1,179 results match your criteria non-respiratory


Supplemental Learning in Respiratory Physiology for Healthcare Professionals Towards Successful Treatment of COVID-19.

Front Physiol 2021 20;12:624528. Epub 2021 Apr 20.

School of Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom.

The immunological and pathophysiological response to COVID-19 can cause severe respiratory impairment affecting gas exchange and lung mechanics. Such was the scale of the respiratory support needed during the first wave of the pandemic, that recruitment of non-respiratory clinical staff was essential to help deal with the growing number of cases. It quickly became apparent that it was vital to rapidly equip these healthcare professionals with appropriate physiological knowledge and practical skills if therapies were to be applied effectively. Read More

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Ac-SDKP Attenuates Activation of Lung Macrophages and Bone Osteoclasts in Rats Exposed to Silica by Inhibition of TLR4 and RANKL Signaling Pathways.

J Inflamm Res 2021 27;14:1647-1660. Epub 2021 Apr 27.

Basic Medical College, Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei Province, 063210, People's Republic of China.

Background: Silica-induced inflammatory activation is associated with silicosis and various non-respiratory conditions. The present study was designed to examine the anti-inflammatory effects of N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) on lung macrophages and bone osteoclasts after silica inhalation in rats.

Methods: Wistar rats and NR8383 and RAW 264. Read More

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Vitamin D deficiency in children with acute bronchiolitis: a prospective cross-sectional case- control study.

BMC Pediatr 2021 Apr 30;21(1):211. Epub 2021 Apr 30.

Department of Pediatrics, Soroka University Medical Center, Beer-Sheva, Israel.

Background: 25(OH) vitamin D levels are inversely associated with respiratory infections and childhood wheezing.

Objective: To evaluate serum 25(OH) vitamin D levels in infants and toddlers with acute bronchiolitis, compared to subjects with non-respiratory febrile illness.

Methods: A prospective cross-sectional case-control study which compared serum 25(OH) vitamin D levels between infants and toddlers diagnosed with acute bronchiolitis to subjects with non-respiratory febrile illness. Read More

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Cardiovascular Outcomes in the Acute Phase of COVID-19.

Int J Mol Sci 2021 Apr 15;22(8). Epub 2021 Apr 15.

Department of Cardiology, Tokyo Medical University, Tokyo 160-0023, Japan.

The cumulative number of cases in the current global coronavirus disease 19 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has exceeded 100 million, with the number of deaths caused by the infection having exceeded 2.5 million. Recent reports from most frontline researchers have revealed that SARS-CoV-2 can also cause fatal non-respiratory conditions, such as fatal cardiovascular events. Read More

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Non-Respiratory Symptoms of Patients Infected with SARS-CoV-2 (Coronavirus Disease 2019): Lessons from Their Initial Presentation at the Hospital.

Medicina (Kaunas) 2021 Apr 2;57(4). Epub 2021 Apr 2.

Infection Control Unit, General Hospital of Thessaloniki "Papageorgiou", 56403 Thessaloniki, Greece.

As the COVID-19 pandemic spreads, it is becoming increasingly evident that this coronavirus is not limited to the respiratory system and that the musculoskeletal system can also be affected. The purpose of the present study was to describe non-respiratory symptoms of laboratory-confirmed COVID-19 cases. All patients with SARS-CoV-2 admitted to our hospital, between 1 August and 30 September 2020, were included in this retrospective study. Read More

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Prediction of successful de-cannulation of tracheostomised patients in medical intensive care units.

Respir Res 2021 Apr 28;22(1):131. Epub 2021 Apr 28.

Department of Critical Care Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Republic of Korea.

Background: Limited data are available on practical predictors of successful de-cannulation among the patients who undergo tracheostomies. We evaluated factors associated with failed de-cannulations to develop a prediction model that could be easily be used at the time of weaning from MV.

Methods: In a retrospective cohort of 346 tracheostomised patients managed by a standardized de-cannulation program, multivariable logistic regression analysis identified variables that were independently associated with failed de-cannulation. Read More

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Chronic obstructive pulmonary disease exacerbation fundamentals: Diagnosis, treatment, prevention and disease impact.

Respirology 2021 Apr 24. Epub 2021 Apr 24.

Department of Translational Medicine, University of Ferrara, Ferrara, Italy.

