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Abnormal Body Phenomena in Persons with Major Depressive Disorder.

Psychopathology 2021 Jun 1:1-11. Epub 2021 Jun 1.

Department of Psychological, Health and Territorial Sciences, "G. d'Annunzio" University, Chieti, Italy.

Background: Depressive disorders, despite being classified as mood or affective disorders, are known to include disturbances in the experience of body, space, time, and intersubjectivity. However, current diagnostic manuals largely ignore these aspects of depressive experience. In this article, we use phenomenological accounts of embodiment as a theoretical foundation for a qualitative study of abnormal body phenomena (ABP) in depressive disorders. Read More

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The relationship between working alliance with peer mentors and eating psychopathology in a digital 6-week guided self-help intervention for anorexia nervosa.

Int J Eat Disord 2021 May 27. Epub 2021 May 27.

Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy.

Objective: The quality of working alliance (WA) is associated with treatment outcomes across several types of psychiatric disorders and psychological interventions. This study examined the role of WA with peer mentors (people with lived experience of illness) and student mentors (graduated psychology students) in a 6-week, digital, guided self-help (GSH) intervention for anorexia nervosa.

Method: Ninety-nine patients rated weekly, for 6 weeks: (a) eating psychopathology using the short version of the Eating Disorder Examination Questionnaire (EDE-QS) and (b) WA with a student mentor (n = 14) or a peer mentor (n = 10). Read More

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Psychometric properties of the Norwegian translation of the Tinnitus Handicap Inventory (THI-NOR).

Int J Audiol 2021 May 25:1-6. Epub 2021 May 25.

Faculty of Medicine and Dentistry, Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Objective: To assess the psychometric properties of a Norwegian translation of the Tinnitus Handicap Inventory (THI-NOR).

Design: A survey was sent by post to patients referred with tinnitus as their main complaint to an audiology department. Patients completed a Norwegian version of the Tinnitus Handicap Inventory (THI-NOR), a Norwegian translation of two revised subscales of the Abbreviated profile of hearing aid benefit (APHAB), the General Health Questionnaire (GHQ-12) as well as questionnaires measuring coping expectancies (TOMCATS) and neuroticism (EPI). Read More

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Sofosbuvir/velpatasvir for 12 vs. 6 weeks for the treatment of recently acquired hepatitis C infection.

J Hepatol 2021 May 20. Epub 2021 May 20.

St Vincent's Hospital, Sydney, Australia.

Background And Aims: Shortened duration therapy for acute and recent hepatitis C virus (HCV) infection has been shown to be highly effective in several small non-randomised studies with direct-acting antiviral regimens, however large randomised studies are lacking.

Methods: REACT was an NIH-funded multicentre international, open-label, randomised, phase 4 non-inferiority trial examining the efficacy of short course (6 weeks) versus standard course (12 weeks) therapy with sofosbuvir-velpatasvir for recent HCV infection (estimated duration of infection <= 12 months). Randomisation occurred at week 6. Read More

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Factors affecting the stability of maxillary extraction site closure.

Dental Press J Orthod 2021 17;26(2):e2119187. Epub 2021 May 17.

Universidade de São Paulo, Departamento de Ortodontia da Faculdade de Odontologia de Bauru (Bauru/SP, Brazil).

Introduction: A side effect observed in cases treated with extractions is the instability of orthodontic space closure.

Objective: The aim of this study was to investigate the influence of gingival invagination, presence of third molars and facial pattern, on the stability of orthodontic space-closure in the maxillary arch.

Methods: Ninety-nine subjects (41 male and 58 female) with Class I malocclusion treated with four premolars extraction were evaluated. Read More

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Knowledge and attitudes toward epilepsy among Libyan people with and without epilepsy in a tertiary medical center.

Epilepsy Behav 2021 May 14;121(Pt A):108023. Epub 2021 May 14.

Department of Medicine, Neurology Unit, University Hospital, Benghazi, Libya.

Background: Although patients with epilepsy (PWE) constitute a considerable sector of the population in Benghazi, there is no adequate knowledge about this disease.

Objectives: To assess knowledge and attitudes toward epilepsy among Libyan people who live in Benghazi city.

Methods: A cross-sectional prospective hospital-based study was conducted in the year 2020, from June to August. Read More

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Urinary Dopamine Excretion Rate Decreases during Acute Dietary Protein Deprivation and Is Associated with Increased Plasma Pancreatic Polypeptide Concentration.

Nutrients 2021 Apr 8;13(4). Epub 2021 Apr 8.

Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ 85016, USA.

Dopamine, a key neurotransmitter in the autonomic nervous system participating in the homeostatic balance between sympathetic and parasympathetic divisions, is involved in food intake regulation. We investigated whether dopamine is altered by acute fasting or overfeeding diets with varying macronutrient content. Ninety-nine healthy subjects underwent 24-h dietary interventions including eucaloric feeding, fasting, and five different overfeeding diets in a crossover design. Read More

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Epidemiology, treatment patterns and survival of chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) in Taiwan, 2006-2015.

Int J Clin Pract 2021 Apr 22:e14258. Epub 2021 Apr 22.

Graduate Institute of Clinical Pharmacy, National Taiwan University, Taipei, Taiwan.

Aim/objective: Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is one of the most frequent types of leukaemia/lymphoma in adults in Western countries. However, there are few studies regarding its epidemiology and treatment patterns in Asian countries.

Methods: To investigate CLL/SLL in Asian populations, we identified CLL/SLL patients diagnosed during 2006 to 2015 from the Taiwan Cancer Registry Database and estimated the incidence. Read More

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Inflammation and future depressive symptoms among recently bereaved spouses.

Psychoneuroendocrinology 2021 Jun 27;128:105206. Epub 2021 Mar 27.

Department of Psychological Sciences, Rice University, Houston, TX, USA; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. Electronic address:

Major depressive disorder (MDD) is an important contributor to the total disease burden because of its high comorbidity with chronic illnesses. Many people with high levels of depressive symptoms exhibit elevated systemic inflammation, but inflammation is not a necessary determinant of depression onset. Among those who recently experienced the death of a spouse, we investigated whether (a) inflammation assessed early in bereavement predicted future depressive symptoms and whether (b) inflammation predicted change in depressive symptoms from baseline to follow-up. Read More

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[Validation of patient health Questionnaire-2 to detect depressive symptoms in diabetic or hypertensive patients].

Rev Med Chil 2020 Nov;148(11):1614-1618

Departamento de Psiquiatría y Salud Mental, Hospital Clínico, Universidad de Chile, Santiago, Chile.

Background: Patient Health Questionnaire (PHQ-9) has nine questions and is used in diabetic or hypertensive patients to detect depressive symptoms. The PHQ-2 uses the first two questions of the PHQ-9 to rapidly detect those patients that should answer the whole questionnaire.

Aim: To validate the PHQ-2 to detect depressive symptoms in diabetic or hypertensive patients consulting at Primary Health Care (PHC). Read More

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November 2020

Rubella and tick-borne encephalitis vaccination rates among staff and students at Austrian University of Applied Sciences.

Cent Eur J Public Health 2021 Mar;29(1):18-22

University of Applied Sciences Wiener Neustadt, Wiener Neustadt, Austria.

Objectives: Rubella and tick-borne encephalitis (TBE) are infectious diseases caused by viruses. Rubella is an air-borne infection. TBE, on the other hand, is transmitted by virus-infected ticks. Read More

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Cerebral Venous Thrombosis in Sub-Saharan Africa: A Systematic Review.

J Stroke Cerebrovasc Dis 2021 Jun 31;30(6):105712. Epub 2021 Mar 31.

Serviço de Neurologia, Departamento de Neurociências e Saúde Mental, Hospital Santa Maria- CHULN, Lisboa, Portugal; Faculdade de Medicina, Universidade de Lisboa. Electronic address:

Background: The clinical epidemiology of cerebral venous thrombosis (CVT) in Sub-Saharan Africa is unknown. Such information may be relevant for service planning, prevention and for adapting existing CVT management guidelines to that zone of the World.

Aims: Systematic review to describe the demography, associated conditions, clinical and neuroimaging features, treatment and outcome of CVT in Sub-Saharan Africa. Read More

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The Formation of Biofilm and Bacteriology in Otitis Media with Effusion in Children: A Prospective Cross-Sectional Study.

Int J Environ Res Public Health 2021 03 30;18(7). Epub 2021 Mar 30.

Independent Otoneurological Laboratory, Medical University of Lublin, 20-093 Lublin, Poland.

Background: Otitis media with effusion (OME) can cause serious complications such as hearing impairment or development delays. The aim of the study was to assess the microbiological profile of organisms responsible for OME and to determine if a biofilm formation can be observed.

Methods: Ninety-nine samples from 76 patients aged from 6 months to 12 years were collected for microbiological and molecular studies. Read More

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Treatment outcomes in persons with severe haemophilia B in the Nordic region: The B-NORD study.

