547 results match your criteria neuropathy learned

Supporting the Assessment of Hereditary Transthyretin Amyloidosis Patients Based On 3-D Gait Analysis and Machine Learning.

IEEE Trans Neural Syst Rehabil Eng 2021 20;29:1350-1362. Epub 2021 Jul 20.

Hereditary Transthyretin Amyloidosis (vATTR-V30M) is a rare and highly incapacitating sensorimotor neuropathy caused by an inherited mutation (Val30Met), which typically affects gait, among other symptoms. In this context, we investigated the possibility of using machine learning (ML) techniques to build a model(s) that can be used to support the detection of the Val30Met mutation (possibility of developing the disease), as well as symptom onset detection for the disease, given the gait characteristics of a person. These characteristics correspond to 24 gait parameters computed from 3-D body data, provided by a Kinect v2 camera, acquired from a person while walking towards the camera. Read More

View Article and Full-Text PDF

Machine Learning Approaches to Predict Risks of Diabetic Complications and Poor Glycemic Control in Nonadherent Type 2 Diabetes.

Front Pharmacol 2021 22;12:665951. Epub 2021 Jun 22.

Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

The objective of this study was to evaluate the efficacy of machine learning algorithms in predicting risks of complications and poor glycemic control in nonadherent type 2 diabetes (T2D). This study was a real-world study of the complications and blood glucose prognosis of nonadherent T2D patients. Data of inpatients in Sichuan Provincial People's Hospital from January 2010 to December 2015 were collected. Read More

View Article and Full-Text PDF

Case Report: Intensive Inpatient Neurorehabilitation Achieves Sustained Real-World Benefits in Severe Alcohol-Related Wernicke-Korsakoff Syndrome: A Case Study With 7-Years Follow-Up.

Front Psychol 2021 16;12:693920. Epub 2021 Jun 16.

P.A.N. Zentrum für Post-Akute Neurorehabilitation, Berlin, Germany.

About 85% of survivors of acute Wernicke's Encephalopathy (WE), a frequent and serious consequence of thiamine deficiency and alcohol misuse, sustain chronic neurocognitive deficits also known as chronic Wernicke-Korsakoff syndrome (WKS). If alcoholism is combined with smoking, tobacco alcohol optic neuropathy (TAON) may occur which leads to visual impairment. In contrast to WKS, TAON may be treated successfully by early vitamin substitution and detoxification. Read More

View Article and Full-Text PDF

NMJ-Analyser identifies subtle early changes in mouse models of neuromuscular disease.

Sci Rep 2021 Jun 10;11(1):12251. Epub 2021 Jun 10.

MRC Unit for Lifelong Health and Ageing, Department of Population Science and Experimental Medicine, University College London, London, WC1E 6BT, UK.

The neuromuscular junction (NMJ) is the peripheral synapse formed between a motor neuron axon terminal and a muscle fibre. NMJs are thought to be the primary site of peripheral pathology in many neuromuscular diseases, but innervation/denervation status is often assessed qualitatively with poor systematic criteria across studies, and separately from 3D morphological structure. Here, we describe the development of 'NMJ-Analyser', to comprehensively screen the morphology of NMJs and their corresponding innervation status automatically. Read More

View Article and Full-Text PDF

Awareness of diagnosis, treatment and risk of late effects in Chinese survivors of childhood cancer in Hong Kong.

Health Expect 2021 Jun 8. Epub 2021 Jun 8.

School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Background: For survivors of childhood cancer, awareness of personal health risks is a critical component of long-term health management.

Objective: To evaluate the awareness of the diagnosis, treatment and risk of late effects among survivors of childhood cancer in Hong Kong.

Methods: Between June 2019 and March 2020, this cross-sectional study recruited 155 adult survivors (mean age = 26. Read More

View Article and Full-Text PDF

A Phase I Trial of Oxaliplatin, Irinotecan, and S-1 Combination Therapy (OX-IRIS) as Chemotherapy for Unresectable Pancreatic Cancer (HGCSG 1403).

Oncologist 2021 May 28. Epub 2021 May 28.

Division of Cancer Center, Hokkaido University Hospital, Sapporo, Japan.

Lessons Learned: Because S-1 is orally administered, OX-IRIS does not necessitate the continuous infusion of 5-FU and is more convenient. The recommended dose of OX-IRIS was determined to be level -1 (oxaliplatin, 65 mg/m ; irinotecan, 100 mg/m ; S-1, 80 mg/m ), which has manageable safety and promising anticancer activities.