In chronic obstructive pulmonary disease (COPD), exacerbations (ECOPD), characterized by an acute deterioration in respiratory symptoms, are fundamental events impacting negatively upon disease progression, comorbidities, wellbeing and mortality. ECOPD also represent the largest component of the socioeconomic burden of COPD. ECOPDs are currently defined as acute worsening of respiratory symptoms that require additional therapy. Read More

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Reconstruction of COVID-19-Related Compartment Syndrome With Massive Soft Tissue Necrosis.

Wounds 2021 Apr;33(4):99-105

Rubin Institute for Advanced Orthopedics, Baltimore, Maryland.

Introduction: The COVID-19 virus is caused by the new coronavirus, SARS-CoV-2. COVID-19 has drastically changed the medical landscape. Although predominantly impacting the respiratory system, COVID-19 has several non-respiratory symptoms associated with its presentation and course. Read More

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Considerations and perspectives on digestive diseases during the COVID-19 pandemic: a narrative review.

Ann Palliat Med 2021 Apr 1;10(4):4858-4867. Epub 2021 Apr 1.

Department of Gastroenterology, the First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory for Gastrointestinal Diseases, Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.

Coronavirus disease 2019 (COVID-19) was initially reported in December 2019, and since then it has become a pandemic with newly confirmed cases and deaths increasing continuously. The COVID-19 pandemic has dramatically impacted the organization and execution of activities in the clinical sector. Asymptomatic infections are increasingly being identified when patients seek medical advice for non-respiratory system illnesses, particularly digestive system symptoms. Read More

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Sedentary time in people with obstructive airway diseases.

Respir Med 2021 Mar 24;181:106367. Epub 2021 Mar 24.

National Health and Medical Research Council Centre of Excellence in Severe Asthma, Australia; Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, Australia; Hunter Medical Research Institute, Newcastle, Australia; Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia; School of Nursing and Midwifery, University of Newcastle, Australia. Electronic address:

Sedentary time (ST) and light-intensity physical activity (LIPA) are movement behaviours associated with important health outcomes, but are not widely explored in respiratory diseases. We aimed to describe their volume and/or accumulation patterns in moderate-severe COPD, bronchiectasis and severe asthma using the accurate postural-based accelerometer activPAL, contrasting these values with a non-respiratory population. We also sought to test the cross-sectional associations of these behaviours with disease characteristics by diagnostic group, and as a combined label-free disease group. Read More

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Coexistence of asthmatic and non-respiratory allergic symptoms in children of Batumi Region, Georgia: occurrence and association with known diagnosis of asthma.

Cent Eur J Public Health 2021 Mar;29(1):23-27

Department of Epidemiology, Faculty of Medical Sciences, Medical University of Silesia in Katowice, Katowice, Poland.

Objectives: Our recent studies showed that in children in the Batumi region, Georgia, underdiagnosis of asthma is 65%, and that not all children with known asthma had a history of allergic disorders. So, we decided to assess the association of known diagnosis of paediatric asthma with asthma-like symptoms and non-respiratory allergic symptoms and diseases using questionnaire-derived data provided by respiratory health survey.

Methods: Subjects of the cross-sectional population-based study were 3,239 urban and 2,113 rural children aged 5-17 years whose respiratory status was assessed using the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Read More

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COVID-19 (SARS-CoV-2) in Non-Airborne body fluids: A systematic review & Meta-analysis.

Turk J Urol 2021 Mar 1;47(2):87-97. Epub 2021 Mar 1.

Bristol Medical School, University of Bristol, Bristol, UK.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has been predominantly respiratory. This study aimed to evaluate the presence of virus in non-airborne body fluids as transmission vehicles. Medline, EMBASE, and Cochrane Library databases were searched from December 01, 2019, to July 01, 2020, using terms relating to SARS-CoV-2 and non-airborne clinical sample sources (feces, urine, blood, serum, serum, and peritoneum). Read More

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The Weight of Obesity in Immunity from Influenza to COVID-19.

Front Cell Infect Microbiol 2021 17;11:638852. Epub 2021 Mar 17.

Laboratory of Immunothrombosis, Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Juiz de Fora, Brazil.

