11,985 results match your criteria non-diabetic adult

[The Association Between Abdominal Obesity and Diabetes among Middle-aged and Older Adults with Normal BMI].

Sichuan Da Xue Xue Bao Yi Xue Ban 2021 Mar;52(2):340-344

Department of Health Behavior and Social Medicine, West China School of Public Health and West China Forth Hospital, Sichuan University, Chengdu 610041, China.

Objective: To explore the relationship between abdominal obesity and diabetes among middle-aged and older adults with normal body mass index (BMI) and to provide reference information for formulating targeted diabetes prevention and control measures for this population.

Methods: Data were extracted from the China Health and Retirement Longitudinal Study (CHARLS) done in 2015. Middle-aged and older adults who were aged 45 and older and had normal BMI were included in the study. Read More

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Angiotensin II up-regulates sodium-glucose co-transporter 2 expression and SGLT2 inhibitor attenuates Ang II-induced hypertensive renal injury in mice.

Clin Sci (Lond) 2021 Apr;135(7):943-961

Département de Médecine, Université de Montréal, Centre de recherche du Centre hospitalier de l'Université de Montréal (CRCHUM), Tour Viger-Pavillon R, 900 Saint Denis Street, Montréal, Quebec H2X 0A9, Canada.

Clinical trials indicate that sodium/glucose co-transporter 2 (SGLT2) inhibitors (SGLT2i) improve kidney function, yet, the molecular regulation of SGLT2 expression is incompletely understood. Here, we investigated the role of the intrarenal renin-angiotensin system (RAS) on SGLT2 expression. In adult non-diabetic participants in the Nephrotic Syndrome Study Network (NEPTUNE, n=163), multivariable linear regression analysis showed SGLT2 mRNA was significantly associated with angiotensinogen (AGT), renin, and angiotensin-converting enzyme (ACE) mRNA levels (P<0. Read More

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Impact of adipose tissue in chronic kidney disease development (Review).

Exp Ther Med 2021 May 23;21(5):539. Epub 2021 Mar 23.

Department of Family Medicine and Clinical Base, Dr. Carol Davila Central Military Emergency University Hospital, 010825 Bucharest, Romania.

Obesity is a worldwide pandemic health issue. Obesity is associated with the pathogenesis of type 2 diabetes, hypertension, dyslipidemia, cardiovascular diseases, cancer, and kidney diseases. This systemic disease can affect the kidneys by two mechanisms: Indirectly through diabetes mellitus (DM) and hypertension and directly through adipokines secreted by adipose tissue. Read More

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Effect of Correction of Hyperthyroidism with Anti-thyroid Drugs on the Glycated Hemoglobin in Non-diabetic Patients with Primary Hyperthyroidism.

Int J Endocrinol Metab 2021 Jan 19;19(1):e105751. Epub 2021 Jan 19.

Department of Pathology, Sri Venkateswara Institute of Medical Sciences, Tirupati, India.

Background: Glycated hemoglobin (HbA1c) levels are dependent not only on the average blood glucose levels over the preceding 2 - 3 months but also on the turnover of erythrocytes. Hyperthyroidism is known to be associated with an increase in erythrocyte turnover that may falsely lower the HbA1c in relation to the level of glycemia.

Objectives: To assess the impact of medical correction of hyperthyroidism on HbA1c, independent of changes in the fasting plasma glucose and 2-hour post-oral glucose tolerance test plasma glucose. Read More

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January 2021

Immunological Characteristics in Type 2 Diabetes Mellitus Among COVID-19 Patients.

Front Endocrinol (Lausanne) 2021 11;12:596518. Epub 2021 Mar 11.

Department of Pediatrics, Center for the Diagnosis of Genetic Metabolic Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Clinical Trial Registration: www.ClinicalTrials.gov, identifier: NCT04365634. Read More

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The hepatokine fetuin-A disrupts functional maturation of pancreatic beta cells.

Diabetologia 2021 Mar 25. Epub 2021 Mar 25.

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard Karls University of Tuebingen (IDM), Tuebingen, Germany.

