3,161 results match your criteria non-pharmacological interventions


Probiotics for preventing gestational diabetes.

Cochrane Database Syst Rev 2021 Apr 19;4:CD009951. Epub 2021 Apr 19.

School of Chemistry and Molecular Biosciences, The University of Queensland, St. Lucia, Australia.

Background: Gestational diabetes mellitus (GDM) is associated with a range of adverse pregnancy outcomes for mother and infant. The prevention of GDM using lifestyle interventions has proven difficult. The gut microbiome (the composite of bacteria present in the intestines) influences host inflammatory pathways, glucose and lipid metabolism and, in other settings, alteration of the gut microbiome has been shown to impact on these host responses. Read More

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Intraoperative Laryngeal Mask Airway-Related Hiccup: An Overview.

Transl Perioper Pain Med 2020 14;7(1):145-151. Epub 2019 Oct 14.

Department of Anesthesiology, Drexel University College of Medicine, Reading Hospital/Tower Health System, 420 S 5th Avenue, West Reading, PA 19611, USA.

Hiccup is an involuntary contraction of the diaphragm and intercostal muscles resulting in sudden inspiration and closure of the glottis. The presence of hiccup in the perioperative period can be a challenging problem. Sudden movements of the patient from hiccups can interfere preoperative diagnostic procedures, intraoperative hiccup may delay the beginning of surgery, interfere with the surgical process, and affect intraoperative monitoring, and postoperative hiccup may affect would healing and hemodynamic stability. Read More

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October 2019

Understanding the Multiple Role of Mitochondria in Parkinson's Disease and Related Disorders: Lesson From Genetics and Protein-Interaction Network.

Front Cell Dev Biol 2021 1;9:636506. Epub 2021 Apr 1.

Unit of Neurology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

As neurons are highly energy-demanding cell, increasing evidence suggests that mitochondria play a large role in several age-related neurodegenerative diseases. Synaptic damage and mitochondrial dysfunction have been associated with early events in the pathogenesis of major neurodegenerative diseases, including Parkinson's disease, atypical parkinsonisms, and Huntington disease. Disruption of mitochondrial structure and dynamic is linked to increased levels of reactive oxygen species production, abnormal intracellular calcium levels, and reduced mitochondrial ATP production. Read More

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[Long-term effect analysis of a cognitive stimulation program in mild cognitive impairment elderly in Primary Care: A randomized controlled trial].

Aten Primaria 2021 Apr 14;53(7):102053. Epub 2021 Apr 14.

Residencia Reyes de Aragón/Orpea, Zaragoza, España. Electronic address:

Objective: To provide evidence about the efficacy of a community health intervention through a cognitive stimulation program at long term in older people with mild cognitive impairment.

Design: Randomized controlled trial (CONSORT group norms).

Location: San José Norte-Centro Primary Care Center and La Caridad Foundation (Zaragoza, Spain). Read More

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Implementation conditions leading to the scale-up of an innovation involving the optimal use of antipsychotics in long-term care centers: The Optimizing Practices, use, Care and Services-Antipsychotics (OPUS-AP) program.

Res Social Adm Pharm 2021 Apr 12. Epub 2021 Apr 12.

University of Sherbrooke, Canada; Research Center on Aging of CIUSSS de L'Estrie-CHUS, Canada. Electronic address:

Background: Antipsychotics are often used for the first-line management of behavioral and psychological symptoms of dementia despite their limited efficacy and the risk of serious adverse drug events, compounded with disregard for guidelines recommending prioritizing non-pharmacological interventions. Some innovative interventions promote the deprescription of antipsychotics in long term care (LTC) settings.

Objective: The objective of this article is to present the conditions leading to the scale-up of an innovative program on the appropriate use of antipsychotics in LTC centers. Read More

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Effectiveness of multimodal interventions focused on smoking cessation in patients with schizophrenia: A systematic review.

Schizophr Res 2021 Apr 12;231:145-153. Epub 2021 Apr 12.

