64,472 results match your criteria non-invasive diagnosis


Ventriculoatrial shunting: an escape option in idiopathic normal pressure hydrocephalus patients failing ventriculoperitoneal drainage.

World Neurosurg 2021 Oct 11. Epub 2021 Oct 11.

Department of Neurosurgery, Università Politecnica delle Marche, Azienda Ospedali Riuniti Ancona, Italy.

Background: Ventriculoperitoneal (VP) shunting is widely accepted as the golden standard treatment for idiopathic normal pressure hydrocephalus (iNPH). However, a restricted group of patients experiences only minimal or no improvement after the operation. In such cases, the question whether the diagnosis was incorrect or the shunt is malfunctioning remains unanswered. Read More

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October 2021

Clinical applications of magnetic resonance imaging based functional and structural connectivity.

Neuroimage 2021 Oct 11;244:118649. Epub 2021 Oct 11.

Victor Horsley Department of Neurosurgery, National Hospital for Neurology and Neurosurgery, 33 Queen Square, London WC1N 3BG, UK; Unit of Functional Neurosurgery, UCL Queen Square Institute of Neurology, 33 Queen Square, London WC1N 3BG, UK. Electronic address:

Advances in computational neuroimaging techniques have expanded the armamentarium of imaging tools available for clinical applications in clinical neuroscience. Non-invasive, in vivo brain MRI structural and functional network mapping has been used to identify therapeutic targets, define eloquent brain regions to preserve, and gain insight into pathological processes and treatments as well as prognostic biomarkers. These tools have the real potential to inform patient-specific treatment strategies. Read More

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October 2021

Masson's Lesion - A very rare cardiac mass.

Can J Cardiol 2021 Oct 11. Epub 2021 Oct 11.

Department of Cardiac Surgery, Hospital Santa Cruz, Centro Hospitalar Lisboa Ocidental, Carnaxide, Portugal.

Masson's lesion is a rare type of vascular tumor usually found in the skin and soft tissues. Histological examination remains the gold-standard for diagnosis. Treatment involves complete surgical excision and correct diagnosis is essential to avoid unnecessary aggressive therapy. Read More

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October 2021

A combined postoperative nomogram for survival prediction in clear cell renal carcinoma.

Abdom Radiol (NY) 2021 Oct 13. Epub 2021 Oct 13.

Department of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No. 324, Jingwu Road, Huaiyin District, Jinan, 250012, Shandong, China.

Purpose: To investigate and validate the prognostic value of nomogram models for predicting disease-free survival (DFS) and overall survival (OS) in patients with clear cell renal cell carcinoma (ccRCC).

Methods: In this retrospective study, 223 patients (age 54.38 ± 10. Read More

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October 2021

acNASH index to diagnose nonalcoholic steatohepatitis: a prospective derivation and global validation study.

EClinicalMedicine 2021 Nov 1;41:101145. Epub 2021 Oct 1.

MAFLD Research Center, Department of Hepatology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

Background: There is an unmet need for non-invasive biomarkers for the diagnosis of nonalcoholic steatohepatitis (NASH) in non-specialized settings. We aimed to develop and validate a non-invasive test for diagnosing NASH in individuals with biopsy-proven nonalcoholic fatty liver disease (NAFLD).

Methods: We developed a non-invasive test named the that combines serum creatinine and aspartate aminotransferase levels in a derivation cohort of 390 Chinese NAFLD patients admitted to the hepatology center of the First Affiliated Hospital of Wenzhou Medical University (China) between December 2016 and September 2019 and subsequently validated in five external cohorts of different ethnicities of patients with biopsy-confirmed NAFLD (pooled n=1,089). Read More

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November 2021

Diagnosis of Cardiac Involvement in Amyloid A Amyloidosis by Cardiovascular Magnetic Resonance Imaging.

Front Cardiovasc Med 2021 27;8:757642. Epub 2021 Sep 27.

Division of Cardiovascular Imaging, Department of Cardiology I, University Hospital Münster, Albert Schweitzer Campus 1, Münster, Germany.

Diagnosis of cardiac involvement in amyloid A (AA) amyloidosis is challenging since AA amyloidosis is a rare disease and cardiac involvement even less frequent. The diagnostic yield of currently available non-invasive imaging methods is not well-studied and rather limited, and invasive endomyocardial biopsy (EMB) is rarely performed due to the potential risk of this procedure. Cardiovascular magnetic resonance (CMR)-based myocardial tissue characterization by late-gadolinium-enhancement (LGE) imaging and novel-mapping approaches may increase the diagnostic yield in AA amyloidosis. Read More

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September 2021

Management of Acute Exacerbation of Idiopathic Pulmonary Fibrosis in Specialised and Non-specialised ILD Centres Around the World.

