40,935 results match your criteria neuropsychiatric


Psychiatric and cognitive characteristics of older adults admitted to a Video-EEG monitoring (VEM) unit.

Epilepsy Behav 2021 May 9;120:107987. Epub 2021 May 9.

Department of Medicine (RMH), The University of Melbourne, Australia; Department of Neurology, Royal Melbourne Hospital, Parkville, Australia; Melbourne School of Psychological Sciences, The University of Melbourne, Australia.

Objective: To compare the clinical, psychiatric, and cognitive characteristics of older with younger patients presenting to a video-EEG monitoring (VEM) unit.

Method: This was a retrospective case-control study involving patients admitted for VEM over a two-year period (from April 2018 to April 2020) at two comprehensive epilepsy units. Patients were categorized into an older (≥60 years) and a younger (<60 years) group. Read More

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Structural neuroimaging phenotypes of a novel multi-gene risk score in youth bipolar disorder.

J Affect Disord 2021 Apr 28;289:135-143. Epub 2021 Apr 28.

University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Bipolar disorder (BD) is among the most heritable psychiatric disorders, particularly in early-onset cases, owing to multiple genes of small effect. Here we examine a multi-gene risk score (MGRS), to address the gap in multi-gene research in early-onset BD.

Methods: MGRS was derived from 34 genetic variants relevant to neuropsychiatric diseases and related systemic processes. Read More

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Anxiety and Alzheimer's disease: Behavioral Analysis and Neural Basis in Rodent Models of Alzheimer's-Related Neuropathology.

Neurosci Biobehav Rev 2021 May 9. Epub 2021 May 9.

Department of Psychology, University of New Mexico, Albuquerque, NM, 87109, Mexico. Electronic address:

Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is also composed of neuropsychiatric symptoms including psychological distress and alterations in mood, including anxiety and depression. Emotional dysfunction in AD is frequently modeled using tests of anxiety-like behavior in transgenic rodents. These tests often include the elevated plus-maze, light/dark test and open field test. Read More

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Universal and Selective Interventions to Prevent Poor Mental Health Outcomes in Young People: Systematic Review and Meta-analysis.

Harv Rev Psychiatry 2021 May-Jun 01;29(3):196-215

From the Early Psychosis: Interventions and Clinical-Detection (EPIC) Laboratory, Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London (Drs. Salazar de Pablo, De Micheli, Catalan, Verdino, Di Maggio, Radua, Provenzani, Montealegre, Signorini, and Fusar-Poli, and Mr. Oliver); Departments of Child and Adolescent Psychiatry (Dr. Salazar de Pablo) and of Psychosis Studies (Drs. Bonoldi and Baccaredda Boy), Institute of Psychiatry, Psychology & Neuroscience, King's College London; Institute of Psychiatry and Mental Health. Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Marañón School of Medicine, Universidad Complutense, Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), CIBERSAM, Madrid (Drs. Salazar de Pablo and Arango); National Institute for Health Research, Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, London (Drs. De Micheli and Fusar-Poli); Department of Brain and Behavioral Sciences, University of Pavia (Drs. Di Maggio, Provenzani, Ruzzi, Calorio, Nosari, Di Marco, Famularo, Molteni, Filosi, Mensi, Balottin, Politi, and Fusar-Poli); Neurosciences Department, University of Padova (Dr. Solmi); Mental Health Department, Biocruces Bizkaia Health Research Institute, Basurto University Hospital, Facultad de Medicina y Odontología, Campus de Leioa, University of the Basque Country, UPV/EHU, Barakaldo, Bizkaia, Spain (Dr. Catalan); Department of Molecular and Developmental Medicine, Division of Psychiatry, University of Siena (Dr. Verdino); Imaging of Mood- and Anxiety-Related Disorders (IMARD) group, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERSAM, Barcelona (Dr. Radua); Department of Clinical Neuroscience, Centre for Psychiatric Research and Education, Karolinska Institutet, Stockholm (Dr. Radua); Scientific Institute for Research, Hospitalization and Healthcare (IRCCS) Mondino Foundation, Child and Adolescent Neuropsychiatric Unit (Dr. Mensi); Department of Paediatrics, Yonsei University College of Medicine, Seoul (Dr. Shin); Zucker Hillside Hospital, Department of Psychiatry, Northwell Health, Glen Oaks, NY (Dr. Correll); Department of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY (Dr. Correll); Center for Psychiatric Neuroscience, Feinstein Institute for Medical Research, Manhasset, NY (Dr. Correll); Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin Berlin (Dr. Correll); OASIS service, South London and Maudsley NHS Foundation Trust, London (Dr. Fusar-Poli).