Department of Biomedicine-Pharmacology and Therapeutics unit, Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200 - 319 Porto, Portugal; Department of Psychiatry and Mental Health, University Hospital Center of São João, Alameda Prof. Hernâni Monteiro, 4200 - 319 Porto, Portugal. Electronic address:

Background: Smoking is a significant risk factor for mortality and morbidity among patients with schizophrenia.

Objective: To clarify the effectiveness of multimodal smoking cessation interventions in adult smokers diagnosed with schizophrenia.

Methods: A systematic review was conducted according to PRISMA guidelines. Read More

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Opioid-Induced Constipation in Advanced Cancer Patients.

Cureus 2021 Apr 9;13(4):e14386. Epub 2021 Apr 9.

Oncology Department/Palliative Care, Princess Noorah Oncology Center, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Jeddah, SAU.

The present study discusses opioid-induced constipation (OIC) in advanced cancer patients, focusing on the OIC definition, pathophysiology, and treatment. OIC is any change from baseline defecation patterns and bowel habits that developed after starting opioid therapy. The condition is characterized by bowel frequency reduction, worsening or development of straining, a sensation of incomplete defecation, or distress associated with bowel habits. Read More

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Effectiveness of treatments for acute and subacute mechanical non-specific low back pain: a systematic review with network meta-analysis.

Br J Sports Med 2021 Apr 13. Epub 2021 Apr 13.

Unit of Clinical Epidemiology, IRCCS Istituto Ortopedico Galeazzi, Milano, Lombardia, Italy.

Objective: To assess the effectiveness of interventions for acute and subacute non-specific low back pain (NS-LBP) based on pain and disability outcomes.

Design: A systematic review of the literature with network meta-analysis.

Data Sources: Medline, Embase and CENTRAL databases were searched from inception until 17 October 2020. Read More

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Parkinson's disease.

Lancet 2021 Apr 9. Epub 2021 Apr 9.

Institute of Neurogenetics and Department of Neurology, University of Lübeck and University Hospital Schleswig-Holstein, Lübeck, Germany.

Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; the rising prevalence worldwide resembles the many characteristics typically observed during a pandemic, except for an infectious cause. In most populations, 3-5% of Parkinson's disease is explained by genetic causes linked to known Parkinson's disease genes, thus representing monogenic Parkinson's disease, whereas 90 genetic risk variants collectively explain 16-36% of the heritable risk of non-monogenic Parkinson's disease. Read More

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Current Management of Age-Related Macular Degeneration.

Adv Exp Med Biol 2021 ;1256:295-314

Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.

Age-related macular degeneration (AMD) remains a leading cause of blindness worldwide. The assessment and management of patients with this condition has evolved in the last decades. In this chapter, current standards for diagnosis, follow-up, and treatment of patients with AMD are reviewed and summarized. Read More

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Pediatric dental treatments with pharmacological and non-pharmacological interventions: a cross-sectional study.

BMC Oral Health 2021 Apr 12;21(1):186. Epub 2021 Apr 12.

Alfarabi Dental College, Jeddah, Saudi Arabia.

Objectives: Behaviour management strategies involving pharmacological or non-pharmacological interventions during dental procedures should be considered to attain safe and successful treatment outcomes. This study compared the frequencies of use and the completeness of treatment with these interventions.

Methods: A total of 1725 dental records of patients up to 18 years old, who were treated in the King Abdulaziz Medical City in Jeddah City from October 2018 to June 2019, were used in this retrospective, cross-sectional study. Read More

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Nutraceuticals with anti-inflammatory and anti-oxidant properties as intervention for reducing the health effects of fine particulate matter: Potential and Prospects.

Comb Chem High Throughput Screen 2021 Apr 12. Epub 2021 Apr 12.

ICMR- National Institute for Research in Environmental Health (NIREH), Bhopal-462030, Madhya Pradesh. India.