Front Med (Lausanne) 2021 27;8:699644. Epub 2021 Sep 27.

Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus C, Denmark.

Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a severe complication associated with a high mortality. However, evidence and guidance on management is sparse. The aim of this international survey was to assess differences in prevention, diagnostic and treatment strategies for AE-IPF in specialised and non-specialised ILD centres worldwide. Read More

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September 2021

Giant Cell Arteritis as an Uncommon Cause of Chronic Cough: A Case Report.

Am J Case Rep 2021 Oct 14;22:e932945. Epub 2021 Oct 14.

Department of Pulmonary Medicine, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

BACKGROUND Chronic cough is a common medical concern. Giant cell arteritis (GCA) is an uncommon cause of chronic cough and is not usually suspected since symptoms can be non-specific. We present a case of chronic cough due to GCA in which symptoms were subtle but imaging was remarkable and clearly disclosed the diagnosis. Read More

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October 2021

COVID-19 identification from volumetric chest CT scans using a progressively resized 3D-CNN incorporating segmentation, augmentation, and class-rebalancing.

Inform Med Unlocked 2021 28;26:100709. Epub 2021 Aug 28.

Department of Computer Science & Engineering, Pabna University of Science and Technology, Pabna-6600, Bangladesh.

The novel COVID-19 is a global pandemic disease overgrowing worldwide. Computer-aided screening tools with greater sensitivity are imperative for disease diagnosis and prognosis as early as possible. It also can be a helpful tool in triage for testing and clinical supervision of COVID-19 patients. Read More

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Artificial Intelligence Techniques for the Non-invasive Detection of COVID-19 Through the Analysis of Voice Signals.

Arab J Sci Eng 2021 Oct 8:1-11. Epub 2021 Oct 8.

Institute of High-Performance Computing and Networking (ICAR) - National Research Council of Italy (CNR), via Pietro Castellino, 111, 80131 Naples Italy.

Healthcare sensors represent a valid and non-invasive instrument to capture and analyse physiological data. Several vital signals, such as voice signals, can be acquired anytime and anywhere, achieved with the least possible discomfort to the patient thanks to the development of increasingly advanced devices. The integration of sensors with artificial intelligence techniques contributes to the realization of faster and easier solutions aimed at improving early diagnosis, personalized treatment, remote patient monitoring and better decision making, all tasks vital in a critical situation such as that of the COVID-19 pandemic. Read More

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October 2021

Longitudinal Bottom-Up Proteomics of Serum, Serum Extracellular Vesicles, and Cerebrospinal Fluid Reveals Candidate Biomarkers for Early Detection of Glioblastoma in a Murine Model.

Molecules 2021 Oct 2;26(19). Epub 2021 Oct 2.

Fondazione Pisana per la Scienza ONLUS, 56017 San Giuliano Terme, Italy.

Glioblastoma Multiforme (GBM) is a brain tumor with a poor prognosis and low survival rates. GBM is diagnosed at an advanced stage, so little information is available on the early stage of the disease and few improvements have been made for earlier diagnosis. Longitudinal murine models are a promising platform for biomarker discovery as they allow access to the early stages of the disease. Read More

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October 2021

A Novel Capacitive Measurement Device for Longitudinal Monitoring of Bone Fracture Healing.

Sensors (Basel) 2021 Oct 8;21(19). Epub 2021 Oct 8.

The BioRobotics Institute, Scuola Superiore Sant'Anna, 56025 Pisa, Italy.

The healing process of surgically-stabilised long bone fractures depends on two main factors: (a) the assessment of implant stability, and (b) the knowledge of bone callus stiffness. Currently, X-rays are the main diagnostic tool used for the assessment of bone fractures. However, they are considered unsafe, and the interpretation of the clinical results is highly subjective, depending on the clinician's experience. Read More

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October 2021

Comparison between PtCO and PaCO and Derived Parameters in Heart Failure Patients during Exercise: A Preliminary Study.

Sensors (Basel) 2021 Oct 7;21(19). Epub 2021 Oct 7.

Centro Cardiologico Monzino, IRCCS, 20138 Milan, Italy.

