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Who stays in medication treatment for opioid use disorder? A national study of outpatient specialty treatment settings.

J Subst Abuse Treat 2021 Jul 18;126:108329. Epub 2021 Feb 18.

Department of Population Health, NYU Grossman School of Medicine, United States of America.

Background: Maintenance treatments with medications for opioid use disorder (MOUD) are highly effective at reducing overdose risk while patients remain in care. However, few patients initiate medication and retention remains a critical challenge across settings. Much remains to be learned about individual and structural factors that influence successful retention, especially among populations dispensed MOUD in outpatient settings. Read More

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Systematic review and network meta-analysis of the efficacy of existing treatments for patients with recurrent glioblastoma.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab052. Epub 2021 Apr 9.

Competence Center for Methodology and Statistics, Department of Population Health, Luxembourg Institute of Health, Strassen, Luxembourg.

Background: Despite advances in the treatment of cancers over the last years, treatment options for patients with recurrent glioblastoma (rGBM) remain limited with poor outcomes. Many regimens have been investigated in clinical trials; however, there is a lack of knowledge on comparative effectiveness. The aim of this systematic review is to provide an overview of existing treatment strategies and to estimate the relative efficacy of these regimens in terms of progression-free survival (PFS) and overall survival (OS). Read More

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Activity-Based Exposure Levels and Cancer Risk Assessment Due to Naturally Occurring Asbestos for the Residents Near Abandoned Asbestos Mines in South Korea.

Int J Environ Res Public Health 2021 May 14;18(10). Epub 2021 May 14.

Department of Occupational and Environmental Medicine, Pusan National University Yangsan Hospital, Yangsan 50612, Korea.

This study aims to evaluate the overall asbestos exposure intensity and assess the health risk to residents due to naturally occurring asbestos (NOA) near abandoned asbestos mines in South Korea. Of 38 mines, we found 19 with measured concentrations of NOA. We evaluated the average of airborne NOA concentrations according to the environmental exposure category. Read More

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Lemon Oils Attenuate the Pathogenicity of by Quorum Sensing Inhibition.

Molecules 2021 May 12;26(10). Epub 2021 May 12.

INBIOFAL (Institute of Pharmaceutical and Food Biotechnology), CONICET NOA Sur, Avenida Kirchner 1900, Tucumán 4000, Argentina.

The chemical composition of three oils: lemon essential oil (LEO), lemon terpenes (LT) and lemon essence (LE), and their influence in the virulence factors production and motility (swarming and swimming) of two strains (ATCC 27853 and a multidrug-resistant HT5) were investigated. The main compound, limonene, was also tested in biological assays. Eighty-four compounds, accounting for a relative peak area of 99. Read More

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Characteristics of diffuse hemispheric gliomas, H3 G34-mutant in adults.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab061. Epub 2021 Apr 19.

Cancer Initiation and Tumoral Cell Identity Department, Cancer Research Centre of Lyon (CRCL) INSERM 1052, CNRS 5286, Lyon, France.

Background: Diffuse hemispheric gliomas, H3 G34-mutant (DHG H3G34-mutant) constitute a distinct type of aggressive brain tumors. Although initially described in children, they can also affect adults. The aims of this study were to describe the characteristics of DHG H3G34-mutant in adults and to compare them to those of established types of adult WHO grade IV gliomas. Read More

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Bintrafusp alfa (M7824), a bifunctional fusion protein targeting TGF-β and PD-L1: results from a phase I expansion cohort in patients with recurrent glioblastoma.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab058. Epub 2021 Apr 9.

Austin Brain Tumor Center, Austin, Texas, USA.

Background: For patients with recurrent glioblastoma (rGBM), there are few options following treatment failure with radiotherapy plus temozolomide. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β "trap") fused to a human IgG1 antibody blocking PD-L1.

