477 results match your criteria non-respiratory patients

Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study.

BMC Pediatr 2021 Apr 30;21(1):211. Epub 2021 Apr 30.

Department of Pediatrics, Soroka University Medical Center, Beer-Sheva, Israel.

Background: 25(OH) vitamin D levels are inversely associated with respiratory infections and childhood wheezing.

Objective: To evaluate serum 25(OH) vitamin D levels in infants and toddlers with acute bronchiolitis, compared to subjects with non-respiratory febrile illness.

Methods: A prospective cross-sectional case-control study which compared serum 25(OH) vitamin D levels between infants and toddlers diagnosed with acute bronchiolitis to subjects with non-respiratory febrile illness. Read More

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Cardiovascular Outcomes in the Acute Phase of COVID-19.

Int J Mol Sci 2021 Apr 15;22(8). Epub 2021 Apr 15.

Department of Cardiology, Tokyo Medical University, Tokyo 160-0023, Japan.

The cumulative number of cases in the current global coronavirus disease 19 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has exceeded 100 million, with the number of deaths caused by the infection having exceeded 2.5 million. Recent reports from most frontline researchers have revealed that SARS-CoV-2 can also cause fatal non-respiratory conditions, such as fatal cardiovascular events. Read More

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Non-Respiratory Symptoms of Patients Infected with SARS-CoV-2 (Coronavirus Disease 2019): Lessons from Their Initial Presentation at the Hospital.

Medicina (Kaunas) 2021 Apr 2;57(4). Epub 2021 Apr 2.

Infection Control Unit, General Hospital of Thessaloniki "Papageorgiou", 56403 Thessaloniki, Greece.

As the COVID-19 pandemic spreads, it is becoming increasingly evident that this coronavirus is not limited to the respiratory system and that the musculoskeletal system can also be affected. The purpose of the present study was to describe non-respiratory symptoms of laboratory-confirmed COVID-19 cases. All patients with SARS-CoV-2 admitted to our hospital, between 1 August and 30 September 2020, were included in this retrospective study. Read More

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Prediction of successful de-cannulation of tracheostomised patients in medical intensive care units.

Respir Res 2021 Apr 28;22(1):131. Epub 2021 Apr 28.

Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: Limited data are available on practical predictors of successful de-cannulation among the patients who undergo tracheostomies. We evaluated factors associated with failed de-cannulations to develop a prediction model that could be easily be used at the time of weaning from MV.

Methods: In a retrospective cohort of 346 tracheostomised patients managed by a standardized de-cannulation program, multivariable logistic regression analysis identified variables that were independently associated with failed de-cannulation. Read More

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Chronic obstructive pulmonary disease exacerbation fundamentals: Diagnosis, treatment, prevention and disease impact.

Respirology 2021 Apr 24. Epub 2021 Apr 24.

Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized by an acute deterioration in respiratory symptoms, are fundamental events impacting negatively upon disease progression, comorbidities, wellbeing and mortality. ECOPD also represent the largest component of the socioeconomic burden of COPD. ECOPDs are currently defined as acute worsening of respiratory symptoms that require additional therapy. Read More

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Reconstruction of COVID-19-Related Compartment Syndrome With Massive Soft Tissue Necrosis.

Wounds 2021 Apr;33(4):99-105

Rubin Institute for Advanced Orthopedics, Baltimore, Maryland.

Introduction: The COVID-19 virus is caused by the new coronavirus, SARS-CoV-2. COVID-19 has drastically changed the medical landscape. Although predominantly impacting the respiratory system, COVID-19 has several non-respiratory symptoms associated with its presentation and course. Read More

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Considerations and perspectives on digestive diseases during the COVID-19 pandemic: a narrative review.

Ann Palliat Med 2021 Apr 1;10(4):4858-4867. Epub 2021 Apr 1.

Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases, Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.

Coronavirus disease 2019 (COVID-19) was initially reported in December 2019, and since then it has become a pandemic with newly confirmed cases and deaths increasing continuously. The COVID-19 pandemic has dramatically impacted the organization and execution of activities in the clinical sector. Asymptomatic infections are increasingly being identified when patients seek medical advice for non-respiratory system illnesses, particularly digestive system symptoms. Read More

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COVID-19 (SARS-CoV-2) in Non-Airborne body fluids: A systematic review & Meta-analysis.

