3,189 results match your criteria non-melanoma skin


Fluorescence-guided surgery for non-melanoma and melanoma skin cancer: Case-series and a brief review of the literature.

Photodermatol Photoimmunol Photomed 2021 Apr 20. Epub 2021 Apr 20.

Dermatological Unit, Department of Clinical and Molecular Sciences, Polytechnic University of the Marche Region.

surgery is the primary mode of treatment for non-melanoma (NMSC) and melanoma skin cancer (MSC). The main purpose of surgery is to completely remove the neoplastic lesion, since the presence of residual tumor cells is considered a strong predictor of tumor recurrence, new surgical approach and, therefore, survival. Read More

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Exogenous sex hormones, menstrual and reproductive history, and risk of non-melanoma skin cancer among women: a systematic literature review and meta-analysis.

Sci Rep 2021 Apr 19;11(1):8524. Epub 2021 Apr 19.

Department of Experimental Oncology, European Institute of Oncology (IEO), IRCCS, Milan, Italy.

Non-melanoma skin cancers (NMSC) are more frequent among men, but women (especially those aged < 40 years) have experienced steeper growth in their incidence rates in recent years. Hormonal factors were hypothesized to be playing a role in modulating NMSC risk, but the studies published to date provided conflicting results. We systematically reviewed and meta-analysed the studies focusing on the association between hormone-related characteristics (use of exogenous sex hormones, and aspects of menstrual and reproductive history) and the risk of NMSC among women. Read More

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Systemic photoprotection in 2021.

Clin Exp Dermatol 2021 Apr 19. Epub 2021 Apr 19.

Department of Dermatology, Aalborg University Hospital, Aalborg, Denmark.

Systemic photoprotection aims to negate the negative effects of ultraviolet radiation-induced DNA damage. Systemic supplements might be used as a monotherapy or in combination with topical sunscreens. Using the keywords 'carotenoids,' 'flavonoids,' 'systemic photoprotection,' 'polyphenols' and 'polypodium leucotomos extract," we searched the databases MEDLINE and EMBASE to find relevant English-language articles. Read More

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United States Burden of Melanoma and Non-Melanoma Skin Cancer from 1990 to 2019.

J Am Acad Dermatol 2021 Apr 11. Epub 2021 Apr 11.

College of Medicine, University of Cincinnati, 3230 Eden Ave, Cincinnati, OH 45267, US.

Background: Skin cancer is the most common cancer worldwide.

Objective: To evaluate burden of skin cancer in the US from 1990 to 2019.

Methods: Age-standardized incidence, prevalence, disability adjusted life years (DALY) and mortality rates from skin cancer in the US were evaluated from the Global Burden of Disease (GBD) 2019. Read More

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Comparison of the Skin Cancer Quality of Life Impact Tool and the Skin Cancer Index Questionnaire in Measurement of Health-Related Quality of Life and the Effect of Patient Education Brochures in Patients with Actinic Keratosis, Non-melanoma, and Cutaneous Melanoma.

Dermatol Ther (Heidelb) 2021 Apr 13. Epub 2021 Apr 13.

Department of Dermatology, Venereology and Allergology, Ruhr-University Bochum, Bochum, Germany.

Introduction: Few studies have evaluated patient-reported outcome measures and the effect of patient educational materials in German patients with skin cancer. We conducted a prospective study to measure the impact of treatment on health-related quality of life in German patients with skin cancer, identify variables that may contribute to changes in health-related quality of life, and evaluate the effect of providing additional information through a patient education brochure.

Methods: A total of 461 patients diagnosed with actinic keratosis, nonmetastatic nonmelanoma skin cancer, melanoma in situ, or nonmetastatic cutaneous melanoma treated between August 2018 and July 2020 were included. Read More

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Incidence of Infections and Malignancy Among Elderly Male Patients with IBD Exposed to Vedolizumab, Prednisone, and 5-ASA Medications: A Nationwide Retrospective Cohort Study.

