69,299 results match your criteria nodules

Liver cirrhosis.

Lancet 2021 Sep 17. Epub 2021 Sep 17.

Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Cirrhosis is widely prevalent worldwide and can be a consequence of different causes, such as obesity, non-alcoholic fatty liver disease, high alcohol consumption, hepatitis B or C infection, autoimmune diseases, cholestatic diseases, and iron or copper overload. Cirrhosis develops after a long period of inflammation that results in replacement of the healthy liver parenchyma with fibrotic tissue and regenerative nodules, leading to portal hypertension. The disease evolves from an asymptomatic phase (compensated cirrhosis) to a symptomatic phase (decompensated cirrhosis), the complications of which often result in hospitalisation, impaired quality of life, and high mortality. Read More

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September 2021

Dystrophic epidermolysis bullosa pruriginosa: a new case series of a rare phenotype unveils skewed Th2 immunity.

J Eur Acad Dermatol Venereol 2021 Sep 20. Epub 2021 Sep 20.

Department of Dermatology, Hôpital Saint Louis, Assistance Publique des Hôpitaux de Paris (AP-HP), Paris, France.

Importance: Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of hereditary epidermolysis bullosa, with a poorly understood pathogenesis and no satisfactory treatment.

Objective: To assess the clinical and biological features, genetic basis and therapeutic management in order to better characterize this rare genodermatosis.

Design: We have conducted a retrospective study, reviewing the clinical presentation, genetic diagnosis, biological analyses and management of patients with dystrophic epidermolysis bullosa pruriginosa. Read More

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September 2021

Primary Hyperparathyroidism in Pregnancy Followed by Successful Delivery: a Case Report.

Clin Lab 2021 Sep;67(9)

Background: Primary hyperparathyroidism (PHPT) in pregnancy has a negative impact. Effective treatment should be timely adopted.

Methods: We report a case of a 24-year-old pregnant woman admitted with PHPT, hypercalcemia crisis, hypokalemia, thyroid nodules, hyperthyroidism, and intrauterine single live fetus in the 2nd trimester of pregnancy. Read More

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September 2021

A cross-sectional assessment of long-term effects in adolescent and young adult head and neck cancer survivors treated with radiotherapy.

J Cancer Surviv 2021 Sep 20. Epub 2021 Sep 20.

BC Cancer - Vancouver Centre, Vancouver, BC, Canada.

Purpose: Adolescent and young adult (AYA) head and neck (H&N) cancer survivors are at risk of long-term complications. A cross-sectional study of survivors recalled for clinical evaluation was performed to evaluate late effects in this population.

Methods: Surviving patients who had been diagnosed with H&N cancer between the ages of 15 and 39 years and treated with radiation therapy (RT) in British Columbia between 1970 and 2010 were invited to participate in this study. Read More

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September 2021

Localised Versus Systemic Granulomatosis with Polyangiitis: Data from the French Vasculitis Study Group Registry.

Rheumatology (Oxford) 2021 Sep 20. Epub 2021 Sep 20.

National Referral Center for Rare Systemic Autoimmune Diseases, Université de Paris, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France.

Objective: To describe the main features at diagnosis and evolution over time of patients with localised granulomatosis with polyangiitis (L-GPA) compared to those of systemic GPA (S-GPA).

Methods: EULAR definitions of L-GPA, i.e. Read More

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September 2021

Nano-hydroxyapatite accelerates vascular calcification via lysosome impairment and autophagy dysfunction in smooth muscle cells.

Bioact Mater 2022 Feb 14;8:478-493. Epub 2021 Jun 14.

Department of Cardiology, Cardiovascular Key Laboratory of Zhejiang Province, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, 310009, China.

Vascular calcification (VC) is a common characteristic of aging, diabetes, chronic renal failure, and atherosclerosis. The basic component of VC is hydroxyapatite (HAp). Nano-sized HAp (nHAp) has been identified to play an essential role in the development of pathological calcification of vasculature. Read More

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February 2022

Tuberous sclerosis complex-lymphangioleiomyomatosis involving several visceral organs: A case report.

World J Clin Cases 2021 Aug;9(24):7085-7091

Department of Echocardiography, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China.

Background: Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease characterized by the proliferation, metastasis, and infiltration of smooth muscle cells in the lung and other tissues, which can be associated with tuberous sclerosis complex (TSC). The disorder of TSC has a variable expression, and there is great phenotypic variability.