Turk J Urol 2021 Mar 1;47(2):87-97. Epub 2021 Mar 1.

Bristol Medical School, University of Bristol, Bristol, UK.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been predominantly respiratory. This study aimed to evaluate the presence of virus in non-airborne body fluids as transmission vehicles. Medline, EMBASE, and Cochrane Library databases were searched from December 01, 2019, to July 01, 2020, using terms relating to SARS-CoV-2 and non-airborne clinical sample sources (feces, urine, blood, serum, serum, and peritoneum). Read More

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Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo-controlled, phase 2b trial.

Lancet Respir Med 2021 05 30;9(5):476-486. Epub 2021 Mar 30.

Center for Interstitial and Rare Lung Diseases, Justus-Liebig University Giessen, Giessen, Germany; Member of the German Center for Lung Research and Cardiopulmonary Institute, and Agaplesion Lung Clinic Waldhof-Elgershausen, Greifenstein, Germany.

Background: Pirfenidone has been shown to slow disease progression in patients with idiopathic pulmonary fibrosis (IPF). However, there are few treatment options for progressive fibrotic interstitial lung diseases (ILDs)) other than IPF. In view of the pathomechanistic and clinical similarities between IPF and other progressive fibrotic ILDs, we aimed to assess the efficacy and safety of pirfenidone in patients with four non-IPF progressive fibrotic ILDs. Read More

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Prediction of extubation outcome in mechanically ventilated patients: Development and validation of the Extubation Predictive Score (ExPreS).

PLoS One 2021 18;16(3):e0248868. Epub 2021 Mar 18.

Universidade do Oeste de Santa Catarina (UNOESC), Joaçaba, Santa Catarina, Brazil.

Despite the best efforts of intensive care units (ICUs) professionals, the extubation failure rates in mechanically ventilated patients remain in the range of 5%-30%. Extubation failure is associated with increased risk of death and longer ICU stay. This study aimed to identify respiratory and non-respiratory parameters predictive of extubation outcome, and to use these predictors to develop and validate an "Extubation Predictive Score (ExPreS)" that could be used to predict likelihood of extubation success in patients receiving invasive mechanical ventilation (IMV). Read More

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TaSCA, an Agile Survey on Chemosensory Impairments for Self-Monitoring of COVID-19 Patients: A Pilot Study.

Front Neurol 2021 24;12:633574. Epub 2021 Feb 24.

Padova Neuroscience Center, Padua, Italy.

During the COVID-19 pandemic, smell and taste disorders emerged as key non-respiratory symptoms. Due to widespread presence of the disease and to difficult objective testing of positive persons, the use of short surveys became mandatory. Most of the existing resources are focused on smell, very few on taste or trigeminal chemosensation called chemesthesis. Read More

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February 2021

Diagnostic accuracy of symptoms as a diagnostic tool for SARS-CoV 2 infection: a cross-sectional study in a cohort of 2,173 patients.

BMC Infect Dis 2021 Mar 11;21(1):255. Epub 2021 Mar 11.

Endocrinology Service, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 330 Cuauhtémoc Avenue, 06720, Mexico City, Mexico.

Background: The SARS-CoV-2 pandemic continues to be a priority health problem; According to the World Health Organization data from October 13, 2020, 37,704,153 confirmed COVID-19 cases have been reported, including 1,079,029 deaths, since the outbreak. The identification of potential symptoms has been reported to be a useful tool for clinical decision-making in emergency departments to avoid overload and improve the quality of care. The aim of this study was to evaluate the performances of symptoms as a diagnostic tool for SARS -CoV-2 infection. Read More

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Predictors of failure with high-flow nasal oxygen therapy in COVID-19 patients with acute respiratory failure: a multicenter observational study.

J Intensive Care 2021 Mar 5;9(1):23. Epub 2021 Mar 5.

Department of Anesthesiology and Critical Care, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Villarroel 170, 08025, Barcelona, Spain.

Purpose: We aimed to describe the use of high-flow nasal oxygen (HFNO) in patients with COVID-19 acute respiratory failure and factors associated with a shift to invasive mechanical ventilation.

