11,928 results match your criteria non-invasive biomarker


Early detection of kidney cancer using urinary proteins: a truly non-invasive strategy.

BJU Int 2021 Sep 27. Epub 2021 Sep 27.

Department of Surgery, University of Cambridge, Addenbrooke's Hospital, Cambridge Biomedical Campus, Hill's Road, Cambridge, CB2 0QQ, UK.

Objectives: To review urinary protein biomarkers as potential non-invasive, easily obtainable, early diagnostic tools in renal cell carcinoma (RCC).

Methods: A PubMed database search was performed up to the year 2020 to identify primary studies reporting potential urinary protein biomarkers for RCC. Separate searches were conducted to identify studies describing appropriate methods of developing cancer screening programmes and detection of cancer biomarkers. Read More

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September 2021

Investigating Auditory Electrophysiological Measures of Participants with Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review and Meta-Analysis of Event-Related Potential Studies.

J Alzheimers Dis 2021 Sep 18. Epub 2021 Sep 18.

Ear Science Institute Australia, Subiaco, WA, Australia.

Background: Objectively measuring auditory functions has been proposed as an avenue in differentiating normal age-related cognitive dysfunction from Alzheimer's disease (AD) and its prodromal states. Previous research has suggested auditory event-related potentials (AERPs) to be non-invasive, cost-effective, and efficient biomarkers for the diagnosis of AD.

Objective: The objective of this paper is to review the published literature on AERPs measures in older adults diagnosed with AD and those at higher risk of developing AD, i. Read More

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September 2021

Using Optical Coherence Tomography to Screen for Cognitive Impairment and Dementia.

J Alzheimers Dis 2021 Sep 22. Epub 2021 Sep 22.

Comprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.

Background: Screening for Alzheimer's disease and related disorders (ADRD) and mild cognitive impairment (MCI) could increase case identification, enhance clinical trial enrollment, and enable early intervention. MCI and ADRD screening would be most beneficial if detection measures reflect neurodegenerative changes. Optical coherence tomography (OCT) could be a marker of neurodegeneration (part of the amyloid-tau-neurodegeneration (ATN) framework). Read More

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September 2021

SERS and MALDI-TOF MS based plasma exosome profiling for rapid detection of osteosarcoma.

Analyst 2021 Sep 27. Epub 2021 Sep 27.

Department of Chemistry, and Shanghai Stomatological Hospital, Fudan University, Shanghai 200000, China.

Osteosarcoma is the most frequent primary bone cancer, particularly among children and adolescents. The early diagnosis of osteosarcoma is significant for timely clinical treatment to reduce the mortality of patients. Exosomes play a significant role in intercellular communication and serve as promising biomarkers in liquid biopsy for the diagnosis and monitoring of tumors. Read More

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September 2021

Taiwanese Clinical Experience with Noninvasive Prenatal Testing for DiGeorge Syndrome.

Fetal Diagn Ther 2021 Sep 16:1-6. Epub 2021 Sep 16.

College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Objective: DiGeorge syndrome (DGS) is associated with microdeletions of chromosome 22q11. It is the second most common cause of congenital heart disease and is an important consideration whenever a conotruncal cardiac anomaly is identified. The availability of noninvasive prenatal testing (NIPT) is altering the practice of prenatal genetics and maternal-fetal medicine, resulting in a decline in invasive testing. Read More

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September 2021

Profoundly lower muscle mass and rate of contractile protein synthesis in boys with Duchenne muscular dystrophy.

J Physiol 2021 Sep 26. Epub 2021 Sep 26.

Department of Nutritional Sciences and Toxicology, University of California, Berkeley.

Duchenne muscular dystrophy results in a progressive loss of functional skeletal muscle but total body functional muscle mass or rates of muscle protein synthesis have not previously been assessed in these patients. D creatine dilution was used to measure total functional muscle mass and oral H O was used to examine the rates of muscle protein synthesis non-invasively in boys with DMD and healthy controls using urine samples. Muscle mass was profoundly lower in DMD compared to control subjects, particularly in older, non-ambulant patients. Read More

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September 2021

Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure.

Int J Cancer 2021 Sep 27. Epub 2021 Sep 27.

Epigenomics and Mechanisms Branch, International Agency for Research on Cancer, WHO, Lyon, France.