Background: OX-IRIS is a new combination therapy of oxaliplatin, irinotecan, and S-1 for unresectable pancreatic ductal adenocarcinoma (PDAC), which may be beneficial because S-1 is administered orally and continuous infusion of 5-fluorouracil (5-FU) is not needed. Read More

View Article and Full-Text PDF

Modeling of Activity-Induced Changes in Signal Propagation Speed of Mechano-Electrically Stimulated Nerve Fiber.

Stud Health Technol Inform 2021 May;281:93-97

Institute of Medical Informatics, Medical Faculty, RWTH Aachen University, Aachen, Germany.

One of the important questions in the research on neural coding is how the preceding axonal activity affects the signal propagation speed of the following one. We present an approach to solving this problem by introducing a multi-level spike count for activity quantification and fitting a family of linear regression models to the data. The best-achieved score is R2=0. Read More

View Article and Full-Text PDF

Predictive variables for peripheral neuropathy in treated HIV-1 infection revealed by machine learning.

AIDS 2021 May 24. Epub 2021 May 24.

Departments of Mathematical & Statistical Sciences Medicine University of Alberta, Edmonton AB; Departments of Medicine Psychiatry Microbiology, Immunology & Infectious Diseases University of Calgary, Calgary, AB. Department of Public Health Sciences Canadian Cancer Trials Group, Queen's University, Kingston, ON Canada.

Objective: Peripheral neuropathies in HIV-infected patients are highly debilitating because of neuropathic pain and physical disabilities. We defined prevalence and associated predictive variables for peripheral neuropathy subtypes in a cohort of persons living with HIV (PWH).

Design: Adult PWH in clinical care were recruited to a longitudinal study examining neurological complications. Read More

View Article and Full-Text PDF

Prevalence and incidence of diabetic peripheral neuropathy in Latin America and the Caribbean: A systematic review and meta-analysis.

PLoS One 2021 13;16(5):e0251642. Epub 2021 May 13.

Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima, Perú.

Aims: The objective of this systematic review and meta-analysis is to estimate the prevalence and incidence of diabetic peripheral neuropathy (DPN) in Latin America and the Caribbean (LAC).

Materials And Methods: We searched MEDLINE, SCOPUS, Web of Science, EMBASE and LILACS databases of published observational studies in LAC up to December 2020. Meta-analyses of proportions were performed using random-effects models using Stata Program 15. Read More

View Article and Full-Text PDF

Literature Commentary.


J Neuroophthalmol 2020 Sep;40(3):434-441

In this issue of Journal of Neuro-Ophthalmology, M. Tariq Bhatti, MD, and Mark L. Moster, MD will discuss the following 6 articles: Powell G, Derry-Sumner H, Rajenderkumar D, Rushton SK, Sumner P. Read More

View Article and Full-Text PDF
September 2020

Treatment for diabetic peripheral neuropathy: What have we learned from animal models?

Mark Yorek

Curr Diabetes Rev 2021 May 3. Epub 2021 May 3.

Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242 . United States.

Introduction: Animal models have been widely used to investigate the etiology and potential treatments for diabetic peripheral neuropathy. What we have learned from these studies and the extent that this information has been adaptable to the human condition will be the subject of this review article.

Methods: A comprehensive search of the PubMed database was performed, and relevant articles on the topic were included in this review. Read More

View Article and Full-Text PDF

Diabetic foot complications-lessons learned from real-world data derived from a specialized Austrian hospital.

Wien Klin Wochenschr 2021 May 3. Epub 2021 May 3.

Research Unit for Diabetes Epidemiology, Department of Public Health, Health Services Research and Health Technology Assessment, UMIT-Private University for Health Sciences, Medical Informatics and Technology, Hall i.T., Austria.

Background: Diabetic foot complications, one of the most severe late complications of type 2 diabetes mellitus, are associated with a tremendous personal and financial burden. In order to drive the prevention of diabetic foot complications forward and facilitate early detection and personalized screening of high-risk patients, longitudinal studies are needed to identify risk factors associated with diabetic foot complications in large patient datasets.

Methods: This is a retrospective cohort study on 3002 patients with type 2 diabetes mellitus aged ≥ 18 years without prior foot complications. Read More

View Article and Full-Text PDF

Performance Analysis of Conventional Machine Learning Algorithms for Diabetic Sensorimotor Polyneuropathy Severity Classification.

