1,287 results match your criteria non-elderly


Safety of Eslicarbazepine Acetate in Elderly Versus Non-Elderly Patients with Focal Seizures: From Pooled Data of Clinical Studies to 8 Years of Post-Marketing Experience.

Drug Saf 2021 Sep 18. Epub 2021 Sep 18.

Division of Research and Development, Bial-Portela & Cª, S.A., À Avenida da Siderurgia Nacional, 4745‑457, Coronado (S. Romão e S. Mamede), Portugal.

Introduction: The prevalence of epilepsy increases in elderly patients aged > 65 years, and treatment is challenging because clinical data are limited.

Objective: Our objective was to evaluate the safety of eslicarbazepine acetate (ESL) in patients aged ≥ 65 years versus non-elderly patients with focal seizures.

Methods: The safety data of seven phase II and III, double-blind, open-label, randomized clinical studies of ESL in adults were pooled. Read More

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September 2021

Ross for Valve replacement In AduLts (REVIVAL) pilot trial: rationale and design of a randomised controlled trial.

BMJ Open 2021 Sep 16;11(9):e046198. Epub 2021 Sep 16.

Cardiac Surgery, Bristol Royal Hospital for Children, Bristol, UK.

Introduction: In non-elderly adults, aortic valve replacement (AVR) with conventional prostheses yield poor long-term outcomes. Recent publications suggest a benefit of the Ross procedure over conventional AVR and highlight the need for high-quality randomised controlled trial (RCTs) on the optimal AVR. We have initiated a pilot trial assess two feasibility criteria and one assumption: (1) evaluate the capacity to enrol six patients per centre per year in at least five international centre, (2) validate greater than 90% compliance with allocation and (3) to validate the proportion of mechanical (≥65%) vs biological (≤35%) valves in the conventional arm. Read More

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September 2021

The prognostic value of cardiac troponin T in different age groups of traumatic brain injury patients.

Acta Neurol Belg 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurosurgery, West China Hospital, Sichuan University, No. 37, Guoxue Alley, Chengdu, 610041, Sichuan province, People's Republic of China.

Background: The cardiac dysfunction has been confirmed as a common non-neurological complication and associated with increased mortality in traumatic brain injury (TBI) patients. As a biological marker of cardiac injury, the cardiac troponin T (TnT) has been verified correlated with the outcome of some non-traumatic brain injury patients. However, the prognostic value of TnT in TBI patients has not been clearly illustrated. Read More

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September 2021

Preventing Financial Strain for Low- and Moderate-Income Adults: a Comparison of Medicaid, Marketplace, and Employer-Sponsored Insurance.

J Gen Intern Med 2021 Sep 15. Epub 2021 Sep 15.

Cambridge Health Alliance, Cambridge Massachusetts and Harvard Medical School, Boston, MA, USA.

Background: Medicaid expansion and subsidized private plans purchased on the Affordable Care Act's (ACA) Marketplaces accounted for most of the ACA's coverage gains.

Objective: Compare access to care and financial strain between Medicaid and Marketplace plans, and benchmark these against employer-sponsored insurance (ESI) plans.

Design: Cross-sectional survey PARTICIPANTS: A nationally representative, non-institutionalized sample of 37,219 non-elderly adults with incomes up to 400% of the federal poverty level between 2015 and 2018, and a sub-group of individuals with chronic diseases. Read More

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September 2021

Comparison of the factors associated with the short-term prognosis between elderly and non-elderly patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: a retrospective observational study.

Clin Exp Rheumatol 2021 Sep 9. Epub 2021 Sep 9.

Department of Nephrology, Shinshu University Hospital, Matsumoto, Japan.

Objectives: The difference in factors associated with the prognosis between elderly and non-elderly patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV) is uncertain. We aimed to elucidate the clinical factors associated with the short-term prognosis (within 6 months from the start of the treatment) and investigate the differences in the associated factors between elderly and non-elderly individuals.

Methods: We performed a dual centre retrospective observational study of patients newly treated with AAV (eosinophilic granulomatous with polyangiitis was excluded). Read More

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September 2021

Is the Long-term Disease Course of Elderly-Onset Ulcerative Colitis Different from That of Non-Elderly-Onset Ulcerative Colitis?