Recurrent upper urinary tract carcinomas (UTUC) arise in the context of nephropathy linked to exposure to the herbal carcinogen aristolochic acid (AA). Here we delineated the molecular programs underlying UTUC tumorigenesis in patients from endemic aristolochic acid nephropathy (AAN) regions in Southern Europe. We applied an integrative multi-omics analysis of UTUCs, corresponding unaffected tissues and of patient urines. Read More

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September 2021

Serum exosomal miR-122-5p, GAS, and PGR in the non-invasive diagnosis of CAG.

Open Med (Wars) 2021 8;16(1):1350-1355. Epub 2021 Sep 8.

Department of Traditional Chinese Medicine, The First Affiliated Hospital of Guangdong Pharmaceutical University, Gonghexiheng Street 1, Guangzhou 510080, Guangdong, People's Republic of China.

Objective: The aim of this study was to integrate the serum exosomal miRNA miR-122-5p with canonical serological biomarkers for the non-invasive screening of chronic atrophic gastritis (CAG) patients.

Methods: miR-122-5p and U6 were amplified by the quantitative reverse transcription polymerase chain reaction (RT-qPCR), gastrin (GAS), pepsinogen I (PG-I), and PG-II and were measured by ELISA. The area under the receiver operating characteristic (ROC) curves and their correlation were analyzed. Read More

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September 2021

Urinary Exosomes Diagnosis of Urological Tumors: A Systematic Review and Meta-Analysis.

Front Oncol 2021 10;11:734587. Epub 2021 Sep 10.

Experimental Research Center, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, China.

Purpose: Exosomes could be released directly into the urine by the urological tumoral cells, so testing urinary exosomes has great potential for non-invasive diagnosis and monitor of urological tumors. The objective of this study is to systematically review and meta-analysis of urinary exosome for urological tumors diagnosis.

Materials And Methods: A systematic review of the recent English-language literature was conducted according to the PRISMA statement recommendations (CRD42021250613) using PubMed, Embase, Cochrane Library, Web of Science, and Scopus databases up to April 30, 2021. Read More

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September 2021

The role of diffusion tensor imaging in idiopathic sensorineural hearing loss: is it significant?

Pol J Radiol 2021 9;86:e474-e480. Epub 2021 Aug 9.

Department of Diagnostic Radiology, Mansoura University, Egypt.

Purpose: To assess the role of diffusion tensor imaging metrics in the evaluation of the microstructural integrity of the central auditory tract in patients with idiopathic sensorineural hearing loss (SNHL), and to compare these patients with healthy controls.

Material And Methods: This prospective study, which was conducted upon 30 subjects (21 males, 9 females; age range from 16 to 65 years, mean age 45years) with SNHL proven by audiometric tests. Ten age- and sex-matched healthy volunteers were included as a control group. Read More

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Maternal Circulating Exosomal miRNAs as Non-invasive Biomarkers for the Prediction of Fetal Ventricular Septal Defect.

Front Genet 2021 9;12:717208. Epub 2021 Sep 9.

Department of Prenatal Diagnostic, Jiaxing Maternity and Children Health Care Hospital, Jiaxing University, Jiaxing, China.

This study aimed to identify maternal circulating exosomal miRNAs as potential non-invasive biomarkers for the early detection of fetal ventricular septal defects (VSDs). In total, 182 pregnant women, comprising 91 VSD cases and 91 matched controls, were included in this study. Exosomes were isolated; dysregulated exosomal miRNAs were profiled using next-generation sequencing. Read More

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September 2021

Ophthalmic Biomarkers for Alzheimer's Disease: A Review.

Front Aging Neurosci 2021 10;13:720167. Epub 2021 Sep 10.

Medical School, University of Exeter, Exeter, United Kingdom.

Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by neuronal loss, extracellular amyloid-β (Aβ) plaques, and intracellular neurofibrillary tau tangles. A diagnosis is currently made from the presenting symptoms, and the only definitive diagnosis can be done post-mortem. Over recent years, significant advances have been made in using ocular biomarkers to diagnose various neurodegenerative diseases, including AD. Read More

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September 2021

Feasibility and utility of MRI and dynamic F-FDG-PET in an orthotopic organoid-based patient-derived mouse model of endometrial cancer.

J Transl Med 2021 Sep 26;19(1):406. Epub 2021 Sep 26.

Department of Clinical Medicine, University of Bergen, 5021, Bergen, Norway.