Air pollution, especially particulate matter pollution adversely affects human health. A growing pool of evidence has emerged which underscores the potential of individual-level nutritional interventions in attenuating the adverse health impact of exposure to PM2.5. Read More

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Face mask use during the Covid-19 pandemic - the significance of culture and the symbolic meaning of behaviour.

Ann Epidemiol 2021 Apr 6. Epub 2021 Apr 6.

Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden; Department of Anthropology, Ball State University, Muncie, IN, United States. Electronic address:

During public emergencies, a door can open on the fundamental elements upon which a society's social order is built. The Covid-19 pandemic has opened such a door in societies worldwide. We outline in this commentary some of these social elements and how they may have influenced face mask use during the early stages of the pandemic. Read More

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Untypical Metabolic Adaptations in Spontaneously Hypertensive Rats to Free Running Wheel Activity Includes Uncoupling Protein-3 (UCP-3) and Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Expression.

Front Physiol 2021 23;12:598723. Epub 2021 Mar 23.

Department of Medicine, Institute of Physiology, Justus Liebig University Giessen, Giessen, Germany.

Obesity and hypertension are common risk factors for cardiovascular disease whereas an active lifestyle is considered as protective. However, the interaction between high physical activity and hypertension is less clear. Therefore, this study investigates the impact of high physical activity on the muscular and hepatic expression of glucose transporters (Glut), uncoupling proteins (UCPs), and proprotein convertase subtilisin/kexin type 9 (PCSK9) in spontaneously hypertensive rats (SHRs). Read More

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What is the lived experience of anxiety for people with Parkinson's? A phenomenological study.

PLoS One 2021 8;16(4):e0249390. Epub 2021 Apr 8.

Department of Occupational Therapy and Human Nutrition and Dietetics, School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Scotland, United Kingdom.

Purpose: Anxiety is a common non-motor symptom of Parkinson's and there is no specific pharmacological intervention for people with Parkinson's who experience anxiety. Yet there is little specific research documenting how individuals with this condition experience anxiety. It is important to explore the experiences of people with Parkinson's to identify potential issues in developing future non-pharmacological interventions. Read More

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Paediatrics: how to manage functional constipation.

Drugs Context 2021 26;10. Epub 2021 Mar 26.

Department of Paediatrics, The Chinese University of Hong Kong, Shatin, Hong Kong.

Background: Despite being a common problem in childhood, functional constipation is often difficult to manage. This article provides a narrative updated review on the evaluation, diagnosis and management of childhood functional constipation.

Methods: A PubMed search was performed with Clinical Queries using the key term 'functional constipation'. Read More

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Pain management nursing practice assessment in older adults with dementia.

Nurs Open 2021 Apr 7. Epub 2021 Apr 7.

Research Group on Methodology, Methods, Models and Health and social Outcomes (M3O), Faculty of Health Science and Welfare, Centre for Health and Social Care Research (CESS), University of Vic-Central University of Catalonia (UVIC-UCC). C. Sagrada Família, Vic, Barcelona, Spain.

Aim: To assess pain management nursing practice in older adults with dementia through electronic health records (EHR).

Design: Retrospective study.

Methods: Data were collected from EHR related to pain management in older adults with dementia treated at the Acute Geriatrics Unit (AGU) of a university hospital in early 2018. Read More

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Portuguese multidisciplinary recommendations for non-pharmacological and non-surgical interventions in patients with rheumatoid arthritis.

Acta Reumatol Port 2021 Jan-Mar;46(1):40-54

Background: Patients with rheumatoid arthritis (RA) report significant levels of disease impact, which are improved, but not fully abrogated by immunosuppressive therapy, even when remission is achieved. This imposes the need for adjuvant interventions targeting the uncontrolled domains of disease impact. Non-pharmacological interventions are widely used for this purpose, but they have not been the object of professional recommendations or guidelines. Read More

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Healthcare professional-led interventions on lifestyle modifications for hypertensive patients - a systematic review and meta-analysis.

BMC Fam Pract 2021 Apr 5;22(1):63. Epub 2021 Apr 5.