Diagnostics (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Department Electrical and Electronic Engineering, Xiamen University Malaysia, Bandar Sunsuria, Sepang 43900, Selangor, Malaysia.

Background: Diabetic peripheral neuropathy (DSPN), a major form of diabetic neuropathy, is a complication that arises in long-term diabetic patients. Even though the application of machine learning (ML) in disease diagnosis is a very common and well-established field of research, its application in diabetic peripheral neuropathy (DSPN) diagnosis using composite scoring techniques like Michigan Neuropathy Screening Instrumentation (MNSI), is very limited in the existing literature.

Method: In this study, the MNSI data were collected from the Epidemiology of Diabetes Interventions and Complications (EDIC) clinical trials. Read More

View Article and Full-Text PDF

Pretreatment with High Mobility Group Box-1 Monoclonal Antibody Prevents the Onset of Trigeminal Neuropathy in Mice with a Distal Infraorbital Nerve Chronic Constriction Injury.

Molecules 2021 Apr 2;26(7). Epub 2021 Apr 2.

Department of Pharmacology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan.

Persistent pain following orofacial surgery is not uncommon. High mobility group box 1 (HMGB1), an alarmin, is released by peripheral immune cells following nerve injury and could be related to pain associated with trigeminal nerve injury. Distal infraorbital nerve chronic constriction injury (dIoN-CCI) evokes pain-related behaviors including increased facial grooming and hyper-responsiveness to acetone (cutaneous cooling) after dIoN-CCI surgery in mice. Read More

View Article and Full-Text PDF

Painless foot drop: an unusual acute presentation of new onset type 1 diabetes mellitus.

Endocrinol Diabetes Metab Case Rep 2021 Mar 16;2021. Epub 2021 Mar 16.

Department of Diabetes and Endocrinology, Guy's and St Thomas' NHS Foundation trust, London, UK and School of Cardiovascular Medicine and Sciences, King's College London UK.

Summary: A 26-year-old Caucasian female with no past medical history or family history of auto-immune disease presented to the emergency department with new onset painless left foot drop. A panel of blood tests revealed blood glucose of 49.9 mmol/L and raised blood ketone levels. Read More

View Article and Full-Text PDF

Assessment and prediction of restless leg syndrome (RLS) in patients with diabetes mellitus type II through artificial intelligence (AI).

Pak J Pharm Sci 2020 Sep;33(5(Special)):2399-2403

Department of Medicine, King Edward Medical University (KEMU), Mayo Hospital Lahore Pakistan.

This study aimed to diagnose the incidence of restless leg syndrome (RLS) in patients with diabetes mellitus (DM) type-2, thorough artificial intelligence based multilayer perceptron (MLP). 300 cases of diabetes mellitus type-2, of age between 18-80 years were included. Point-biserial correlation/Pearson Chi-Square correlations were conducted between RLS and risk factors. Read More

View Article and Full-Text PDF
September 2020

Drugmonizome and Drugmonizome-ML: integration and abstraction of small molecule attributes for drug enrichment analysis and machine learning.

Database (Oxford) 2021 03;2021

Department of Pharmacological Sciences; Mount Sinai Center for Bioinformatics; Big Data to Knowledge, Library of Integrated Network-Based Cellular Signatures, Data Coordination and Integration Center (BD2K-LINCS DCIC); Knowledge Management Center for Illuminating the Druggable Genome (KMC-IDG); Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, Box 1603, New York, NY 10029, USA.

Understanding the underlying molecular and structural similarities between seemingly heterogeneous sets of drugs can aid in identifying drug repurposing opportunities and assist in the discovery of novel properties of preclinical small molecules. A wealth of information about drug and small molecule structure, targets, indications and side effects; induced gene expression signatures; and other attributes are publicly available through web-based tools, databases and repositories. By processing, abstracting and aggregating information from these resources into drug set libraries, knowledge about novel properties of drugs and small molecules can be systematically imputed with machine learning. Read More

View Article and Full-Text PDF

Development and evaluation of a deep learning model for the detection of multiple fundus diseases based on colour fundus photography.

Br J Ophthalmol 2021 Mar 30. Epub 2021 Mar 30.

Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

Aim: To explore and evaluate an appropriate deep learning system (DLS) for the detection of 12 major fundus diseases using colour fundus photography.