Background: Pelvic magnetic resonance imaging (MRI) and whole-body positron emission tomography-computed tomography (PET-CT) play an important role at primary diagnostic work-up and in detecting recurrent disease in endometrial cancer (EC) patients, however the preclinical use of these imaging methods is currently limited. We demonstrate the feasibility and utility of MRI and dynamic F-fluorodeoxyglucose (FDG)-PET imaging for monitoring tumor progression and assessing chemotherapy response in an orthotopic organoid-based patient-derived xenograft (O-PDX) mouse model of EC.

Methods: 18 O-PDX mice (grade 3 endometrioid EC, stage IIIC1), selectively underwent weekly T2-weighted MRI (total scans = 32), diffusion-weighted MRI (DWI) (total scans = 9) and dynamic F-FDG-PET (total scans = 26) during tumor progression. Read More

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September 2021

Differential Glycosylation Levels in Saliva from Patients with Lung or Breast Cancer: A Preliminary Assessment for Early Diagnostic Purposes.

Metabolites 2021 Aug 24;11(9). Epub 2021 Aug 24.

Department of Biological and Environmental Sciences and Technologies, Campus Ecotekne, University of Salento, via Monteroni, 73100 Lecce, Italy.

Glycans play a fundamental role in several biological processes, such as cell-cell adhesion, signaling, and recognition. Similarly, abnormal glycosylation is involved in many pathological processes, among which include tumor growth and progression. Several highly glycosylated proteins found in blood are currently used in clinical practice as cancer biomarkers (e. Read More

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MicroRNAs as Potential Biomarkers in Pituitary Adenomas.

Noncoding RNA 2021 Sep 3;7(3). Epub 2021 Sep 3.

Fondazione Italiana Ricerca sulle Malattie dell'Osso (FIRMO Onlus), 50141 Florence, Italy.

Pituitary adenomas (PAs) are one of the most common lesions of intracranial neoplasms, occurring in approximately 15% of the general population. They are typically benign, although some adenomas show aggressive behavior, exhibiting rapid growth, drug resistance, and invasion of surrounding tissues. Despite ongoing improvements in diagnostic and therapeutic strategies, late first diagnosis is common, and patients with PAs are prone to relapse. Read More

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September 2021

Predictive value of gadoxetic acid-enhanced MRI for posthepatectomy liver failure: a systematic review.

Eur Radiol 2021 Sep 25. Epub 2021 Sep 25.

Division of Medical Imaging and Technology, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden.

Objectives: Effective and non-invasive biomarkers to predict and avoid posthepatectomy liver failure (PHLF) are urgently needed. This systematic review aims to evaluate the efficacy of gadoxetic acid-enhanced MRI-derived parameters as an imaging biomarker in preoperative prediction of PHLF.

Methods: A systematic literature search was performed in the databases of PubMed/Medline, Web of Science, Embase, and Cochrane Library up to 11 December 2020. Read More

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September 2021

Pressure-Mediated Reflection Spectroscopy Criterion Validity as a Biomarker of Fruit and Vegetable Intake: A Two-Site Cross-Sectional Study of Four Racial Or Ethnic Groups.

J Nutr 2021 Sep 25. Epub 2021 Sep 25.

Division of Epidemiology and Community Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454.

Background: Valid biomarkers of fruit and vegetable (FV) intake are needed for field-based nutrition research.

Objective: To examine criterion-related validity of pressure-mediated reflection spectroscopy as a proxy measure of FV intake, using plasma carotenoids and self-reported FV and carotenoid intake as primary and secondary criterion measures, respectively.

Methods: Healthy adults 18-65 years of age, self-identifying as African American/ black (n = 61), Asian (n = 53), white (n = 70), or Hispanic (n = 29) in North Carolina and Minnesota were recruited. Read More

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September 2021

Prenatal diagnosis of maternal serum from mothers carrying β-thalassemic fetus.

Pediatr Int 2021 Sep 24. Epub 2021 Sep 24.

Dr. Zafar H. Zaidi Center for Proteomics, University of Karachi, Karachi, 75270, Pakistan.

Background: Current study focused on discovering protein biomarkers from the maternal serum of β-thalassemic trait mothers carrying the normal fetus and β-thalassemic major fetus.

Method: Serum samples from β-thalassemic trait mothers carrying major (N=5) and normal fetuses (N=5) were studied. IVS1-5 thalassemia mutation was common among β-thalassemic trait mothers who were carrying homozygous β-thalassemic fetus (IVS1-5/ IVS1-5 mutation) or normal fetus (no mutation). Read More

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September 2021

Doppler Ultrasound to assess the pharmacodynamic effects of splanchnic vasoactive compounds.