Evaluation of arterial carbon dioxide pressure (PaCO) and dead space to tidal volume ratio (V/V) during exercise is important for the identification of exercise limitation causes in heart failure (HF). However, repeated sampling of arterial or arterialized ear lobe capillary blood may be clumsy. The aim of our study was to estimate PaCO by means of a non-invasive technique, transcutaneous PCO (PtCO), and to verify the correlation between PtCO and PaCO and between their derived parameters, such as V/V, during exercise in HF patients. Read More

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October 2021

EEG Monitoring Is Feasible and Reliable during Simultaneous Transcutaneous Electrical Spinal Cord Stimulation.

Sensors (Basel) 2021 Oct 2;21(19). Epub 2021 Oct 2.

Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong.

Transcutaneous electrical spinal cord stimulation (tSCS) is a non-invasive neuromodulatory technique that has in recent years been linked to improved volitional limb control in spinal-cord injured individuals. Although the technique is growing in popularity there is still uncertainty regarding the neural mechanisms underpinning sensory and motor recovery. Brain monitoring techniques such as electroencephalography (EEG) may provide further insights to the changes in coritcospinal excitability that have already been demonstrated using other techniques. Read More

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October 2021

High-Frequency Ultrasound Assessment of Skin and Oral Mucosa in Metabolic Syndrome Patients-A Cross-Sectional Study.

J Clin Med 2021 Sep 28;10(19). Epub 2021 Sep 28.

Oral Rehabilitation Department, Faculty of Dentistry, "Iuliu Haţieganu" University of Medicine and Pharmacy Cluj-Napoca, Babeș Street No. 15, 400012 Cluj-Napoca, Cluj County, Romania.

Background: Exogenous factors (such as sun exposure, smoking habits, and diet) and endogenous (inflammatory status, general diseases) have a direct influence on skin and soft tissue characteristics. The study's objective was to assess the impact of metabolic syndrome (MS) on characteristics of skin layers in sun-exposed and non-exposed maxillofacial tissues evaluated by high-frequency ultrasound (HFU), as a potential diagnosis and monitoring tool for the aging process.

Material And Methods: The present study included 102 subjects (24 with MS; 78 without MS). Read More

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September 2021

Electroencephalography as a Non-Invasive Biomarker of Alzheimer's Disease: A Forgotten Candidate to Substitute CSF Molecules?

Int J Mol Sci 2021 Oct 8;22(19). Epub 2021 Oct 8.

CIBERFES, Department of Physiology, Institute INCLIVA, Faculty of Medicine, Health Research University of Valencia, Avda. Blasco Ibanez 17, 46010 Valencia, Spain.

Biomarkers for disease diagnosis and prognosis are crucial in clinical practice. They should be objective and quantifiable and respond to specific therapeutic interventions. Optimal biomarkers should reflect the underlying process (pathological or not), be reproducible, widely available, and allow measurements repeatedly over time. Read More

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October 2021

Potential of Salivary Biomarkers in Autism Research: A Systematic Review.

Int J Mol Sci 2021 Oct 8;22(19). Epub 2021 Oct 8.

Institute of Physiology, Faculty of Medicine, Comenius University in Bratislava, 81372 Bratislava, Slovakia.

The diagnostic process for autism spectrum disorders (ASD) is based on a behavioral analysis of the suspected individual. Despite intensive research, no specific and valid biomarker has been identified for ASD, but saliva, with its advantages such as non-invasive collection, could serve as a suitable alternative to other body fluids. As a source of nucleic acid of both human and microbial origin, protein and non-protein molecules, saliva offers a complex view on the current state of the organism. Read More

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October 2021

Characterization of the Human Eccrine Sweat Proteome-A Focus on the Biological Variability of Individual Sweat Protein Profiles.

Int J Mol Sci 2021 Oct 8;22(19). Epub 2021 Oct 8.

Mass Spectrometry Laboratory, MolSys Research Unit, Liège Université, B-4000 Liège, Belgium.

The potential of eccrine sweat as a bio-fluid of interest for diagnosis and personalized therapy has not yet been fully evaluated, due to the lack of in-depth sweat characterization studies. Thanks to recent developments in omics, together with the availability of accredited sweat collection methods, the analysis of human sweat may now be envisioned as a standardized, non-invasive test for individualized monitoring and personalized medicine. Here, we characterized individual sweat samples, collected from 28 healthy adult volunteers under the most standardized sampling methodology, by applying optimized shotgun proteomics. Read More

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October 2021

Nanobody-Based Theranostic Agents for HER2-Positive Breast Cancer: Radiolabeling Strategies.

Int J Mol Sci 2021 Oct 4;22(19). Epub 2021 Oct 4.