Methods: This is a multicenter, observational study from a prospectively collected database of consecutive COVID-19 patients admitted to 36 Spanish and Andorran intensive care units (ICUs) who received HFNO on ICU admission during a 22-week period (March 12-August 13, 2020). Outcomes of interest were factors on the day of ICU admission associated with the need for endotracheal intubation. Read More

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Implications of SARS-CoV-2 infection for neurogastroenterology.

Neurogastroenterol Motil 2021 03 16;33(3):e14104. Epub 2021 Feb 16.

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Background: Coronavirus disease 2019 (COVID-19) is associated with gastrointestinal and hepatic manifestation in up to one fifth of patients. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, infects gastrointestinal epithelial cells expressing angiotensin-converting enzyme 2 (ACE2) receptors triggering a cascade of events leading to mucosal and systemic inflammation. Symptomatic patients display changes in gut microbiota composition and function which may contribute to intestinal barrier dysfunction and immune activation. Read More

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Comprehensive rehabilitation treatment for sub-acute COVID-19 patients: an observational study.

Eur J Phys Rehabil Med 2021 Apr 4;57(2):208-215. Epub 2021 Feb 4.

Department of Rehabilitation, Versilia Hospital, AUSL Toscana Nord Ovest, Lucca, Italy -

Background: COVID-19 is a respiratory infection, but it should be considered as a systemic illness with increasing interest on the survivors' sequelae and their management. Considering multi-organ disabilities, a comprehensive rehabilitation provided in sub-acute phase could be considered a suitable setting for these patients.

Aim: The aim of this article was to report the features and rehabilitative outcomes of patients requiring rehabilitation due to disabilities related to severe COVID-19 infection. Read More

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For which infants with viral bronchiolitis could it be deemed appropriate to use albuterol, at least on a therapeutic trial basis?

Allergol Immunopathol (Madr) 2021 2;49(1):153-158. Epub 2021 Jan 2.

Department of Pediatrics, Sapienza University, Rome, Italy.

Although there is increasing evidence showing that infants with viral bronchiolitis exhibit a high degree of heterogeneity, a core uncertainty shared by many clinicians is with regard to understanding which patients are most likely to benefit from bronchodilators such as albuterol. Based on our review, we concluded that older infants with rhinovirus (RV) bronchiolitis, especially those with a nasopharyngeal microbiome dominated by Haemophilus influenzae; those affected during nonpeak months or during non-respiratory syncytial virus (RSV) predominant months; those with wheezing at presentation; those with clinical characteristics such as atopic dermatitis or a family history of asthma in a first-degree relative; and those infants infected with RSV genotypes ON1 and BA, have the greatest likelihood of benefiting from albuterol. Presently, this patient profile could serve as the basis for rational albuterol administration in patients with viral bronchiolitis, at least on a therapeutic trial basis, and it could also be the starting point for future targeted randomized clinical trials (RCTs) on the use of albuterol among a subset of infants with bronchiolitis. Read More

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January 2021

Psychological impact of the COVID-19 pandemic on patients with allergic diseases.

World Allergy Organ J 2021 Mar 22;14(3):100510. Epub 2021 Jan 22.

Regional Center of Allergy and Clinical Immunology, University Hospital "Dr. José Eleuterio González", Gonzalitos y Madero s/n Colonia Mitras Centro, Monterrey, Nuevo León, CP 64460, Mexico.

Background: On March 2020, World Health Organization (WHO) declared COVID-19 to be a pandemic disease. Interactions between allergy-related inflammatory and psychiatric disorders including depression, anxiety, and post-traumatic stress disorder (PTSD) have been documented. Therefore, those who have pre-existing allergic conditions may have an increased psychiatric reaction to the stresses of the COVID-19 pandemic. Read More

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Noninvasive ventilation in critically ill very old patients with pneumonia: A multicenter retrospective cohort study.

PLoS One 2021 27;16(1):e0246072. Epub 2021 Jan 27.

Barcelona Institute for Global Health, ISGlobal, Barcelona, Spain.

Background: Very old patients (≥ 80 years-old, VOP) are increasingly admitted to intensive care units (ICUs). Community-acquired pneumonia (CAP) is a common reason for admission and the best strategy of support for respiratory failure in this scenario is not fully known. We evaluated whether noninvasive ventilation (NIV) would be beneficial compared to invasive mechanical ventilation (IMV) regarding hospital mortality. Read More

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January 2021

Delayed emergencies: The composition and magnitude of non-respiratory emergency department visits during the COVID-19 pandemic.