Haemophilia 2021 May 29;27(3):366-374. Epub 2021 Mar 29.

Clinical Coagulation Research, Department of Translational Medicine, Lund University, Malmö, Sweden.

Introduction: Data on outcome in persons with haemophilia B (PwHB) are limited and mainly extrapolated from studies of haemophilia A (HA).

Aim: To characterize treatment outcomes in persons with severe HB in the Nordic region, with a focus on joint health, compared with matched controls with HA.

Methods: PwHB attending haemophilia centres in Denmark, Finland, Norway and Sweden were enrolled and matched with controls with HA. Read More

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Should atraumatic restorative treatment be the preferred treatment for older patients?

Abigail Oliver

Evid Based Dent 2021 01;22(1):32-33

DCT, Restorative and Research Departments, Glasgow Dental Hospital, Scotland, UK.

Design Randomised controlled trial study.Case selection Ninety-nine subjects were chosen from 219 potential subjects. The 99 who met the inclusion criteria were randomly allocated to two treatment groups: atraumatic restorative treatment (ART) and conventional treatment (CT). Read More

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January 2021

Lifestyle exercise attenuates immunosenescence; flow cytometry analysis.

BMC Geriatr 2021 03 22;21(1):200. Epub 2021 Mar 22.

Department of Applied and Clinical Physiology, Collegium Medicum University of Zielona Gora, 28 Zyty Str., 65-046, Zielona Gora, Poland.

Background: Interaction of physical activity and overall immune profile is very complex and depends on the intensity, duration and frequency of undertaken physical activity, the exposure to cytomegalovirus (CMV) infection and the age-related changes in the immune system. Daily physical activity, which particularly influences immunity, declines dramatically with age. Therefore, the aim of the study was to explain whether physical activity sustained throughout life can attenuate or reverse immunosenescence. Read More

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The Effect of Cartoon Watching and Distraction Card on Physiologic Parameters and Fear Levels During Inhalation Therapy in Children: A Randomized Controlled Study.

J Trop Pediatr 2021 01;67(1)

Faculty of Health Sciences, Istanbul Okan University, Istanbul, Turkey.

Objective: The study was conducted as a randomized controlled study to investigate the effect of cartoon watching and distraction cards on physiologic parameters and fear levels in children with acute bronchitis in the emergency department.

Methods: Ninety-nine children with acute bronchitis aged 3-6 years were randomized in the emergency department. The study was conducted with three groups: cartoon group, distraction card group, and the control group. Read More

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January 2021

The lobular neoplasia enigma: management and prognosis in a long follow-up case series.

World J Surg Oncol 2021 Mar 18;19(1):80. Epub 2021 Mar 18.

Department of Medical Sciences, University of Turin, Via Santena 7, 10126, Turin, Italy.

Background: Many oncologists debate if lobular neoplasia (LN) is a risk factor or an obligatory precursor of more aggressive disease. This study has three aims: (i) describe the different treatment options (surgical resection vs observation), (ii) investigate the upgrade rate in surgically treated patients, and (iii) evaluate the long-term occurrences of aggressive disease in both operated and unoperated patients.

Methods: A series of 122 patients with LN bioptic diagnosis and follow-up information were selected. Read More

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Rehabilitation duration and time of starting sport-related activities associated with return to the previous level of sports after anterior cruciate ligament reconstruction.

Phys Ther Sport 2021 May 5;49:164-170. Epub 2021 Mar 5.

Department of Rehabilitation Sciences, Jordan University of Science and Technology (JUST), P.O.Box 3030, Irbid, 22110, Jordan.

Objectives: To determine predictors for return to previous level of sports after anterior cruciate ligament reconstruction (ACLR).

Design: Cross-sectional; SETTING: Athletic teams.

Participants: Ninety-one athletes who had ACLR with hamstring-tendon autograft within 1-5 years participated in this study. Read More

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A multidisciplinary evaluation of suspected, non-confirmed cases of COVID-19 including chest CT, as compared to World Health Organization recommendations.

Clin Radiol 2021 05 23;76(5):384-390. Epub 2021 Feb 23.

Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland; University College Dublin, Belfield, Dublin 4, Ireland.

Aim: To report an audit of the evaluation of suspected, unconfirmed cases of COVID-19 including chest computed tomography (CT), as compared to World Health Organization recommendations.

