158 results match your criteria nham

Cardiovascular rna markers and artificial intelligence may improve covid-19 outcome: position paper from the eu-cardiorna cost action ca17129.

Cardiovasc Res 2021 Apr 11. Epub 2021 Apr 11.

Cardiovascular Research Unit, Luxembourg Institute of Health, Strassen, Luxembourg.

The coronavirus disease 2019 (COVID-19) pandemic has been as unprecedented as unexpected, affecting more than 105 million people worldwide as of February 8th, 2020 and causing more than 2.3 million deaths according the World Health Organization. Not only affecting the lungs and provoking acute respiratory distress, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is able to infect multiple cell types including cardiac and vascular cells. Read More

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Peanut allergen reaction thresholds during controlled food challenges in 2 Canadian randomized studies (Canada-ARM1 and PISCES).

J Allergy Clin Immunol Pract 2021 Feb 16. Epub 2021 Feb 16.

Department of Medicine, McMaster University, Hamilton, Ontario, Canada; The Research Institute of St. Joe's Hamilton, Hamilton, ON, Canada. Electronic address:

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February 2021

Gene expression of type II collagen is regulated by direct interaction with Kruppel-like factor 4 and AT-rich interactive domain 5B.

Gene 2021 Mar 29;773:145381. Epub 2020 Dec 29.

Department of Tissue Regeneration, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8549, Japan. Electronic address:

We have previously found and characterized two pairs of enhancer elements, E1 and E2, in the type II collagen alpha 1 chain (COL2A1) gene. Subsequent studies have suggested that these enhancers function differently in the regulation of gene expression. For example, histone deacetylase 10 modifies only the E2 enhancer region to affect gene expression. Read More

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Moieties of Complement iC3b Recognized by the I-domain of Integrin αXβ2.

Mol Cells 2020 12;43(12):1023-1034

Division of Science Education, Kangwon National University, Chuncheon 24341, Korea.

Complement fragment iC3b serves as a major opsonin for facilitating phagocytosis via its interaction with complement receptors CR3 and CR4, also known by their leukocyte integrin family names, αMβ2 and αXβ2, respectively. Although there is general agreement that iC3b binds to the αM and αX I-domains of the respective β2-integrins, much less is known regarding the regions of iC3b contributing to the αX I-domain binding. In this study, using recombinant αX I-domain, as well as recombinant fragments of iC3b as candidate binding partners, we have identified two distinct binding moieties of iC3b for the αX I-domain. Read More

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December 2020

Virtual care rotation for internal medicine residents during the COVID-19 pandemic.

Can Med Educ J 2020 Dec 7;11(6):e201-e203. Epub 2020 Dec 7.

Department of Medicine, University of Toronto, Ontario, Canada.

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December 2020

Variation in pre-hospital outcomes after out-of-hospital cardiac arrest in Michigan.

Resuscitation 2021 Jan 8;158:201-207. Epub 2020 Dec 8.

University of Michigan, Michigan Medicine, Ann Arbor, MI, United States; Division of Cardiovascular Diseases and The Department of Internal Medicine, United States.

Aim: Care by emergency medical service (EMS) agencies is critical for optimizing prehospital outcomes following out-of-hospital cardiac arrest (OHCA). We explored whether substantial differences exist in prehospital outcomes across EMS agencies in Michigan-specifically focusing on rates of sustained return of spontaneous circulation (ROSC) upon emergency department (ED) arrival.

Methods: Using data from Michigan Cardiac Arrest Registry to Enhance Survival (MI-CARES) for years 2014-2017, we calculated rates of sustained ROSC upon ED arrival across EMS agencies in Michigan. Read More

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January 2021

Exploring the Impact of the Surgical Exploration and Discovery (SEAD) Program on Medical Students' Perceptions of Gender Biases in Surgery: A Mixed-Method Evaluation.

J Surg Educ 2020 Dec 5. Epub 2020 Dec 5.

