Brain Res Bull 2021 Oct 15;175:37-47. Epub 2021 Jul 15.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, China National Clinical Research Center for Neurological Diseases, Beijing Institute of Brain Disorders, Capital Medical University, No.119 South 4(th) Ring West Road, Fengtai District, Beijing, 100160, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing Institute of Brain Disorders, No.45 Changchun Street, Xicheng District, Beijing, 100053, China. Electronic address:
This study aimed at testing the hypothesis that treatment with icariin (ICA, a type of flavonoid) could mitigate the cuprizone (CPZ)-induced acute demyelination in the brain of mice and the potential mechanisms. Female C57BL/6J mice were fed continually with regular rodent chow or the chow supplemented with CPZ (0.2 % w/w) for six weeks to induce acute demyelination. Read More