39 results match your criteria neurotoxicity antimony

Developmental neurotoxicity of antimony (Sb) in the early life stages of zebrafish.

Ecotoxicol Environ Saf 2021 May 8;218:112308. Epub 2021 May 8.

Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China. Electronic address:

Accumulating studies have revealed the toxicity of antimony (Sb) to soil-dwelling and aquatic organisms at the individual level. However, little is known about the neurotoxic effects of antimony and its underlying mechanisms. To assess this issue, we investigated the neurotoxicity of antimony (0, 200, 400, 600 and 800 mg/L) in zebrafish embryos. Read More

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Nuclear Factor-κB Signaling Mediates Antimony-induced Astrocyte Activation.

Biomed Environ Sci 2021 Jan;34(1):29-39

Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, Jiangsu, China;Fudan University Taizhou Institute of Health Sciences, Taizhou 225300, Jiangsu, China.

Objective: Antimony (Sb) has recently been identified as a novel nerve poison, although the cellular and molecular mechanisms underlying its neurotoxicity remain unclear. This study aimed to assess the effects of the nuclear factor kappa B (NF-κB) signaling pathway on antimony-induced astrocyte activation.

Methods: Protein expression levels were detected by Western blotting. Read More

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January 2021

The effects of antimony on Alzheimer's disease-like pathological changes in mice brain.

Sci Total Environ 2021 Mar 26;760:143235. Epub 2020 Oct 26.

Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nantong University, Nantong 226019, China. Electronic address:

We have previously identified antimony (Sb) as a newly nerve poison which leads to neuronal apoptosis. However, the relationship between Sb exposure and Alzheimer's disease (AD) process lacks direct evidence. HE staining and Nissl staining showed significant nerve damage after Sb exposure. Read More

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Positive regulation of the CREB phosphorylation via JNK-dependent pathway prevents antimony-induced neuronal apoptosis in PC12 cell and mice brain.

Neurotoxicology 2020 12 11;81:101-108. Epub 2020 Sep 11.

Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China. Electronic address:

Antimony (Sb) is a potentially toxic chemical element abundantly found in the environment. We previously reported that Sb promoted neuronal deathvia reactive oxygen species-dependent autophagy. Here, we assessed the role of cyclic adenosine monophosphate response element-binding protein (CREB) in Sb-induced neuronal damage. Read More

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December 2020

Akt inhibition-dependent downregulation of the Wnt/β-Catenin Signaling pathway contributes to antimony-induced neurotoxicity.

Sci Total Environ 2020 Oct 17;737:140252. Epub 2020 Jun 17.

Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong 226019, China. Electronic address:

Antimony (Sb), as a newly identified nerve poison, can lead to neuronal apoptosis. However, its neurotoxicological mechanisms remain largely unclear. Here, we evaluated the role and regulation of Wnt/β-catenin pathway in Sb-mediated neurotoxicity. Read More

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October 2020

Antimony, a novel nerve poison, triggers neuronal autophagic death via reactive oxygen species-mediated inhibition of the protein kinase B/mammalian target of rapamycin pathway.

Int J Biochem Cell Biol 2019 09 20;114:105561. Epub 2019 Jun 20.

Department of Occupational Medicine and Environmental Toxicology, School of Public Health, Nangtong University, Nantong, 226019, China. Electronic address:

Antimony (Sb), a naturally occurring metal present in air and drinking water, has been found in the human brain, and there is evidence of its toxic effects on neurobehavioral perturbations, suggesting that Sb is a potential nerve poison. Here, we provide the first study on the molecular mechanism underlying Sb-associated neurotoxicity. Mice exposed to antimony potassium tartrate hydrate showed significantly increased neuronal apoptosis. Read More

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September 2019

Bayesian varying coefficient kernel machine regression to assess neurodevelopmental trajectories associated with exposure to complex mixtures.

Stat Med 2018 12 12;37(30):4680-4694. Epub 2018 Sep 12.

Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Exposure to environmental mixtures can exert wide-ranging effects on child neurodevelopment. However, there is a lack of statistical methods that can accommodate the complex exposure-response relationship between mixtures and neurodevelopment while simultaneously estimating neurodevelopmental trajectories. We introduce Bayesian varying coefficient kernel machine regression (BVCKMR), a hierarchical model that estimates how mixture exposures at a given time point are associated with health outcome trajectories. Read More

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December 2018

The down-regulation of galectin-1 expression is a specific biomarker of arsenic toxicity.

Toxicol Lett 2011 Aug 10;205(1):38-46. Epub 2011 May 10.

Department of Life Science, National Central University, No. 330 Jhongda Road, Jhongli, Taoyuan 320, Taiwan.