Department of Surgery, Eric C. Poulin Office of Surgical Education at University of Ottawa, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Division of Urology, Department of Surgery, The Ottawa Hospital - General Campus, Ottawa, Ontario, Canada.

Objective: Female representation in surgery is increasing; however, many surgical specialties continue to observe disproportionately fewer females entering their residencies. This study assesses how medical students' gender-based perceptions of surgical careers are impacted by attending the Surgical Exploration and Discovery (SEAD) program, a 2-week, immersive procedural program that offers observerships, mentorship, and workshops across 8 surgical specialties.

Design: In this mixed-method prospective cohort study, medical students' awareness, beliefs, and experiences of gender bias in surgery were assessed using a 10-item Gender Bias in Medical Students Assessment-Surgery (GBMSA-S) psychometric survey instrument inspired by the validated Gender Bias in Medical Education Scale (Parker et al. Read More

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December 2020

A novel three-TMH Na/H antiporter and the functional role of its oligomerization.

J Mol Biol 2021 Jan 3;433(2):166730. Epub 2020 Dec 3.

Department of Microbiology and Biotechnology, College of Life Sciences, Northeast Agricultural University, No. 600 Changjiang Road, Xiangfang District, Harbin 150030, China. Electronic address:

Na/Hantiportersare a category of ubiquitous transmembrane proteins with various important physiological roles in almost all living organisms ranging from bacteria to humans. However, the knowledge of novel Na/Hantiporters remains to be broadened, and the functional roles ofoligomerization in theseantiportershave not yet been thoroughly understood. Here, we reported functional analysis of an unknown transmembrane protein composed of 103 amino acid residues. Read More

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January 2021

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1 mutant lung cancer.

Nat Metab 2020 12 30;2(12):1401-1412. Epub 2020 Nov 30.

Children's Medical Center Research Institute, UT Southwestern Medical Center, Dallas, TX, USA.

In non-small-cell lung cancer (NSCLC), concurrent mutations in the oncogene KRAS and the tumour suppressor STK11 (also known as LKB1) encoding the kinase LKB1 result in aggressive tumours prone to metastasis but with liabilities arising from reprogrammed metabolism. We previously demonstrated perturbed nitrogen metabolism and addiction to an unconventional pathway of pyrimidine synthesis in KRAS/LKB1 co-mutant cancer cells. To gain broader insight into metabolic reprogramming in NSCLC, we analysed tumour metabolomes in a series of genetically engineered mouse models with oncogenic KRAS combined with mutations in LKB1 or p53. Read More

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December 2020

Enhancing Prehospital Outcomes for Cardiac Arrest (EPOC) study: sequential mixed-methods study protocol in Michigan, USA.

BMJ Open 2020 11 27;10(11):e041277. Epub 2020 Nov 27.

Acute Care Research Unit, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, Michigan, USA

Introduction: Out-of-hospital cardiac arrest (OHCA) is a common, life-threatening event encountered routinely by first responders, including police, fire and emergency medical services (EMS). Current literature suggests that there is significant regional variation in outcomes, some of which may be related to modifiable factors. Yet, there is a persistent knowledge gap regarding strategies to guide quality improvement efforts in OHCA care and, by extension, survival. Read More

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November 2020

Bacterial compositions of indigenous Lanna (Northern Thai) fermented foods and their potential functional properties.

PLoS One 2020 18;15(11):e0242560. Epub 2020 Nov 18.

Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand.

Many indigenous fermented foods of Northern Thailand and neighbouring regions have traditionally been known for their health benefits. In this study, we explored the communities of bacteria in selected fermented foods which are commonly consumed among ethnic groups around Northern Thailand, for which information on their microbial compositions or their functional properties is still limited. The selected food groups included Thua Nao (alkaline fermented soybean product), Nham (fermented pork sausage/loaf), Nam phak (fermented Chinese cabbage) and Miang (fermented leaves from Miang Tea trees). Read More

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January 2021

Global miRNA to miRNA Interactions: Impacts for miR-21.

Trends Cell Biol 2021 01 11;31(1):3-5. Epub 2020 Nov 11.

