842 results match your criteria non-epithelial neoplasms


Differentiation of lacrimal gland tumors using the multi-model MRI: classification and regression tree (CART)-based analysis.

Acta Radiol 2021 May 31:2841851211021039. Epub 2021 May 31.

Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai, PR China.

Background: Little is known about the value of dynamic contrast-enhanced (DCE) in combination with diffusion-weighted imaging (DWI) for the differentiation of lacrimal gland tumors.

Purpose: To evaluate the ability of DCE and DWI in differentiating lacrimal gland tumors.

Material And Methods: DCE and DWI were performed in 72 patients with lacrimal gland tumors. Read More

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Prognostic Value and Therapeutic Implications of Pleural Carcinosis and Malignant Pleural Effusion in Advanced Epithelial Ovarian Cancer.

Anticancer Res 2021 Apr;41(4):2033-2038

Department of Gynecological Oncology and Tumor Surgery, European Competence Center for Ovarian Cancer, Charité Campus Virchow Clinic, Berlin, Germany;

Aim: To demonstrate the prognostic value of pleural carcinosis/effusion in a cohort of patients with advanced epithelial ovarian cancer (EOC) and the associated therapeutic implications.

Patients And Methods: Overall, data for 388 patients with EOC with confirmed malignant pleural effusion (MPE) or pleural carcinosis were retrospectively analyzed. Exclusion criteria were non-epithelial ovarian malignancies and presence of other comorbidities associated with pleural effusions. Read More

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Hereditary ovarian tumour syndromes: current update on genetics and imaging.

Clin Radiol 2021 Apr 19;76(4):313.e15-313.e26. Epub 2021 Jan 19.

Department of Radiology, The University of Texas MD Anderson Cancer Center, 1515 Holocombe Blvd, Houston, TX 77030, USA. Electronic address:

Hereditary ovarian tumour syndromes are a diverse group of hereditary syndromes characterised by the development of specific histotypes of ovarian neoplasms. While BRCA syndromes are exclusively associated with high-grade serous carcinomas, patients with Lynch syndrome show a preponderance of endometrioid subtype of ovarian and endometrial carcinomas. Distinct non-epithelial phenotypes, such as sex cord stromal tumours with annular tubules, Sertoli-Leydig cell tumours, and small cell carcinoma of the hypercalcaemic type occur in patients with Peutz-Jeghers, DICER1, and rhabdoid tumour predisposition syndromes, respectively. Read More

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[Pathohistology of polyps of the gastrointestinal tract].

Internist (Berl) 2021 Feb;62(2):123-132

Institut für Pathologie der Ruhr-Universität Bochum, Universitätsklinikum Bergmannsheil, Bürkle-de-la-Camp-Platz 1, 44789, Bochum, Deutschland.

Polyps of the gastrointestinal tract encompass a variety of epithelial and non-epithelial tumour-like conditions. The most common polyps are epithelial lesions. In the upper gastrointestinal tract, reactive inflammatory changes and hyperplastic polyps dominate, whereas true neoplastic polyps, like adenomas, are much more common in the colorectum. Read More

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February 2021

Voluminous abdominal gastrointestinal stromal tumor of unknown origin manifested with bleeding in a young man: synchronous management of the emergency and oncological approach-case report.

AME Case Rep 2020 30;4:33. Epub 2020 Oct 30.

Dipartimento di Scienze Mediche, University of Ferrara, Ferrara, Italy.

Gastrointestinal stromal tumors (GISTs) are rare tumors of the gastrointestinal tract, which cover about 1-2% of gastrointestinal neoplasms with an unadjusted incidence of around 1/100,000/year. They are also the most common non-epithelial neoplasms of the gastrointestinal tract and they are associated with a high rate of malignant transformation. They are more common in the stomach (40-60%) while a minor part repeatedly involves jejunum/ileus (25-30%), duodenum (5%), colorectal (5-15%) and esophagus (<1%). Read More

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October 2020

Ultrasound, macroscopic and histological features of malignant ovarian tumors. Non-epithelial ovarian carcinomas: tubal choriocarcinoma and granulosa cell tumor.

Int J Gynecol Cancer 2020 Nov 2. Epub 2020 Nov 2.