Adv Ther 2021 Apr 12. Epub 2021 Apr 12.

Department of Gastroenterology, Corporal Michael J Crescenz VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA, 19104, USA.

Introduction: Vedolizumab (VDZ) is postulated to have a potentially safer side effect profile than other biologic medications owing to its gut-selective mechanism. However, extrapolating these safety data to older patients is challenging because of their underrepresentation in or exclusion from most clinical trials, higher rates of withdrawal, and higher rates of comorbidities. Our aim was to evaluate the absolute risk of infections and malignancies in an elderly group of patients with inflammatory bowel disease (IBD) exposed to VDZ vs. Read More

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Association of HLA mismatch and MTOR inhibitor regimens with malignancy and mortality after kidney transplantation.

Transpl Immunol 2021 Apr 8;66:101391. Epub 2021 Apr 8.

Department of Pharmacy Practice, College of Pharmacy, University of Rhode Island, Kingston, RI, USA.

Background The association of mammalian target of rapamycin inhibitors (MTORI) with malignancies and mortality in kidney transplant recipients (KTR) with different degrees of human leukocyte antigen mismatch (HLA-mm) at transplant has not been previously studied. Methods Our observational cohort study included 166, 256 adult KTRs in 2000-2018. Immunosuppression in the first post-transplant year were MTORIs in 13,056 (7. Read More

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Safety of topical interventions for the treatment of actinic keratosis.

Expert Opin Drug Saf 2021 Apr 9. Epub 2021 Apr 9.

Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Erlangen, Germany.

: Actinic keratosis (AK) are proliferations of atypical keratinocytes that may eventually progress to cutaneous squamous cell carcinoma. Therefore, AK requires consequent and early treatment.: A variety of effective approaches is currently available for the clearance of AK. Read More

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Extended Safety Analysis of Baricitinib 2 mg in Adult Patients with Atopic Dermatitis: An Integrated Analysis from Eight Randomized Clinical Trials.

Am J Clin Dermatol 2021 Apr 7. Epub 2021 Apr 7.

Department of Dermatology, Oregon Health and Science University, Portland, OR, USA.

Background: Baricitinib, a selective Janus kinase 1/Janus kinase 2 inhibitor, is indicated in the European Union and Japan for the treatment of moderate-to-severe atopic dermatitis (AD) in adults who are candidates for systemic therapy.

Objective: The objective of this study was to evaluate the safety of baricitinib 2 mg in the AD clinical program.

Methods: Six double-blind, randomized, placebo-controlled studies, and two long-term extension studies were summarized in two datasets. Read More

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Cancer statistics for the year 2020: an overview.

Int J Cancer 2021 Apr 5. Epub 2021 Apr 5.

Cancer Surveillance Branch, International Agency for Research on Cancer, Lyon, France.

This paper briefly reviews the data sources and methods used in compiling the International Agency for Research on Cancer (IARC) GLOBOCAN cancer statistics for the year 2020, and summarises the main results. National estimates were calculated based on the best available data on cancer incidence from population-based cancer registries (PBCR) and mortality from the World Health Organization (WHO) mortality database. Cancer incidence and mortality rates for 2020 by sex and age groups were estimated for 38 cancer sites and 185 countries or territories worldwide. Read More

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Understanding Dermatologic Concerns Among Persons Experiencing Homelessness: A Scoping Review and Discussion for Improved Delivery of Care.

J Cutan Med Surg 2021 Apr 4:12034754211004558. Epub 2021 Apr 4.

Department of Dermatology, Cumming School of Medicine, Calgary, AB, Canada.

There is a paucity of information surrounding dermatologic care for persons experiencing homelessness (PEH). This scoping review aims to map existing literature and provide a summary of the most common cutaneous manifestations among PEH, risk factors for dermatologic disease, describe any reported interventions, as well as identify research gaps for future studies. Search strategies developed for MEDLINE and hand searching yielded 486 articles. Read More

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Teratogenic effect of isotretinoin in both fertile females and males (Review).