Background: Much is not known about the efficacy of interventions to prevent poor mental health outcomes in young people by targeting either the general population (universal prevention) or asymptomatic individuals with high risk of developing a mental disorder (selective prevention).

Methods: We conducted a PRISMA/MOOSE-compliant systematic review and meta-analysis of Web of Science to identify studies comparing post-test efficacy (effect size [ES]; Hedges' g) of universal or selective interventions for poor mental health outcomes versus control groups, in samples with mean age <35 years (PROSPERO: CRD42018102143). Measurements included random-effects models, I2 statistics, publication bias, meta-regression, sensitivity analyses, quality assessments, number needed to treat, and population impact number. Read More

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A narrative review of the impact of cerebellar dysfunction and sleep disturbances after general anesthesia in patients with Alzheimer's disease.

Ann Palliat Med 2021 Apr 23. Epub 2021 Apr 23.

Department of Anesthesiology, Shengjing Hospital of China Medical University, Shenyang, China.

Alzheimer's disease (AD) is one of the main causes of dementia in the senium and presenium, which is clinically characterized by memory loss, decreased intelligence and loss of fine motor skills. The cerebellum is a key part of distributed neural circuits, not only involved in motor functions, but also in autonomic nervous, limbic and cognitive behaviors. Motor cerebellar lesions may cause movement disorders, and cognitive and limbic cerebellar lesions in the posterior lobe may cause intellectual and emotional sensory disorders. Read More

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Hippocampal atrophy is associated with psychotic symptom severity following traumatic brain injury.

Brain Commun 2021 9;3(2):fcab026. Epub 2021 Mar 9.

Institute of Medical Science, University of Toronto, Toronto, ON M5S 1A8, Canada.

Psychosis is a rare, but particularly serious sequela of traumatic brain injury. However, little is known as to the neurobiological processes that may contribute to its onset. Early evidence suggests that psychotic symptom development after traumatic brain injury may co-occur with hippocampal degeneration, invoking the possibility of a relationship. Read More

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Quinolinic acid is associated with cognitive deficits in schizophrenia but not major depressive disorder.

Sci Rep 2021 May 11;11(1):9992. Epub 2021 May 11.

Division of Adult Psychiatry, Department of Psychiatry, Geneva University Hospitals, Chemin du Petit-Bel-Air, 1225, Chêne-Bourg, Switzerland.

Tryptophan and its catabolites (TRYCATs) have been suggested to link peripheral immune system activation and central neurotransmitter abnormalities with relevance to the etio-pathophysiology of schizophrenia (SZ) and major depressive disorder (MDD). The relationship to different psychopathological dimensions within these disorders however remains to be elucidated. We thus investigated potential group differences of tryptophan, kynurenine, kynurenic acid, 3-hydroxy kynurenine and quinolinic acid in the plasma of 19 healthy controls (HC), 45 patients with SZ and 43 patients with MDD and correlated plasma proteins with the "motivation and pleasure" dimension and cognition. Read More

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The Time Varying Networks of the Interoceptive Attention and Rest.

eNeuro 2021 May 10. Epub 2021 May 10.

Instituto de Neurobiología, Universidad Nacional Autónoma de México, Querétaro, México

Focused attention to spontaneous sensations is a dynamic process that demands interoceptive abilities. Failure to control it has been linked to neuropsychiatric disorders like illness-anxiety disorder. Regulatory strategies, such as focused attention meditation, may enhance the ability to control focused attention particularly to body sensations, which can be reflected on functional neuroanatomy. Read More

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Olfactory modulation of the medial prefrontal cortex circuitry: Implications for social cognition.

Semin Cell Dev Biol 2021 May 8. Epub 2021 May 8.

Department of Neuroscience, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA. Electronic address:

Olfactory dysfunction is manifested in a wide range of neurological and psychiatric diseases, and often emerges prior to the onset of more classical symptoms and signs. From a behavioral perspective, olfactory deficits typically arise in conjunction with impairments of cognition, motivation, memory, and emotion. However, a conceptual framework for explaining the impact of olfactory processing on higher brain functions in health and disease remains lacking. Read More

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Genetic Overlap Profiles of Cognitive Ability in Psychotic and Affective Illnesses: A Multisite Study of Multiplex Pedigrees.