Unit of PharmacoTherapy, -Epidemiology & -Economics, Groningen Research Institute of Pharmacy (GRIP), University of Groningen, Groningen, Netherlands.

Background: About 0.9 billion people in the world have hypertension. The mortality due to hypertension increased dramatically over the last decades. Read More

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The effectiveness of physical exercise interventions in the management of neuropsychiatric symptoms in dementia patients: a systematic review.

Int Psychogeriatr 2021 Apr 5:1-14. Epub 2021 Apr 5.

Professor, First Department of Psychiatry, National and Kapodistrian University of Athens, Eginition Hospital, Athens, Greece.

Background: The management of neuropsychiatric symptoms (NPS) in patients with dementia is a major challenge. Since no effective therapy has been found to date and drug treatments are associatedwith significant side effects, there seems to be a pressing need for alternative non-pharmacological interventions.

Objectives: The current study aims to investigate and compare the effect of different types of physical exercise on the NPS. Read More

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Sodium-glucose co-transporter-2 inhibitors in patients with type 2 diabetes mellitus without established cardiovascular disease: Do they have a role in primary prevention?

Metabol Open 2021 Jun 28;10:100082. Epub 2021 Jan 28.

Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK.

Most guidelines and cardiovascular outcome trials (CVOTs) focus on secondary prevention of cardiovascular disease (CVD) in type 2 diabetes mellitus (T2DM). Patients with T2DM without established CVD (eCVD) also form a critical cohort, for whom primary prevention with timely pharmacological and non-pharmacological interventions can effectively prevent or delay the onset of CVD. Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have demonstrated a promising role for primary prevention of CVD in CVOTs and real-world studies. Read More

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Food, Nutrition, Physical Activity and Microbiota: Which Impact on Lung Cancer?

Int J Environ Res Public Health 2021 Mar 1;18(5). Epub 2021 Mar 1.

Dipartimento di Scienze e Tecnologie Ambientali, Biologiche e Farmaceutiche, Università della Campania "Luigi Vanvitelli", Via G. Vivaldi 42, 81100 Caserta, Italy.

Lung cancer still represents the leading cause of cancer-related death, globally. Likewise, malnutrition and inactivity represent a major risk for loss of functional pulmonary capacities influencing overall lung cancer severity. Therefore, the adhesion to an appropriate health lifestyle is crucial in the management of lung cancer patients despite the subtype of cancer. Read More

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Effect of Training-Detraining Phases of Multicomponent Exercises and BCAA Supplementation on Inflammatory Markers and Albumin Levels in Frail Older Persons.

Nutrients 2021 Mar 28;13(4). Epub 2021 Mar 28.

University of Coimbra, Faculty of Sports Sciences and Physical Education-(FCDEF-UC), 3040-248 Coimbra, Portugal.

Nowadays, it is accepted that the regular practice of exercise and branched-chain amino acids supplementation (BCAAs) can benefit the immune responses in older persons, prevent the occurrence of physical frailty (PF), cognitive decline, and aging-related comorbidities. However, the impact of their combination (as non-pharmacological interventions) in albumin and the inflammatory markers is not fully understood. Therefore, we investigated the effect of a 40-week multifactorial intervention [MIP, multicomponent exercise (ME) associated or not with BCAAs] on plasma levels of inflammatory markers and albumin in frail older persons (≥75 years old) living at residential care homes (RCH). Read More

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Systematic review on reporting of components and outcomes in randomized clinical trials of paraoesophageal hernia mesh repair.

Br J Surg 2021 Jan 24. Epub 2021 Jan 24.

Regional Oesophagogastric Unit, Royal Surrey County Hospital, Guildford, UK.

Background: Surgical interventions, such as paraoesophageal hernia (POH) repair, are complex with multiple components that require consideration in the reporting of clinical trials. Many aspects of POH repair, including mesh hiatal reinforcement and fundoplication type, are contentious. This review summarizes the reporting of components and outcomes in RCTs of POH repair. Read More

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January 2021

Pharmacological and non-pharmacological treatment of delirium in an oncological hospital service: an integrative review.