Gut Liver 2021 Sep;15(5):639-640

Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.

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September 2021

Safety, Pharmacokinetics, and Pharmacodynamics of a Single Bolus of the γ-aminobutyric Acid (GABA) Receptor Potentiator HSK3486 in Healthy Chinese Elderly and Non-elderly.

Front Pharmacol 2021 27;12:735700. Epub 2021 Aug 27.

Department of Anesthesiology, First Hospital, Jilin University, Jilin, China.

The present clinical trial investigated the potential influences of dosage and age on the pharmacokinetic properties and safety profile of HSK3486, and whether any adjustment in dosing regimen is necessary in elderly patients. Twenty-four elderly participants (65-73 years) were apportioned to three equal cohorts to receive a single IV bolus of 0.2, 0. Read More

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A Case of Duloxetine-induced Syndrome of Inappropriate Secretion of Antidiuretic Hormone in a Super-elderly Patient.

Intern Med 2021 Sep 11. Epub 2021 Sep 11.

Department of Internal Medicine, National Health Insurance Kuma-Kogen Town Hospital, Japan.

Duloxetine is widely used for pain control and depressive syndromes. One of its potential side effects is syndrome of inappropriate secretion of antidiuretic hormone (SIADH). Duloxetine-induced SIADH causes hyponatremia, which leads to a variety of symptoms and has previously been reported in the elderly. Read More

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September 2021

Clinical impact of pembrolizumab combined with chemotherapy in elderly patients with advanced non-small-cell lung cancer.

Lung Cancer 2021 Aug 31;161:26-33. Epub 2021 Aug 31.

Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kajii-cho, Kamigyo-ku, Kyoto, Japan.

Objectives: Combination therapy of immune checkpoint inhibitors and chemotherapy is considered to be one of the standard treatment options for patients with advanced non-small-cell lung cancer (NSCLC). However, the clinical significance of immune checkpoint inhibitors combined with chemotherapy in elderly patients with NSCLC has not yet been fully understood. Therefore, this study aimed to evaluate how aging affects the therapeutic impact of chemotherapy combine with immune checkpoint inhibitors in elderly patients. Read More

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Insulin-like growth factor 2 and incidence of liver cancer in a nested case-control study.

Cancer Epidemiol Biomarkers Prev 2021 Sep 8. Epub 2021 Sep 8.

Department of Public Health, Hokkaido University Faculty of Medicine.

Background: Insulin-like growth factor (IGF)2 is a potent mitogen. To elucidate the relationship between IGF2 and risk of tumorigenesis, we analyzed associations between serum levels of IGF2 and incidence of liver cancer in a prospective case-control study nested in the Japan Collaborative Cohort study.

Methods: A baseline survey was conducted from 1988 using blood samples from 39,242 subjects. Read More

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September 2021

The choice of operation timing of laparoscopic cholecystectomy (LC) after percutaneous transhepatic gallbladder drainage (PTGBD) for acute cholecystitis: a retrospective clinical analysis.

Ann Palliat Med 2021 Aug;10(8):9096-9104

Department of Hepatobiliary and Pancreatic Surgery, Tianjin Nankai Hospital, Tianjin, China.

Background: This study aimed to evaluate the timing of laparoscopic cholecystectomy (LC) after percutaneous transhepatic gallbladder drainage (PTGBD).

Methods: Patients with acute moderate to severe cholecystitis treated by LC after PTGBD in the Department of Hepatobiliary and Pancreatic Surgery, Nankai Hospital (N-362) between January 2017 and August 2019were retrospectively enrolled into this study. According to the interval times from PTGBD to LC, the patients were divided into six groups, including group A (105 cases, within 1 week), group B (62 cases, 1-2 weeks), group C (34 cases, 3-4 weeks), group D (54 cases, 5-8 weeks), group E (24 cases, 9-12 weeks), and group F (83 cases, over 12 weeks). Read More

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Early outcome of anatomical lung resection for non-small cell lung cancer in the elderly.

Eur Rev Med Pharmacol Sci 2021 Aug;25(16):5129-5136

Department of Thoracic Surgery, San Giovanni Hospital, Ente Ospedaliero Cantonale Bellinzona, Bellinzona, Switzerland and Università della Svizzera Italiana, Lugano, Switzerland.