Biol Psychiatry 2021 Mar 17. Epub 2021 Mar 17.

Department of Psychiatry, Boston Children's Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut.

Background: Cognitive impairment is a key feature of psychiatric illness, making cognition an important tool for exploring of the genetics of illness risk. It remains unclear which measures should be prioritized in pleiotropy-guided research. Here, we generate profiles of genetic overlap between psychotic and affective disorders and cognitive measures in Caucasian and Hispanic groups. Read More

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Efficacy and safety of amantadine as a treatment for apathy after brain injury: Two single-case experimental design studies.

Neuropsychol Rehabil 2020 Nov 30:1-25. Epub 2020 Nov 30.

Limburg Brain Injury Center, Maastricht, The Netherlands.

Studies on the efficacy of amantadine as a treatment for apathy after brain injury are scarce and of low quality. We examined the efficacy and safety of amantadine for treatment of apathy in two individuals with brain injury.Two double-blind, randomized, single-case experimental (baseline-amantadine-placebo-withdrawal) design (SCED) studies. Read More

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November 2020

Apathy Measures in Older Adults and People with Dementia: A Systematic Review of Measurement Properties Using the COSMIN Methodology.

Dement Geriatr Cogn Disord 2021 May 11:1-13. Epub 2021 May 11.

School of Health Sciences, University of Nottingham, Nottingham, United Kingdom,

Background: Apathy is highly prevalent in dementia and is also seen in mild cognitive impairment and the general population. Apathy contributes to failure to undertake daily activities and can lead to health problems or crises. It is therefore important to assess apathy. Read More

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An Agitated Patient With COVID-19 Infection and Early-onset Alzheimer Disease.

Alzheimer Dis Assoc Disord 2021 May 11. Epub 2021 May 11.

Mayo Clinic Alix School of Medicine Department of Psychiatry and Psychology, Mayo Clinic, Scottsdale, AZ.

Encephalopathy, delirium, and agitation are documented symptoms of coronavirus disease (COVID-19) infection, but research into the management of agitation in the setting of COVID-19 and pre-existing neuropsychiatric disease is ongoing. We present a 55-year-old male patient with early-onset Alzheimer disease and deteriorating mental and functional status who presented to our institution with agitation and persistent COVID-19 positivity on polymerase chain reaction testing. His agitation was improved through pharmacologic optimization including the avoidance of benzodiazepines and initiation of clonidine and prazosin, which temporally coincided with the resolution of his nearly 2-month long COVID-19 positivity. Read More

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Cognitive performance and lifetime cannabis use in patients with first-episode schizophrenia spectrum disorder.

Cogn Neuropsychiatry 2021 May 11:1-16. Epub 2021 May 11.

National Institute of Mental Health, Klecany, Czech Republic.

Introduction: Cognitive impairment is among the core features of schizophrenia. In a healthy population, the cognitive deficit is often linked with cannabis abuse, and although the same would be expected in patients with schizophrenia, research has presented contradictory results.

Methods: Participants were patients with first-episode schizophrenia (FES) spectrum disorder who had been lifetime cannabis users ( = 30), FES non-users ( = 53) as well as healthy controls (HC) also divided into cannabis users ( = 20) and non-users ( = 49). Read More

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Metabolic disturbance affects postoperative cognitive function in patients undergoing cardiopulmonary bypass.

Neurol Sci 2021 May 10. Epub 2021 May 10.

Department of Cardiovascular Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Objectives: Postoperative delirium is a common neuropsychiatric syndrome after coronary artery bypass grafting (CABG). We aimed to assess and compare clinical outcomes of CABG patients with delirium with a specific focus on the blood biochemical parameters.

Methods: This investigation was carried out on the 90 eligible patients undergoing CABG. Read More

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Causal influences of neuroticism on mental health and cardiovascular disease.

Hum Genet 2021 May 11. Epub 2021 May 11.

Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, 200030, China.

We investigated the relationship between neuroticism and 16 mental and 18 physical traits using summary results of genome-wide association studies for these traits. LD score regression was used to investigate genetic correlations between neuroticism and the 34 health outcomes. Mendelian randomization was performed to investigate mutual causal relationships between neuroticism and the 34 health outcomes. Read More

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Regulatory rare variants of the dopaminergic gene ANKK1 as potential risk factors for Parkinson's disease.

