64-channel coil. Read More

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Ultrasound evaluation of the placenta in healthy and placental syndrome pregnancies: A systematic review.

Eur J Obstet Gynecol Reprod Biol 2021 May 4;262:45-56. Epub 2021 May 4.

Department of Obstetrics and Gynecology, Maastricht University Medical Centre (MUMC+), the Netherlands.

Introduction: An antepartum screening method to determine normal and abnormal placental function is desirable in the prevention of maternal and fetal pregnancy complications. Placental appearance can easily be obtained and evaluated using 2D ultrasonography, but surprisingly little is known about the change in placental appearance during gestation. Aim of this systematic review was to describe the antepartum placental appearance in placenta syndrome (PS) pregnancies, and to compare this to the appearance in healthy pregnancies. Read More

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Environmental exposure to perfluoroalkyl substances in early pregnancy, maternal glucose homeostasis and the risk of gestational diabetes: A prospective cohort study.

Environ Int 2021 May 11;156:106621. Epub 2021 May 11.

Ministry of Education -Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Jiao Tong University School of Public Health, Shanghai, China. Electronic address:

Background: Humans are widely exposed to environmental perfluoroalkyl substances (PFAS), which may affect glucose homeostasis. However, research linking PFAS exposure to glucose homeostasis during pregnancy is limited and the results were inconsistent. We aimed to investigate the association between PFAS exposure and glucose homeostasis in pregnancy in a large prospective cohort. Read More

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Prevalence and predictors of abnormal glucose tolerance and its resolution in acromegaly: Single Centre retrospective study of 90 cases.

Growth Horm IGF Res 2021 Apr 30;59:101394. Epub 2021 Apr 30.

Department of Endocrinology, Bai Yamunabai Laxman (BYL) Nair Charitable Hospital and Topiwala National Medical College, Mumbai, Maharashtra, India.

Aims The aim of the study was to evaluate the prevalence and predictors of abnormal glucose tolerance (Diabetes + Prediabetes) and its resolution in Acromegaly.

Settings And Design: Retrospective observational study.

Methods And Material: Ninety patients with acromegaly and followed up post operatively for 1 year were included. Read More

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5-Lipoxygenase as an emerging target against age-related brain disorders.

Ageing Res Rev 2021 May 10:101359. Epub 2021 May 10.

College of Pharmacy, School of Medicine, Hangzhou Normal University, Hangzhou, 311121, China; Hangzhou Key Laboratory of Medical Neurobiology, Hangzhou Normal University, Hangzhou, 311121, China; Engineering Laboratory of Development and Application of Traditional Chinese Medicines, Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province, Hangzhou Normal University, Hangzhou, 311121, China. Electronic address:

Neuroinflammation is a common feature of age-related brain disorders including Alzheimer's disease (AD), Parkinson's disease (PD) and cerebral ischemia. 5-lipoxygenase (5-LOX), a proinflammatory enzyme, modulates inflammation by generating leukotrienes. Abnormal activation of 5-LOX and excessive production of leukotrienes have been detected in the development of age-related brain pathology. Read More

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The value of adding a single co-test in HPV primary screening.

Prev Med 2021 May 10:106617. Epub 2021 May 10.

Department of Laboratory Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

The screening program for cervical cancer in Sweden, recommends screening with HPV test primarily for women over 30 years, but at the first screening test that is performed after the age of 40, both HPV test and cytology is recommended, so-called co-testing. The aim of this study was to examine how many cases of HPV negative cervical dysplasia that were found in this age-group, to be able to estimate the value of adding a co-test in an HPV screening program. A retrospective study of all abnormal cytological samples found in the cytology based screening program in the age group 41-45 years during the years 2012-2016 in the Region of Örebro County was performed. Read More

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Cerebral Visual Impairment Characterized by Abnormal Visual Orienting Behavior With Preserved Visual Cortical Activation.

Invest Ophthalmol Vis Sci 2021 May;62(6):15

University of Washington, Department of Ophthalmology, Seattle, Washington, United States.

Purpose: Children with cerebral visual impairment (CVI) often have abnormal visual orienting behaviors due to impaired or damaged visual cortex. Alternatively, visual-cortical function is intact but visual information is not transformed downstream into an appropriate oculomotor output (visuomotor dysfunction). We examined visual, anatomic, and oculomotor assessments to distinguish visuomotor dysfunction from CVI associated with severely reduced visual-cortical response. Read More

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Abnormally abrupt transitions from sleep-to-wake in Huntington's disease sheep (Ovis aries) are revealed by automated analysis of sleep/wake transition dynamics.

PLoS One 2021 13;16(5):e0251767. Epub 2021 May 13.

Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom.

Sleep disturbance is a common and disruptive symptom of neurodegenerative diseases such as Alzheimer's and Huntington's disease (HD). In HD patients, sleep fragmentation appears at an early stage of disease, although features of the earliest sleep abnormalities in presymptomatic HD are not fully established. Here we used novel automated analysis of quantitative electroencephalography to study transitions between wake and non-rapid eye movement sleep in a sheep model of presymptomatic HD. Read More

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Can laboratory findings predict pulmonary involvement in children with COVID-19 infection?