J Am Coll Emerg Physicians Open 2021 Feb 14;2(1):e12349. Epub 2021 Jan 14.

Departments of Emergency Medicine and Medical Ethics and Health Policy Blue Cross and Blue Shield of Louisiana USA.

Importance: COVID-19 has been associated with excess mortality among patients not diagnosed with COVID-19, suggesting disruption of acute health care provision may play a role.

Objective: To determine the degree of declines in emergency department (ED) visits attributable to COVID-19 and determine whether these declines were concentrated among patients with fewer comorbidities and lower severity visits.

Design: We conducted a differences-in-differences analysis of all commercial health insurance claims for ED visits in the first 20 weeks of 2018, 2019, and 2020. Read More

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February 2021

The diagnostic accuracy of pre-hospital assessment of acute respiratory failure.

Br Paramed J 2020 Dec;5(3):15-22

University of Sheffield.

Introduction: Acute respiratory failure (ARF) is a common medical emergency. Pre-hospital management includes controlled oxygen therapy, supplemented by specific management options directed at the underlying disease. The aim of the current study was to characterise the accuracy of paramedic diagnostic assessment in acute respiratory failure. Read More

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December 2020

Early Diagnosis of COVID-19 on Non-Chest CT Studies in the Emergency Setting: A Case Series and Review of the Literature.

Cureus 2020 Nov 28;12(11):e11748. Epub 2020 Nov 28.

Radiology, Newark Beth Israel Medical Center, Newark, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel strain of coronavirus that has spread throughout the globe causing coronavirus disease 2019 (COVID-19). As the number of cases rises in the United States (US), it has become more imperative to detect COVID-19 at its earliest radiologic stage to decrease community transmission. In this case series, we discuss five patients who presented with non-respiratory-related symptoms and underwent non-chest CT imaging, such as abdominal and neck CT, with a portion of the lungs visualized in each respective study. Read More

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November 2020

Cardiopulmonary resuscitation in quaternary neonatal intensive care units: a multicenter study.

Resuscitation 2021 02 24;159:77-84. Epub 2020 Dec 24.

Department of Pediatrics, Division of Perinatal-Neonatal Medicine, University of Washington, School of Medicine, Seattle, Washington, United States.

Background: The reported incidence of cardiopulmonary resuscitation (CPR) in quaternary NICU is approximately 10-times higher than in the delivery room. However, the etiologies and outcomes of CPR in quaternary NICUs are poorly understood. We hypothesized that demographic characteristics, diagnoses, interventions, and arrest etiologies would be associated with survival to discharge after CPR. Read More

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February 2021

Seventy patients treated for COVID-19 by Østfold Hospital Trust.

Tidsskr Nor Laegeforen 2020 12 14;140(18). Epub 2020 Dec 14.

Background: There is a need for further data on the COVID-19 situation in Norway. Our aim was to describe the patients admitted to our local hospital with COVID-19 in the spring of 2020.

Material And Method: Data were retrieved retrospectively from our local quality register for COVID-19 and include all patients admitted to Østfold Hospital in the period 10 March 2020-31 May 2020. Read More

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December 2020

Genomic epidemiology of nontoxigenic from King County, Washington State, USA between July 2018 and May 2019.

Microb Genom 2020 12 4;6(12). Epub 2020 Dec 4.

Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Between July 2018 and May 2019, was isolated from eight patients with non-respiratory infections, seven of whom experienced homelessness and had stayed at shelters in King County, WA, USA. All isolates were microbiologically identified as nontoxigenic biovar mitis. Whole-genome sequencing confirmed that all case isolates were genetically related, associated with sequence type 445 and differing by fewer than 24 single-nucleotide polymorphisms (SNPs). Read More

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December 2020

The impact of COVID-19 on morbidity and mortality in neck of femur fracture patients: a prospective case-control cohort study.

Bone Jt Open 2020 Nov 2;1(11):669-675. Epub 2020 Nov 2.

Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK.

Aims: Within the UK, around 70,000 patients suffer neck of femur (NOF) fractures annually. Patients presenting with this injury are often frail, leading to increased morbidity and a 30-day mortality rate of 6.1%. Read More

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November 2020

The cystic fibrosis gut as a potential source of multidrug resistant pathogens.