Methods: In this phase I, open-label expansion cohort (NCT02517398), patients with rGBM that progressed after radiotherapy plus temozolomide received bintrafusp alfa 1200 mg Q2W until disease progression, unacceptable toxicity, or trial withdrawal. Read More

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NBAT1/CASC15-003/USP36 control MYCN expression and its downstream pathway genes in neuroblastoma.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab056. Epub 2021 Apr 9.

Department of Medical Biochemistry and Cell Biology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden.

Background: has been an attractive therapeutic target in neuroblastoma considering the widespread amplification of the locus in neuroblastoma, and its established role in neuroblastoma development and progression. Thus, understanding neuroblastoma-specific control of expression at the transcriptional and post-transcriptional level would lead to identification of novel -dependent oncogenic pathways and potential therapeutic strategies.

Methods: By performing loss- and gain-of-function experiments of the neuroblastoma hotspot locus 6p22. Read More

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Timing of glioblastoma surgery and patient outcomes: a multicenter cohort study.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab053. Epub 2021 Apr 8.

Amsterdam University Medical Centers, location VU University Medical Center, Neurosurgical Center Amsterdam, Amsterdam, Netherlands.

Background: The impact of time-to-surgery on clinical outcome for patients with glioblastoma has not been determined. Any delay in treatment is perceived as detrimental, but guidelines do not specify acceptable timings. In this study, we relate the time to glioblastoma surgery with the extent of resection and residual tumor volume, performance change, and survival, and we explore the identification of patients for urgent surgery. Read More

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Multiparametric MRI texture analysis in prediction of glioma biomarker status: added value of MR diffusion.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab051. Epub 2021 Apr 8.

Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: Early identification of glioma molecular phenotypes can lead to understanding of patient prognosis and treatment guidance. We aimed to develop a multiparametric MRI texture analysis model using a combination of conventional and diffusion MRI to predict a wide range of biomarkers in patients with glioma.

Methods: In this retrospective study, patients were included if they (1) had diagnosis of gliomas with known , , , , , and status from surgical pathology and (2) had preoperative MRI including FLAIR, T1c+ and diffusion for radiomic texture analysis. Read More

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Hypermetabolism and impaired cerebrovascular reactivity beyond the standard MRI-identified tumor border indicate diffuse glioma extended tissue infiltration.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab048. Epub 2021 Mar 30.

Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background: Diffuse gliomas exhibit diffuse infiltrative growth, often beyond the magnetic resonance imaging (MRI)-detectable tumor lesion. Within this lesion, hypermetabolism and impaired cerebrovascular reactivity (CVR) are found, but its exact distribution pattern into the peritumoral environment is unknown. Our aim was to better characterize the extent of diffuse glioma tissue infiltration, beyond the visible lesion (ie, beyond the T1-contrast-enhancing lesion and/or T2/FLAIR-defined tumor border), with metabolic positron emission tomography (PET), and functional MRI CVR (blood oxygenation-level-dependent CVR [BOLD-CVR]) mapping. Read More

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CovidNeuroOnc: A UK multicenter, prospective cohort study of the impact of the COVID-19 pandemic on the neuro-oncology service.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab014. Epub 2021 Jan 28.

Department of Neurosurgery, The Walton Centre NHS Foundation Trust, Liverpool, UK.

Background: The COVID-19 pandemic has profoundly affected cancer services. Our objective was to determine the effect of the COVID-19 pandemic on decision making and the resulting outcomes for patients with newly diagnosed or recurrent intracranial tumors.

Methods: We performed a multicenter prospective study of all adult patients discussed in weekly neuro-oncology and skull base multidisciplinary team meetings who had a newly diagnosed or recurrent intracranial (excluding pituitary) tumor between 01 April and 31 May 2020. Read More

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January 2021

Comparison of the Effects of Different Testicular Sperm Extraction Methods on the Embryonic Development of Azoospermic Men in Intracytoplasmic Sperm Injection (ICSI) Cycles: A Retrospective Cohort Study.