Galectin-1 (GAL1) is known as a β-galactoside-binding protein that also can bind with arsenic to regulate cell functions. Using RNA interference technique, we investigated the possible mechanism involved in GAL1 modulation of arsenite-inhibited cell survival in 3T3 fibroblast and KB oral cancer cells. GAL1 gene knockdown significantly attenuated sodium arsenite (NaAsO(2)) and arsenic trioxide (As(2)O(3)) inhibition of cell survival. Read More

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Genotoxicity studies of heavy metals: lead, bismuth, indium, silver and antimony.

J Occup Health 2009 23;51(6):498-512. Epub 2009 Oct 23.

Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo 160-8582, Japan.

Objectives: Many kinds of heavy metals are used in industry; thus, it is important for us to clarify their toxicity. For example, lead, which is a component of solder, is notorious for its neurotoxicity, and substitute materials have been sought for many years. Therefore, we examined the genotoxicity of lead and also those of metallic bismuth, indium, silver and antimony which are possible substitutes for lead in solder. Read More

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January 2010

Study of arsenic content in mine groundwater commonly used for human consumption in Utah.

Environ Technol 2008 Feb;29(2):217-24

Utah State Department of Health, Environmental Chemistry, Salt Lake City, 46 No. Medical Drive, UT 84113, USA.

Of the various sources of arsenic released in to the environment, the presence of arsenic in water probably poses the greatest threat to human health. Arsenic is released in to the environment through water by dissolution of minerals and ores. Natural release is slow, but in some areas the concentration of arsenic in groundwater (commonly referred to as Acid Mine Drainage (or AMD)) is accelerated by mining activity. Read More

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February 2008

Multi-element screening by ICP-MS of two specimens of Napoleon's hair.

J Anal Toxicol 2006 Oct;30(8):621-3

Laboratoire ChemTox, 3 rue Gruninger, F-67400 Illkirch, France.

Since 1960, it has been demonstrated by various analytical procedures that high concentrations of arsenic were present in Napoleon's hair. Various authors, indicating that the detected arsenic levels are a consequence of external contamination, have challenged the results of these examinations. In order to shed more light on this historical controversy, we have tested two samples of Napoleon's hair by inductively coupled plasma-mass spectrometry (ICP-MS). Read More

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October 2006

Environmental distribution, analysis, and toxicity of organometal(loid) compounds.

Crit Rev Toxicol 2004 May-Jun;34(3):301-33

Institut für Hygiene und Arbeitsmedizin, Universitätsklinikum Essen, Essen, Germany.

The biochemical modification of the metals and metalloids mercury, tin, arsenic, antimony, bismuth, selenium, and tellurium via formation of volatile metal hydrides and alkylated species (volatile and involatile) performs a fundamental role in determining the environmental processing of these elements. In most instances, the formation of such species increases the environmental mobility of the element, and can result in bioaccumulation in lipophilic environments. While inorganic forms of most of these compounds are well characterized (e. Read More

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Antimony: an unlikely confounder in the relationship between well water arsenic and health outcomes in Bangladesh.

Environ Health Perspect 2004 Jun;112(8):809-11

Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA.

Recent in vitro studies have suggested a potential role for antimony as a confounder in human health studies related to arsenic in drinking water. We measured tube-well water concentrations of antimony and arsenic in the Pabna region of Bangladesh, where arsenic concentrations are known to be elevated and the concentrations of antimony have not yet been thoroughly documented. Two hundred forty-five tube-well water samples were collected from various regions in Pabna, Bangladesh, as part of an ongoing case-control study. Read More

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Environmental variables in a holistic evaluation of land contaminated by historic mine wastes: a study of multi-element mine wastes in West Devon, England using arsenic as an element of potential concern to human health.

E I Hamilton

Sci Total Environ 2000 Apr;249(1-3):171-221

Phoenix Research Laboratory, Tavistock, Devon, UK.

Unusual and unexpected concentrations of a number of elements were identified in samples of house dust, that indicated the presence of mine wastes in an area where they were not expected. In pursuing this matter, several other very unusual observations and practices, involving highly contaminated mine wastes, were also identified. Here, using an available, but not a custom-made database, the matter is pursued. Read More

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Confounding variables in the environmental toxicology of arsenic.

T Gebel

Toxicology 2000 Apr;144(1-3):155-62

Medical Institute of General Hygiene and Environmental Health, University of Goettingen, Windausweg 2, D-37073, Goettingen, Germany.

Arsenic is one of the most important global environmental toxicants. For example, in regions of West Bengal and Inner Mongolia, more than 100000 persons are chronically exposed to well water often strongly contaminated with As. Unfortunately, a toxicologically safe risk assessment and standard setting, especially for long-term and low-dose exposures to arsenic, is not possible. Read More

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Suppression of arsenic-induced chromosome mutagenicity by antimony.

T Gebel

Mutat Res 1998 Feb;412(3):213-8

Medical Institute of General Hygiene and Environmental Health, Goettingen, Germany.