J Cyst Fibros 2020 Nov 26. Epub 2020 Nov 26.

SAHMRI Microbiome Research Laboratory, Flinders University College of Medicine and Public Health, Adelaide, SA, Australia; Microbiome and Host Health, South Australia Health and Medical Research Institute, North Terrace, Adelaide, SA, Australia.

Background: The emergence of multidrug resistant (MDR) pathogens represents a profound threat to global health. Individuals with CF have amongst the highest cumulative antibiotic exposure of any patient group, including to critically-important last-line agents. While there is little evidence that antibiotic resistance in airway pathogens results in worse clinical outcomes for CF patients, the potential emergence of MDR pathogens in non-respiratory systems, as a consequence of CF care, represents a potential health threat to the wider population, including family and carers. Read More

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November 2020

Extra-pulmonary manifestations of COPD and the role of pulmonary rehabilitation: a symptom-centered approach.

Expert Rev Respir Med 2021 Jan 10;15(1):131-142. Epub 2020 Dec 10.

REVAL - Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University , Diepenbeek, Belgium.

: Chronic obstructive pulmonary disease (COPD) is a complex and heterogenous disease that is associated with a range of respiratory and non-respiratory symptoms, which highly contribute to the daily burden of the disease. Symptoms burden remains high despite optimal bronchodilator therapy, but pulmonary rehabilitation (PR) is an effective intervention to improve patients' symptoms. A comprehensive interdisciplinary approach within the framework of a PR program is warranted to tackle these complex symptoms and their consequences. Read More

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January 2021

Protocol for a case-control study of vitamin D status, adult multidrug-resistant tuberculosis disease and tuberculosis infection in Mumbai, India.

BMJ Open 2020 11 12;10(11):e039935. Epub 2020 Nov 12.

Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

Introduction: Vitamin D status may be an important determinant of multidrug-resistant tuberculosis (MDR-TB) infection, progression to disease and treatment outcomes. Novel and potentially cost-effective therapies such as vitamin D supplementation are needed to stem the tide of TB and MDR-TB globally, particularly in India, a country that accounts for the largest fraction of the world's TB incidence and MDR-TB incidence, and where vitamin D deficiency is endemic. While vitamin D has shown some promise in the treatment of MDR-TB, its role in the context of MDR-TB infection and progression to disease is largely unknown. Read More

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November 2020

Newly Reported Studies on the Increase in Gastrointestinal Symptom Prevalence withCOVID-19 Infection: A Comprehensive Systematic Review and Meta-Analysis.

Diseases 2020 Nov 10;8(4). Epub 2020 Nov 10.

Division of Gastroenterology & Hepatology, Department of Internal Medicine, University of Missouri, Columbia, MO 65212, USA.

Background And Aim: Although constitutional and respiratory symptoms such as cough and fever are the most common symptoms in patients infected with COVID-19, gastrointestinal (GI) tract involvement has been observed by endoscopic biopsies. Multiple GI symptoms, including diarrhea, nausea or vomiting and abdominal pain, have also been reported. This review aims to present the currently available data regarding the GI symptoms of COVID-19 patients, and to compare the frequency of GI symptoms in early stage (Eastern) mostly Chinese data to the current stage (Western) non-Chinese data. Read More

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November 2020

Epidemiology and outcomes of invasive mechanical ventilation without ICU admission in acute care hospitals in Texas: A population-based cohort study.

Lavi Oud John Garza

J Crit Care 2021 Feb 24;61:107-114. Epub 2020 Oct 24.

Texas Tech University Health Sciences Center at the Permian Basin, 701 W. 5(th) Street, Odessa, TX 79763, United States; Department of Mathematics, The University of Texas of the Permian Basin, 4901 E. University Blvd, Odessa, Texas 79762, United States.

Purpose: The high ICU bed capacity in the United States (US) allows ICU care of patients requiring invasive mechanical ventilation (IMV), absent public health crisis. The use of IMV without ICU admission (non-ICU) in acute care hospitals in the US and its impact on patients' outcomes were not examined.

Methods: A retrospective cohort study was performed using statewide inpatient data in Texas to identify hospitalizations aged ≥18 years receiving IMV in acute care hospitals with ICU care capability during January 2014 through September 2015. Read More

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February 2021