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Fondazione Policlinico Universitario A Gemelli, IRCCS, Rome, Italy

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November 2020

Ventriculoperitoneal shunt-associated abdominal cerebrospinal fluid pseudocysts and the role of laparoscopy and a proposed management algorithm in its treatment. A report of 2 cases.

Neurosciences (Riyadh) 2020 Aug;25(4):320-326

Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia. E-mail:

Abdominal cerebrospinal fluid pseudocyst (APC) is a rare complication associated with a ventriculoperitoneal shunt (VPS) placement. Abdominal cerebrospinal fluid pseudocyst is defined as a cyst surrounded by a non-epithelial lining and filled with the cerebrospinal fluid (CSF). In general, 1% - 4. Read More

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Non-Neoplastic and Neoplastic Cysts of the Pancreas.

Monogr Clin Cytol 2020 28;26:53-73. Epub 2020 Sep 28.

Office of Chief Medical Examiner, New York, New York, USA.

Inflammatory, developmental, and neoplastic lesions may all present as cystic masses on imaging. Pseudocyst is the most common of these and presents in association with a history of pancreatitis. Pancreatic cystic neoplasms are uncommon compared to solid neoplasms. Read More

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September 2020

Large lipoma of the ascending colon: a case report and review of literature.

J Surg Case Rep 2020 Sep 17;2020(9):rjaa354. Epub 2020 Sep 17.

Department of Medicine, King Faisal Specialist Hospital & Research Center, Riyadh 11211, Saudi Arabia.

Gastrointestinal lipomas are a rare benign non-epithelial neoplasms derived from mature adipocytes. The colon is the commonest organ involved in the entire digestive tract and has an incidence rate ~4.4% in autopsy series. Read More

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September 2020

Imaging of non-epithelial neoplasms of the prostate.

Abdom Radiol (NY) 2020 12 22;45(12):4117-4132. Epub 2020 Sep 22.

Department of Radiology, University of Texas Health, San Antonio, TX, USA.

The purpose of this article is to review the spectrum of rare non-epithelial tumors of the prostate. This focused article will help the readers to understand the imaging findings of such rare entities attributed to their clinicopathological features. Radiologists must be familiar with the spectrum of non-epithelial tumors of the prostate, which helps to suggest alternate diagnosis other than adenocarcinoma, when imaging features are atypical. Read More

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December 2020

The world cancer patient population (WCPP): An updated standard for international comparisons of population-based survival.

Cancer Epidemiol 2020 12 14;69:101802. Epub 2020 Sep 14.

Section of Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.

Purpose: This study addresses the need for a global cancer patient-based standard population that adjusts for the expected age structure of different cancers, thus aiding the comparison of survival estimates worldwide.

Methods: Counts of age-specific incidence for 36 cancer sites in 185 countries for the year 2018 were extracted from IARC's GLOBOCAN database of national estimates. We used a multinomial mixture regression to identify clusters of cancer sites with similar age-specific profiles. Read More

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December 2020

Syndecan-1 in the Tumor Microenvironment.

Adv Exp Med Biol 2020 ;1272:39-53

Service d'Anatomie pathologique; APHP GHU Avicenne, University Sorbonne Paris Nord, Bobigny, France.

Syndecan-1 along with the other three syndecan proteins is present in the varied components of the tumor microenvironment: fibroblasts, inflammatory tumor immunity-associated cells, vessels, and extracellular matrix. Epithelial and non-epithelial tumors may show stromal syndecans. The main relevance of stromal syndecans as tumor biomarker resides in the relationships to tumor features such as type and differentiation as well as to prognosis. Read More

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October 2020

Survival and recurrence after intraperitoneal chemotherapy use: Retrospective review of ovarian cancer hospital registry data.

Cancer Med 2020 10 19;9(20):7388-7397. Epub 2020 Aug 19.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.

Background: Intraperitoneal/intravenous chemotherapy (IP/IV) was associated with improved survival for ovarian cancer (OC) patients in several randomized clinical trials. However, the uptake of IP/IV in clinical practice is varied due to conflicting evidence about its impact on survival and recurrence. The aim of this study was to explore the uptake of IP/IV treatment and to evaluate its impact on survival and recurrence in OC patients. Read More

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October 2020

The clinical impact of intra- and extracellular miRNAs in ovarian cancer.

