2,578 results match your criteria non-healing


Therapeutic Biomaterial Approaches to Alleviate Chronic Limb Threatening Ischemia.

Adv Sci (Weinh) 2021 Apr 8;8(7):2003119. Epub 2021 Feb 8.

CÚRAM SFI Research Centre for Medical Devices National University of Ireland Galway Ireland.

Chronic limb threatening ischemia (CLTI) is a severe condition defined by the blockage of arteries in the lower extremities that leads to the degeneration of blood vessels and is characterized by the formation of non-healing ulcers and necrosis. The gold standard therapies such as bypass and endovascular surgery aim at the removal of the blockage. These therapies are not suitable for the so-called "no option patients" which present multiple artery occlusions with a likelihood of significant limb amputation. Read More

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Effectiveness of different types of skin grafting for treating venous leg ulcers: A protocol for systematic review and network meta-analysis.

Medicine (Baltimore) 2021 Apr;100(15):e25597

Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, Jiangxi Province, China.

Background: Venous leg ulcers (VLUs) are the most common ulcer on the lower extremity, with 4% of patients over the age of 65 suffering from VLUs worldwide. As a recurrent, chronic, disabling disease, VLUs are associated with prolonged disability, substantial socioeconomic impact, and significant psychosocial morbidity. At present, Skin grating is one of the most effective treatments for non-healing ulcers. Read More

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A filter-assisted culture method for isolation of spp. from bovine digital dermatitis and their identification by MALDI-TOF MS.

J Vet Diagn Invest 2021 Apr 9:10406387211008511. Epub 2021 Apr 9.

Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

Digital dermatitis (DD) is a major infectious foot disease of cattle worldwide. Some DD stages are associated with lameness, and the disease has significant economic and animal welfare consequences. The pathogenesis of the disease is not yet fully understood, but spp. Read More

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Endoscopic Surgery for Delayed Wound Healing After Achilles Tendon Suture Repair: A Report of Three Cases.

Orthop Surg 2021 Apr 7. Epub 2021 Apr 7.

Department of Sports Medicine, Peking University Third Hospital, Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China.

Background: Delayed wound healing is a potention complication after Achilles tendon suture repair and occurs for various reasons. The conventional treatment for delayed wound healing is open surgery, but patients face long recovery times and postoperative care is difficult.

Case Presentation: This report presents three patients who were seen at our institute from April 2008 to October 2017 due to long-term non-healing wounds after surgery. Read More

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Potential cost-effectiveness of using adjunctive dehydrated human amnion/chorion membrane allograft in the management of non-healing diabetic foot ulcers in the United Kingdom.

Int Wound J 2021 Apr 7. Epub 2021 Apr 7.

Diabetes Care Centre, South Tees Hospitals NHS Foundation Trust, Middlesbrough, UK.

The aim of this study was to estimate the cost-effectiveness of using dehydrated human amnion/chorion membrane (dHACM) allografts (Epifix) as an adjunct to standard care, compared with standard care alone, to manage non-healing diabetic foot ulcers (DFUs) in secondary care in the United Kingdom, from the perspective of the National Health Service (NHS). A Markov model was constructed to simulate the management of diabetic lower extremity ulcers over a period of 1 year. The model was used to estimate the cost-effectiveness of using adjunctive dHACM, compared with standard care alone, to treat non-healing DFUs in the United Kingdom, in terms of the incremental cost per quality-adjusted life year (QALY) gained at 2019/2020 prices. Read More

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Hospital-acquired Skin and Skin-structure Infection in COVID-19 Infected Patient with Prolonged Hospitalization.

Acta Med Indones 2021 Jan;53(1):105-107

Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Acute bacterial skin and skin-structure infections (ABSSSI) is defined in 2013 by the US Food and Drug Administration as a bacterial cellulitis/erysipelas, major skin abscesses, and wound infections. The Infectious Diseases Society of America (IDSA) in 2014 classifies skin and soft-tissue infection (SSTI) as either non-purulent (which includes cellulitis, erysipelas, and necrotizing infection) or purulent (including furuncle, carbuncle, and abscess). Among hospitalized patients with SSTI, healthcare-associated infections account for 73. Read More

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January 2021

3D Bioprinted Bacteriostatic Hyperelastic Bone Scaffold for Damage-Specific Bone Regeneration.

Polymers (Basel) 2021 Mar 30;13(7). Epub 2021 Mar 30.

Department of Biomedical Engineering, Georgia Institute of Technology, School of Medicine, Emory University, Atlanta, GA 30322, USA.