Case Summary: A 32-year-old Chinese woman with a history of multiple renal angioleiomyolipoma presented with a productive cough persisting for over 2 wk. Read More

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Ultrasound-Based Indications for Thyroid Fine-Needle Aspiration: Outcome of a TIRADS-Based Approach versus Operators' Expertise.

Eur Thyroid J 2021 Jul 25;10(5):416-424. Epub 2020 Nov 25.

Division of Endocrinology, Department of Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Background: Thyroid nodule image reporting and data systems (TIRADS) provide the indications for fine-needle aspiration (FNA) based on a combination of nodule sonographic features and size. We compared the TIRADS-based recommendations for FNA with those based on the personal expertise of qualified US investigators in the diagnosis of thyroid malignancy.

Methods: Seven highly experienced ultrasound (US) investigators from 4 countries evaluated, online, the US video recordings of 123 histologically verified thyroid nodules. Read More

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Prognostic Value of Inflammatory Biomarkers in Patients With Stage I Lung Adenocarcinoma Treated With Surgical Dissection.

Front Oncol 2021 1;11:711206. Epub 2021 Sep 1.

Department of Radiation Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.

Objective: Inflammation plays a crucial role in tumorigenesis and progression. Our purpose was to investigate the prognostic value of neutrophil-to-lymphocyte ratio (NLR), systemic inflammation response index (SIRI) and systemic immune-inflammation index (SII), and develop a nomogram to predict the cancer-specific survival (CSS) and disease-free survival (DFS) of stage I lung adenocarcinoma patients.

Methods: 1431 patients undergoing surgical resection with pathologically confirmed stage I lung adenocarcinoma were reviewed. Read More

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September 2021

Co-existing inflammatory bowel disease and Barrett's esophagus is associated with esophageal dysplasia: a propensity score-matched cohort.

Endosc Int Open 2021 Oct 16;9(10):E1524-E1529. Epub 2021 Sep 16.

Division of Gastroenterology, Hepatology, and Nutrition, Virginia Commonwealth University Medical Center, Richmond, Virginia, United States.

 Barrett's esophagus (BE) and inflammatory bowel disease (IBD) predispose to the development of dysplasia and cancer. It is unclear if the inflammatory cascade seen in IBD affects disease progression in BE. We aimed to determine if patients with BE who have co-existing IBD had a higher risk of dysplasia, nodular disease, or longer segments than BE patients without IBD. Read More

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October 2021

Germline mutation analyses of malignant ground glass opacity nodules in non-smoking lung adenocarcinoma patients.

PeerJ 2021 31;9:e12048. Epub 2021 Aug 31.

Department of Cardiothoracic Surgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, Jiangsu, China.

Background: Germline mutations play an important role in the pathogenesis of lung cancer. Nonetheless, research on malignant ground glass opacity (GGO) nodules is limited.

Methods: A total of 13 participants with malignant GGO nodules were recruited in this study. Read More

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Effective treatment of progressive nodular histiocytosis by intermediate-dose cytarabine: a case report and literature review.

Am J Transl Res 2021 15;13(8):9040-9047. Epub 2021 Aug 15.

Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, China.

Background: Progressive nodular histiocytosis (PNH) is a rare, clinically distinct non-Langerhans cell histiocytic neoplasm affecting the skin and mucous membranes with no signs of spontaneous regression of the lesions. Patients typically have hundreds of lesions of superficial xanthomatous papules to nodules and deep larger fibrous nodules, which can be life-threatening if laryngeal mucosa was involved. So far, few cases of PNH have been reported and no effective treatment has been shown to reverse the progressive clinical course. Read More

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Granulomatosis with polyangiitis and neurofibromatosis type 1: a fortuitous association? (a case report).

Pan Afr Med J 2021 1;39:162. Epub 2021 Jul 1.

Department of Endocrinology and Internal Medicine, Tahar Sfar University Hospital of Mahdia, Mahdia, Tunisia.

Neurofibromatosis type 1 is a common neurocutaneous syndrome, caused by an alteration of the NF-1 gene, which is a tumor suppressor. It has been reported to be associated with different types of benign and malignant tumors but its association to systemic diseases is uncommon and has not been reported previously to be associated with vasculitis particularly granulomatosis with polyangiitis (GPA). We report a case of a 17-year-old male patient, who, during his follow-up for neurofibromatosis type 1, in our outpatient consultation; we objectified hypereosinophilia at 1700 eosinophils/μl without a history of asthma or atopy. Read More

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Malignancy Rates of Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance (AUS/FLUS) Cases: A Tertiary Center Study.