Aims/hypothesis: Neonatal beta cells carry out a programme of postnatal functional maturation to achieve full glucose responsiveness. A partial loss of the mature phenotype of adult beta cells may contribute to a reduction of functional beta cell mass and accelerate the onset of type 2 diabetes. We previously found that fetuin-A, a hepatokine increasingly secreted by the fatty liver and a determinant of type 2 diabetes, inhibits glucose-stimulated insulin secretion (GSIS) of human islets. Read More

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A single arm trial using passive simulated jogging for blunting acute hyperglycemia.

Sci Rep 2021 Mar 19;11(1):6437. Epub 2021 Mar 19.

Mount Sinai Medical Center of Greater Miami, Miami Beach, FL, USA.

Glycemic fluctuations increase oxidative stress, promote endothelial dysfunction and cardiovascular disease. Reducing glycemic fluctuations is beneficial. We previously reported that a portable motorized passive simulated jogging device, (JD) reduces 24 h glycemic indices in type 2 and non-diabetic subjects. Read More

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Diabetic and Non-Diabetic Gastroparesis: A Retrospective Comparative Outcome Study From the Nationwide Inpatient Sample.

Gastroenterology Res 2021 Feb 19;14(1):21-30. Epub 2021 Feb 19.

Department of Internal Medicine, Geisinger Commonwealth School of Medicine, Scranton, PA, USA.

Background: Gastroparesis (GP), meaning "gastric palsy", is a chronic medical condition characterized by delayed or absent gastric emptying in the absence of mechanical obstruction. The primary objective of this study was to determine the patient-specific outcomes and the burden of GP on the US healthcare system.

Methods: This was a population-based, retrospective study designed to analyze data available from the Nationwide Inpatient Sample (NIS) for 2016 and 2017. Read More

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February 2021

Metformin use in cancer survivors with diabetes reduces all-cause mortality, based on the Korean National Health Insurance Service between 2002 and 2015.

Medicine (Baltimore) 2021 Mar;100(11):e25045

Department of Family Medicine, Chungbuk National University Hospital, 776 1-Soonwhan-ro, Seowon-gu.

Abstract: Malignant neoplasms are the leading cause of death in Korea. We aimed to examine if metformin use in cancer survivors reduces all-cause mortality. This study was retrospectively designed based on data from the Korean National Health Insurance Service-National Health Screening Cohort (HEALS) between 2002 and 2015. Read More

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Association Between Intraoperative Blood Glucose and Anastomotic Leakage in Colorectal Surgery.

J Gastrointest Surg 2021 Mar 12. Epub 2021 Mar 12.

Department of Surgery, Máxima Medical Center, Veldhoven, The Netherlands.

Background: Perioperative hyperglycemia is a known risk factor for postoperative complications after colorectal surgery. The aim of this study was to investigate whether intraoperative blood glucose values are associated with colorectal anastomotic leakage in diabetic and non-diabetic patients undergoing colorectal surgery.

Methods: This is an additional analysis of a previously published prospective, observational cohort study (the LekCheck study). Read More

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Antioxidative and antidiabetic effects of Capparis spinosa fruit extract on high-fat diet and low-dose streptozotocin-induced type 2 diabetic rats.

Biomed Pharmacother 2021 Jun 3;138:111391. Epub 2021 Mar 3.

Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Capparis spinosa (CS) is known as a hypoglycemic medication in many countries. This study was designed to reveal the protective effects of the hydro-ethanolic extract of CS (HECS) fruit against diabetes and oxidative stress in type 2 diabetic rats (T2D). T2D was induced in 4 groups of adult male Sprague Dawley rats, using high fat diet (HFD) and low dose of streptozotocin (STZ). Read More

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Disentangling the relationship between bone turnover and glucose homeostasis: A prospective, population-based twin study.

Bone Rep 2021 Jun 5;14:100752. Epub 2021 Feb 5.

Department of Endocrinology, Odense University Hospital, Denmark.

Background: Biochemical markers of bone turnover are lower in patients with type 2 diabetes, which may be explained by genetic variants being associated with type 2 diabetes and bone turnover as well as environmental factors. We hypothesized that bone turnover markers associate with and predict changes in glucose homeostasis after control for genetics and shared environment.