Methods: Diagnostic performance of a DLS was tested on the detection of normal fundus and 12 major fundus diseases including referable diabetic retinopathy, pathologic myopic retinal degeneration, retinal vein occlusion, retinitis pigmentosa, retinal detachment, wet and dry age-related macular degeneration, epiretinal membrane, macula hole, possible glaucomatous optic neuropathy, papilledema and optic nerve atrophy. The DLS was developed with 56 738 images and tested with 8176 images from one internal test set and two external test sets. Read More

View Article and Full-Text PDF

Somatosensory network functional connectivity differentiates clinical pain phenotypes in diabetic neuropathy.

Diabetologia 2021 Jun 25;64(6):1412-1421. Epub 2021 Mar 25.

Department of Oncology and Human Metabolism, University of Sheffield, Sheffield, UK.

Aims/hypothesis: The aim of this work was to investigate whether different clinical pain phenotypes of diabetic polyneuropathy (DPN) are distinguished by functional connectivity at rest.

Methods: This was an observational, cohort study of 43 individuals with painful DPN, divided into irritable (IR, n = 10) and non-irritable (NIR, n = 33) nociceptor phenotypes using the German Research Network of Neuropathic Pain quantitative sensory testing protocol. In-situ brain MRI included 3D T1-weighted anatomical and 6 min resting-state functional MRI scans. Read More

View Article and Full-Text PDF

Chronic pain and cognitive impairment: a cross-sectional study in people living with HIV.

AIDS Care 2021 Mar 19:1-14. Epub 2021 Mar 19.

Pain Research Group, Department of Surgery & Cancer, Imperial College London, London, UK.

Cognitive impairment and chronic pain are amongst the most prevalent neurological sequelae of HIV infection, yet little is understood about the potential bidirectional relationship between the two conditions. Cognitive dysfunction can occur in chronic pain populations whilst those with cognitive impairment can display modified responses to experimentally induced painful stimuli. To date, this has not been explored in HIV cohorts. Read More

View Article and Full-Text PDF

Hybrid artificial fish particle swarm optimizer and kernel extreme learning machine for type-II diabetes predictive model.

Med Biol Eng Comput 2021 Apr 18;59(4):841-867. Epub 2021 Mar 18.

Department of Information Technology, K S Rangasamy College of Engineering, Tiruchengode, India.

The World Health Organization (WHO) estimated that in 2016, 1.6 million deaths caused were due to diabetes. Precise and on-time diagnosis of type-II diabetes is crucial to reduce the risk of various diseases such as heart disease, stroke, kidney disease, diabetic retinopathy, diabetic neuropathy, and macrovascular problems. Read More

View Article and Full-Text PDF

Serum Biomarkers in Neuro-Ophthalmology: When to Test.

Semin Ophthalmol 2021 May 10;36(4):322-328. Epub 2021 Mar 10.

Department of Ophthalmology, Harvard Medical School, Boston.

Discovery and characterization of serologic biomarkers has revolutionized the diagnostic framework of systemic and paraneoplastic autoimmune neuro-ophthalmic diseases. Expanding recognition of the multiple ocular and visual manifestations of these conditions highlights the important role of the referring provider in identifying potential cases. Increasing ease of access to serologic testing also enables these practitioners to initiate the diagnostic work-up in suspected cases. Read More

View Article and Full-Text PDF

Toward Machine-Learning-Based Decision Support in Diabetes Care: A Risk Stratification Study on Diabetic Foot Ulcer and Amputation.

Front Med (Lausanne) 2020 18;7:601602. Epub 2021 Feb 18.

Steno Diabetes Center, Copenhagen, Denmark.

Diabetes mellitus is associated with serious complications, with foot ulcers and amputation of limbs among the most debilitating consequences of late diagnosis and treatment of foot ulcers. Thus, prediction and on-time treatment of diabetic foot ulcers (DFU) are of great importance for improving and maintaining patients' quality of life and avoiding the consequent socio-economical burden of amputation. In this study, we use Danish national registry data to understand the risk factors of developing diabetic foot ulcers and amputation among patients with diabetes. Read More

View Article and Full-Text PDF
February 2021

Sonographic evaluation of leprosy of ulnar nerve.

Radiol Case Rep 2021 May 24;16(5):1057-1060. Epub 2021 Feb 24.

