AIDS 2021 Jun 9. Epub 2021 Jun 9.
Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden Region Västra Götaland, Sahlgrenska University Hospital, Department of Infectious Diseases, Gothenburg, Sweden Institute of Medical Biochemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria Institute of Biological Chemistry, Biocenter, Medical University of Innsbruck, Innsbruck, Austria Mathematical Sciences, Chalmers University of Technology, Gothenburg, Sweden Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenburg, Mölndal, Sweden UK Dementia Research Institute at UCL, London, United Kingdom Department of Neurodegenerative Disease, UCL Institute of Neurology, London, United Kingdom.
Objective: Persistent immune activation in the central nervous system and systemically are common in people living with HIV (PLHIV) despite antiretroviral therapy. It is not known whether this is generated by HIV replication or other components such as coinfections and lifestyle-related factors.
Design: To determine the importance of different factors, it is crucial to find well-matched HIV-negative controls. Read More