Arsenic and antimony are two semimetals sharing some chemical as well as toxicological properties. Both elements are clastogenic but not point mutagenic in their trivalent state of valency. Environmental exposure to arsenic was proven to be associated with increased rates of various types of cancers. Read More

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February 1998

The Saccharomyces cerevisiae ACR3 gene encodes a putative membrane protein involved in arsenite transport.

J Biol Chem 1997 Nov;272(48):30061-6

Institute of Microbiology, Wroclaw University, Przybyszewskiego 63/77, 51-148 Wroclaw, Poland.

The cluster of three genes, ACR1, ACR2, and ACR3, previously was shown to confer arsenical resistance in Saccharomyces cerevisiae. The overexpression of ACR3 induced high level arsenite resistance. The presence of ACR3 together with ACR2 on a multicopy plasmid was conducive to increased arsenate resistance. Read More

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November 1997

Trypanothione overproduction and resistance to antimonials and arsenicals in Leishmania.

Proc Natl Acad Sci U S A 1996 Sep;93(19):10383-7

Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Leishmania resistant to arsenicals and antimonials extrude arsenite. Previous results of arsenite uptake into plasma membrane-enriched vesicles suggested that the transported species is a thiol adduct of arsenite. In this paper, we demonstrate that promastigotes of arsenite-resistant Leishmania tarentolae have increased levels of intracellular thiols. Read More

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September 1996

Sudden infant death syndrome: a possible primary cause.

B A Richardson

J Forensic Sci Soc 1994 Jul-Sep;34(3):199-204

Penarth Research International Limited, St Peter Port, Guernsey, Channel Islands.

The hypothesis that poisoning by phosphines, arsines and stibines might be the primary cause of sudden infant death syndrome (SIDS) was investigated. Most mattress materials contain phosphorus or antimony compounds as fire retardant additives. Mattress materials in areas affected by the warmth and perspiration of the sleeping infant were found to be naturally infected by the fungus Scopulariopsis brevicaulis which is thought to be capable of generating phosphines, arsines and stibines from materials containing phosphorus, arsenic or antimony compounds. Read More

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November 1994

Interaction of the catalytic and the membrane subunits of an oxyanion-translocating ATPase.

Arch Biochem Biophys 1994 Jun;311(2):418-24

Department of Biochemistry, Wayne State University, School of Medicine, Detroit, Michigan 48201.

Resistance to arsenical and antimonial compounds in Escherichia coli is due to active extrusion of these compounds from cells expressing the ars operon. The arsenical pump is an ion-translocating ATPase which consists of two polypeptide components, the ArsA and ArsB proteins. The ArsB protein, the inner membrane component of the pump, has been shown to function as the membrane anchor for the catalytic subunit, the ArsA protein. Read More

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The arsenical ATPase efflux pump mediates tellurite resistance.

J Bacteriol 1992 May;174(9):3092-4

Department of Biochemistry, University of Alberta, Edmonton, Canada.

The ars operon of the resistance plasmid R773 was found to produce moderate levels of resistance to tellurite. A MIC of 64 micrograms of TeO3(2-) per ml was found for Escherichia coli cells harboring plasmids which contained all three of the structural genes (arsA, arsB, and arsC) of the anion-translocating ATPase. MICs specified by plasmids carrying only one or two structural elements or the cloning vector alone were 2 to 4 micrograms/ml. Read More

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Cardiovascular disease and work place exposures.

K D Rosenman

Arch Environ Health 1984 May-Jun;39(3):218-24

The typical occupational cohort study includes all causes of mortality. However, emphasis is usually placed on the presence or absence of excess cancer mortality. A systematic review of completed occupational cohort studies to assess the findings and patterns of cardiovascular mortality would be useful. Read More

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September 1984

Arsine (arsenic hydride) poisoning in the workplace.

Am Ind Hyg Assoc J 1979 Oct;40(10):A56-61

The National Institute for Occupational Safety and Health (NIOSH) recommends that appropriate workpractices be implemented to reduce the risk of worker exposure to arsine (AsH3) gas. There is a high potential for the generation of arsine gas when inorganic arsenic is exposed to nascent (freshly formed) hydrogen. This recommendation is based on several reports of worker exposure to arsine resulting in severe toxic effects or death. Read More

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October 1979

Acute arsine posioning in two workers cleaning a clogged drain.

Arch Environ Health 1979 Jul-Aug;34(4):224-7

On February 6, 1978, two maintenance workers employed by a chemical company in Atlanta, Georgia, became ill after cleaning a clogged drain. Both were hospitalized with acute fulminant hemolytic anemia and renal failure. While the clinical picture suggested arsine or stibine poisoning, preliminary investigation of the plant revealed no obvious source of arsenic, antimony, or hydrogen gas. Read More

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October 1979