Hamad Medical Corporation, Doha, Qatar.

Leprosy is a chronic granulomatous infection caused by Mycobacterium Leprae that predominantly affects the skin and peripheral nerves. The disease is prevalent in developing countries of Asia and Africa, with occasional cases reported from United States. In this case report we highlight a 33-year-old man from Qatar, who presented with symptoms of progressive weakness in his left wrist and hand for six months and was later found to have a granuloma of the ulnar nerve secondary to leprosy. Read More

View Article and Full-Text PDF

Segmentation Approaches for Diabetic Foot Disorders.

Sensors (Basel) 2021 Jan 30;21(3). Epub 2021 Jan 30.

IACTEC Medical Technology Group, Instituto de Astrofísica de Canarias (IAC), 38205 San Cristóbal de La Laguna, Spain.

Thermography enables non-invasive, accessible, and easily repeated foot temperature measurements for diabetic patients, promoting early detection and regular monitoring protocols, that limit the incidence of disabling conditions associated with diabetic foot disorders. The establishment of this application into standard diabetic care protocols requires to overcome technical issues, particularly the foot sole segmentation. In this work we implemented and evaluated several segmentation approaches which include conventional and Deep Learning methods. Read More

View Article and Full-Text PDF
January 2021

Combining In Vivo Corneal Confocal Microscopy With Deep Learning-Based Analysis Reveals Sensory Nerve Fiber Loss in Acute Simian Immunodeficiency Virus Infection.

Cornea 2021 May;40(5):635-642

Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD.

Purpose: To characterize corneal subbasal nerve plexus features of normal and simian immunodeficiency virus (SIV)-infected macaques by combining in vivo corneal confocal microscopy (IVCM) with automated assessments using deep learning-based methods customized for macaques.

Methods: IVCM images were collected from both male and female age-matched rhesus and pigtailed macaques housed at the Johns Hopkins University breeding colony using the Heidelberg HRTIII with Rostock Corneal Module. We also obtained repeat IVCM images of 12 SIV-infected animals including preinfection and 10-day post-SIV infection time points. Read More

View Article and Full-Text PDF

Wide-Range Measurement of Thermal Preference-A Novel Method for Detecting Analgesics Reducing Thermally-Evoked Pain in Mice.

Molecules 2021 Jan 25;26(3). Epub 2021 Jan 25.

Faculty of Electrical and Computer Engineering, Cracow University of Technology, 24 Warszawska St., 31-155 Krakow, Poland.

Background: Wide use of oxaliplatin as an antitumor drug is limited by severe neuropathy with pharmacoresistant cold hypersensitivity as the main symptom. Novel analgesics to attenuate cold hyperalgesia and new methods to detect drug candidates are needed.

Methods: We developed a method to study thermal preference of oxaliplatin-treated mice and assessed analgesic activity of intraperitoneal duloxetine and pregabalin used at 30 mg/kg. Read More

View Article and Full-Text PDF
January 2021

Tau associated peripheral and central neurodegeneration: Identification of an early imaging marker for tauopathy.

Neurobiol Dis 2021 Apr 19;151:105273. Epub 2021 Jan 19.

Department of Pathology, University of California San Diego, USA. Electronic address:

Pathological hyperphosphorylated tau is a key feature of Alzheimer's disease (AD) and Frontotemporal dementia (FTD). Using transgenic mice overexpressing human non-mutated tau (htau mice), we assessed the contribution of tau to peripheral and central neurodegeneration. Indices of peripheral small and large fiber neuropathy and learning and memory performances were assessed at 3 and 6 months of age. Read More

View Article and Full-Text PDF

An objective structural and functional reference standard in glaucoma.

Sci Rep 2021 Jan 18;11(1):1752. Epub 2021 Jan 18.

Vision, Imaging and Performance (VIP) Laboratory, Department of Ophthalmology, Duke Eye Center, Duke University, 2351 Erwin Rd, Durham, NC, 27701, USA.

The current lack of consensus for diagnosing glaucoma makes it difficult to develop diagnostic tests derived from deep learning (DL) algorithms. In the present study, we propose an objective definition of glaucomatous optic neuropathy (GON) using clearly defined parameters from optical coherence tomography and standard automated perimetry. We then use the proposed objective definition as reference standard to develop a DL algorithm to detect GON on fundus photos. Read More

View Article and Full-Text PDF
January 2021