Current strategies for regeneration of large bone fractures yield limited clinical success mainly due to poor integration and healing. Multidisciplinary approaches in design and development of functional tissue engineered scaffolds are required to overcome these translational challenges. Here, a new generation of hyperelastic bone (HB) implants, loaded with superparamagnetic iron oxide nanoparticles (SPIONs), are 3D bioprinted and their regenerative effect on large non-healing bone fractures is studied. Read More

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Highly Porous and Superabsorbent Biomaterial Made of Marine-Derived Polysaccharides and Ascorbic Acid as an Optimal Dressing for Exuding Wound Management.

Materials (Basel) 2021 Mar 4;14(5). Epub 2021 Mar 4.

Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1 Street, 20-093 Lublin, Poland.

There are many modern wound dressings that have promising properties for repairing skin damage. However, due to various types of wounds and the problems they cause, there is still a great demand for new, effective healing strategies. The aim of this study was to create superabsorbent wound dressing made of marine-derived polysaccharides (agarose and chitosan) using the freeze-drying method. Read More

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Chronic Diabetic Wounds and Their Treatment with Skin Substitutes.

Cells 2021 Mar 15;10(3). Epub 2021 Mar 15.

Department of Regenerative Medicine and Immune Regulation, Medical University of Bialystok, 15-269 Bialystok, Poland.

With the global prevalence of type 2 diabetes mellitus steeply rising, instances of chronic, hard-healing, or non-healing diabetic wounds and ulcers are predicted to increase. The growing understanding of healing and regenerative mechanisms has elucidated critical regulators of this process, including key cellular and humoral components. Despite this, the management and successful treatment of diabetic wounds represents a significant therapeutic challenge. Read More

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A pH-sensitive oxidized-dextran based double drug-loaded hydrogel with high antibacterial properties.

Int J Biol Macromol 2021 Mar 30. Epub 2021 Mar 30.

School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China. Electronic address:

Delayed healing or non-healing of wounds caused by bacterial infection is still a difficult medical problem. Nowadays, the topical application of antibiotics is a common treatment for infections. However, subinhibitory concentrations or high dose of antibiotics leads to the antibacterial effect counterproductive. Read More

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Solid Platelet‑rich Plasma Combined with Silicone-hydrogel Soft Contact Lens for Non-healing Corneal Ulcers: A Case Series.

Ocul Immunol Inflamm 2021 Apr 1:1-6. Epub 2021 Apr 1.

Cornea and Refractive Surgery Department, Asociación Para Evitar la Ceguera en México, Mexico City, Mexico.

: To present a case series of non-healing corneal ulcers treated by solid activated platelet-rich plasma (PRP) combined with silicone-hydrogel soft contact lens.: Three eyes from three patients with unresponsive corneal ulcers were included. A clot of PRP was applied directly onto the corneal ulcer and covered with a soft contact lens. Read More

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Pyridoxamine ameliorates methylglyoxal-induced macrophage dysfunction to facilitate tissue repair in diabetic wounds.

Int Wound J 2021 Mar 31. Epub 2021 Mar 31.

Department of Burn, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Methylglyoxal (MGO) is a highly reactive dicarbonyl compound formed during hyperglycaemia. MGO combines with proteins to form advanced glycation end products (AGEs), leading to cellular dysfunction and organ damage. In type 2 diabetes mellitus (T2DM), the higher the plasma MGO concentration, the higher the lower extremity amputation rate. Read More

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Non-healing parastomal ulcer: think nicorandil.

ANZ J Surg 2021 Mar 31. Epub 2021 Mar 31.

General Surgery Department, Rockhampton Hospital, Rockhampton, Queensland, Australia.

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Use of Sponge-Foam Inserts in Compression Bandaging of Non-Healing Venous Leg Ulcers.

Ann Vasc Dis 2021 Mar;14(1):46-51

Department of Plastic and Reconstructive Surgery, Juntendo University School of Medicine, Sapporo, Hokkaido, Japan.

Venous leg ulcers (VLUs) caused by chronic venous insufficiency are difficult to treat. Outcomes after compression therapy and the current standard of care often used in conjunction with other options vary widely. We examined the effects of foam inserts on sub-bandage pressures in patients with VLUs and compared use of foam inserts in elastic and inelastic compression bandaging. Read More

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Self-assembled elastin-like polypeptide fusion protein coacervates as competitive inhibitors of advanced glycation end-products enhance diabetic wound healing.

J Control Release 2021 Mar 27;333:176-187. Epub 2021 Mar 27.

Department of Biomedical Engineering, Rutgers University, Piscataway, NJ 08854, USA. Electronic address:

Chronic and non-healing skin wounds are some of the most significant complications in patients with advanced diabetes. A contributing mechanism to this pathology is the non-enzymatic glycation of proteins due to hyperglycemia, leading to the formation of advanced glycation end products (AGEs). AGEs bind to the receptor for AGEs (RAGE), which triggers pro-inflammatory signals that may inhibit the proliferative phase of wound healing. Read More

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Chronic prosthesis-related residual limb ulcer treated with autologous micro-fragmented adipose tissue.