Cancer Sci 2020 Oct 27;111(10):3435-3444. Epub 2020 Aug 27.

Division of Cellular Signaling, National Cancer Center Research Institute, Tokyo, Japan.

Ovarian cancer is the most lethal gynecological cancer due to lack of early screening methods and acquired drug resistance. MicroRNAs (miRNAs) are effective post-transcriptional regulators that are transferred by extracellular vesicles, such as exosomes. Numerous studies have revealed that miRNAs are differentially expressed in epithelial ovarian cancer and act either as oncogenes or tumor suppressor genes. Read More

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October 2020

Non-epithelial ovarian carcinoma: what is the optimal staging surgery?

Chin Clin Oncol 2020 Aug 13;9(4):50. Epub 2020 Jul 13.

Department of Surgery, Section of Surgical Oncology, National Institute of Medical Sciences and Nutrition "Salvador Zubirán", Mexico City, Mexico.

Non-epithelial ovarian neoplasms are a group of infrequent, heterogenous clinical and histological tumors that account from 6% to 10% of ovarian malignancies, the two most common non-epithelial ovarian neoplasms are germ cell tumors and sex cord-stromal cell tumors, each of these classifications is divided in multiple histologic subtypes. In the case of epithelial ovarian tumors comprehensive surgical staging has remained as the gold standard for staging, nonetheless for non-epithelial ovarian neoplasms the use of staging surgery has remained debatable and controversial throughout the years in order to correctly stage non-epithelial ovarian carcinomas. Despite the fact that the role of surgery remains critical in the adequate management of all ovarian tumors, there are several manners to surgically approach an ovarian tumor depending on the type of tumor, risk factors and staging of disease. Read More

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ESGO-SIOPE guidelines for the management of adolescents and young adults with non-epithelial ovarian cancers.

Lancet Oncol 2020 07;21(7):e360-e368

Paediatric Oncology, University Hospital Bonn, Bonn, Germany.

The European Society of Gynaecological Oncology and the European Society for Paediatric Oncology jointly developed clinically relevant and evidence-based guidelines for the management of adolescents and young adults aged 15 to 25 years with non-epithelial ovarian cancers, including malignant ovarian germ cell tumours, sex cord-stromal tumours, and small cell carcinoma of the ovary of hypercalcaemic type. The developmental process of these guidelines is based on a systematic literature review and critical appraisal process involving an international multidisciplinary developmental group consisting of experts from relevant disciplines (paediatric oncology, paediatric surgery, medical oncology, pathology, psycho-oncology, gynaecological oncology, and reproductive endocrinology). Given the specific and often complex issues involved in treating this group of patients, fertility sparing surgery and decrease of acute and long-term toxicities from treatment were important criteria for guidelines definition. Read More

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Role of high-dose salvage radiotherapy for oligometastases of the localised abdominal/pelvic lymph nodes: a retrospective study.

BMC Cancer 2020 Jun 9;20(1):540. Epub 2020 Jun 9.

Department of Radiology, Aichi Medical University Hospital, 1-1 Yazako-Karimata, Nagakute, Aichi, 480-1195, Japan.

Background: Abdominal/pelvic lymph node (LN) oligometastasis, a pattern of treatment failure, is observed occasionally, and radiotherapy may work as salvage therapy. The optimal prescription dose, however, is yet to be determined. This study assessed the efficacy of high-dose radiotherapy. Read More

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Clinical and Pathological Data of 17 Non-Epithelial Pancreatic Tumors in Cats.

Vet Sci 2020 Apr 27;7(2). Epub 2020 Apr 27.

LABOKLIN GmbH & Co. KG, 97688 Bad Kissingen, Germany.

Tumors of mesenchymal origin are rarely reported in the pancreas. Therefore, this study characterized 17 feline non-epithelial pancreatic tumors, including clinical data, histopathology, and immunohistochemistry. Seventeen feline pancreatic tissue samples were investigated histopathologically and immunohistochemically. Read More

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Pregnancy-related risk factors for sex cord-stromal tumours and germ cell tumours in parous women: a registry-based study.

Br J Cancer 2020 07 27;123(1):161-166. Epub 2020 Apr 27.

Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.

Background: Non-epithelial ovarian cancers are divided into sex cord-stromal tumours (SCSTs) and germ cell tumours (GCTs). Whereas parity and other pregnancy-related factors are protective for epithelial ovarian cancer, their associations with SCSTs and GCTs remains unclear.