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged in December 2019 and rapidly outspread worldwide endangering human health. The coronavirus disease 2019 (COVID-19) manifests itself through a wide spectrum of symptoms that can evolve to severe presentations as pneumonia and several non-respiratory complications. Increased susceptibility to COVID-19 hospitalization and mortality have been linked to associated comorbidities as diabetes, hypertension, cardiovascular diseases and, recently, to obesity. Read More

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COVID-19 Infection among Older People Admitted to Hospital: A Cross-Sectional Analysis.

Geriatrics (Basel) 2021 Mar 8;6(1). Epub 2021 Mar 8.

Geriatric Medicine Unit, Department of Medicine, University Malaya Medical Centre, Kuala Lumpur 59100, Malaysia.

(1) Background: Older people with COVID-19 infection report worse clinical outcomes. There is a paucity of local data and this study aimed to describe the clinical progression of older people admitted to a university hospital in Malaysia with COVID-19 infection. (2) Methods: Older people (≥60 years) admitted with COVID-19 infection confirmed with RT-PCR from 27 February 2020-25 May 2020 were included in this study. Read More

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Pirfenidone in patients with progressive fibrotic interstitial lung diseases other than idiopathic pulmonary fibrosis (RELIEF): a double-blind, randomised, placebo-controlled, phase 2b trial.

Lancet Respir Med 2021 05 30;9(5):476-486. Epub 2021 Mar 30.

Center for Interstitial and Rare Lung Diseases, Justus-Liebig University Giessen, Giessen, Germany; Member of the German Center for Lung Research and Cardiopulmonary Institute, and Agaplesion Lung Clinic Waldhof-Elgershausen, Greifenstein, Germany.

Background: Pirfenidone has been shown to slow disease progression in patients with idiopathic pulmonary fibrosis (IPF). However, there are few treatment options for progressive fibrotic interstitial lung diseases (ILDs)) other than IPF. In view of the pathomechanistic and clinical similarities between IPF and other progressive fibrotic ILDs, we aimed to assess the efficacy and safety of pirfenidone in patients with four non-IPF progressive fibrotic ILDs. Read More

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Lung recruitment manoeuvres for reducing mortality and respiratory morbidity in mechanically ventilated neonates.

Cochrane Database Syst Rev 2021 03 30;3:CD009969. Epub 2021 Mar 30.

School of Allied Health, Australian Catholic University, Brisbane, Australia.

Background: Preterm infants and neonates with respiratory conditions commonly require intubation and conventional mechanical ventilation (CMV) to maintain airway patency and support their respiration. Whilst this therapy is often lifesaving, it simultaneously carries the risk of lung injury. The use of lung recruitment manoeuvres (LRMs) has been found to reduce the incidence of lung injury, and improve oxygenation and lung compliance in ventilated adults. Read More

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Prediction of extubation outcome in mechanically ventilated patients: Development and validation of the Extubation Predictive Score (ExPreS).

PLoS One 2021 18;16(3):e0248868. Epub 2021 Mar 18.

Universidade do Oeste de Santa Catarina (UNOESC), Joaçaba, Santa Catarina, Brazil.

Despite the best efforts of intensive care units (ICUs) professionals, the extubation failure rates in mechanically ventilated patients remain in the range of 5%-30%. Extubation failure is associated with increased risk of death and longer ICU stay. This study aimed to identify respiratory and non-respiratory parameters predictive of extubation outcome, and to use these predictors to develop and validate an "Extubation Predictive Score (ExPreS)" that could be used to predict likelihood of extubation success in patients receiving invasive mechanical ventilation (IMV). Read More

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Hemopexin: A Novel Anti-inflammatory Marker for Distinguishing COPD From Asthma.

Allergy Asthma Immunol Res 2021 May;13(3):450-467

National Health and Medical Research Council Centre for Research Excellence in Severe Asthma and The Priority Research Centre for Health Lungs, The University of Newcastle, Newcastle, NSW, Australia.

Purpose: Systemic inflammatory biomarkers can improve diagnosis and assessment of chronic obstructive pulmonary disease (COPD) and asthma. We aimed to validate an airway disease biomarker panel of 4 systemic inflammatory biomarkers, α2-macroglobulin, ceruloplasmin, haptoglobin and hemopexin, to establish their relationship to airway disease diagnosis and inflammatory phenotypes and to identify an optimized biomarker panel for disease differentiation.

Methods: Participants with COPD or asthma were classified by inflammatory phenotypes. Read More

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TaSCA, an Agile Survey on Chemosensory Impairments for Self-Monitoring of COVID-19 Patients: A Pilot Study.