Methods: 1071 healthy, non-diabetic (at baseline, 1997-2000) adult mono- and dizygotic twins participating in the prospective study GEMINAKAR were reassessed between 2010 and 2012 with clinical evaluation, biochemical tests and oral glucose tolerance test. Read More

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Metformin is associated with lower hospitalizations, mortality and severe coronavirus infection among elderly medicare minority patients in 8 states in USA.

Diabetes Metab Syndr 2021 Mar-Apr;15(2):513-518. Epub 2021 Feb 18.

Department of Medicine, Miller School of Medicine at the University of Miami, Miami, FL, USA; Department of Medicine, Veterans Affairs Medical Center, Miami, FL, USA. Electronic address:

Background And Aims: Metformin has antiviral and anti-inflammatory effects and several cohort studies have shown that metformin lower mortality in the COVID population in a majority white population. There is no data documenting the effect of metformin taken as an outpatient on COVID-19 related hospitalizations. Our aim was to evaluate if metformin decreases hospitalization and severe COVID-19 among minority Medicare patients who acquired the SARS-CoV2 virus. Read More

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Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study.

Diabetologia 2021 Mar 2. Epub 2021 Mar 2.

Department of Surgical Sciences, Orthopaedics, Uppsala University, Uppsala, Sweden.

Aims/hypothesis: Observational studies indicate that type 2 diabetes mellitus and fasting glucose levels are associated with a greater risk for hip fracture, smaller bone area and higher bone mineral density (BMD). However, these findings may be biased by residual confounding and reverse causation. Mendelian randomisation (MR) utilises genetic variants as instruments for exposures in an attempt to address these biases. Read More

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Prevalence of advanced liver fibrosis and steatosis in type-2 diabetics with normal transaminases: A prospective cohort study.

World J Gastroenterol 2021 Feb;27(6):523-533

Division of Gastroenterology, Department of Medicine, BronxCare Health System, Bronx, NY 10457, United States.

Background: Nonalcoholic fatty liver disease (NAFLD) and type-2 diabetes mellitus (T2DM) have an intricate bidirectional relationship. Individuals with T2DM, not only have a higher prevalence of non-alcoholic steatosis, but also carry a higher risk of progression to nonalcoholic steatohepatitis. Experts still differ in their recommendations of screening for NAFLD among patients with T2DM. Read More

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February 2021

Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study.

Eur J Endocrinol 2021 Mar;184(3):419-425

Endocrinology Unit, IRCCS AOU San Martino, Genoa, Italy.

Context: Colonic polyps occur in 30-40% of acromegalic patients, increasing the risk of colon carcinoma. Although debated, there is emerging evidence that metformin may play a protective role in diabetic and non-diabetic patients with colonic polyps and its use in chemoprevention is currently explored.

Objective: Evaluate the prevalence of colonic polyps in acromegalic patients treated or not with metformin and explore its possible protective role. Read More

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Atherogenic dyslipidemia, but not hyperglycemia, is an independent factor associated with liver fibrosis in subjects with type 2 diabetes and NAFLD: a population-based study.

Eur J Endocrinol 2021 Apr;184(4):587-596

Department of Endocrinology and Nutrition, Hospital Germans Trias I Pujol, Badalona, Barcelona, Spain.

Objective: To investigate the prevalence and risks factors associated with the presence of liver fibrosis in subjects with nonalcoholic fatty liver disease (NAFLD) with and without type 2 diabetes mellitus (T2D).

Design And Methods: This study was part of a population-based study conducted in the Barcelona metropolitan area among subjects aged 18-75 years old. Secondary causes of steatosis were excluded. Read More

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HbA as a Biomarker of Non-alcoholic Fatty Liver Disease: Comparison with Anthropometric Parameters.

J Clin Transl Hepatol 2021 Feb 2;9(1):15-21. Epub 2021 Jan 2.

Dow University of Health Sciences, Karachi, Pakistan.

Background And Aims: Multiple non-invasive methods including radiological, anthropometric and biochemical markers have been reported with variable performance. The present study assessed glycosylated hemoglobin (HbA) as a biomarker to predict non-alcoholic fatty liver disease (NAFLD) and its severity, compared with body mass index (BMI), waist to hip ratio (WHR) and waist circumference (WC).