Pediatr Pulmonol 2021 May 13. Epub 2021 May 13.

Department of Pediatric Infectious Diseases, University of Health Sciences Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, İzmir, Turkey.

Background: Studies investigating clinical and imaging findings of coronavirus disease 2019 (COVID-19) pneumonia and predictors for lung injury mostly focus on adults. In this study, we aimed to evaluate the role of laboratory findings in predicting lung involvement in children with COVID-19.

Methods: Children with COVID-19 confirmed by reverse-transcription polymerase chain reaction or COVID-19 IgM and who underwent chest computed tomography (CT) scans were reviewed retrospectively. Read More

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Ratiometric Detection of Glutathione Based on Disulfide Linkage Rupture between a FRET Coumarin Donor and a Rhodamine Acceptor.

Chembiochem 2021 May 13. Epub 2021 May 13.

Department of Chemistry, Michigan Technological University, 1400 Townsend Drive, Houghton, MI 49931, USA.

Abnormal levels of glutathione, a cellular antioxidant, can lead to a variety of diseases. We have constructed a near-infrared ratiometric fluorescent probe to detect glutathione concentrations in biological samples. The probe consists of a coumarin donor, which is connected through a disulfide-tethered linker to a rhodamine acceptor. Read More

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[Effect of Dendrobium officinale superfine powder on stomach Yin deficiency model mice induced by "spicy overeating"].

Zhongguo Zhong Yao Za Zhi 2021 Apr;46(7):1651-1657

Zhejiang Chinese Medical University Hangzhou 310053, China.

Dendrobium officinale is a traditional Chinese medicine for nourishing Yin and benefiting stomach. Its superfine powder has many advantages, such as good dissolution, high utilization rate, strong integrity and easy to use. However, the researches on effect of D. Read More

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Autocrine and paracrine purinergic signaling in the most lethal types of cancer.

Purinergic Signal 2021 May 12. Epub 2021 May 12.

Departamento de Neurobiología Celular y Molecular, Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, Querétaro, México.

Cancer comprises a collection of diseases that occur in almost any tissue and it is characterized by an abnormal and uncontrolled cell growth that results in tumor formation and propagation to other tissues, causing tissue and organ malfunction and death. Despite the undeniable improvement in cancer diagnostics and therapy, there is an urgent need for new therapeutic and preventive strategies with improved efficacy and fewer side effects. In this context, purinergic signaling emerges as an interesting candidate as a cancer biomarker or therapeutic target. Read More

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Ordinal losses for classification of cervical cancer risk.

PeerJ Comput Sci 2021 23;7:e457. Epub 2021 Apr 23.

Institute for Systems and Computer Engineering, Technology and Science, Porto, Portugal.

Cervical cancer is the fourth leading cause of cancer-related deaths in women, especially in low to middle-income countries. Despite the outburst of recent scientific advances, there is no totally effective treatment, especially when diagnosed in an advanced stage. Screening tests, such as cytology or colposcopy, have been responsible for a substantial decrease in cervical cancer deaths. Read More

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RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function.

J Hum Genet 2021 May 13. Epub 2021 May 13.

The Genetics Institute, Rambam Health Care Campus, Haifa, Israel.

RBL2/p130, a member of the retinoblastoma family of proteins, is a key regulator of cell division and propagates irreversible senescence. RBL2/p130 is also involved in neuronal differentiation and survival, and eliminating Rbl2 in certain mouse strains leads to embryonic lethality accompanied by an abnormal central nervous system (CNS) phenotype. Conflicting reports exist regarding a role of RBL2/p130 in transcriptional regulation of DNA methyltransferases (DNMTs), as well as the control of telomere length. Read More

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Echocardiographic left ventricular geometry profiles for prediction of stroke, coronary heart disease and all-cause mortality in the Chinese community: a rural cohort population study.

BMC Cardiovasc Disord 2021 May 12;21(1):238. Epub 2021 May 12.

Department of Cardiology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Heping District, Shenyang, 110001, Liaoning Province, People's Republic of China.

Background: The utility of echocardiographic left ventricular (LV) geometry in the prediction of stroke/coronary heart disease (CHD) and all-cause mortality is not well characterized. This study aimed to evaluate the overall and sex-specific prognostic value of different geometric patterns on the incidence of stroke/CHD and all-cause mortality in a Chinese population-based cohort.

Methods: We conducted a prospective study in the general population in Northeast China, and a total of 9940 participants aged ≥ 35 years underwent echocardiography for LV geometry and were successfully followed up for incident stroke/CHD and all-cause death. Read More

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Value of second-trimester uterine artery pulsatility index in pregnancies with systemic lupus erythematosus and/or antiphospholipid syndrome.

J Matern Fetal Neonatal Med 2021 May 12:1-7. Epub 2021 May 12.

Department of Obstetrics and Gynecology, Hospital General de Granollers, Barcelona, Spain.

Objective: To assess the value of the second trimester mean pulsatility index of the uterine arteries (MPI-UtA) to predict adverse perinatal outcome (APO) in women with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS).

Methods: Pregnancies with either an SLE diagnosis or with primary APS controlled at our Hospital during a 10 years period were included. MPI-UtA was performed between 19-23 weeks' gestation. Read More

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