Br J Clin Pharmacol 2021 Sep 23. Epub 2021 Sep 23.

Center for Clinical Pharmacology, University Hospitals Leuven, Leuven, Belgium.

Aim: In search of non-invasive biomarkers to assess the pharmacodynamic effects of portal pressure-lowering drugs, the reproducibility of flow measurements in the superior mesenteric artery (SMA) was evaluated using Doppler ultrasound.

Methods: A reproducibility study was conducted in 15 healthy male volunteers (18-50 years). Per subject, eight ultrasound measurements were performed: two observers each conducted two measurements during two separate visits. Read More

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September 2021

Eosinophils and T cell surface molecule transcript levels in the blood differentiate eosinophilic esophagitis (EoE) from GERD.

Int J Basic Clin Immunol 2021 ;4(1-2):1-8

John W. Deming Department of Medicine, Pulmonary Diseases, Tulane Eosinophilic Disorder Center, Tulane University School of Medicine, New Orleans, LA 70112, USA.

We recently rereported that blood mRNA levels of T cells and IgE receptors are the novel non-invasive biomarkers for eosinophilic esophagitis (EoE) with the aim to establish the panel of T cells and IgE receptor as the novel non-invasive biomarkers for EoE. In addition to earlier proposed cell surface molecules, we now added T cell receptor CXCR6 and eosinophils expressed cell surface molecules CD101 and CD274 mRNA levels. The mRNA levels of eosinophils cell surface molecule CD101 and CD274 and T cell receptor CXCR6, Vβ11, CD1d and chemokine CXCL16 levels were examined using the blood of normal, EoE and GERD patients. Read More

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January 2021

Plasma p-tau181 Level Predicts Neurodegeneration and Progression to Alzheimer's Dementia: A Longitudinal Study.

Front Neurol 2021 7;12:695696. Epub 2021 Sep 7.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Plasma-based biomarkers would be potential biomarkers for early diagnosis of Alzheimer's disease (AD) because they are more available and cost-effective than cerebrospinal fluid (CSF) or neuroimaging. Therefore, we aimed to evaluate whether phosphorylated tau181 (p-tau181) in plasma could be an accurate AD predictor. Participants from the ADNI database included 185 cognitively unimpaired subjects with negative Aβ (CU-), 66 subjects with pre-clinical AD (CU with positive Aβ), 164 subjects with mild cognitive impairment with negative Aβ (MCI-), 254 subjects with prodromal AD (MCI with positive Aβ), and 98 subjects with dementia. Read More

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September 2021

Histology to 3D in vivo MR registration for volumetric evaluation of MRgFUS treatment assessment biomarkers.

Sci Rep 2021 Sep 23;11(1):18923. Epub 2021 Sep 23.

Utah Center for Advanced Imaging Research, University of Utah, Salt Lake City, UT, USA.

Advances in imaging and early cancer detection have increased interest in magnetic resonance (MR) guided focused ultrasound (MRgFUS) technologies for cancer treatment. MRgFUS ablation treatments could reduce surgical risks, preserve organ tissue and function, and improve patient quality of life. However, surgical resection and histological analysis remain the gold standard to assess cancer treatment response. Read More

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September 2021

Lysophosphatidic acid species are associated with exacerbation in chronic obstructive pulmonary disease.

BMC Pulm Med 2021 Sep 23;21(1):301. Epub 2021 Sep 23.

Product Development Immunology, Infectious Disease and Ophthalmology, Genentech, Inc., South San Francisco, CA, USA.

Background: Chronic obstructive pulmonary disease (COPD) exacerbations are heterogenous and profoundly impact the disease trajectory. Bioactive lipid lysophosphatidic acid (LPA) has been implicated in airway inflammation but the significance of LPA in COPD exacerbation is not known. The aim of the study was to investigate the utility of serum LPA species (LPA16:0, 18:0, 18:1, 18:2, 20:4) as biomarkers of COPD exacerbation. Read More

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September 2021

Collagen Glycation Detected by Its Intrinsic Fluorescence.

J Phys Chem B 2021 Sep 24. Epub 2021 Sep 24.

Photophysics Group, Department of Physics, University of Strathclyde, Scottish Universities Physics Alliance, Glasgow G4 0NG, U.K.