Biomed Res Int 2021 17;2021:5515247. Epub 2021 May 17.

Reproductive Medical Center, Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.

Background: The effects of different testicular sperm extraction methods on the embryonic development and clinical outcome of azoospermic men in intracytoplasmic sperm injection (ICSI) cycles have not been researched. Our goal was to evaluate the effect of different sperm retrieval methods used for patients with OA or NOA on the embryonic development and clinical outcomes during the ICSI cycles.

Methods: This was a retrospective cohort study. Read More

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Lessons learned from contemporary glioblastoma randomized clinical trials through systematic review and network meta-analysis: part 2 newly diagnosed disease.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab028. Epub 2021 Feb 12.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Background: Glioblastoma (GB) is the most common malignant brain tumor with a dismal prognosis despite standard of care (SOC). Here we used a network meta-analysis on treatments from randomized control trials (RCTs) to assess the effect on overall survival (OS) and progression-free survival (PFS) beyond the SOC.

Methods: We included RCTs that investigated the addition of a new treatment to the SOC in patients with newly diagnosed GB. Read More

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February 2021

Lessons learned from contemporary glioblastoma randomized clinical trials through systematic review and network meta-analysis: part 2 recurrent glioblastoma.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab029. Epub 2021 Feb 12.

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Background: There exists no consensus standard of treatment for patients with recurrent glioblastoma (GB). Here we used a network meta-analysis on treatments from randomized control trials (RCTs) to assess the effect on overall survival (OS) and progression-free survival (PFS) to determine if any consensus treatment can be determined for recurrent GB.

Methods: We included all recurrent GB RCTs with at least 20 patients in each arm, and for whom patients underwent standard of care at the time of their GB initial diagnosis. Read More

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February 2021

Integrative molecular characterization of pediatric spinal ependymoma: the UK Children's Cancer and Leukaemia Group study.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab043. Epub 2021 Mar 8.

Children's Brain Tumour Research Centre, School of Medicine, University of Nottingham, Nottingham, UK.

Background: Pediatric spinal ependymomas (SP-EPNs) are rare primary central nervous system tumors with heterogeneous clinical course. Considering that ependymomas in children are biologically distinct from their adult counterparts, this study aimed to define the molecular landscape of SP-EPNs in children.

Methods: In this retrospective study, we have collected tumor samples from 27 SP-EPN patients younger than 18 years and carried out the histological review, DNA methylation, and gene expression profiling. Read More

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A Novel Balanced Chromosomal Translocation in an Azoospermic Male: A Case Report.

J Reprod Infertil 2021 Apr-Jun;22(2):133-137

Molecular Stress and Stem Cell Biology Group, School of Biotechnology, KIIT University, Bhubaneswar, Odisha, India.

Background: Balanced translocation and azoospermia as two main reasons for recurrent pregnancy loss are known to be the leading causes of infertility across the world. Balanced translocations in azoospermic males are very rare and extensive studies need to be performed to elucidate the translocation status of the affected individuals.

Case Presentaion: The cytogenetic characterization of a 28 year old male and his female partner is reported in this study. Read More

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Evaluation of Microdissection Testicular Sperm Extraction (mTESE), Outcomes and Predictive Factors in Ireland: The Gold Standard for Men with Non-Obstructive Azoospermia.

J Reprod Infertil 2021 Apr-Jun;22(2):103-109

Department of Urology, University Hospital Waterford, Waterford, Ireland.

Background: Microdissection testicular sperm extraction (mTESE) is the gold standard approach in sperm retrieval in men with non-obstructive azoospermia (NOA). The purpose of the study was to assess the outcomes for Irish men who have undergone mTESE with a single surgeon.

Methods: This is a retrospective, single cohort study. Read More

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Combined F-FET PET and diffusion kurtosis MRI in posttreatment glioblastoma: differentiation of true progression from treatment-related changes.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab044. Epub 2021 Mar 10.