ICNAS-Produção Unipessoal, Lda.-University of Coimbra, 3000-548 Coimbra, Portugal.

The overexpression of human epidermal growth factor 2 (HER2) in breast cancer (BC) has been associated with a more aggressive tumor subtype, poorer prognosis and shorter overall survival. In this context, the development of HER2-targeted radiotracers is crucial to provide a non-invasive assessment of HER2 expression to select patients for HER2-targeted therapies, monitor response and identify those who become resistant. Antibodies represent ideal candidates for this purpose, as they provide high contrast images for diagnosis and low toxicity in the therapeutic setting. Read More

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October 2021

Increased Plasma Levels of lncRNAs , and Correlate with Negative Prognostic Factors in Myelofibrosis.

Cancers (Basel) 2021 Sep 22;13(19). Epub 2021 Sep 22.

Department of Medical and Surgical Sciences, University of Modena and Reggio Emilia, AOU Policlinico, 41124 Modena, Italy.

Long non-coding RNAs (lncRNAs) have been recently described as key mediators in the development of hematological malignancies. In the last years, circulating lncRNAs have been proposed as a new class of non-invasive biomarkers for cancer diagnosis and prognosis and to predict treatment response. The present study is aimed to investigate the potential of circulating lncRNAs as non-invasive prognostic biomarkers in myelofibrosis (MF), the most severe among Philadelphia-negative myeloproliferative neoplasms. Read More

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September 2021

Current Applications and Future Development of Magnetic Resonance Fingerprinting in Diagnosis, Characterization, and Response Monitoring in Cancer.

Cancers (Basel) 2021 Sep 22;13(19). Epub 2021 Sep 22.

High Dimensional Neurology Group, Queen's Square Institute of Neurology, University College London, London WC1N 3BG, UK.

Magnetic resonance imaging (MRI) has enabled non-invasive cancer diagnosis, monitoring, and management in common clinical settings. However, inadequate quantitative analyses in MRI continue to limit its full potential and these often have an impact on clinicians' judgments. Magnetic resonance fingerprinting (MRF) has recently been introduced to acquire multiple quantitative parameters simultaneously in a reasonable timeframe. Read More

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September 2021

Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives.

Cancers (Basel) 2021 Sep 22;13(19). Epub 2021 Sep 22.

Department of Gastroenterology and Digestive Oncology, Institut du Cancer Paris Carpem, Assistance Publique des Hôpitaux de Paris, European Georges Pompidou Hospital, 75015 Paris, France.

Gastrointestinal (GI) cancers are major health burdens worldwide and biomarkers are needed to improve the management of these diseases along their evolution. Circulating tumor DNA (ctDNA) is a promising non-invasive blood and other bodily-fluid-based biomarker in cancer management that can help clinicians in various cases for the detection, diagnosis, prognosis, monitoring and personalization of treatment in digestive oncology. In addition to the well-studied prognostic role of ctDNA, the main real-world applications appear to be the assessment of minimal residual disease to further guide adjuvant therapy and predict relapse, but also the monitoring of clonal evolution to tailor treatments in metastatic setting. Read More

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September 2021

[Research progress of non-invasive examination in the screening of chronic liver disease among the general community population].

Authors:
S Q Yang H D Yan

Zhonghua Gan Zang Bing Za Zhi 2021 Sep;29(9):825-829

Department of Infectious Disease, Shulan, Hangzhou, Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou 310022, China.

Due to its insidious nature, chronic liver disease usually only appears after a decompensating event, and delays in diagnosis lead to a high mortality. Non-invasive examination can help diagnose and intervene early stage liver fibrosis in patients with chronic liver disease. In a hospital population, this test has been widely used and appropriate; however, its value is unclear in the general community population. Read More

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September 2021

Diagnostic performance of elastography for breast non-mass lesions: A systematic review and meta-analysis.

Eur J Radiol 2021 Oct 2;144:109991. Epub 2021 Oct 2.

Department of Ultrasound, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology), Shenzhen 518020, Guangdong, China. Electronic address:

Purpose: This systematic review and meta-analysis aimed to evaluate the diagnostic performance of ultrasound elastography in the differentiation of benign and malignant breast non-mass lesions (NMLs).

Methods: PubMed, Cochrane Library, and Embase databases were searched for eligible studies up to end of June 2021. The diagnostic performance of elastography for NMLs was investigated using pooled sensitivity and specificity, likelihood ratio, diagnostic odds ratio (DOR), post-test probability, and the area under hierarchical summary receiver operating characteristic curve (HSROC). Read More

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October 2021

Photoactivatable Biomedical Materials Based on Luminogens with Aggregation-Induced Emission (AIE) Characteristics.