Front Neurol 2021 24;12:633574. Epub 2021 Feb 24.

Padova Neuroscience Center, Padua, Italy.

During the COVID-19 pandemic, smell and taste disorders emerged as key non-respiratory symptoms. Due to widespread presence of the disease and to difficult objective testing of positive persons, the use of short surveys became mandatory. Most of the existing resources are focused on smell, very few on taste or trigeminal chemosensation called chemesthesis. Read More

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February 2021

Diagnostic accuracy of symptoms as a diagnostic tool for SARS-CoV 2 infection: a cross-sectional study in a cohort of 2,173 patients.

BMC Infect Dis 2021 Mar 11;21(1):255. Epub 2021 Mar 11.

Endocrinology Service, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, 330 Cuauhtémoc Avenue, 06720, Mexico City, Mexico.

Background: The SARS-CoV-2 pandemic continues to be a priority health problem; According to the World Health Organization data from October 13, 2020, 37,704,153 confirmed COVID-19 cases have been reported, including 1,079,029 deaths, since the outbreak. The identification of potential symptoms has been reported to be a useful tool for clinical decision-making in emergency departments to avoid overload and improve the quality of care. The aim of this study was to evaluate the performances of symptoms as a diagnostic tool for SARS -CoV-2 infection. Read More

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Breathomics: Review of Sample Collection and Analysis, Data Modeling and Clinical Applications.

Crit Rev Anal Chem 2021 Mar 11:1-27. Epub 2021 Mar 11.

Food and Drug Safety Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Metabolomics research is rapidly gaining momentum in disease diagnosis, on top of other Omics technologies. Breathomics, as a branch of metabolomics is developing in various frontiers, for early and noninvasive monitoring of disease. This review starts with a brief introduction to metabolomics and breathomics. Read More

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Predictors of failure with high-flow nasal oxygen therapy in COVID-19 patients with acute respiratory failure: a multicenter observational study.

J Intensive Care 2021 Mar 5;9(1):23. Epub 2021 Mar 5.

Department of Anesthesiology and Critical Care, Hospital Clínic, Institut D'investigació August Pi i Sunyer, Villarroel 170, 08025, Barcelona, Spain.

Purpose: We aimed to describe the use of high-flow nasal oxygen (HFNO) in patients with COVID-19 acute respiratory failure and factors associated with a shift to invasive mechanical ventilation.

Methods: This is a multicenter, observational study from a prospectively collected database of consecutive COVID-19 patients admitted to 36 Spanish and Andorran intensive care units (ICUs) who received HFNO on ICU admission during a 22-week period (March 12-August 13, 2020). Outcomes of interest were factors on the day of ICU admission associated with the need for endotracheal intubation. Read More

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Prolonged acute intermittent hypoxia improves forelimb reach-to-grasp function in a rat model of chronic cervical spinal cord injury.

Exp Neurol 2021 Jun 27;340:113672. Epub 2021 Feb 27.

Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK S7N 5B4, Canada. Electronic address:

Repetitive acute intermittent hypoxia (AIH - brief, episodes of low inspired oxygen) elicits spinal motor plasticity, resulting in sustained improvements of respiratory and non-respiratory motor function in both animal models and humans with chronic spinal cord injury (SCI). We previously demonstrated that 7 days of AIH combined with task-specific training improves performance on a skilled locomotor task for at least 3 weeks post-treatment in rats with incomplete SCI. Here we investigated the effect of repetitive AIH administered for 12 wks on a forelimb reach-to-grasp task in a rat model of chronic, incomplete cervical SCI. Read More

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Impact of non-pharmaceutical interventions (NPIs) for SARS-CoV-2 on norovirus outbreaks: an analysis of outbreaks reported by 9 US States.

J Infect Dis 2021 Feb 19. Epub 2021 Feb 19.

Epidemiology Department, Rollins School of Public Health, Emory University, Atlanta, GA,USA.

In April 2020, the incidence of norovirus outbreaks reported to the National Outbreak Reporting System (NORS) dramatically declined. We used regression models to determine if this decline was best explained by underreporting, seasonal trends, or reduced exposure due to non-pharmaceutical interventions (NPIs) implemented for SARS-CoV-2 using data from 9 states from July 2012-July 2020. The decline in norovirus outbreaks was significant for all 9 states and underreporting or seasonality are unlikely to be the primary explanations for these findings. Read More

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February 2021

Socioeconomic circumstances and lung function growth from early adolescence to early adulthood.