Regen Ther 2021 Dec 18;18:21-23. Epub 2021 Mar 18.

New Jersey Regenerative Institute, USA.

A 56-year-old male with a past medical history significant for a left below-knee amputation and a left total knee replacement presented with knee pain at a non-healing stage 2 prosthesis-related residual limb ulcer. The ulcer at the weight-bearing surface at the anterior patella had not closed despite three years of conservative management; including offloading and wound clinic follow up. To assist with the healing process, the ulcer was treated with autologous micro-fragmented adipose tissue therapy. Read More

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December 2021

sQUIZ your knowledge! A non-healing ulcer on the chest.

Eur J Dermatol 2021 Feb;31(1):135-137

Department of Dermatology, Venereology, and Leprosy; R.G. Kar Medical College, Kolkata, India.

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February 2021

Cord Lining Mesenchymal Stem Cells Have a Modest Positive Effect on Angiogenesis in Hindlimb Ischemia.

Front Cell Dev Biol 2020 8;8:596170. Epub 2021 Mar 8.

Novena Vascular and Varicose Vein Centre, Mount Elizabeth Novena Specialist Centre, Singapore, Singapore.

We investigated the use of human Cord Lining Mesenchymal Stem Cells (CL-MSCs) (US Patent number 9,737,568), in a rabbit hindlimb ischemia model, and evaluated their potential in stimulating neovascularization. Allogenic human CL- MSCs could potentially be used to treat patients with lower limb ischemia and non-healing wounds. Twenty rabbits were divided into two separate groups. Read More

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Recurrent squamous cell carcinoma in a post cardiac transplant patient.

Int J Surg Case Rep 2021 Feb 15;79:275-280. Epub 2021 Jan 15.

Hunter Holmes McGuire Veterans Administration Medical Center, Richmond, VA, United States. Electronic address:

Introduction And Importance: Solid organ transplantation has evolved along with dramatic advancements in definitive treatment for irreversible and uncompensated organ failure. Transplanted organ survival has improved as a result of reduced allograft rejection. However, negative long-term outcomes which were largely due to the adverse effects of rapidly evolving immunosuppressive regimens are still evident. Read More

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February 2021

Optimization of extracellular matrix production from human induced pluripotent stem cell-derived fibroblasts for scaffold fabrication for application in wound healing.

J Biomed Mater Res A 2021 Mar 23. Epub 2021 Mar 23.

Tissue Engineering Research Group, Royal College of Surgeons in Ireland (RCSI), Dublin 2, Ireland.

Extracellular matrix is a key component of all tissues, including skin and it plays a crucial role in the complex events of wound healing. These events are impaired in chronic wounds, with chronic inflammation and infection often present in these non-healing wounds. Many tissue engineering approaches for wound healing provide a scaffold to mimic the native matrix. Read More

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Current applications of platelet gels in wound healing-A review.

Wound Repair Regen 2021 Mar 22. Epub 2021 Mar 22.

Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China.

Human platelets play important roles in several physiologic and pathologic processes. Platelet concentrates are activated with thrombin or calcium, resulting in a viscous coagulum (platelet gel [PG]), composed of 95% platelets at least. PG is increasingly used for the treatment of a variety of soft and hard tissue defects, most notably in the management of chronic non-healing wounds. Read More

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The Z-plasty contributes to the coalescence of a chronic non-healing wound.

Int Wound J 2021 Mar 17. Epub 2021 Mar 17.

Department of Plastic Surgery, Peking University Third Hospital, Beijing, China.

This study aimed to explore the treatment effect of Z-plasty on a non-healing wound. A total of 72 patients diagnosed with a chronic non-healing wound in Peking University Third Hospital from November 2009 to August 2019 were retrospectively analysed. Among them, 27 patients were treated with Z-plasty, and 45 patients were treated with the general method. Read More

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Cancer metastasis as a non-healing wound.

Br J Cancer 2021 Mar 17. Epub 2021 Mar 17.

Institute for Computational Biomedicine, Weill Cornell Medicine, New York, NY, USA.

Most cancer deaths are caused by metastasis: recurrence of disease by disseminated tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour cells are released from the primary tumour, even during the early stages of tumour growth. However, only a minority survive as potential seeds for future metastatic outgrowths. Read More

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Cytomegalovirus and Herpes Simplex Virus Co-Infection in an HIV-Negative Patient: A Case Report.

Cureus 2021 Feb 8;13(2):e13214. Epub 2021 Feb 8.

Internal Medicine, Rutgers New Jersey Medical School, Newark, USA.