Adv Healthc Mater 2021 Oct 12:e2101177. Epub 2021 Oct 12.

Shenzhen Institute of Molecular Aggregate Science and Engineering, School of Science and Engineering, The Chinese University of Hong Kong (Shenzhen), Shenzhen, 518172, China.

Fluorescent probes with aggregation-induced emission (AIE) property have become fascinating and vital in biological fields due to their bright fluorescence in the solid state. In contrast traditional AIE materials are obscured by the off-target effects and the lack of spatial and temporal control. Photoactivatable materials with AIE characteristics, whose physicochemical behaviors can be remotely activated by light, provide great potentials in biochemical information acquisition with high spatial and temporal resolution. Read More

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October 2021

An Update in Imaging Evaluation of Histopathological Grade of Soft Tissue Sarcomas Using Structural and Quantitative Imaging and Radiomics.

J Magn Reson Imaging 2021 Oct 12. Epub 2021 Oct 12.

Department of Radiology, The Second Hospital, Dalian Medical University, Dalian, China.

Over the past two decades, considerable efforts have been made to develop non-invasive methods for determining tumor grade or surrogates for predicting the biological behavior, aiding early treatment decisions, and providing prognostic information. The development of new imaging tools, such as diffusion-weighted imaging, diffusion kurtosis imaging, perfusion imaging, and magnetic resonance spectroscopy have provided leverage in the diagnosis of soft tissue sarcomas. Artificial intelligence is a new technology used to study and simulate human thinking and abilities, which can extract and analyze advanced and quantitative image features from medical images with high throughput for an in-depth characterization of the spatial heterogeneity of tumor tissues. Read More

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October 2021

Integrating Highly Porous and Flexible Au Hydrogels with Soft-MEMS Technologies for High-Performance Wearable Biosensing.

Anal Chem 2021 Oct 12. Epub 2021 Oct 12.

State Key Laboratory of Solidification Processing, School of Materials Science and Engineering, Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene (NPU), Xi'an 710072, P. R. China.

Wearable biosensors for real-time and non-invasive detection of biomarkers are of importance in early diagnosis and treatment of diseases. Herein, a high-performance wearable biosensing platform was proposed by combining a three-dimensional hierarchical porous Au hydrogel-enzyme electrode with high biocompatibility, activity, and flexibility and soft-MEMS technologies with high precision and capability of mass production. Using glucose oxidase as the model enzyme, the glucose sensor exhibits a sensitivity of 10. Read More

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October 2021

A multifunctional targeted nanoprobe with high NIR-II PAI/MRI performance for precise theranostics of orthotopic early-stage hepatocellular carcinoma.

J Mater Chem B 2021 Oct 12. Epub 2021 Oct 12.

Department of Hepatobiliary Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510280, China.

Early diagnosis and effective treatment of hepatocellular carcinoma (HCC) is quite critical for improving patients' prognosis. The combination of second near-infrared window photoacoustic imaging (NIR-II PAI) and -magnetic resonance imaging (-MRI) is promising for achieving omnibearing information on HCC diagnosis due to the complementary advantages of outstanding optical contrast, high temporospatial resolution and soft-tissue resolution. Thus, the rational design of a multifunctional targeted nanoplatform with outstanding performance in dual-modal NIR-II PAI/-MRI is particularly valuable for precise diagnosis and imaging-guided non-invasive photothermal therapy (PTT) of early-stage HCC. Read More

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October 2021

Comparison of Non-Invasive Clinical Algorithms for Liver Fibrosis in Patients With Chronic Hepatitis B to Reduce the Need for Liver Biopsy: Application of Enhanced Liver Fibrosis and Mac-2 Binding Protein Glycosylation Isomer.

Ann Lab Med 2022 Mar;42(2):249-257

Department of Laboratory Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Background: Non-invasive clinical algorithms for the detection of liver fibrosis (LF) can reduce the need for liver biopsy (LB). We explored the implementation of two serum biomarkers, enhanced liver fibrosis (ELF) and Mac-2 binding protein glycosylation isomer (M2BPGi), in clinical algorithms for LF in chronic hepatitis B (CHB) patients.

Methods: Two clinical algorithms were applied to 152 CHB patients: (1) transient elastography (TE) followed by biomarkers (TE/ELF and TE/M2GPGi); (2) biomarker test followed by TE (ELF/TE and M2BPGi/TE). Read More

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