Sci Rep 2021 May 10;11(1):9879. Epub 2021 May 10.

Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), ISCIII, Madrid, Spain.

Parkinson's disease (PD) is characterized by cerebral dopamine depletion that causes motor and cognitive deficits. The dopamine-related gene ANKK1 has been associated with neuropsychiatric disorders with a dopaminergic deficiency in the striatum. This study aims to define the contribution of ANKK1 rare variants in PD. Read More

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Responsive manipulation of neural circuit pathology by fully implantable, front-end multiplexed embedded neuroelectronics.

Proc Natl Acad Sci U S A 2021 May;118(20)

Department of Electrical Engineering, Columbia University, New York, NY 10027;

Responsive neurostimulation is increasingly required to probe neural circuit function and treat neuropsychiatric disorders. We introduce a multiplex-then-amplify (MTA) scheme that, in contrast to current approaches (which necessitate an equal number of amplifiers as number of channels), only requires one amplifier per multiplexer, significantly reducing the number of components and the size of electronics in multichannel acquisition systems. It also enables simultaneous stimulation of arbitrary waveforms on multiple independent channels. Read More

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Wild-type α-synuclein inherits the structure and exacerbated neuropathology of E46K mutant fibril strain by cross-seeding.

Proc Natl Acad Sci U S A 2021 May;118(20)

Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, 201210, China;

Heterozygous point mutations of α-synuclein (α-syn) have been linked to the early onset and rapid progression of familial Parkinson's diseases (fPD). However, the interplay between hereditary mutant and wild-type (WT) α-syn and its role in the exacerbated pathology of α-syn in fPD progression are poorly understood. Here, we find that WT mice inoculated with the human E46K mutant α-syn fibril (hE46K) strain develop early-onset motor deficit and morphologically different α-syn aggregation compared with those inoculated with the human WT fibril (hWT) strain. Read More

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Accuracy of the Hospital Anxiety and Depression Scale Depression subscale (HADS-D) to screen for major depression: systematic review and individual participant data meta-analysis.

BMJ 2021 05 10;373:n972. Epub 2021 May 10.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, QC, Canada

Objective: To evaluate the accuracy of the depression subscale of the Hospital Anxiety and Depression Scale (HADS-D) to screen for major depression among people with physical health problems.

Design: Systematic review and individual participant data meta-analysis.

Data Sources: Medline, Medline In-Process and Other Non-Indexed Citations, PsycInfo, and Web of Science (from inception to 25 October 2018). Read More

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Posttranslational modifications & lithium's therapeutic effect - potential biomarkers for clinical responses in psychiatric & neurodegenerative disorders.

Neurosci Biobehav Rev 2021 May 7. Epub 2021 May 7.

Montreal Neurological Institute, Department of Neurology & Neurosurgery, McGill University, Montréal, Quebec, Canada.

Several neurodegenerative diseases and neuropsychiatric disorders display aberrant posttranslational modifications (PTMs) of one, or many, proteins. Lithium treatment has been used for mood stabilization for many decades, and is highly effective for large subsets of patients with diverse neurological conditions. However, the differential effectiveness and mode of action are not fully understood. Read More

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Magic Shotgun Nature with Scattergun Approach of Curcumin Repurposing in Obsessive-Compulsive disorder: A Novel Metaphysician of Drug Discovery.

CNS Neurol Disord Drug Targets 2021 May 6. Epub 2021 May 6.

Department of Pharmacognosy, Faculty of Pharmacy, Goel Institute of Pharmacy, Lucknow (Dr A P J Abdul Kalam Technical University Lucknow)- U.P , India.

Background: Obsessive-compulsive disorder (OCD) is an intricate, debilitating neuropsychiatric disorder. Exclusively Selective serotonin reuptake inhibitors (SSRIs) are effective agents use for the treatment of OCD. However, SSRIs (Selective serotonin reuptake inhibitors) are not a magic pill-they do not respond adequately to everybody. Read More

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Relationship between hyperuricemia and serositis in patients with lupus nephritis.

Int Urol Nephrol 2021 May 10. Epub 2021 May 10.

The Department of Nephropathy, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, 130041, Jilin Province, China.