School of Biomedical Engineering, Centre for Health Technologies, Faculty of Engineering and IT, University of Technology Sydney, Sydney, NSW, Australia; Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, Camperdown, NSW, Australia. Electronic address:

miRNAs inherently alter the cellular environment by regulating target genes. miRNAs may also regulate other miRNAs, with far-reaching influence on miRNA and mRNA expression. We explore this realm of small RNA regulation with a focus on the role of the oncogenic miR-21 and its impact on other miRNA species. Read More

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January 2021

Functional imaging of RAS pathway targeting in malignant peripheral nerve sheath tumor cells and xenografts.

Pediatr Blood Cancer 2020 12 25;67(12):e28639. Epub 2020 Sep 25.

Department of Pediatrics Division of Hematology/Oncology, University of Texas Southwestern Medical Center, Dallas, Texas.

Background: Malignant peripheral nerve sheath tumor (MPNST) is an aggressive form of soft-tissue sarcoma (STS) in children. Despite intensive therapy, relatively few children with metastatic and unresectable disease survive beyond three years. RAS pathway activation is common in MPNST, suggesting MEK pathway inhibition as a targeted therapy, but the impact on clinical outcome has been small to date. Read More

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December 2020

Calpain-2 as a therapeutic target in repeated concussion-induced neuropathy and behavioral impairment.

Sci Adv 2020 Jul 1;6(27). Epub 2020 Jul 1.

Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA.

Repeated concussion represents a serious health problem as it can result in various brain pathologies, ranging from minor focal tissue injury to severe chronic traumatic encephalopathy. The calcium-dependent protease, calpain, participates in the development of neurodegeneration following concussion, but there is no information regarding the relative contribution of calpain-1 and calpain-2, the major calpain isoforms in the brain. We used a mouse model of repeated concussions, which reproduces most of the behavioral and neuropathological features of the human condition, to address this issue. Read More

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Safety and efficacy of nivolumab as a second line therapy in metastatic renal cell carcinoma: a retrospective chart review.

Croat Med J 2020 Aug;61(4):326-332

Robert Likic, University Hospital Centre Zagreb, Department of Internal Medicine Unit of Clinical Pharmacology, Kispaticeva 12, 10000 Zagreb, Croatia,

Aim: To assess diseases outcomes and tolerability of real-life second-line nivolumab in a series of metastatic renal cell carcinoma (mRCC) patients.

Methods: This retrospective chart review involved prospectively monitored patients (named patient program) treated with second-line nivolumab for mRCC at the University Hospital Centre Zagreb from February 2016 to March 2018.

Results: The study enrolled 30 patients, 5 of whom (16. Read More

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The Role of Dendritic Cells in TB and HIV Infection.

J Clin Med 2020 Aug 17;9(8). Epub 2020 Aug 17.

College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.

Dendritic cells are the principal antigen-presenting cells (APCs) in the host defense mechanism. An altered dendritic cell response increases the risk of susceptibility of infections, such as (), and the survival of the human immunodeficiency virus (HIV). The altered response of dendritic cells leads to decreased activity of T-helper-1 (Th1), Th2, Regulatory T cells (Tregs), and Th17 cells in tuberculosis (TB) infections due to a diminishment of cytokine release from these APCs, while HIV infection leads to DC maturation, allowing DCs to migrate to lymph nodes and the sub-mucosa where they then transfer HIV to CD4 T cells, although there is controversy around this topic. Read More

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Premature Activation of Immune Transcription Programs in Autoimmune-Predisposed Mouse Embryonic Stem Cells and Blastocysts.

Int J Mol Sci 2020 Aug 11;21(16). Epub 2020 Aug 11.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, Medical Center-University of Freiburg, Mathildenstraße 1, 79106 Freiburg, Germany.