Collagen's long half-life (in skin approximately 10 years) makes this protein highly susceptible to glycation and formation of the advanced glycation end products (AGEs). Accumulation of cross-linking AGEs in the skin collagen has several detrimental effects; thus, the opportunity for non-invasive monitoring of skin glycation is essential, especially for diabetic patients. In this paper, we report using the time-resolved intrinsic fluorescence of collagen as a biomarker of its glycation. Read More

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September 2021

Impact of Preanalytical and Analytical Methods on Cell-Free DNA Diagnostics.

Front Cell Dev Biol 2021 6;9:686149. Epub 2021 Sep 6.

Department of Medical Biology, School of Medicine, University of Zagreb, Zagreb, Croatia.

While tissue biopsy has for the longest time been the gold-standard in biomedicine, precision/personalized medicine is making the shift toward liquid biopsies. Cell-free DNA (cfDNA) based genetic and epigenetic biomarkers reflect the molecular status of its tissue-of-origin allowing for early and non-invasive diagnostics of different pathologies. However, selection of preanalytical procedures (including cfDNA isolation) as well as analytical methods are known to impact the downstream results. Read More

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September 2021

The Potential of Metabolomic Analyses as Predictive Biomarkers of Preterm Delivery: A Systematic Review.

Front Endocrinol (Lausanne) 2021 6;12:668417. Epub 2021 Sep 6.

Division of Obstetrics and Prenatal Diagnosis, Erasmus University Medical Centre, Rotterdam, Netherlands.

Scope: as the leading cause of perinatal mortality and morbidity worldwide, the impact of premature delivery is undisputable. Thus far, non-invasive, cost-efficient and accurate biochemical markers to predict preterm delivery are scarce. The aim of this systematic review is to investigate the potential of non-invasive metabolomic biomarkers for the prediction of preterm delivery. Read More

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September 2021

Evaluating Methylation of the Oxytocin Receptor Gene and the Oxytocin Intergenic Region.

Methods Mol Biol 2022 ;2384:81-103

Jewish General Hospital, Lady Davis Institute for Medical Research and Department of Psychiatry, McGill University, Montreal, QC, Canada.

Oxytocin and its paralogue, vasopressin, are widely studied biomarkers in relation to pregnancy and birth, maternal and social behavior, and mental health. Epigenetics is a biological mechanism that mediates the link between environmental influences and behavioral patterns. In a candidate gene approach, we describe here a DNA methylation assay of two regions within the oxytocin system, using human buccal cells and next-generation sequencing. Read More

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January 2022

ImmunoPET: harnessing antibodies for imaging immune cells.

Mol Imaging Biol 2021 Sep 22. Epub 2021 Sep 22.

Molecular Imaging &Therapy Svc, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Dramatic, but uneven, progress in the development of immunotherapies for cancer has created a need for better diagnostic technologies including innovative non-invasive imaging approaches. This review discusses challenges and opportunities for molecular imaging in immuno-oncology and focuses on the unique role that antibodies can fill. ImmunoPET has been implemented for detection of immune cell subsets, activation and inhibitory biomarkers, tracking adoptively transferred cellular therapeutics, and many additional applications in preclinical models. Read More

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September 2021

Micro-Chamber/Thermal Extractor (µ-CTE) as a new sampling system for VOCs emitted by feces.

Sci Rep 2021 Sep 21;11(1):18780. Epub 2021 Sep 21.

Interdisciplinary Centre of Modern Technologies - BioSep, Nicolaus Copernicus University, Wileńska 4, 87-100, Toruń, Poland.

VOCs (volatile organic compounds) are increasingly wished to be used in diagnosis of diseases. They present strategic advantages, when compared to classical methods used, such as simplicity and current availability of performant non-invasive sample collection methods/systems. However, standardized sampling methods are required in order to achieve reproducible results. Read More

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September 2021

Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression.

Aging (Albany NY) 2021 Sep 21;13(undefined). Epub 2021 Sep 21.

Faculty of Medicine and Biomedical Sciences (FMCB), University of Algarve, Campus de Gambelas, Faro 8005-139, Portugal.

Colorectal cancer is one of the leading causes of cancer-related deaths worldwide. This complex disease still holds severe problems concerning diagnosis due to the high invasiveness nature of colonoscopy and the low accuracy of the alternative diagnostic methods. Additionally, patient heterogeneity even within the same stage is not properly reflected in the current stratification system. Read More

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September 2021