Objective: Surgery is the mainstay of early-stage lung cancer treatment. However, since life expectancy is constantly increasing, we wanted to investigate whether this principle also applies to elderly (≥70-year-old) patients.

Patients And Methods: We analyzed a prospectively maintained database on anatomical lung resections at our institute. Read More

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Sleep-disordered breathing and risk of the breast cancer: A meta-analysis of cohort studies.

Int J Clin Pract 2021 Sep 5:e14793. Epub 2021 Sep 5.

Department of Radiotherapy, Cancer Hospital of China Medical University, Shenyang, China.

Background: Sleep-disordered breathing (SDB) has been related to a higher risk of breast cancer whereas the results of previous studies are inconsistent. We, therefore, performed a meta-analysis to evaluate the association between SDB and subsequent risk of breast cancer in women.

Methods: Cohort studies that investigated the temporal relationship between SDB and breast cancer incidence were obtained via search of PubMed, Embase and Web of Science from inception to 30 January 2021. Read More

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September 2021

Comparison of profile and treatment outcomes between elderly and non-elderly tuberculosis patients in Puducherry and Tamil Nadu, South India.

PLoS One 2021 27;16(8):e0256773. Epub 2021 Aug 27.

Department of Preventive & Social Medicine, JIPMER, Puducherry, India.

The rising geriatric population and the increased susceptibility of this age group to tuberculosis (TB), the deadliest single infectious agent, is bothersome for India. This study tried to explore the demographic and treatment outcome differences between the elderly (aged 60 years and above) and non-elderly TB (<60 years) patients from South India. This study was part of a large ongoing cohort study under the RePORT India consortium. Read More

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Effect of Mobile-Based Lifestyle Intervention on Weight Loss among the Overweight and Obese Elderly Population in China: A Randomized Controlled Trial.

Int J Environ Res Public Health 2021 08 21;18(16). Epub 2021 Aug 21.

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China.

Background And Objective: Overweight or obesity, as an independent risk factor for chronic diseases, has been on the rise globally. Adopting a healthy lifestyle is positive to weight control. Mobile-based lifestyle interventions have shown potential benefits in weight loss, but most studies were carried out among non-elderly population, so it is necessary to perform well-designed randomized controlled trials among the elderly with overweight or obesity. Read More

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Low-dose rivaroxaban plus aspirin in older patients with peripheral artery disease undergoing acute limb revascularization: insights from the VOYAGER PAD trial.

Eur Heart J 2021 Aug 25. Epub 2021 Aug 25.

CPC Clinical Research, 2115 N Scranton Street, Suite 2040, Aurora, CO, USA.

Aims: In this secondary analysis of the VOYAGER trial, rivaroxaban 2.5 mg twice/day plus aspirin 100 mg/day was assessed in older adults. Advanced age is associated with elevated bleeding risk and unfavourable net benefit for dual antiplatelet therapy in chronic coronary artery disease. Read More

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Perspective on the clone library method for infectious diseases.

Respir Investig 2021 Aug 14. Epub 2021 Aug 14.

Department of Respiratory Medicine, Unit of Translational Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki City, Nagasaki, 852-8501, Japan.

Recently, culture-independent molecular methods, such as DNA sequencing techniques targeting the 16S-ribosomal RNA (rRNA) gene and/or other housekeeping genes with Sanger method-based technologies, next generation sequencing (NGS), and metagenomic analysis, have been developed for detecting microorganisms in the human body; these can provide information on microbiomes of samples from individuals with or without infectious diseases. Determining the bacterial species is crucial in identifying causative bacteria of upper and lower respiratory tract infections, especially for Streptococcus species, but NGS analysis is often not precise enough to identify bacteria at the species level. This review briefly introduces previous observations of the microbiome of samples from various respiratory and other infections assessed using the clone library method with Sanger sequencing of the 16S-rRNA gene. Read More

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Age as a Risk Factor for Complications Following Anterior Cervical Discectomy and Fusion: Analysis From the Michigan Spine Surgery Improvement Collaborative (MSSIC).

Spine (Phila Pa 1976) 2021 Aug 13. Epub 2021 Aug 13.