Methods: A clinical audit was undertaken examining the evaluation of patients with suspected COVID-19 with negative SARS-CoV-2 reverse transcriptase polymerase chain reaction (RT-PCR) results, with comparison to WHO recommendations. A retrospective chart review was undertaken for 90 patients examining investigations, in particular CT, used to clarify the diagnosis. Read More

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Fear-of-falling and associated risk factors in persons with rheumatoid arthritis: a 1 year prospective study.

BMC Musculoskelet Disord 2021 Mar 10;22(1):260. Epub 2021 Mar 10.

School of Health Sciences and Manchester Academic Health Science Centre (MAHSC), Jean McFarlane Building, University Place, University of Manchester, Manchester, M13 9LP, UK.

Background: Falls, associated injuries and fear-of-falling are common in adults with RA. Fear-of-falling can be a major consequence of, and as debilitating as falling, resulting in a cycle of activity restriction, reduced quality of life, institutionalisation and potentially increase risk of falls. The objective of this study was to examine the relationship between fear-of-falling and risk factors associated with fear-of-falling in adults with rheumatoid arthritis (RA) over a 1 year period. Read More

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Using Positive Attribute Framing to Attenuate Nocebo Side Effects: A Cybersickness Study.

Ann Behav Med 2021 Mar 1. Epub 2021 Mar 1.

School of Psychology, University of Sydney, Australia.

Background: Side effect warnings can contribute directly to their occurrence via the nocebo effect. This creates a challenge for clinicians and researchers, because warnings are necessary for informed consent, but can cause harm. Positive framing has been proposed as a method for reducing nocebo side effects whilst maintaining the principles of informed consent, but the limited available empirical data are mixed. Read More

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Neurodevelopmental Outcomes and Gut Bifidobacteria in Term Infants Fed an Infant Formula Containing High sn-2 Palmitate: A Cluster Randomized Clinical Trial.

Nutrients 2021 Feb 22;13(2). Epub 2021 Feb 22.

Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100191, China.

A few studies suggested high stereo-specifically numbered (sn)-2 palmitate in a formula might favor the gut Bifidobacteria of infants. The initial colonization and subsequent development of gut microbiota in early life might be associated with development and later life functions of the central nervous system via the microbiota-gut-brain axis, such as children with autism. This study aims to assess the hypothesized effect of increasing the amount of palmitic acid esterified in the sn-2 position in infant formula on neurodevelopment in healthy full-term infants and to explore the association of this effect with the altered gut Bifidobacteria. Read More

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February 2021

Nursing Students' Attitudes Toward Older Adults After Their First Intentional Encounter: A Cross-Sectional, Correlational Study.

Nurs Educ Perspect 2021 May-Jun 01;42(3):148-151

About the Authors Susan Hovey, PhD, RN, is a clinical assistant professor, College of Nursing, University of Illinois at Chicago, Chicago, Illinois. Michele Shropshire, PhD, RN, is an assistant professor, Mennonite College of Nursing, Illinois State University, Normal, Illinois. The work was supported by Xi Pi Chapter, Sigma Theta Tau International. For more information, contact Dr. Shropshire at

Aim: This study examined how intentional first encounters as a nursing student, as well as prior relationships with older adults, influenced baccalaureate prelicensure nursing students' attitudes toward this population.

Background: There is a growing demand for knowledgeable and skilled nurses to provide person-centered care to an aging population. An ongoing challenge is lack of interest in practicing within gerontological settings following graduation. Read More

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Teleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury.

Neurology 2021 04 26;96(15):e1999-e2005. Epub 2021 Feb 26.

From the Department of Neurology (M.M., A.C.T., J.E., C.M.W., L.S.), Massachusetts General Hospital, Harvard Medical School, Boston; Department of Critical Care Medicine (B.T.K.), Emerson Hospital, Concord; Department of Medicine (P.T.L.), North Shore Medical Center, Salem; Institute for Medical Engineering and Science (U.G., R.P.), Massachusetts Institute of Technology, Boston; Institute for Research in Technology (R.P.), Universidad Pontificia Comillas, Madrid, Spain; and Soar Management Consulting Group (P.S.), Boston, MA.

Objective: To determine whether providing teleneurology (TN) consultations aiding in determination of death by neurologic criteria (DNC) to a bedside intensivist is feasible and whether timely access and expert input increase the quality of the DNC examination and identification of potential organ donors, we reviewed retrospective data related to outcomes of such consultations.