Acta Endocrinol (Buchar) 2021 Apr-Jun;17(1):77-82

Erzurum Training and Research Hospital - Pathology, Erzurum, Turkey.

Aim: To evaluate the malignancy rates of Atypia of undetermined significance /follicular lesion of undetermined significance (AUS/FLUS) cases in the light of clinical and sonographic features.

Material And Methods: The percentage of AUS/FLUS cases, second fine needle aspiration cytology (FNAC) results, cyto-histopathological correlations and risk of malignancy were analyzed.

Results: 113 out of 1461 thyroid FNAC samples (7. Read More

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October 2021

The Role of Superb Microvascular Imaging and Shear Wave Elastography in Differentiation of Thyroid Nodules from Intrathyroidal Ectopic Thymus in Children.

Acta Endocrinol (Buchar) 2021 Apr-Jun;17(1):33-41

Istanbul University, Istanbul Medical Faculty, Radiology Department, Istanbul, Turkey.

Background: Ectopic thymus could be located intrathyroidal, therefore fine ultrasound details are useful for this differentiation.

Aim: To investigate differences in stiffness and vascularity properties among thyroid nodules and intrathyroidal ectopic thymus (IET) by obtaining quantitative data in children.

Patients And Methods: Twenty-seven thyroid nodules and 20 IET in children were evaluated in terms of vascularity index (VI) via superb microvascular imaging (SMI) and stiffness by shear wave elastography (SWE). Read More

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October 2021

Pulmonary Epithelioid Hemangioendothelioma: Imaging and Clinical Features.

J Comput Assist Tomogr 2021 Sep 17. Epub 2021 Sep 17.

From the Department of Radiology Department of Interventional Radiology Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.

Objective: The aim of this study was to analyze the computed tomography (CT), fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT), and clinical findings of pulmonary epithelioid hemangioendothelioma.

Methods: Eighteen patients were included. We reviewed CT and PET/CT features and clinical information. Read More

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September 2021

Strain Imaging in the Evaluation of Thyroid Nodules: The Associated Factors Leading to Misdiagnosis.

Ultrasound Med Biol 2021 Sep 16. Epub 2021 Sep 16.

In-patient Ultrasound Department, Second Affiliated Hospital of Harbin Medical University, Surgeon's Hall, No. 246, Xuefu Road, Nangang District, Harbin City, Heilongjiang prov, China.. Electronic address:

This study analyzed which imaging characteristics may contribute to misdiagnosis of benign and malignant thyroid nodules (TNs) through strain imaging (SI). We analyzed SI parameters and conventional ultrasound (CUS) characteristics of 264 nodules with histopathology results and we applied binary logistic regression analysis to select independent variables for incorrect SI results. The elastography imaging (EI) score and the virtual touch tissue imaging (VTI) score of malignant TNs were remarkably higher than that in benign TNs. Read More

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September 2021

tRNA-derived small RNAs: novel regulators of cancer hallmarks and targets of clinical application.

Cell Death Discov 2021 Sep 18;7(1):249. Epub 2021 Sep 18.

Department of Thoracic Surgery, Xiangya Hospital, Central South University, Xiangya Road 87th, Changsha, 410008, Hunan, P. R. China.

tRNAs are a group of conventional noncoding RNAs (ncRNAs) with critical roles in the biological synthesis of proteins. Recently, tRNA-derived small RNAs (tsRNAs) were found to have important biological functions in the development of human diseases including carcinomas, rather than just being considered pure degradation material. tsRNAs not only are abnormally expressed in the cancer tissues and serum of cancer patients, but also have been suggested to regulate various vital cancer hallmarks. Read More

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September 2021

Pulmonary necrotizing sarcoid granulomatosis

Orv Hetil 2021 09 19;162(38):1541-1547. Epub 2021 Sep 19.

4 Szegedi Tudományegyetem, Általános Orvostudományi Kar, Patológiai Intézet, Szeged, Állomás u. 2., 6701.

Összefoglaló. A nekrotizáló sarcoid granulomatosis a granulomatosus pulmonalis angitisek közé tartozó, ritka kórkép. Egyesek a sarcoidosis variánsának, mások primer pulmonalis vasculitisnek tartják. Read More

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September 2021

Radiofrequency ablation and thyroid cancer: review of the current literature.