Pediatr Res 2021 Feb 18. Epub 2021 Feb 18.

EPIUnit, Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.

Background: A reduced lung function in early adulthood is associated with respiratory and non-respiratory diseases and is a long-term predictor of mortality. This study investigated the association between early socioeconomic circumstances (SEC) and lung function growth trajectories from early adolescence until early adulthood.

Methods: We analysed data from the EPITeen population-based study, including adolescents born in 1990. Read More

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February 2021

COVID-19 symptoms: a case-control study, Portugal, March-April 2020.

Epidemiol Infect 2021 02 19;149:e54. Epub 2021 Feb 19.

Division of Epidemiology and Statistics, Directorate-General of Health, Lisbon, Portugal.

COVID-19, although a respiratory illness, has been clinically associated with non-respiratory symptoms. We conducted a negative case-control study to identify the symptoms associated with SARS-CoV-2-positive results in Portugal. Twelve symptoms and signs included in the clinical notification of COVID-19 were selected as predictors, and the dependent variable was the RT-PCR test result. Read More

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February 2021

Implications of SARS-CoV-2 infection for neurogastroenterology.

Neurogastroenterol Motil 2021 03 16;33(3):e14104. Epub 2021 Feb 16.

IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.

Background: Coronavirus disease 2019 (COVID-19) is associated with gastrointestinal and hepatic manifestation in up to one fifth of patients. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, infects gastrointestinal epithelial cells expressing angiotensin-converting enzyme 2 (ACE2) receptors triggering a cascade of events leading to mucosal and systemic inflammation. Symptomatic patients display changes in gut microbiota composition and function which may contribute to intestinal barrier dysfunction and immune activation. Read More

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Beyond denitrification: The role of microbial diversity in controlling nitrous oxide reduction and soil nitrous oxide emissions.

Glob Chang Biol 2021 Feb 5. Epub 2021 Feb 5.

Departments of Plant Biology and Geology, University of Illinois at Urbana-Champaign, Urbana, IL, USA.

Many biotic and abiotic processes contribute to nitrous oxide (N O) production in the biosphere, but N O consumption in the environment has heretofore been attributed primarily to canonical denitrifying microorganisms. The nosZ genes encoding the N O reductase enzyme, NosZ, responsible for N O reduction to dinitrogen are now known to include two distinct groups: the well-studied Clade I which denitrifiers typically possess, and the novel Clade II possessed by diverse groups of microorganisms, most of which are non-denitrifiers. Clade II N O reducers could play an important, previously unrecognized role in controlling N O emissions for several reasons, including: (1) the consumption of N O produced by processes other than denitrification, (2) hypothesized non-respiratory functions of NosZ as an electron sink or for N O detoxification, (3) possible differing enzyme kinetics of Clade II NosZ compared to Clade I NosZ, and (4) greater nosZ gene abundance for Clade II compared to Clade I in soils of many ecosystems. Read More

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February 2021

Comprehensive rehabilitation treatment for sub-acute COVID-19 patients: an observational study.

Eur J Phys Rehabil Med 2021 Apr 4;57(2):208-215. Epub 2021 Feb 4.

Department of Rehabilitation, Versilia Hospital, AUSL Toscana Nord Ovest, Lucca, Italy -

Background: COVID-19 is a respiratory infection, but it should be considered as a systemic illness with increasing interest on the survivors' sequelae and their management. Considering multi-organ disabilities, a comprehensive rehabilitation provided in sub-acute phase could be considered a suitable setting for these patients.

Aim: The aim of this article was to report the features and rehabilitative outcomes of patients requiring rehabilitation due to disabilities related to severe COVID-19 infection. Read More

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Respiratory therapy for the treatment of anxiety: Meta-analytic review and regression.

Clin Psychol Rev 2021 Jan 24;84:101980. Epub 2021 Jan 24.

Department of Psychiatry, Rutgers Robert Wood Johnson Medical School, United States.

Objective: Respiratory abnormalities are a hallmark of anxiety symptomatology and may serve as clinically useful modifiers for alleviating anxiety symptoms. However, gold-standard anxiety treatments (e.g. Read More

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January 2021