Herpes simplex virus (HSV) and cytomegalovirus (CMV) infections are commonly seen in immunocompromised patients, particularly in patients with HIV. However, fulminant CMV infection and concurrent infection with HSV and CMV in non-HIV patients are quite rare. We present the case of a 72-year-old HIV-negative man with a history of oropharyngeal carcinoma in remission and recent treatment of immune thrombocytopenic purpura with high-dose steroids who was transferred from an outside hospital for Ear Nose and Throat (ENT) evaluation of a non-healing buccal ulcer. Read More

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February 2021

Burn Center Management of Severe Necrotic Cutaneous Polyarteritis Nodosa in a Patient With a History of Thymoma.

Cureus 2021 Feb 4;13(2):e13134. Epub 2021 Feb 4.

Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, USA.

Cutaneous polyarteritis nodosa (cPAN) is a rare, necrotizing vasculitis involving the small- and medium-sized vessels of the dermis and subcutaneous tissues. We report a severe case of cPAN in a patient with an atypical presentation of extensive bilateral lower extremity ulcerations with full-thickness necrosis managed at a burn center. A 70-year-old female with a three-month history of necrotizing cPAN to the bilateral lower extremities underwent surgical excision and autografting at an outside hospital. Read More

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February 2021

Does vitamin C supplementation improve rotator cuff healing? A preliminary study.

Eur J Orthop Surg Traumatol 2021 Mar 16. Epub 2021 Mar 16.

Centre Hospitalier Universitaire de Toulouse, Hôpital Pierre Paul Riquet, Place Baylac, 31059, Toulouse Cedex09, France.

Purpose: One of the complications after rotator cuff repair is a tendon non-healing. It has already been posited in the literature that vitamin C (VC) promotes tendon healing through its antioxidant properties and its role as a cofactor in collagen synthesis. The aim of this study was to evaluate the effect of postoperative VC supplementation on the tendon healing following repair. Read More

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The role of shockwaves in the enhancement of bone repair - from basic principles to clinical application.

Injury 2021 Mar 2. Epub 2021 Mar 2.

Ludwig Boltzmann Institute for experimental and clinical traumatology, Vienna, Austria; AUVA trauma research center, Vienna, Austria; Austrian Cluster for Tissue Engineering, Vienna, Austria; AUVA Medical Board, Vienna, Austria.

Extracorporeal shockwave therapy is a treatment modality, originally introduced into the clinic as lithotripsie, which has also been successfully used in the last two decades in the non-invasive treatment of delayed or non-healing fractures. Initially, the mechanism of action was attributed to microfracture-induced repair, but intensive basic research has now shown that the shockwave generates its effect in tissue via mechanotransduction. Numerous signal transduction pathways have already been demonstrated, which in their entirety trigger an endogenous regeneration process via cell proliferation, migration and differentiation. Read More

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A toolkit for the quantitative evaluation of chronic wounds evolution for early detection of non-healing wounds.

J Tissue Viability 2021 Mar 2. Epub 2021 Mar 2.

The Quantitative BioImaging (QuBI) Lab, University of Vic - Central University of Catalonia (UVic-UCC), C. de La Laura, 13, 08500, Vic, Spain.

Background: Chronic wounds resulting from a number of conditions do not heal properly and can pose serious health problems. Beyond clinician visual inspection, an objective evaluation of the wound is required to assess wound evolution and the effectiveness of therapies.

Aim: Our objective is to provide a methodology for the analysis of wound area vs. Read More

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[Related factors for bile duct infection after surgical treatment of biliary dilatation].

Zhonghua Wai Ke Za Zhi 2021 Apr 1;59(4):284-288. Epub 2021 Apr 1.

Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China.

To analyze the related factors of bile duct infection in patients with biliary dilatation in the short and long term after operation. The data of the patients with biliary dilatation admitted in Peking Union Medical College Hospital between May 2012 and October 2020 were analyzed retrospectively. A total of 121 patients were enrolled in the study. Read More

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Epigenetic regulation of cellular functions in wound healing.

Exp Dermatol 2021 Mar 10. Epub 2021 Mar 10.

Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Wound Healing and Regenerative Medicine Research Program, University of Miami Miller School of Medicine, Miami, FL, USA.

Stringent spatiotemporal regulation of the wound healing process involving multiple cell types is associated with epigenetic mechanisms of gene regulation, such as DNA methylation, histone modification and chromatin remodelling, as well as non-coding RNAs. Here, we discuss the epigenetic changes that occur during wound healing and the rapidly expanding understanding of how these mechanisms affect healing resolution in both acute and chronic wound milieu. We provide a focussed overview of current research into epigenetic regulators that contribute to wound healing by specific cell type. Read More

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