383 results match your criteria nonintubated patients

Effect of Hyperbaric Oxygen Therapy Initiation Time in Acute Carbon Monoxide Poisoning.

Crit Care Med 2021 Jun 2. Epub 2021 Jun 2.

Department of Emergency Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Research Institute, of Hyperbaric Medicine and Science, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea. Department of Biostatistics and Center of Biomedical Data Science, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Objectives: Hyperbaric oxygen therapy (HBO2) is recommended for symptomatic patients within 24-hour postcarbon monoxide poisoning. Previous studies have reported significantly better outcomes with treatment administered within 6 hours after carbon monoxide poisoning. Thus, we aimed to compare the neurocognitive outcomes according to HBO2 delay intervals. Read More

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Investigating the construct and concurrent validity of the Richards-Campbell Sleep Questionnaire with intensive care unit patients and home sleepers.

Aust Crit Care 2021 May 25. Epub 2021 May 25.

Department of Nursing Science, University of Turku, FI-20014 TURUN YLIOPISTO, Finland; Turku University Hospital, PO Box 52, FI-20521 TURKU, Finland. Electronic address:

Background: Sleep is vital to our wellbeing. Critically ill patients are vulnerable with effects of sleep deprivation including weakened immune function, decreased glucose tolerance, and increased sympathetic activity. Intensive care unit (ICU) patients' sleep evaluation is difficult and often not reliable. Read More

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Inhaled Nitric Oxide Delivery Systems for Mechanically Ventilated and Nonintubated Patients: A Review.

Respir Care 2021 Jun;66(6):1021-1028

Department of Anaesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.

Nitric oxide (NO) is a biologically active molecule approved for the treatment of pulmonary hypertension in newborn patients. Commercially available NO delivery systems use pressurized cylinders as the source of NO and a sensor to control the concentrations of NO and nitrogen dioxide (NO) delivered. Cylinder-based delivery systems are safe and widely used around the world, but they are bulky, expensive, and reliant on a robust supply chain. Read More

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Long-term outcomes after nonintubated versus intubated thoracoscopic lobectomy for clinical stage I non-small cell lung cancer: A propensity-matched analysis.

J Formos Med Assoc 2021 May 13. Epub 2021 May 13.

Division of Thoracic Surgery, Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Department of Surgical Oncology, National Taiwan University Cancer Center, Taiwan. Electronic address:

Background: Nonintubated thoracoscopic lobectomy has been described as a feasible surgical treatment for early-stage lung cancer since 2011. Despite promising perioperative results, studies on tumor recurrence and long-term survival are very limited. This study was aimed to compare outcomes after thoracoscopic lobectomy with versus without intubation for stage I non-small cell lung cancer. Read More

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Standard Care Versus Awake Prone Position in Adult Nonintubated Patients With Acute Hypoxemic Respiratory Failure Secondary to COVID-19 Infection-A Multicenter Feasibility Randomized Controlled Trial.

J Intensive Care Med 2021 May 5:8850666211014480. Epub 2021 May 5.

Department of Critical Care Medicine, Apollo Main Hospital, Chennai, Tamilnadu, India.

Rationale: The feasibility and safety of awake prone positioning and its impact on outcomes in non-intubated patients with acute respiratory distress syndrome secondary to COVID-19 is unknown. Results of the observational studies published during this pandemic have been conflicting. In this context, we conducted a multi-center, parallel group, randomized controlled feasibility study on awake prone positioning in non-intubated patients with COVID-19 pneumonia requiring supplemental oxygen. Read More

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Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019-A Systematic Review and Meta-Analysis.

Crit Care Med 2021 Apr 30. Epub 2021 Apr 30.

Department of Intensive Care Medicine, Calvary Hospital, ACT, Australia. Department of Intensive Care Medicine, Peninsula Health, Frankston, VIC, Australia. Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, VIC, Australia. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. Department of Intensive Care Medicine, Ballarat Health Services, Ballarat, VIC, Australia. Department of Emergency, Monash Health, Clayton, VIC, Australia. Yong Loo Lin School of Medicine, National University of Singapore, Singapore. National University Hospital, Singapore. Faculty of Medicine, Bond University, Gold Coast, QLD, Australia. Department of Medicine, Columbia University College of Physicians and Surgeons, and Center for Acute Respiratory Failure, New York-Presbyterian Hospital, New York, NY. Interdepartmental Division of Critical Care Medicine and Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, ON, Canada. Adult Intensive Care Services, the Prince Charles Hospital, Brisbane, QLD, Australia. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane; Faculty of Medicine, University of Queensland, Brisbane, QLD, Australia.