Institute of Neuroscience and Medicine, Research Centre Juelich, Juelich, Germany.

Background: Radiological differentiation of tumor progression (TPR) from treatment-related changes (TRC) in pretreated glioblastoma is crucial. This study aimed to explore the diagnostic value of diffusion kurtosis MRI combined with information derived from -(2-[F]-fluoroethyl)-l-tyrosine (F-FET) PET for the differentiation of TPR from TRC in patients with pretreated glioblastoma.

Methods: Thirty-two patients with histomolecularly defined and pretreated glioblastoma suspected of having TPR were included in this retrospective study. Read More

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Receptor-driven invasion profiles in diffuse intrinsic pontine glioma.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab039. Epub 2021 Feb 28.

Children's Cancer Therapy Development Institute, Beaverton, Oregon, USA.

Background: Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric cancer with unmet clinical need. DIPG is invasive in nature, where tumor cells interweave into the fiber nerve tracts of the pons making the tumor unresectable. Accordingly, novel approaches in combating the disease are of utmost importance and receptor-driven cell invasion in the context of DIPG is under-researched area. Read More

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February 2021

H3K27M and promoter mutations are poor prognostic factors in surgical cases of adult thalamic high-grade glioma.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab038. Epub 2021 Feb 28.

Department of Neurosurgery, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Thalamic high-grade gliomas (HGGs) are rare tumors with a dismal prognosis. H3K27M and telomerase reverse transcriptase promoter () mutations reportedly contribute to poor prognoses in HGG cases. We investigated the outcomes of surgically treated adult thalamic HGGs to evaluate the prognostic significance of H3K27M and mutations. Read More

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February 2021

The state of neuro-oncology during the COVID-19 pandemic: a worldwide assessment.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab035. Epub 2021 Feb 20.

Departments of Medicine and Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

Background: It remains unknown how the COVID-19 pandemic has changed neuro-oncology clinical practice, training, and research efforts.

Methods: We performed an international survey of practitioners, scientists, and trainees from 21 neuro-oncology organizations across 6 continents, April 24-May 17, 2020. We assessed clinical practice and research environments, institutional preparedness and support, and perceived impact on patients. Read More

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February 2021

The Oxygen Saturation in the Retinal Vessels of Patients with Diabetes Mellitus - The Search for Determinants.

Klin Monbl Augenheilkd 2021 May 17. Epub 2021 May 17.

Augenklinik, Technische Universität Dresden, Deutschland.

Introduction: Oxygen saturation in retinal vessels can be non-invasively measured by a new method. It is known that oxygen extraction is lowered in diabetic retinopathy. In the cross-sectional study presented here, it has been investigated whether diabetes-specific changes and typical accompanying diseases could influence the measurements in oximetry. Read More

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Genome medicine in male infertility: From karyotyping to single-cell analysis.

Koji Shiraishi

J Obstet Gynaecol Res 2021 May 16. Epub 2021 May 16.

Department of Urology, Yamaguchi University School of Medicine, Ube, Japan.

Male infertility is a multifactorial pathological condition that affects half of infertile couples. The majority of cases are categorized as idiopathic, especially in cases of nonobstructive azoospermia (NOA). An increasing number of genetic abnormalities have been shown to cause spermatogenic impairment with the development of microarray technologies and next-generation sequencing (NGS), moving beyond classical karyotype and polymerase chain reaction analyses of targeted genes. Read More

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Pathogenic variants of ATG4D in infertile men with non-obstructive azoospermia identified using whole-exome sequencing.

Clin Genet 2021 May 14. Epub 2021 May 14.