Exp Ther Med 2021 May 23;21(5):534. Epub 2021 Mar 23.

Department of Dermatology, 'Elias' Emergency University Hospital, 011461 Bucharest, Romania.

Isotretinoin is an oral derivate of vitamin A that has been used since 1982 for the treatment of multiple dermatologic conditions such as severe acne, rosacea, scarring alopecia, ichthyosis or non-melanoma skin cancer prophylaxis. The recommended dose is 0.5-1 mg/kg/day for a period of 4-6 months in sebaceous gland pathologies. Read More

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Screening for Melanoma and Other Skin Cancer Shows a Higher Early Melanoma Incidence: Social Educational Program "Life Fear-Free".

Dermatopathology (Basel) 2021 Mar 15;8(1):54-68. Epub 2021 Mar 15.

Russian Melanoma Professional Association (Melanoma.PRO), Moscow 119192, Russia.

Background: The screening program Life Fear-Free (LFF) aimed at early diagnosis of cutaneous melanoma (CM) was introduced in Samara, Chelyabinsk, Yekaterinburg, and Krasnodar (Russia) in 2019.

Objectives: To analyze the impact of the program on early CM and non-melanoma skin cancer (NMSC) detection.

Methods: According to the social educational campaign, people were informed about CM risk factors and symptoms and were invited for skin examination. Read More

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Editorial: HPV and Host Interaction.

Front Cell Infect Microbiol 2021 11;11:638005. Epub 2021 Mar 11.

Infections and Cancer Biology Group, International Agency for Research on Cancer, Lyon, France.

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Inflammation-targeted therapies and cancer.

Joint Bone Spine 2021 Mar 23;88(4):105176. Epub 2021 Mar 23.

Inserm U1184, service de rhumatologie, fédération hospitalo-universitaire CARE (Cancer and Autoimmunity Relationship), université Paris-Saclay, hôpital Bicêtre, AP-HP, Le-Kremlin-Bicêtre, France. Electronic address:

Objective: To review and analyze the current knowledge on the risk of malignancy associated with inflammation-targeted therapies in rheumatic diseases.

Methods: We performed a non-systematic literature review on PubMEd MEDLINE by screening randomized controlled trials, meta-analyses, reviews, and observational studies focusing on malignancies and inflammation-targeted therapies including TNF inhibitors, other biologics and JAK inhibitors in rheumatic diseases.

Results: Data from literature are reassuring regarding the overall risk of incident and recurrent cancer with TNF inhibitors. Read More

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Phenolic Compounds in Prevention and Treatment of Skin Cancers: a review.

Curr Med Chem 2021 Mar 24. Epub 2021 Mar 24.

Department of Pharmacy, University of Pisa, Pisa. Italy.

Several clinical studies have shown that exposure of skin to solar ultraviolet (UV) radiation causes adverse effects, such as inflammation, oxidative stress and DNA damage. As a result, different skin disorders can arise among which skin cancer, including non-melanoma skin cancer (NMSC) and melanoma (MM). Phenolic compounds are plant-derived secondary metabolites with a well-known antioxidant activity, able to counteract the negative effects of UV radiation. Read More

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Recurrent squamous cell carcinoma in a post cardiac transplant patient.

Int J Surg Case Rep 2021 Feb 15;79:275-280. Epub 2021 Jan 15.

Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, VA, United States. Electronic address:

Introduction And Importance: Solid organ transplantation has evolved along with dramatic advancements in definitive treatment for irreversible and uncompensated organ failure. Transplanted organ survival has improved as a result of reduced allograft rejection. However, negative long-term outcomes which were largely due to the adverse effects of rapidly evolving immunosuppressive regimens are still evident. Read More

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February 2021

Hedgehog Pathway Inhibitors: Clinical Implications and Resistance in the Treatment of Basal Cell Carcinoma.

Cureus 2021 Mar 12;13(3):e13859. Epub 2021 Mar 12.

Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer and is on the rise. Most BCCs are benign; however, a very small percentage are locally advanced and metastatic. The pathway that normally regulates cell growth and proliferation is directed by the hedgehog pathway (HP). Read More

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Age and insulin-like growth factor-1 impact PCNA mono-ubiquitination in UVB-irradiated human skin.

J Biol Chem 2021 Mar 19:100570. Epub 2021 Mar 19.

Departments of Pharmacology and Toxicology. Electronic address:

Non-melanoma skin cancers occur primarily in individuals over the age of 60 and are characterized by an abundance of ultraviolet (UV) signature mutations in keratinocyte DNA. Though geriatric skin removes UV photoproducts from DNA less efficiently than young adult skin, it is not known whether the utilization of other pro-survival but potentially mutagenic DNA damage tolerance systems such as translesion synthesis (TLS) is altered in older individuals. Using mono-ubiquitination of the replicative DNA polymerase clamp protein PCNA (proliferating cell nuclear antigen) as a biochemical marker of TLS pathway activation, we find that UVB exposure of skin from individuals over the age of 65 results in a higher level of PCNA mono-ubiquitination than in the skin of young adults. Read More

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Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer.

Int J Epidemiol 2021 Mar 22. Epub 2021 Mar 22.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Background: Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases.

Methods: We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Read More

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Protection Against Solar Ultraviolet Radiation in Outdoor Construction Workers: Study Protocol for a Non-randomized Controlled Intervention Study.

Front Public Health 2021 4;9:602933. Epub 2021 Mar 4.

Amsterdam University Medical Centers, University of Amsterdam, Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam, Netherlands.

Non-melanoma skin cancer (NMSC) incidence is increasing, and occupational solar exposure contributes greatly to the overall lifetime ultraviolet radiation (UVR) dose. This is reflected in an excess risk of NMSC showing up to three-fold increase in outdoor workers. Risk of NMSC can be reduced if appropriate measures to reduce UVR-exposure are taken. Read More

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Neoadjuvant Therapy for Non-melanoma Skin Cancer: Updated Therapeutic Approaches for Basal, Squamous, and Merkel Cell Carcinoma.

Curr Treat Options Oncol 2021 Mar 16;22(4):35. Epub 2021 Mar 16.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Piazza dell'Ospitale 1, 34129, Trieste, Italy.

Opinion Statement: Recently introduced systemic therapies for locally advanced and metastatic non-melanoma skin cancers (NMSCs) are paving the way for neoadjuvant approach. Although none of the therapeutic options has currently gained indication in this setting, neoadjuvant approach for NMSCs is an open field and we are likely to see huge developments in the near future. Targeted therapy with sonic hedgehog pathway inhibitors is very effective in locally advanced or multiple basal cell carcinomas while immunotherapy with immune checkpoint inhibitors appears to be promising for advanced cutaneous squamous cell carcinoma and Merkel cell carcinoma. Read More

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Sunscreens and their usefulness: have we made any progress in the last two decades?

Authors:
Nick Serpone

Photochem Photobiol Sci 2021 Feb 18;20(2):189-244. Epub 2021 Feb 18.

Dipartimento di Chimica, Universita degli Studi di Pavia, Via Taramelli 12, Pavia, 27100, QC, Italy.

Sunscreens have now been around for decades to mitigate the Sun's damaging ultraviolet (UV) radiation which, although essential for the existence of life, is a recognized prime carcinogen. Accordingly, have suncreams achieved their intended purposes towards protection against sunburns, skin photo-ageing and the like? Most importantly, however, have they provided the expected protection against skin cancers that current sunscreen products claim to do? In the last two decades, there have been tens, if not hundreds of studies on sunscreens with respect to skin protection against UVB (280‒320 nm)-traditionally sunscreens with rather low sun protection factors (SPF) were intended to protect against this type of radiation-and UVA (320‒400 nm) radiation; a distinction between SPF and UVA protection factor (UVA-PF) is made. Many of the studies of the last two decades have focused on protection against the more skin-penetrating UVA radiation. Read More

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February 2021

Risk factors of de novo malignancies after liver transplantation: a French national study on 11004 adult patients.