Objectives: Several studies have reported prone positioning of nonintubated patients with coronavirus diseases 2019-related hypoxemic respiratory failure. This systematic review and meta-analysis evaluated the impact of prone positioning on oxygenation and clinical outcomes.

Design And Setting: We searched PubMed, Embase, and the coronavirus diseases 2019 living systematic review from December 1, 2019, to November 9, 2020. Read More

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Risk Factors for the Development of Intraoperative Hypoxia in Patients Undergoing Nonintubated Video-Assisted Thoracic Surgery: A Retrospective Study from a Single Center.

Med Sci Monit 2021 Apr 26;27:e928965. Epub 2021 Apr 26.

Department of Cardiothoracic Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (mainland).

BACKGROUND Nonintubated video-assisted thoracic surgery (NIVATS) has been demonstrated to be safe and effective in patients. However, the risk factors for intraoperative hypoxia are unclear. This retrospective study aimed to identify the risk factors for the development of intraoperative hypoxia in patients undergoing NIVATS. Read More

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Comparison of perioperative outcomes between intubated and nonintubated thoracoscopic surgery in children.

J Formos Med Assoc 2021 Apr 19. Epub 2021 Apr 19.

Department of Surgery, National Taiwan University College of Medicine, Taipei, Taiwan; National Taiwan University Cancer Center, Taipei, Taiwan.

Background/purpose: This study aimed to compare our experiences of nonintubated video-assisted thoracoscopic surgery (VATS) for pneumothorax and lung tumor resections with that of intubated VATS in pediatric patients.

Methods: In total, 17 nonintubated and 64 intubated pediatric VATS were performed between January 2012 and December 2018. Patient characteristics, operation period, comorbidities, precedent lung surgery, diagnosis, type of anesthesia, side and type of procedure, and perioperative outcomes were collected from medical records. Read More

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Impact of Body Mass Index and Initial Respiratory Support on Pediatric Subjects in Acute Respiratory Failure.

Respir Care 2021 Apr 20. Epub 2021 Apr 20.

Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania.

Background: It is unknown how the initial choice of respiratory support by pediatric ICU providers contributes to outcomes of nonintubated obese children with respiratory failure. We hypothesized that body mass index and the type of initial respiratory support applied are associated with poor clinical outcomes in patients who carry respiratory failure-associated diagnoses.

Methods: This is a retrospective analysis of de-identified patient data obtained from the Virtual PICU System database (2009-2018). Read More

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Extracorporeal Membrane Oxygenation with Right Ventricular Assist Device for COVID-19 ARDS.

J Surg Res 2021 Mar 18;264:81-89. Epub 2021 Mar 18.

Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

Background: Right ventricular failure is an underrecognized consequence of COVID-19 pneumonia. Those with severe disease are treated with extracorporeal membrane oxygenation (ECMO) but with poor outcomes. Concomitant right ventricular assist device (RVAD) may be beneficial. Read More

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Prone positioning in children with respiratory failure because of coronavirus disease 2019.

Curr Opin Pediatr 2021 06;33(3):319-324

Section of Pediatric Critical Care, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.

Purpose Of Review: Acute respiratory distress syndrome (ARDS) is a common manifestation of severe COVID-19. Prone positioning has been used successfully in adult patients with ARDS and has been shown to decrease mortality. The efficacy of prone positioning in pediatric ARDS is less clear. Read More

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Early Usage of Extracorporeal Membrane Oxygenation in the Absence of Invasive Mechanical Ventilation to Treat COVID-19-related Hypoxemic Respiratory Failure.

ASAIO J 2021 04;67(4):392-394

From the Houston Heart, HCA Houston Healthcare, Houston, Texas.