Methods: Using data from the medical birth registries from Denmark, Finland, Norway and Sweden, we compared all parous women with a diagnosis of SCSTs (n = 420) or GCTs (n = 345) 1970-2013 with up to 10 parous controls (SCSTs n = 4041; GCTs n = 2942) matched on the cases' birth year and country. Read More

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A phase II trial of cytoreductive surgery combined with niraparib maintenance in platinum-sensitive, secondary recurrent ovarian cancer: SGOG SOC-3 study.

J Gynecol Oncol 2020 05;31(3):e61

Ovarian Cancer Program, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Zhongshan Hospital, Fudan University, Shanghai, China.

Background: In China, secondary cytoreductive surgery (SCR) has been widely used in ovarian cancer (OC) over the past two decades. Although Gynecologic Oncology Group-0213 trial did not show its overall survival benefit in first relapsed patients, the questions on patient selection and effect of subsequent targeting therapy are still open. The preliminary data from our pre-SOC1 phase II study showed that selected patients with second relapse who never received SCR at recurrence may still benefit from surgery. Read More

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Targeting TJP1 attenuates cell-cell aggregation and modulates chemosensitivity against doxorubicin in leiomyosarcoma.

J Mol Med (Berl) 2020 05 21;98(5):761-773. Epub 2020 Apr 21.

Division of Translational Science, Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, Gyeonggi, 10408, South Korea.

Tight junction protein 1 (TJP1) is a membrane-associated cytosolic protein important for cell-cell communication in intercellular barriers in epithelial and non-epithelial cells. Here, we explored the functional involvement of TJP1 in non-epithelial tumors such as soft tissue sarcoma, especially in leiomyosarcoma (LMS). TJP1 expression in soft tissue sarcoma was analyzed in normal and tumor tissues as well as from public datasets such as the TCGA provisional dataset, in which TJP1 expression was compared with other subtypes such as undifferentiated sarcomas, and myxofibrosarcomas. Read More

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Expression of epithelial-mesenchymal transition-related markers and phenotypes during breast cancer progression.

Breast Cancer Res Treat 2020 Jun 16;181(2):369-381. Epub 2020 Apr 16.

Division of Surgery, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden.

Purpose: The study aimed to investigate expression of epithelial-to-mesenchymal transition (EMT)-related proteins and phenotypes during breast cancer progression and to relate this to patient outcome.

Methods: Protein expression patterns of E-cadherin, N-cadherin, twist, and vimentin were examined by immunohistochemistry on formalin-fixed paraffin-embedded samples from primary tumors (PTs) (n = 419), synchronous lymph node metastases (LNMs) (n = 131) and recurrences (n = 34) from patients included in an observational prospective primary breast cancer study. Markers were evaluated individually and combined as defined EMT phenotypes (epithelial, mesenchymal, partial EMT, and negative). Read More

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Non-epithelial ovarian cancer in Denmark - Incidence and survival over nearly 40 years.

Gynecol Oncol 2020 06 27;157(3):693-699. Epub 2020 Mar 27.

Unit of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark; Department of Gynecology, Rigshospitalet, University of Copenhagen, 2100 Copenhagen, Denmark. Electronic address:

Objective: To examine trends in incidence and survival of non-epithelial ovarian cancer in Denmark over nearly 40 years, using nationwide, population-based cancer registry data.

Methods: From 1978 to 2016, we identified the non-epithelial ovarian cancer cases among all ovarian malignancies in the Danish Cancer Registry. Age-specific incidence rates, age-standardized incidence rates, and average annual percentage change (AAPC) were estimated with 95% confidence intervals (CIs). Read More

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Prominent entrapment of respiratory epithelium in primary and metastatic intrapulmonary non-epithelial neoplasms: a frequent morphological pattern closely mimicking adenofibroma and other biphasic pulmonary lesions.

Virchows Arch 2020 Aug 19;477(2):195-205. Epub 2020 Mar 19.

Institute of Pathology, Friedrich-Alexander University Erlangen-Nürnberg (FAU), University Hospital, Krankenhausstrasse 8-10, 91054, Erlangen, Germany.