Division of Neurosurgery, Ascension Providence Hospital, College of Human Medicine, Michigan State University, Southfield, MI Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI Division of Neurosurgery, Ascension Macomb-Oakland Hospital, Warren, MI Department of Neurosurgery, Henry Ford Hospital, Detroit, MI Department of Neurosurgery, University of Michigan, Ann Arbor, MI.

Study Design: Retrospective analysis of prospectively collected registry data using multivariable analyses of imputed data.

Objective: We sought to demonstrate that age would not be associated with complications in patients undergoing anterior cervical discectomy and fusion (ACDF).

Summary Of Background Data: Elderly patients (≥70 yrs) undergoing ACDF are considered a higher risk for complications. Read More

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The clinical practice of ulcerative colitis in elderly patients: An investigation using a nationwide database in Japan.

JGH Open 2021 Aug 4;5(8):842-848. Epub 2021 Apr 4.

Division of Gastroenterology Tohoku University Hospital Sendai Japan.

Background And Aim: The number of elderly patients with ulcerative colitis (UC) is increasing worldwide. The clinical practice of associated treatment is still unclear. Therefore, we aimed to analyze clinical treatment realities and mortality in elderly and non-elderly patients with UC. Read More

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Predictors of lymph node metastases in patients with malignant adenomatous polyps of the colon.

Am J Surg 2021 Jul 6. Epub 2021 Jul 6.

Surgery Group of Los Angeles, Los Angeles, CA, USA; Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Background: We sought to describe predictors of lymph node positivity in patients with malignant colon polyps to identify low risk patients who may potentially avoid radical surgery.

Design: The National Cancer Database (2010-2015) was queried for all patients with malignant colonic polyps who underwent formal colonic resection. Univariate and multivariate methods were used to determine independent predictors of lymph node metastasis. Read More

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Six air pollutants and cause-specific mortality: a multi-area study in nine counties or districts of Anhui Province, China.

Environ Sci Pollut Res Int 2021 Jul 31. Epub 2021 Jul 31.

Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, 230032, Anhui, China.

Air pollution and its negative effects on health of people have been a global concern. Many studies had found a strong association between air pollutants and risk of death, but few had focused on the effects of six pollutants and rural areas. Our study aimed to investigate the effects of six air pollutants (CO, NO, O, PM, PM, and SO) on non-accidental and respiratory deaths in rural areas of Anhui Province by adjusting for confounding factors, and to further clarify which populations were susceptible to death associated with air pollution. Read More

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Health services utilization, out-of-pocket expenditure, and underinsurance among insured non-elderly cancer survivors in the United States, 2011-2015.

Cancer Med 2021 Aug 30;10(16):5513-5523. Epub 2021 Jul 30.

Population Informatics Laboratory, Department of Health Policy and Management, School of Public Health, Texas A&M University, College Station, TX, USA.

Background: High out-of-pocket (OOP) expenditure and inadequate insurance coverage may adversely affect cancer survivors. We aimed to characterize the extent and correlates of healthcare utilization, OOP expenditures, and underinsurance among insured cancer survivors.

Methods: We used 2011-2015 Medical Expenditure Panel Survey data to identify a nationally representative sample of insured non-elderly adult (age 18-64 years) cancer survivors. Read More

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Association of cardiovascular risk factor profile and financial hardship from medical bills among non-elderly adults in the United States.

Am J Prev Cardiol 2020 Jun 13;2:100034. Epub 2020 Jul 13.

Division of Cardiovascular Prevention & Wellness, Houston Methodist DeBakey Heart & Vascular Center, Houston, TX, USA.

Background: While optimal cardiovascular risk factor (CRF) profile is associated with lower mortality, morbidity, and healthcare expenditures among individuals with atherosclerotic cardiovascular disease (ASCVD), less is known regarding its impact on financial hardship from medical bills. Therefore, we assessed whether an optimal CRF profile is associated with a lower burden of financial hardship from medical bills and a reduction in cost-related barriers to health.

Methods: We used a nationally representative sample of adults between 18 and 64 years from the National Health Interview Survey between 2013 and 2017. Read More

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Association Between High Deductible Health Plans and Cost-Related Non-adherence to Medications Among Americans with Diabetes: an Observational Study.

J Gen Intern Med 2021 Jul 29. Epub 2021 Jul 29.

Cambridge Health Alliance, Cambridge, MA, USA.