A subset of patients with coronavirus disease 2019 (COVID-19) develop profound respiratory failure and are treated via invasive mechanical ventilation (IMV). Of these, a smaller subset has severe gas exchange abnormalities that are refractory to maximal levels of IMV support. Extracorporeal membrane oxygenation (ECMO) has been used successfully in these circumstances. Read More

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Prone Positioning in Spontaneously Breathing Subjects With Moderate or Severe ARDS During Invasive Ventilation.

Respir Care 2021 05 2;66(5):724-732. Epub 2021 Mar 2.

Department of Critical Care Medicine, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.

Background: Prone positioning (PP) during invasive mechanical ventilation improves outcomes of patients with severe ARDS. Recent studies suggest that PP in spontaneously breathing, nonintubated patients with acute respiratory failure is well tolerated and improves oxygenation. However, little is known regarding patient triggered ventilation in intubated patients with ARDS undergoing PP. Read More

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A Case-Control Study of Prone Positioning in Awake and Nonintubated Hospitalized Coronavirus Disease 2019 Patients.

Crit Care Explor 2021 Feb 11;3(2):e0348. Epub 2021 Feb 11.

Department of Medicine, Division of Critical Care, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

To determine the association between prone positioning in nonintubated patients with coronavirus disease 2019 and frequency of invasive mechanical ventilation or inhospital mortality.

Design: A nested case-matched control analysis.

Setting: Three hospital sites in Bronx, NY. Read More

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February 2021

Prone Positioning of Patients With Coronavirus Disease 2019 Who Are Nonintubated in Hypoxic Respiratory Distress: Single-Site Retrospective Health Records Review.

J Emerg Nurs 2021 Mar 26;47(2):279-287.e1. Epub 2020 Dec 26.

Introduction: In March and April 2020 of the coronavirus disease 2019 pandemic, site clinical practice guidelines were implemented for prone positioning of patients with suspected coronavirus disease 2019 in hypoxic respiratory distress who are awake, alert, and spontaneously breathing. The purpose of this pandemic disaster practice improvement project was to measure changes in pulse oximetry associated with prone positioning of patients with coronavirus disease 2019 infection in adult acute respiratory distress or adult respiratory distress syndrome, who are awake, alert, spontaneously breathing, and nonintubated.

Methods: A retrospective chart review of patients who were coronavirus disease 2019 positive in the emergency department from March 30, 2020 to April 30, 2020 was conducted for patients with a room air pulse oximetry <90% and a preprone position pulse oximetry ≤94% who tolerated prone positioning for at least 30 minutes. Read More

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Effect of Prone Positioning on the Respiratory Support of Nonintubated Patients With COVID-19 and Acute Hypoxemic Respiratory Failure: A Retrospective Matching Cohort Study.

Chest 2021 Jan 29. Epub 2021 Jan 29.

Médecine Intensive Réanimation, Assistance Publique-Hôpitaux de Marseille, Marseille, France; Centre d'Études et de Recherches sur les Services de Santé et qualité de vie Aix-Marseille Université, Marseille, France.

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January 2021

To tube or not to tube: a skeptic's guide to nonintubated thoracic surgery.

Curr Opin Anaesthesiol 2021 Feb;34(1):1-6

Department of Anaesthesiology and Intensive Care Medicine, Medical Centre Cologne-Merheim, University Witten/Herdecke, Cologne, Germany.

Purpose Of Review: The aim of this review is to provide an overview of the rationale and evidence for nonintubated thoracic surgery and guide clinicians, considering the implementation of nonintubated thoracic surgery, to find an anesthetic approach suitable for their department.

Recent Findings: Based on physiologic considerations alone, nonintubated thoracic surgery would be expected to be an advantageous concept in thoracic anesthesia, especially in patients at high risk for pulmonary complications. Currently existing evidence, however, does not support these claims. Read More

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February 2021

Prevalence of Comorbid Asthma and Related Outcomes in COVID-19: A Systematic Review and Meta-Analysis.

J Allergy Clin Immunol Pract 2021 Feb 9;9(2):693-701. Epub 2020 Dec 9.