Am J Otolaryngol 2021 Sep 10;43(1):103204. Epub 2021 Sep 10.

Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore 21287, MD, USA. Electronic address:

Background: Thyroid nodules are commonly being diagnosed in general population and have a potential for malignant transformation. Historically, surgery has been considered as the first line treatment for these tumors. However, with passage of time newer minimally invasive techniques such as RFA (radiofrequency ablation) has been adapted. Read More

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September 2021

Macroscopic characteristics of the native liver in children with MPV17-related mitochondrial DNA depletion syndrome: an indication for performing liver transplantation?

Liver Transpl 2021 Sep 18. Epub 2021 Sep 18.

Center for Medical Genetics, Department of Metabolism, Chiba Children's Hospital, Chiba, Japan.

Mitochondrial respiratory chain disorders (MRCDs) are rare conditions with various clinical manifestations that depend on the genetic type, with subsequent severity of the liver disease. Clinical presentations include acute liver failure or chronic liver failure with liver cirrhosis, which are cruelly progressive and fatal. We report six cases of LT for acute liver failure diagnosed pathogenic MPV17 variants. Read More

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September 2021

Photodynamic therapy combined with carbon dioxide laser for successful treatment of cutaneous squamous cell carcinoma within a long-stand and huge seborrheic keratosis.

Photodiagnosis Photodyn Ther 2021 Sep 15:102536. Epub 2021 Sep 15.

Institute of Photomedicine, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai 200092, China. Electronic address:

Seborrheic keratosis (SK) is a common benign lesion in which malignancies like cutaneous squamous cell carcinoma (cSCC) can arise rarely. We report a case of an 81-year-old man who presented a well-demarcated reddish-brown plaque with central raised coarse nodules on the top of his head. Dermoscopy and reflectance confocal microscopy (RCM) showed the possibility of malignant transformation. Read More

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September 2021

Surveillance of indeterminate pulmonary nodules detected with CT in a Swedish population-based study (SCAPIS): psychosocial consequences and impact on health-related quality of life-a multicentre prospective cross-sectional study.

BMJ Open 2021 Sep 17;11(9):e048721. Epub 2021 Sep 17.

Department of Medical Imaging and Physiology, Skåne University Hospital, Malmö, Sweden

Objectives: To investigate whether surveillance of pulmonary nodules detected with low-dose CT (LDCT) impacted health-related quality of life and psychosocial consequences in the Swedish population-based study, Swedish CArdioPulmonary bioImage Study (SCAPIS).

Design: A prospective cross-sectional study.

Settings And Participants: This multicentre (five sites) observational study, which included a cohort from SCAPIS, consisted of 632 participants with indeterminate pulmonary nodules detected with LDCT. Read More

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September 2021

Tuberous Sclerosis: Current Update.

Radiographics 2021 Sep 17:210103. Epub 2021 Sep 17.

From the Department of Diagnostic Radiology, University of Texas MD Anderson Cancer Center, Pickens Academic Tower, 1400 Pressler St, Unit 1473, Houston, TX 77030-4009 (M.X.W., D.G.); Department of Radiology, Mayo Clinic Arizona, Scottsdale, Ariz (N.S.); Mallinckrodt Institute of Radiology, Section of Abdominal Imaging, Washington University School of Medicine, St Louis, Mo (S.B.); Department of Radiology, University of Wisconsin School of Medicine and Public Health, Madison, Wis (P.J.P., M.G.L.); and Department of Radiology, University of Texas at San Antonio, San Antonio, Tex (V.S.K.).

Tuberous sclerosis complex (TSC) is a relatively rare autosomal dominant neurocutaneous disorder secondary to mutations in the or tumor suppressor genes. Although manifestation of the classic triad of seizures, intellectual disability, and facial angio-fibromas may facilitate timely diagnosis of TSC, the multisystem features that may indicate TSC in the absence of these manifestations remain highly variable. In addition, patients with TSC are at risk of developing multiple benign and malignant tumors in various organ systems, resulting in increased morbidity and mortality. Read More

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September 2021

Impact of the ultrasonography assessment method on the malignancy risk and diagnostic performance of five risk stratification systems in thyroid nodules.

Endocrine 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology, GangNeung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea.