Methods: This case control study included 450 individuals, including 150 cases and 300 age- and gender-matched controls recruited from the Dow Radiology Institute on the basis of radiological findings of fatty infiltration on abdominal ultrasound through convenient sampling. Read More

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February 2021

Effect of Vitex Agnus-Castus Ethanolic Extract on Sex Hormones in Streptozotocin-Induced Diabetic Rats.

J Family Reprod Health 2020 Jun;14(2):102-105

Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.

Diabetes mellitus is recognized as one of the serious global health problems. There are evidences regarding the high prevalence of sexual dysfunction in diabetic patients. Experimental studies revealed a positive effect of Vitex agnus-castus (Vitex), on sexual function and behaviors. Read More

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Plasma lipocalin-2/NGAL is stable over 12 weeks and is not modulated by exercise or dieting.

Sci Rep 2021 Feb 18;11(1):4056. Epub 2021 Feb 18.

Hypertension Research Laboratory, School of Biological Sciences, Faculty of Science, Monash University, 25 Rainforest Walk, Melbourne, Clayton, VIC, 3800, Australia.

Amongst other immune cells, neutrophils play a key role in systemic inflammation leading to cardiovascular disease and can release inflammatory factors, including lipocalin-2 (LCN2). LCN2 drives cardiac hypertrophy and plays a role in maladaptive remodelling of the heart and has been associated with renal injury. While lifestyle factors such as diet and exercise are known to attenuate low-grade inflammation, their ability to modulate plasma LCN2 levels is unknown. Read More

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February 2021

Kidney function and markers of renal damage after renal denervation. Does method of measurement matter? The Reshape CV-Risk Study.

J Clin Hypertens (Greenwich) 2021 Feb 16. Epub 2021 Feb 16.

Clinical Cardiovascular Research Group, UiT The Arctic University of Norway, Tromsø, Norway.

Data suggest that renal denervation (RDN) in treatment-resistant hypertension (TRHT) is safe in terms of renal function. However, most studies report kidney function as creatinine-based estimated glomerular filtration rate (eGFR), which may be biased by non-renal factors. Damage markers other than albuminuria have never been evaluated after RDN. Read More

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February 2021

Effect of ciprofloxacin vs levofloxacin on QTc-interval and dysglycemia in diabetic and non-diabetic patients.

Int J Clin Pract 2021 Feb 8:e14072. Epub 2021 Feb 8.

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

Background: Levofloxacin and ciprofloxacin are more commonly used amongst fluoroquinolone class and the question of cardiac safety and glucose hemostasis of this class has been raised.

Objective: To compare intravenous levofloxacin and ciprofloxacin regarding their risk on QTc prolongation and dysglycemia in diabetic and non-diabetic patients.

Methods: A randomised prospective study at Beni-Suef university hospital was conducted on 200 adult patients over 6 months. Read More

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February 2021

COVID-19 and emergencies in patients with diabetes: two case reports.

J Med Case Rep 2021 Feb 2;15(1):57. Epub 2021 Feb 2.

Department of Internal Medicine, Indira Gandhi Memorial Hospital, Male', Maldives.

Background: Maldives reported its first Coronavirus disease 2019 (COVID-19) case on March 7th, 2020. Since then more than 9400 positive cases and 33 deaths have been reported. Recently studies have shown that COVID-19 patients with diabetes had a poor prognosis and a higher mortality rate when compared to the non-diabetic patients. Read More

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February 2021

Increased Sestrin3 Contributes to Post-ischemic Seizures in the Diabetic Condition.

Front Neurosci 2020 15;14:591207. Epub 2021 Jan 15.

Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, United States.

Seizures are among the most common neurological sequelae of stroke, and diabetes notably increases the incidence of post-ischemic seizures. Recent studies have indicated that Sestrin3 (SESN3) is a regulator of a proconvulsant gene network in human epileptic hippocampus. But the association of SESN3 and post-ischemic seizures in diabetes remains unclear. Read More

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January 2021

The relationship between obesity, hemoglobin A1c and the severity of COVID-19 at an urban tertiary care center in New York City: a retrospective cohort study.