Department of Allergy & Clinical Immunology, National Clinical Research Center for Immunologic Diseases, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China. Electronic address:

Background: The impact of asthma on coronavirus disease 2019 (COVID-19) remains largely unknown.

Objective: To investigate the asthma prevalence among patients with COVID-19 and compare outcomes between patients with and without asthma.

Methods: In this systematic review and meta-analysis, we searched PubMed, Embase, Web of Science, bioRxiv, and medRxiv for studies reporting asthma prevalence in general patients with COVID-19 or comparing outcomes between patients with and without asthma, and excluded duplicate publications, reviews, editorials, comments, single case reports, or small case series (<10 cases). Read More

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February 2021

Early, awake proning in emergency department patients with COVID-19.

Am J Emerg Med 2020 Dec 3. Epub 2020 Dec 3.

Department of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States of America; Division of Pulmonary/Critical Care, Department of Internal Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States of America.

Objective: Proning has been shown to improve oxygenation and mortality in certain populations of intubated patients with acute respiratory distress syndrome. Small observational analyses of COVID-19 patients suggest awake proning may lead to clinical improvement. Data on safety and efficacy is lacking. Read More

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December 2020

A novel method using a single lumen tube and extraluminal bronchial blocker for one-lung ventilation in severe tracheal stenosis: a case report.

Ann Palliat Med 2021 Jan 25;10(1):749-753. Epub 2020 Nov 25.

Department of Anesthesiology, First Hospital of China Medical University, Shenyang, China. Email:

Double-lumen tubes (DLT) and bronchial blockers (BB) are usually used to functionally isolate the lungs during thoracic surgery. However, for patients with tracheal stenosis, management of one lung ventilation (OLV) in the anesthesia is still full of challenges due to mismatching between the trachea lumen and tracheal tube diameter. In the past, a small single-lumen tube (SLT) combined with an endobronchial pediatric BB or extraluminal detached BB of a uninvent obtained successful OLV in patients with tracheal stenosis. Read More

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January 2021

Pneumothorax and Pneumomediastinum Secondary to COVID-19 Disease Unrelated to Mechanical Ventilation.

Case Rep Crit Care 2020 23;2020:6655428. Epub 2020 Nov 23.

Division of Academic Affairs and Research, Orlando Regional Healthcare, Orlando, FL, USA.

In the recent worldwide coronavirus 2019 pandemic, a notable rise in pneumomediastinum and pneumothorax complications has been witnessed in numerous mechanically ventilated patients infected with severe acute respiratory syndrome coronavirus 2. Most cases have reported these complications as barotrauma from mechanical ventilation with COVID-19 disease. We aim to report three polymerase chain reaction-confirmed COVID-19 patients who developed pneumomediastinum and pneumothorax unrelated to mechanical ventilation. Read More

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November 2020

Rescue Treatment With High-Dose Gaseous Nitric Oxide in Spontaneously Breathing Patients With Severe Coronavirus Disease 2019.

Crit Care Explor 2020 Nov 16;2(11):e0277. Epub 2020 Nov 16.

Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.

Treatment options are limited for patients with respiratory failure due to coronavirus disease 2019. Conventional oxygen therapy and awake proning are options, but the use of high-flow nasal cannula and continuous positive airway pressure are controversial. There is an urgent need for effective rescue therapies. Read More

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November 2020

High-dose methylprednisolone in nonintubated patients with severe COVID-19 pneumonia.

Eur J Clin Invest 2021 Feb 1;51(2):e13458. Epub 2020 Dec 1.

Division of Cardiology, Department of Medicine, Stony Brook University, Stony Brook, NY, USA.

Background: Recent trials with dexamethasone and hydrocortisone have demonstrated benefit in patients with coronavirus disease 2019 (COVID-19). Data on methylprednisolone are limited.

Methods: Retrospective cohort of consecutive adults with severe COVID-19 pneumonia on high-flow oxygen (FiO  ≥ 50%) admitted to an academic centre in New York, from 1 March to 15 April 2020. Read More

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February 2021

COVIDOSE: A Phase II Clinical Trial of Low-Dose Tocilizumab in the Treatment of Noncritical COVID-19 Pneumonia.