As one of the most common target organs for hematogenous spread from diverse cancers, biopsy interpretation of lung tumors is complicated by the challenging question of primary versus metastatic and by frequent entrapment of native respiratory glands. Nevertheless, the literature dealing with this issue is surprisingly sparse and no single study has been devoted to this topic. We reviewed 47 surgical lung specimens of non-epithelial neoplasms (38 metastases, mainly from sarcomas and 9 primary lesions) for frequency and pattern of intralesional epithelial entrapment. Read More

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[The pathology of hereditary ovarian tumors].

Ann Pathol 2020 Apr 13;40(2):85-94. Epub 2020 Mar 13.

Institut multisite des hospices civils de Lyon, centre hospitalier Lyon Sud, 165, chemin du Grand-Revoyet, 69495 Pierre Bénite cedex, France. Electronic address:

About 23% of adnexal tumors are related to a hereditary syndrome, most often hereditary breast and ovarian cancer syndrome or Lynch syndrome, responsible of epithelial tumors. However, the pathologist should be aware of rare hereditary syndromes responsible of non-epithelial ovarian tumors. Ovarian tumors associated with germline mutation of BRCA genes are essentially high-grade serous carcinomas of tubal origin, while those seen in Lynch syndrome are most often endometrioid or clear cell carcinomas. Read More

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Sheep in Wolf's Clothing: Pedunculated Colonic Lipoma with Overlying Hyperplastic and Ulcerated Epithelium.

Dig Dis Sci 2020 07;65(7):1951-1953

Department of Surgical Sciences, "Sapienza" University of Rome, V.le Regina Elena 324, 00161, Rome, Italy.

Introduction: Lipomas are the most common non-epithelial benign tumors of the gastrointestinal tract with a reported incidence in the colon of 0.2-4.4%. Read More

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Recent advances in pediatric bladder malignancies.

F1000Res 2020 25;9. Epub 2020 Feb 25.

Division of Urology, The Hospital for Sick Children and Department of Surgery, University of Toronto, Toronto, ON, Canada.

Urothelial pediatric neoplasms are relatively rare. Papillary urothelial neoplasms of low malignant potential (PUNLMPs) and rhabdomyosarcoma (RMS) are the most common bladder malignancies in the pediatric population. Clinical presentation encompasses macroscopic hematuria or lower urinary tract symptoms (or both) or is detected incidentally at imaging. Read More

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Detailed overview on rare malignant ovarian tumors.

Bull Cancer 2020 Mar 27;107(3):385-390. Epub 2020 Feb 27.

Department of Medical Oncology, centre Léon-Bérard, University Claude Bernard (UCBL Lyon1), Lyon, France. Electronic address:

The group of rare malignant ovarian tumors includes the group of germ cell tumors, sex cords stromal ovarian tumors, small cell carcinoma, malignant Brenner tumors, rare epithelial tumors such as mucinous carcinoma, clear cell carcinoma, or low-grade serous carcinoma, as well as ovarian carcinosarcoma. Together they comprise about 10% of all ovarian tumors. Due to their low prevalence and their heterogeneity, data and treatment recommendations are limited. Read More

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Physical Biomarkers of Disease Progression: On-Chip Monitoring of Changes in Mechanobiology of Colorectal Cancer Cells.

Sci Rep 2020 02 24;10(1):3254. Epub 2020 Feb 24.

Molecular and Nanoscale Physics group, Department of Physics and Astronomy, University of Leeds, Leeds, UK.

Disease can induce changes to subcellular components, altering cell phenotype and leading to measurable bulk-material mechanical properties. The mechanical phenotyping of single cells therefore offers many potential diagnostic applications. Cells are viscoelastic and their response to an applied stress is highly dependent on the magnitude and timescale of the actuation. Read More

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February 2020

Imaging features of non-epithelial tumours of the larynx.

Clin Radiol 2020 09 21;75(9):711.e5-711.e12. Epub 2020 Feb 21.

Department of Radiology, Cumberland Infirmary, Carlisle, CA2 7HY, UK.

Neoplasms of the head and neck most commonly seen within the larynx are likely malignant and epithelial in origin. Although uncommon, non-epithelial types are occasionally encountered in clinical practice. Owing to the rare nature of these entities, they can lead to diagnostic and treatment uncertainty. Read More

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September 2020