Purpose: To investigate the clinical and pathological characteristics of lupus nephritis (LN) patients with serositis and analyse the relationship between serositis and hyperuricemia (HUA) in LN patients in northeast China.

Methods: The data of patients with LN diagnosed by renal biopsy in our hospital from April 2013 to May 2020 were retrospectively analyzed. The differences between the non-serositis and serositis groups were compared by t tests and Chi-square test. Read More

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Strategies and cognitive reserve to preserve lexical production in aging.

Geroscience 2021 May 10. Epub 2021 May 10.

Leenaards Memory Centre, University Hospital of Lausanne, Lausanne, Switzerland.

In the absence of any neuropsychiatric condition, older adults may show declining performance in several cognitive processes and among them, in retrieving and producing words, reflected in slower responses and even reduced accuracy compared to younger adults. To overcome this difficulty, healthy older adults implement compensatory strategies, which are the focus of this paper. We provide a review of mainstream findings on deficient mechanisms and possible neurocognitive strategies used by older adults to overcome the deleterious effects of age on lexical production. Read More

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Cross-Disorder Analysis of De Novo Mutations in Neuropsychiatric Disorders.

J Autism Dev Disord 2021 May 10. Epub 2021 May 10.

National Clinical Research Center for Geriatric Disorders, Department of Geriatrics, Xiangya Hospital, Central South University, Xiangya Road, Kaifu District, Changsha, 410013, Hunan, China.

The clinical similarity among different neuropsychiatric disorders (NPDs) suggested a shared genetic basis. We catalogued 23,109 coding de novo mutations (DNMs) from 6511 patients with autism spectrum disorder (ASD), 4,293 undiagnosed developmental disorder (UDD), 933 epileptic encephalopathy (EE), 1022 intellectual disability (ID), 1094 schizophrenia (SCZ), and 3391 controls. We evaluated that putative functional DNMs contribute to 38. Read More

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Beliefs: A challenge in neuropsychological disorders.

Authors:
Rüdiger J Seitz

J Neuropsychol 2021 May 9. Epub 2021 May 9.

Department of Neurology, Centre of Neurology and Neuropsychiatry, LVR-Klinikum Düsseldorf, Medical Faculty, Heinrich-Heine-University Düsseldorf, Germany.

Introduction: Beliefs have recently been defined as the neural product of perception of objects and events in the external world and of an affirmative internal affective state reflecting personal meaning. It is, however, undetermined in which way diseases of the brain affect these integrative processes.

Methods: Here, the formation and updating of abnormal beliefs in cerebral disorders are described. Read More

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Review of multi-omics data resources and integrative analysis for human brain disorders.

Brief Funct Genomics 2021 May 8. Epub 2021 May 8.

Department of Biostatistics, Virginia Commonwealth University.

In the last decade, massive omics datasets have been generated for human brain research. It is evolving so fast that a timely update is urgently needed. In this review, we summarize the main multi-omics data resources for the human brains of both healthy controls and neuropsychiatric disorders, including schizophrenia, autism, bipolar disorder, Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, etc. Read More

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Investigating the effects of impairment in non-verbal communication on neuropsychiatric symptoms and quality of life of people living with dementia.

Alzheimers Dement (N Y) 2021 1;7(1):e12172. Epub 2021 May 1.

Exeter University Medical School University of Exeter Exeter UK.

Introduction: People living with dementia in nursing homes have complex needs; impairments in cognition, communication, and daily function; neuropsychiatric symptoms (NPS); and poor quality of life (QoL). The current study examines impairments in non-verbal communication as a potential driver of NPS and QoL.

Methods: One hundred nursing home residents with dementia were assessed using the Emory Dyssemia Index (EDI), Neuropsychiatric Inventory Nursing Home version (NPI-NH), Quality of Life in Alzheimer's Disease (QoL-AD) at baseline, 12-, and 24-week follow-up. Read More

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Trans-Ancestry Mutation Landscape of Hepatoblastoma Genomes in Children.

Front Oncol 2021 21;11:669560. Epub 2021 Apr 21.

Department of Pediatric Surgery, Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China.

Hepatoblastoma (HB) is the most common malignant tumor in the liver of infants and young children. The incidence rate varies among different populations. However, genetic differences in HB patients with different epidemiological and ancestral backgrounds have not been found. Read More

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