Purpose: Ultrasonographic (US) assessment methods may affect the estimated malignancy risk of thyroid nodules. This study aimed to investigate the impact of retrospective and prospective US assessments on the estimated malignancy risk of US features, classified categories, and diagnostic performance of five risk stratification systems (RSSs) in thyroid nodules.

Methods: A total of 3685 consecutive thyroid nodules (≥1 cm) with final diagnoses (retrospective dataset, n = 2180; prospective dataset, n = 1505) were included in this study. Read More

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September 2021

Is Gadoxetic Acid Disodium (Gd-EOB-DTPA)-Enhanced Magnetic Resonance Imaging an accurate diagnostic method for Hepatocellular Carcinoma? a systematic review with meta-analysis.

Curr Med Imaging 2021 Sep 17. Epub 2021 Sep 17.

Department of Radiology , First Hospital of LanZhou University, Lanzhou, Gansu, China.

Background: Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) has become a widely used liver-specific contrast agent worldwide, but its value and limitations as a diagnostic technique with hepatocellular carcinoma (HCC), have not been assessed.

Introduction: A review of the latest evidence available on the diagnostic value of Gd-EOB-DTPA-enhanced MRI for the evaluation of HCC is reported.

Methods: A systematic, comprehensive literature search was conducted with PubMed, Scopus, EMBASE, the Web of Science, the Cochrane Library, CNKI, vip, wanfangdata and CBM from inception to June 31, 2020. Read More

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September 2021

Sporadic superficial angiomyxomas demonstrate loss of PRKAR1A expression.

Histopathology 2021 Sep 17. Epub 2021 Sep 17.

Division of Anatomic Pathology, Mayo Clinic, Rochester, MN, USA.

Superficial angiomyxomas are cutaneous mesenchymal tumors that typically present clinically as slow-growing, solitary, asymptomatic nodules that can occur at any age. Histopathologically, these dermal and subcutaneous tumors are characterized by abundant myxoid stroma, numerous thin-walled and often arborizing blood vessels, and spindled to stellate fibroblast-like cells. While usually sporadic, superficial angiomyxomas can occasionally be associated with Carney complex (CNC), an autosomal dominant disorder characterized by inactivating germline mutations in the 1-alpha regulatory subunit of protein kinase A (PRKAR1A) and various clinical manifestations, including: cardiac myxomas, facial lentigines, epithelioid blue nevi, endocrinopathies, and psammomatous melanotic schwannomas. Read More

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September 2021

Prediction of tuberous sclerosis-associated neurocognitive disorders and seizures via machine learning of structural magnetic resonance imaging.

Neuroradiology 2021 Sep 16. Epub 2021 Sep 16.

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Purpose: Tuberous sclerosis complex (TSC) is a genetic disorder characterized by multiorgan hamartomas, including cerebral lesions, with seizures as a common presentation. Most TSC patients will also experience neurocognitive comorbidities. Our objective was to use machine learning techniques incorporating clinical and imaging data to predict the occurrence of major neurocognitive disorders and seizures in TSC patients. Read More

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September 2021

An investigation of a new cutaneous leishmaniasis endemic area in Western Sri Lanka.

Trans R Soc Trop Med Hyg 2021 Sep 16. Epub 2021 Sep 16.

Department of Parasitology, Faculty of Medicine, University of Kelaniya, Ragama 11010, Sri Lanka.

Background: The aim was to investigate an emerging focus of cutaneous leishmaniasis (CL) in Gampaha district, Western Sri Lanka.

Methods: Sociodemographics of CL patients in Mirigama, Gampaha district, were compared with controls using a structured questionnaire. Clinical data and geographic positioning system coordinates of patients were recorded. Read More

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September 2021

A pilot study of near-infrared fluorescence guided surgery for primary tumor localization and lymph node mapping in colorectal cancer.

Ann Transl Med 2021 Aug;9(16):1342

Department of Biomedical Engineering, College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, Nanjing University, Nanjing, China.

Background: This pilot study aimed to evaluate the feasibility of near-infrared fluorescence imaging for primary tumor localization, lymph node mapping, and metastatic lymph node detection in colorectal cancer (CRC) using indocyanine green (ICG).

Methods: A total of 11 patients with CRC were prospectively enrolled. ICG (25 mg dissolved in 30 mL sterile water) was intravenously injected preoperatively, and the fluorescence intensity of the primary tumor, lymph nodes, and normal tissues, as well as the signal-to-background ratio (SBR) and contrast-to-noise ratio (CNR) were measured at 0. Read More

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