Background: For people with diabetes, adherence to prescribed medications is essential. However, the rising prevalence of high-deductible health plans (HDHPs), and prices of diabetes medications such as insulin, could deter adherence.

Objective: To assess the impact of HDHP on cost-related medication non-adherence (CRN) among non-elderly adults with diabetes in the US. Read More

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Clinical outcomes of hospitalized COVID-19 patients with renal injury: a multi-hospital observational study from Wuhan.

Sci Rep 2021 07 26;11(1):15205. Epub 2021 Jul 26.

Department of Nephrology, Daping Hospital, Army Medical University, Changjiang Branch Road 10, Yu Zhong district, Chongqing, 400042, China.

Renal injury is common in patients with coronavirus disease 2019 (COVID-19). We aimed to determine the relationship of estimated glomerular filtration rate (eGFR) and acute kidney injury (AKI) with the characteristics, progression, and prognosis of COVID-19 in-patients. We retrospectively reviewed 1851 COVID-19 patients admitted to 3 hospitals in Wuhan, China. Read More

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ACA Medicaid expansion reduced disparities in use of high-volume hospitals for pancreatic surgery.

Surgery 2021 Jul 21. Epub 2021 Jul 21.

MedStar-Georgetown Surgical Outcomes Research Center, Washington, DC; MedStar Health Research Institute, Hyattsville, MD; Department of Surgery, MedStar-Georgetown University Hospital, Washington, DC. Electronic address:

Background: Early evaluation of the Affordable Care Act's Medicaid expansion demonstrated persistent disparities among Medicaid beneficiaries in use of high-volume hospitals for pancreatic surgery. Longer-term effects of expansion remain unknown. This study evaluated the impact of expansion on the use of high-volume hospitals for pancreatic surgery among Medicaid and uninsured patients. Read More

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The Impact of Age on Mortality in Chronic Haemodialysis Popu-Lation with COVID-19.

J Clin Med 2021 Jul 7;10(14). Epub 2021 Jul 7.

Nephrology Department, Vall d'Hebrón University Hospital, 08035 Barcelona, Spain.

Age and chronic kidney disease have been described as mortality risk factors for coronavirus disease 2019 (COVID-19). Currently, an important percentage of patients in haemodialysis are elderly. Herein, we investigated the impact of age on mortality among haemodialysis patients with COVID-19. Read More

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Is There a Relationship between County-Level Food Insecurity Rates and Breast Cancer Stage at Diagnosis?

Nutr Cancer 2021 Jul 23:1-8. Epub 2021 Jul 23.

College of Health Solutions, Arizona State University, Phoenix, Arizona, USA.

The relationship between county food insecurity (FI) rate and breast cancer stage at diagnosis is not clear. Using 2010-2016 Surveillance Epidemiology and End Results (SEER) and Feeding America data we analyzed the association between county FI rate in quartiles (low, medium, high, very high) and breast cancer stage at diagnosis among adult females (≥18 years). We also analyzed the effect of insurance status and county poverty level on this relationship, and whether this relationship varies among non-elderly (<65 years) and elderly (≥ 65 years) individuals. Read More

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Intensive multidisciplinary treatment strategies and patient resilience to challenge long-term survival in metastatic colorectal cancer: a case report in real life and clinical practice.

Ann Transl Med 2021 Jun;9(12):1027

Oncology Territorial Care, S. Salvatore Hospital, Oncology Network ASL1 Abruzzo, University of L'Aquila, L'Aquila, Italy.

In fit metastatic colorectal cancer (MCRC), multidisciplinary treatment strategy integrating intensive FIr-B/FOx triplet chemotherapy associated to bevacizumab and secondary metastasectomies significantly improved clinical outcomes up to progression-free survival (PFS) 17 months and overall survival (OS) 44 months. A non-elderly woman affected by rectal cancer, lymph nodes involvement, synchronous unresectable liver metastases, was treated with first-line FIr-B/FOx integrated with two-stage liver resections, short course radiotherapy, anterior rectal resection, with a PFS 9 months and progression-free interval (PFI) 4 months off-treatment. After progression characterized by single liver and lymph node inferior mesenteric axis metastases, FIr-B/FOx was re-introduced, liver and lymph node resections were performed, with a PFS 8 months and PFI 3 months. Read More

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