BMJ Open 2021 01 31;11(1):e044526. Epub 2021 Jan 31.

Department of Medicine, Maimonides Medical Center, Brooklyn, New York, USA.

Objectives: To determine if obesity and diabetes are risk factors for severe outcomes in COVID-19 and to compare patient outcomes in those two conditions.

Design: Retrospective cohort study.

Setting: Urban tertiary care center in New York City. Read More

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January 2021

Diminished substrate-mediated cardiac mitochondrial respiration and elevated autophagy in adult male offspring of gestational diabetic rats.

IUBMB Life 2021 Apr 21;73(4):676-689. Epub 2021 Feb 21.

Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences & Technology, Thiruvananthapuram, India.

Heart diseases are common in the offspring of diabetic mother (ODM). Defects in mitochondrial metabolism and autophagy may, in part, be responsible for the adverse structural and functional alterations in the heart. The principal objective of this study was to investigate cardiac mitochondrial respiration and autophagy in male and female offspring of diabetic pregnancy at two different developmental stages of life, weaning and adult. Read More

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Clinical characteristics and outcomes of COVID-19 infected diabetic patients admitted in ICUs of the southern region of Bangladesh.

Diabetes Metab Syndr 2021 Jan-Feb;15(1):229-235. Epub 2020 Dec 30.

Department of Biochemistry, Chittagong Medical College, Chattogram, 4202, Bangladesh.

Background And Aims: Diabetes mellitus is highly prevalent among critical cases of coronavirus disease 2019 (COVID-19) with poor outcomes. This study aimed to describe the clinical characteristics and outcomes of COVID-19 patients with diabetes, admitted in the intensive care unit (ICU) of the southern region of Bangladesh.

Methods: Epidemiological, clinical, laboratory, treatments, complications, and clinical outcomes data were extracted from electronic medical records of 168 COVID-19 patients admitted into ICU of two COVID-19 dedicated hospitals of Chattogram, Bangladesh and compared between diabetes (n = 88) and non-diabetes (n = 80) groups. Read More

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Prescription of pharmacotherapy and blood pressure control among hypertensive outpatients in two semi-urban hospitals in Cameroon: a cross-sectional study.

Pan Afr Med J 2020 5;37:122. Epub 2020 Oct 5.

Department of Internal Medicine and Subspecialties, Douala General Hospital, Douala, Cameroon.

Introduction: several international guidelines are available on drug treatment for hypertension, but the control of hypertension remains very poor in sub-Saharan Africa (SSA). We investigated the commonly prescribed antihypertensive drugs and their association with blood pressure (BP) control in adult Cameroonians.

Methods: we consecutively recruited hypertensive outpatients attending the Buea and Limbe Regional Hospitals (southwest region of Cameroon). Read More

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January 2021

Association of urogenital and intestinal parasitic infections with type 2 diabetes individuals: a comparative study.

BMC Infect Dis 2021 Jan 7;21(1):20. Epub 2021 Jan 7.

Department of Microecology, College of Basic Medical Sciences, Dalian Medical University, Dalian, Liaoning, China.

Background: Globally, urogenital and intestinal parasitosis remain significant health challenges. They are associated with rising morbidity, death, and many harmful outcomes. A little is known concerning parasitosis and type 2 diabetes mellitus. Read More

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January 2021

Dental implants survival rate in controlled type I diabetic patients: a prospective longitudinal study with a 2-year follow-up.

J Biol Regul Homeost Agents 2020 Nov-Dec;34(6 Suppl. 3):37-45

Associate Professor, Dental School, Vita-Salute San Raffaele University, Milan, Italy and Department of Dentistry, IRCCS San Raffaele Hospital, Milan, Italy.

The aim of the study was to evaluate implant treatment for partial edentulism in a population of controlled type I diabetic patients. The research hypothesis was that implant survival rate, prevalence of peri-implant tissue infection and marginal bone loss at 2 years follow-up would not differ from a non diabetic population. A total of 106 patients (47=women, 59=men, mean age 38. Read More

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February 2021