Clin Res Hepatol Gastroenterol 2021 Mar 11;45(4):101514. Epub 2021 Mar 11.

Hospices Civils de Lyon, Hôpital Edouard Herriot, Unité de Transplantation Hépatique, et Université Claude Bernard Lyon 1, France. Electronic address:

Background: After liver transplantation (LT),de novo malignancies are one of the leading causes of late mortality. The aim of the present retrospective study was to identify the risk factors of de novo malignancies in a large cohort of LT recipients in France, using Fine and Gray competing risks regression analysis.

Methods: The study population consisted in 11004 adults transplanted between 2000 and 2013, who had no history of pre-transplant malignancy, except primary liver tumor. Read More

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Multidisciplinary Management of Locally Advanced and Metastatic Cutaneous Squamous Cell Carcinoma.

Curr Oncol 2020 Aug 1;27(4):399-407. Epub 2020 Aug 1.

Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC, Canada.

Non-melanoma skin cancers are the most prevalent form of cancer, with cutaneous squamous cell carcinoma (cSCC) being the 2nd most common type. Patients presenting with high-risk lesions associated with locally advanced or metastatic cSCC face high rates of recurrence and mortality. Accurate staging and risk stratification for patients can be challenging because no system is universally accepted, and no Canadian guidelines currently exist. Read More

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High-dose-rate brachytherapy for facial skin cancer: Outcome and toxicity assessment for 71 cases.

Brachytherapy 2021 Mar 5. Epub 2021 Mar 5.

Department of Brachytherapy, Institut de Cancérologie de Lorraine, Vandoeuvre-les-Nancy, France.

Purpose: In France, the reference technique for skin cancer was low-dose-rate brachytherapy (BT) delivered via iridium wire. At the end of their commercialization in 2015 we have replaced them by high-dose-rate (HDR) BT via interstitial catheters. We assessed efficacy and tolerance as soon as this technique was implemented. Read More

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Mohs Micrographic Surgery for Genital Skin Cancer: A Review of Cases and Reconstructive Techniques.

J Drugs Dermatol 2021 03;20(3):311-319

As the incidence of non-melanoma skin cancer (NMSC) increases in the United States, one area of particular concern is NMSC arising on the genitalia. In the past, most genital skin tumors have been treated by conventional radical surgical approaches such as penectomy, vulvectomy, or wide local excision. In recent years, tissue sparing Mohs micrographic surgery (MMS) has been established as a safe and effective method of achieving cutaneous genital tumor clearance. Read More

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A Non-Surgical and Cost-Effective Treatment Approach Employing Topical Imiquimod, 5-Fluorouracil, and Tretinoin for Primary Non-Melanoma Skin Cancers.

J Drugs Dermatol 2021 03;20(3):260-267

Background: Minimally invasive alternative approaches to treat non-melanoma skin cancers remain limited and unproven.

Objective: We aim to assess the efficacy of varying combinations of anti-tumor agents—imiquimod 5% cream, 5-fluorouracil 2% solution, and tretinoin 0.1% cream—with brief cryotherapy in treating non-melanoma skin cancers. Read More

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Integrated analysis of miRNA-mRNA networks reveals a strong anti-skin cancer signature in vitiligo epidermis.

Exp Dermatol 2021 Mar 7. Epub 2021 Mar 7.

CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.

Expression of microRNAs (miRNAs) is often dysregulated in several cancers, including non-melanoma skin cancer (NMSC). Individuals with vitiligo possess a deregulated miRnome along with a lower risk of developing NMSCs. We used data sets from our previously published studies on vitiligo epidermis to construct functional miRNA-mRNA networks to understand the molecular basis underlying the lower incidence of NMSC observed in individuals with vitiligo. Read More

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