Reproductive Medicine Centre, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Non-obstructive azoospermia (NOA) is the most severe form of male infertility, and it is primarily associated with genetic defects. We performed whole-exome sequencing of 236 patients with NOA and identified a homozygous pathogenic variant of autophagy-related 4D cysteine peptidase (ATG4D) in two siblings from a consanguineous family and compound heterozygous pathogenic variants of ATG4D in two sporadic cases. The expression of LC3B, a regulator of autophagic activity, was significantly decreased, and the apoptosis rate of spermatogenic cells in testicular tissues was increased. Read More

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Analysis of STAG3 variants in Chinese non-obstructive azoospermia patients with germ cell maturation arrest.

Sci Rep 2021 May 12;11(1):10077. Epub 2021 May 12.

Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, 44 Wenhua Xi Road, Jinan, 250012, Shandong, China.

STAG3 is essential for male meiosis and testis of male Stag3 mice shows the histopathological type of germ cell maturation arrest (MA). Whether variants of the STAG3 gene exist in Chinese idiopathic non-obstructive azoospermia (NOA) patients needs to be determined. We recruited 58 Chinese NOA men with MA who underwent testis biopsy and 192 fertile men as the control group. Read More

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Selumetinib normalizes Ras/MAPK signaling in clinically relevant neurofibromatosis type 1 minipig tissues in vivo.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab020. Epub 2021 Feb 10.

Recombinetics Inc., Eagan, Minnesota, USA.

Background: The MEK1/2 inhibitor selumetinib was recently approved for neurofibromatosis type 1 (NF1)-associated plexiform neurofibromas, but outcomes could be improved and its pharmacodynamic evaluation in other relevant tissues is limited. The aim of this study was to assess selumetinib tissue pharmacokinetics (PK) and pharmacodynamics (PD) using a minipig model of NF1.

Methods: WT ( = 8) and NF1 ( = 8) minipigs received a single oral dose of 7. Read More

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February 2021

MRI-based radiomics for prognosis of pediatric diffuse intrinsic pontine glioma: an international study.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab042. Epub 2021 Mar 5.

Department of Medical Biophysics, Western University, London, Onatrio, Canada.

Background: Diffuse intrinsic pontine gliomas (DIPGs) are lethal pediatric brain tumors. Presently, MRI is the mainstay of disease diagnosis and surveillance. We identify clinically significant computational features from MRI and create a prognostic machine learning model. Read More

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Progress in the genetic studies of spermatogenesis abnormalities.

Yi Chuan 2021 May;43(5):473-486

State Key Laboratory of Reproductive Medicine, Nanjing Medical University. Nanjing 211166, China.

About 15% couples suffer from infertility, half of which are caused by male factors. Male infertility usually manifests as teratozoospermia, oligospermia and/or asthenospermia, of which the most severe form is azoospermia. In this review, we summarize the recent progress in the study of genetic factors involved in nonobstructive azoospermia and teratozoospermia, Recently, with the rapid development of high-throughput chips and sequencing technologies, many genetic factors of spermatogenesis have been discovered and analyzed. Read More

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Adhesion G protein-coupled receptors in glioblastoma.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab046. Epub 2021 Mar 23.

Department of Neurosurgery, NYU Grossman School of Medicine, New York, New York, USA.

Background: Members of the adhesion family of G protein-coupled receptors (GPCRs) have received attention for their roles in health and disease, including cancer. Over the past decade, several members of the family have been implicated in the pathogenesis of glioblastoma.

Methods: Here, we discuss the basic biology of adhesion GPCRs and review in detail specific members of the receptor family with known functions in glioblastoma. Read More

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Temozolomide chronotherapy in patients with glioblastoma: a retrospective single-institute study.

Neurooncol Adv 2021 Jan-Dec;3(1):vdab041. Epub 2021 Mar 2.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.

Background: Chronotherapy is an innovative approach to improving survival through timed delivery of anti-cancer treatments according to patient daily rhythms. Temozolomide (TMZ) is a standard-of-care chemotherapeutic agent for glioblastoma (GBM). Whether timing of TMZ administration affects GBM patient outcome has not previously been studied. Read More

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