Autoimmune diabetes is a complex multifactorial disease with genetic and environmental factors playing pivotal roles. While many genes associated with the risk of diabetes have been identified to date, the mechanisms by which external triggers contribute to the genetic predisposition remain unclear. Here, we derived embryonic stem (ES) cell lines from diabetes-prone non-obese diabetic (NOD) and healthy C57BL/6 (B6) mice. Read More

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"Between a Rock and a Hard Place": A Case Report of Stone Fragment Impaction Causing a Retained Ureteroscope Requiring Open Surgical Intervention.

J Endourol Case Rep 2020 11;6(1):7-9. Epub 2020 Mar 11.

Division of Urology, Department of Surgery, University of Ottawa, Ottawa, Canada.

Ureteroscopy is frequently used for small renal and ureteral calculi. Rarely cases have been reported of retained ureteroscopes as a complication. With the limited number of cases, it is important to add these to the literature to mitigate the future risk from this complication that can lead to significant morbidity. Read More

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Safety and efficacy of fluoxetine on functional outcome after acute stroke (AFFINITY): a randomised, double-blind, placebo-controlled trial.


Lancet Neurol 2020 08;19(8):651-660

Background: Trials of fluoxetine for recovery after stroke report conflicting results. The Assessment oF FluoxetINe In sTroke recoverY (AFFINITY) trial aimed to show if daily oral fluoxetine for 6 months after stroke improves functional outcome in an ethnically diverse population.

Methods: AFFINITY was a randomised, parallel-group, double-blind, placebo-controlled trial done in 43 hospital stroke units in Australia (n=29), New Zealand (four), and Vietnam (ten). Read More

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Prediabetes Induced by a Single Autoimmune B Cell Clone.

Front Immunol 2020 18;11:1073. Epub 2020 Jun 18.

Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, CA, United States.

While B cells play a significant role in the onset of type-1 diabetes (T1D), little is know about their role in those early stages. Thus, to gain new insights into the role of B cells in T1D, we converted a physiological early pancreas-infiltrating B cell into a novel BCR mouse model using Somatic Cell Nuclear Transfer (SCNT). Strikingly, SCNT-derived B1411 model displayed neither developmental block nor anergy. Read More

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SARS-CoV-2 surveillance for a non-human primate breeding research facility.

J Med Primatol 2020 12 3;49(6):322-331. Epub 2020 Jul 3.

Primate Assay Laboratory, California National Primate Research Center, University of California, Davis, California, USA.

Background: The emergence of SARS-CoV-2 and the ensuing COVID-19 pandemic prompted the need for a surveillance program to determine the viral status of the California National Primate Research Center non-human primate breeding colony, both for reasons of maintaining colony health and minimizing the risk of interference in COVID-19 and other research studies.

Methods: We collected biological samples from 10% of the rhesus macaque population for systematic testing to detect SARS-CoV-2 virus by RT-PCR and host antibody response by ELISA. Testing required the development and validation of new assays and an algorithm using in laboratory-developed and commercially available reagents and protocols. Read More

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December 2020

Separating posterior-circulation stroke from vestibular neuritis with quantitative vestibular testing.

Clin Neurophysiol 2020 Aug 8;131(8):2047-2055. Epub 2020 Jun 8.

Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Central Clinical School, University of Sydney, Sydney, NSW, Australia. Electronic address:

Objective: To separate vestibular neuritis (VN) from posteriorcirculation stroke (PCS) using quantitative tests of canal and otolith function.

Methods: Video Head-Impulse tests (vHIT) were used to assess all three semicircular canal pairs; vestibulo-ocular reflex (VOR) gain and saccade metrics were examined. Cervical and ocular-Vestibular-Evoked Myogenic Potentials (c- and oVEMP) and Subjective Visual Horizontal (SVH) were used to assess otolith function. Read More

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Safety Assessment of a Nham Starter Culture Lactobacillus plantarum BCC9546 via Whole-genome Analysis.

Sci Rep 2020 06 24;10(1):10241. Epub 2020 Jun 24.

National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phahonyothin Road, Khlong Nueng, Khlong Luang, Pathum Thani, 12120, Thailand.