Clin Pharmacol Ther 2021 03 10;109(3):688-696. Epub 2020 Dec 10.

Department of Medicine, Section of Rheumatology, The University of Chicago, Chicago, Illinois, USA.

Interleukin-6 (IL-6)-mediated hyperinflammation may contribute to the mortality of coronavirus disease 2019 (COVID-19). The IL-6 receptor-blocking monoclonal antibody tocilizumab has been repurposed for COVID-19, but prospective trials and dose-finding studies in COVID-19 have not yet fully reported. We conducted a single-arm phase II trial of low-dose tocilizumab in nonintubated hospitalized adult patients with COVID-19, radiographic pulmonary infiltrate, fever, and C-reactive protein (CRP) ≥ 40 mg/L. Read More

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Implementation of Venoarterial Extracorporeal Membrane Oxygenation in Nonintubated Patients.

J Chest Surg 2021 Feb;54(1):17-24

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Although extracorporeal membrane oxygenation (ECMO) is generally performed percutaneously, the technology is deployed under sedation and necessitates endotracheal intubation. However, in some patients, the use of venoarterial (VA) ECMO without intubation may be beneficial. Herein, we describe our experiences with VA ECMO performed without prior endotracheal intubation. Read More

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February 2021

Nonintubated Uniportal Video-Assisted Thoracoscopic Surgery for Intrathoracic Diseases: Initial Results in Vietnam.

Innovations (Phila) 2021 Jan-Feb;16(1):63-67. Epub 2020 Nov 12.

435680 Center of Anesthesia and Surgical Intensive Care, Viet Duc University Hospital, Hanoi, Vietnam.

Objective: Nonintubated uniportal video-assisted thoracoscopic surgery (VATS) is a recent controversial procedure in many countries. Hence, the authors would like to present the experience in performing this approach and evaluate its initial results in the treatment, particularly, of intrathoracic diseases in Vietnam.

Methods: A prospective, descriptive study was conducted on 17 patients with intrathoracic diseases treated with nonintubated uniportal VATS from February to July 2019. Read More

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November 2020

Technical efficiency, short-term clinical results and safety of a large-bore aspiration catheter in acute pulmonary embolism - A retrospective case study.

Lung India 2020 Nov-Dec;37(6):485-490

Department of Radiology, Section of Vascular and Interventional Radiology, University of Missouri, Columbia, MO, USA.

Background: Mechanical thrombectomy plays an important role in the management of acute pulmonary embolism (PE), either when rapid clot dissolution is needed or when thrombolytics are contraindicated. We describe our clinical and technical experience with the FlowTriever mechanical thrombectomy device in patients with acute PE.

Materials And Methods: A retrospective analysis was performed on all cases of acute PE treated with the FlowTriever device at a single tertiary care hospital system during the trial period (November 2019-January 2020). Read More

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November 2020

Spontaneous Pneumothorax in an Elderly Patient With Coronavirus Disease (COVID-19) Pneumonia.

Ochsner J 2020 ;20(3):343-345

Department of Internal Medicine, Advocate Christ Medical Center, Oak Lawn, IL.

The relationship between the 2019 novel coronavirus (COVID-19) and pneumothorax is not yet established. As of June 2020, few cases of nonintubated patients developing pneumothorax had been documented. We present the case of an elderly patient with COVID-19 pneumonia that resulted in a prolonged hospital course because of pneumothorax complication. Read More

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January 2020

The POSITIONED Study: Prone Positioning in Nonventilated Coronavirus Disease 2019 Patients-A Retrospective Analysis.

Crit Care Explor 2020 Oct 1;2(10):e0229. Epub 2020 Oct 1.

Division of Pulmonary and Critical Care, Creighton University School of Medicine, Omaha, NE.

Given perceived similarities between coronavirus disease 2019 pneumonia and the acute respiratory distress syndrome, we explored whether awake self-proning improved outcomes in coronavirus disease 2019-infected patients treated in a rural medical center with limited resources during a significant local coronavirus disease 2019 outbreak.

Design: Retrospective analysis of prospectively collected clinical data.

Setting: Single-center rural community-based medical center in Grand Island, NE. Read More

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October 2020