Rev Bras Enferm 2021 24;74(1):e20200200. Epub 2021 Mar 24.

Universidade de São Paulo. São Paulo, São Paulo, Brazil.

Objectives: to analyze the production of scientific articles about the pharmacological and non-pharmacological management of delirium in adult hospitalized cancer patients.

Methods: integrative review whose sample was obtained from the databases Scopus, Cumulative Index to Nursing and Allied Health Literature, EMBASE, Web of Science, and from the portals Biblioteca Virtual em Saúde, and PubMed.

Results: among the ten studies analyzed, 80% described exclusively the pharmacological management, especially with regard to the use of haloperidol; 20% mentioned, superficially, non-pharmacological interventions/actions (educational actions) associated to pharmacological management, and adjusting them could result in the diminution and control of psychomotor agitation, contributing for the safety and comfort of the patient. Read More

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Impact of non-pharmacological interventions on quality of life, anxiety, and depression scores in patients with colorectal cancer: a systematic review and meta-analysis of randomized controlled trials.

Support Care Cancer 2021 Mar 31. Epub 2021 Mar 31.

Mental Health Center of West China Hospital, Sichuan University, Chengdu, China.

Purpose: Different non-pharmacological interventions have been considered and applied to patients with colorectal cancer to improve their quality of life and distress symptoms; however, there is little evidence comparing the effectiveness of these strategies. This review aimed at assessing the effect of non-pharmacological interventions on quality of life, anxiety, and depression scores among patients with colorectal cancer.

Methods: A systematic search for articles published until August 1, 2020, in the English language was performed in Medline, EMBASE, Web of Science, and the Cochrane Library; the reference lists of eligible articles were scanned for other potentially eligible publications. Read More

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The experience of delirium in palliative care settings for patients, family, clinicians and volunteers: A qualitative systematic review and thematic synthesis.

Palliat Med 2021 Mar 30:2692163211006313. Epub 2021 Mar 30.

Wolfson Palliative Care Research Centre, Hull York Medical School, University of Hull, Hull, UK.

Background: Delirium is common in palliative care settings and is distressing for patients, their families and clinicians. To develop effective interventions, we need first to understand current delirium care in this setting.

Aim: To understand patient, family, clinicians' and volunteers' experience of delirium and its care in palliative care contexts. Read More

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Efficacy of a combination of hypnosis and transcutaneous electrical nerve stimulation for chronic non-cancer pain: A randomized controlled trial.

J Adv Nurs 2021 Mar 30. Epub 2021 Mar 30.

Assistance Publique - Hôpitaux de Paris (AP-HP), Pain Department of Saint-Antoine University Hospital and Medical University Sorbonne, Hôpital Saint-Antoine, Paris, France.

Background: Chronic non-cancer pain, which persists for at least three months, seriously affects quality of life. Chronic non-cancer pain patients are usually managed by a multidisciplinary team using pharmacological and non-pharmacological strategies. Nurses perform transcutaneous electrical nerve stimulation (TENS) and hypnosis, which are widely used in France for the treatment of chronic pain in pain departments. Read More

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Systematic review of digital and non-digital non-pharmacological interventions that target quality of life and psychological outcomes in adults with systemic lupus erythematosus.

Lupus 2021 Mar 28:9612033211005085. Epub 2021 Mar 28.

Center for Behavioral Intervention Technologies, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Background: Patients with systemic lupus erythematous (SLE) experience psychological comorbidities and impaired quality of life (QOL). We conducted a systematic review to examine the efficacy of non-pharmacological interventions for improving psychological outcomes and/or QOL in patients with SLE. To expand on a previous systematic review in this area and enhance our understanding of efficacious interventions for this population, our search included quasi-experimental and experimental studies of interventions delivered or supported by remote methods (including digitally) or in person. Read More

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