Methods: Between November 2017 and March 2019, TN consults were requested for sequential comatose patients in the intensive care unit (ICU). We recorded patients' demographic information, causes leading to coma or suspected DNC, and the results of TN consultations. Read More

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Effect of Collaborative Care on Persistent Postconcussive Symptoms in Adolescents: A Randomized Clinical Trial.

JAMA Netw Open 2021 02 1;4(2):e210207. Epub 2021 Feb 1.

Seattle Children's Research Institute, Center for Child Health, Behavior and Development, University of Washington, Seattle.

Importance: Despite the high level of impairment for adolescents with persistent postconcussive symptoms, few studies have tested whether such problems can be remediated.

Objective: To examine whether collaborative care treatment is associated with improvements in postconcussive, quality of life, anxiety, and depressive symptoms over 1 year, compared with usual care.

Design, Setting, And Participants: The Collaborative Care Model for Treatment of Persistent Symptoms After Concussion Among Youth II Trial was a randomized clinical trial conducted from March 2017 to May 2020 with follow-up assessments at 3, 6, and 12 months. Read More

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February 2021

Respiratory failure, clinical course and community management of COVID-19 patients in a large Australian cohort.

Intern Med J 2021 03 25;51(3):334-340. Epub 2021 Feb 25.

Department of Respiratory and Sleep Medicine, Sutherland Hospital, Sydney, New South Wales, Australia.

Background: Coronavirus disease 2019 (COVID-19) has wreaked health and economic damage globally. A thorough understanding of the characteristics of COVID-19 patients in Australia plus the strategies that successfully 'flatten the curve' are vitally important to contain this pandemic.

Aim: To describe the clinical characteristics and outcomes of COVID-19 patients in the Sutherland Shire, and the management model adopted to manage these patients. Read More

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Remote Device Interrogation Kiosks (ReDInK) - Pharmacy Kiosk Remote Testing of Pacemakers and Implantable Cardioverter-Defibrillators for Rural Victorians. A Novel Strategy to Tackle COVID-19.

Heart Lung Circ 2021 Jul 28;30(7):1044-1049. Epub 2021 Jan 28.

Royal Melbourne Hospital, Melbourne, Vic, Australia.

Background: In the era of COVID-19, travel restrictions and social distancing measures have changed the landscape for device interrogations of pacemakers and defibrillators for rural Victorians. Previously, device checks were performed infrequently in large volume, face-to-face rural clinics by visiting cardiologists and technicians. Access to remote areas and social distancing restrictions have made these clinics unfeasible to operate. Read More

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An algorithm in ophthalmic emergencies to evaluate the necessity of physical consultation during COVID-19 lockdown in Paris: Experience of the first 100 patients.

J Fr Ophtalmol 2021 Mar 10;44(3):307-312. Epub 2021 Feb 10.

Department of Ophthalmology III, CHNO des Quinze-Vingts, IHU FOReSIGHT, 28, rue de Charenton, 75012 Paris, France.

Purpose: This study aimed to evaluate the ability of a freely accessible internet algorithm to correctly identify the need for emergency ophthalmologic consultation for correct diagnosis and management.

Method: This retrospective observational cohort study was based on the first 100 patients who requested recommendations on the necessity of breaking the lockdown for emergency ophthalmology consultation during the period from March to May 2020.

Results: Ninety-one patients completed questionnaires. Read More

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Diet, exposure to polycyclic aromatic hydrocarbons during pregnancy, and fetal growth: A comparative study of mothers and their fetuses in industrial and urban areas in Southwest Iran.

Environ Pollut 2021 May 5;276:116668. Epub 2021 Feb 5.

Department of Environmental Health Engineering, Faculty of Health and Nutrition, Bushehr University of Medical Sciences, Bushehr, Iran; Systems Environmental Health and Energy Research Center, The Persian Gulf Biomedical Sciences Research Institute, Bushehr University of Medical Sciences, Bushehr, Iran.

The presence of polycyclic aromatic hydrocarbons (PAHs) in the fetal environment is a high-priority concern due to the fetus being more sensitive than adults to these ubiquitous xenobiotics. The aim of the present study was to compare the maternal and fetal serum levels of ΣPAHs and their effects on fetal growth in an industrial and an urban area in Southwest Iran. The industrial area was the petrochemical and gas area (PGA) of the Central District of Asaluyeh County and the urban area (UA) was the Central District of Bushehr County, Ninety-nine maternal serum (MS) and 99 cord serum (CS) samples from the PGA and 100 MS and 100 CS samples from the UA were collected during May 2018 to February 2019. Read More

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