The safety of microbial cultures utilized for consumption is vital for public health and should be thoroughly assessed. Although general aspects on the safety assessment of microbial cultures have been suggested, no methodological detail nor procedural guideline have been published. Herein, we propose a detailed protocol on microbial strain safety assessment via whole-genome sequence analysis. Read More

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Contralesional subjective visual horizontal predicts endolymphatic hydrops.

Acta Otolaryngol 2020 Oct 18;140(10):833-837. Epub 2020 Jun 18.

Neurology Department, Royal Prince Alfred Hospital and Central Clinical School, University of Sydney, Sydney, Australia.

The subjective visual horizontal (SVH) is a test of utricular function that assesses conjugate ocular torsion which is a component of the ocular tilt reaction (OTR). In unilateral destructive peripheral vestibular lesions, the OTR and so the SVH tilt is usually ipsiversive. Our study aimed to profile the causes of a contraversive SVH tilt in patients with a confirmed unilateral peripheral vestibular deficit. Read More

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October 2020

A treatable cause of vertigo.

Pract Neurol 2020 08 6;20(4):338-342. Epub 2020 May 6.

Institute of Clinical Neurosciences, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia.

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Severe Thrombocytopenia in a Patient with COVID-19.

Infect Chemother 2020 Sep 13;52(3):410-414. Epub 2020 Jul 13.

Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Coronavirus disease 2019 (COVID-19) outbreak is spreading rapidly all over the world, being a major threat to public health. Since clinical feature of COVID-19 has not been fully evaluated yet, empirical antibacterial agents are frequently combined for the treatment of COVID-19 in addition to antiviral agents, concerning co-existing bacterial pathogens. We experienced a case of severe thrombocytopenia with epistaxis and petechiae, while treating a COVID-19 patient with ceftriaxone, levofloxacin, and lopinavir/ritonavir. Read More

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September 2020

Image Analysis Reveals Microstructural and Volumetric Differences in Glioblastoma Patients with and without Preoperative Seizures.

Cancers (Basel) 2020 04 17;12(4). Epub 2020 Apr 17.

Department of Neurosurgery, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675 Munich, Germany.

: Seizures related to tumor growth are common in glioma patients, especially in low-grade glioma patients this is often the first tumor manifestation. We hypothesize that there are associations between preoperative seizures and morphologic features (e.g. Read More

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Characteristics and Clinical Outcomes of Extended-Spectrum beta-lactamase-producing Bacteremia in Cancer Patients.

Infect Chemother 2020 Mar;52(1):59-69

Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Background: Cancer patients can be at a higher risk of infection due to drug-resistant bacteria than the general population for various reasons. We performed a retrospective study to evaluate possible risk factors and outcomes of extended-spectrum beta-lactamase-producing (ESBL-KP) bacteremia in cancer patients.

Materials And Methods: Cases were divided into two groups based on whether or not the isolated strain produced ESBL and multivariable regressions were done to identify possible risk factors of ESBL-KP bacteremia and mortality. Read More

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Images - Adenomatoid tumor of testis, concerning for malignancy after ultrasound.

Can Urol Assoc J 2020 Sep;14(9):E471-E473

Division of Urology, Department of Surgery, University of Ottawa, Ottawa, ONCanada.

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September 2020

On the in-plane electronic thermal conductivity of biased nanosheet β-borophene.

Phys Chem Chem Phys 2020 Mar 5;22(11):6318-6325. Epub 2020 Mar 5.

Division of Computational Physics, Institute for Computational Science, Ton Duc Thang University, Ho Chi Minh City, Vietnam.

The unique physical and chemical properties of β-borophene stem from the coexistence of the Dirac and triplet fermions. The metallic phase of β-borophene transitions to the semiconducting one when it is subjected to a perpendicular electric field or bias voltage. In this work, with the aid of a five-band tight-binding Hamiltonian, the Green's function approach and the Kubo-Greenwood formalism, the electronic thermal conductivity (ETC) of the semiconducting phase of β-borophene is studied. Read More

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