86,703 results match your criteria neurological complications

Efficacy of polyester bands placed under the transverse vertebral process for the correction of adolescent idiopathic scoliosis : A case series of 105 patients with a minimum of 24 months follow-up.

Eur Spine J 2021 Apr 21. Epub 2021 Apr 21.

Service de Chirurgie Orthopédique Pédiatrique, Hôpital Gatien de Clocheville, CHRU de Tours, Tours, 37044 Tours Cedex 9, France.

Purpose: To report an original technique for the surgical correction of adolescent idiopathic scoliosis (AIS) based on hybrid construct using polyester bands placed under the thoracic transverse processes.

Methods: We reviewed 105 patients operated between 2013 to 2017 for AIS with a minimum of 2 years follow-up. Clinical and radiological data, including 2D measurements of scoliosis parameters preoperatively, and at 3- and 24-months postoperatively were analyzed. Read More

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Early-Onset Multiple Sclerosis With Frequent Relapses: A Challenging Diagnosis With a Less Favorable Prognosis.

Cureus 2021 Mar 18;13(3):e13963. Epub 2021 Mar 18.

Paediatrics, Base Hospital Mahaoya, Mahaoya, LKA.

Pediatric multiple sclerosis (MS) is a rare demyelinating disease of the brain, spinal cord, and optic nerve caused by immune modulators mediating against the neuronal axons of the central nervous system. MS is usually characterized by a series of neurological events, without any features of encephalopathy, separated in time and space. The complications arise from the permanent degeneration of the nerves. Read More

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Natalizumab, Fingolimod and Dimethyl Fumarate Use and Pregnancy-Related Relapse and Disability in Women With Multiple Sclerosis.

Neurology 2021 Apr 20. Epub 2021 Apr 20.

Department of Neuroscience, Central Clinical School, Monash University, Melbourne, Victoria, Australia

Objective: To investigate pregnancy-related disease activity in a contemporary multiple sclerosis (MS) cohort.

Methods: Using data from the MSBase Registry, we included pregnancies conceived after 31 Dec 2010 from women with relapsing-remitting MS or clinically isolated syndrome. Predictors of intrapartum relapse, and postpartum relapse and disability progression were determined by clustered logistic regression or Cox regression analyses. Read More

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Retrograde inferior vena caval perfusion for total aortic arch replacement surgery: a randomized pilot study.

BMC Cardiovasc Disord 2021 Apr 20;21(1):193. Epub 2021 Apr 20.

Department of Anesthesiology, West China Hospital, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, Sichuan, China.

Objectives: Antegrade cerebral perfusion (ACP) under moderate hypothermic circulatory arrest is used during total aortic arch replacement surgery (TARS) in patients with acute type A aortic dissection, but it is associated with high mortality and morbidity. We hypothesized that combining ACP with retrograde inferior vena caval perfusion (RIVP) improves outcomes.

Methods: This pilot study was prospective, randomized, controlled and assessor-blinded. Read More

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The Fate of Proximal Junctional Vertebral Fractures after Long-Segment Spinal Fixation : Are There Predictable Radiologic Characteristics for Revision surgery?

J Korean Neurosurg Soc 2021 Apr 21. Epub 2021 Apr 21.

Department of Neurosurgery, Gangnam Severance Hospital, Spine and Spinal Cord Institute, Yonsei University College of Medicine, Seoul, Korea.

Objective: To investigate the radiographic characteristics of the uppermost instrumented vertebrae (UIV) and UIV+1 compression fractures that are predictive of revision surgery following long-segment spinal fixation.

Methods: A total 27 patients who presented newly developed compression fracture at UIV, UIV+1 after long segment spinal fixation (minimum 5 vertebral bodies, lowest instrumented vertebra of L5 or distal) were reviewed retrospectively. Patients were divided into two groups according to following management : revisional surgery (group A, n=13) and conservative care (group B, n=14). Read More

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Long-term cognitive outcome after radiosurgery in epileptic hypothalamic hamartomas and review of the literature.

Epilepsia 2021 Apr 20. Epub 2021 Apr 20.

Department of Functional and Stereotactic Neurosurgery and Gamma Knife Radiosurgery, Timone University Hospital, Aix-Marseille University, Marseille, France.

Objective: Epileptic patients with hypothalamic hamartoma (HH) frequently present cognitive impairments. Surgical techniques aiming at HH can be very efficient for epilepsy relief and cognitive improvement but are also demonstrated to carry a significant risk of additional reduction in memory function in these already disabled patients. Gamma knife radiosurgery (GKS) offers an efficient minimally invasive procedure. Read More

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Intracranial aneurysms in pediatric population: a two-center audit.

Childs Nerv Syst 2021 Apr 20. Epub 2021 Apr 20.

Department of Neurosurgery, Rouen University Hospital, 1 rue de Germont, 76000, Rouen, France.

Objective: Intracranial aneurysms (IA) in children are rare, accounting for less than 5% of all IA. Due to their scarcity, the epidemiology is poorly understood and differs from adults in term of clinical presentation, size, location, and origin. Consequently, the treatment strategies are specific and cannot be only based on data from adult series. Read More

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Severe allo-immune antibody-associated peripheral and central nervous system diseases after allogeneic hematopoietic stem cell transplantation.

Sci Rep 2021 Apr 19;11(1):8527. Epub 2021 Apr 19.

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

Allogeneic hematopoietic stem cell transplantation (alloHSCT) is a curative treatment for hematologic malignancies. Acute and chronic graft-versus-host disease (GvHD) are the major immune-mediated complications after alloHSCT. However, there is controversy whether neurologic complications after alloHSCT might represent manifestations of GvHD. Read More

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Spinal anesthesia in a patient on monoclonal antibody treatment: a poisoned chalice? A case report.

Reg Anesth Pain Med 2021 Apr 19. Epub 2021 Apr 19.

Anesthesiology, Imeldaziekenhuis, Bonheiden, Belgium

Background: Paraplegia is a rare complication of spinal anesthesia.

Case Presentation: We report a case of a 68-year-old man who developed postoperative paraplegia and hypoesthesia after spinal anesthesia for an otherwise uncomplicated transurethral resection of the prostate. Acute transverse myelitis was diagnosed based on urgent MRI. Read More

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Surgery for craniovertebral junction pathologies: minimally invasive anterior submandibular retropharyngeal key-hole approach.

BMC Surg 2021 Apr 19;21(1):199. Epub 2021 Apr 19.

Department of Neurotraumatology, Semmelweis University, Fiumei út 17, 1081, Budapest, Hungary.

Background: Our objective was to develop a new, minimally invasive surgical technique for the resolution of craniovertebral junction pathologies, which can eliminate the complications of the previous methods, like liquor-leakage, velopharyngeal insufficiency and wound-dehiscence associated with the transoral or lateral approaches.

Methods: During the first stage of the operation, three patients underwent occipito-cervical dorsal fusion, while the fourth patient received C1-C2 fusion according to Harms. C1-C2 decompressive laminectomy was performed in all four cases. Read More

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Neurological complications of cancer immunotherapy.

Cancer Treat Rev 2021 Mar 23;97:102189. Epub 2021 Mar 23.

Division of Oncology, Department of Medicine I, Medical University of Vienna, Austria.

Immunotherapy has emerged as a powerful therapeutic approach in many areas of clinical oncology and hematology. The approval of ipilimumab, a monoclonal antibody targeting the immune cell receptor CTLA-4, has marked the beginning of the era of immune checkpoint inhibitors. In the meantime, numerous antibodies targeting the PD-1 pathway have expanded the class of clinically approved immune checkpoint inhibitors. Read More

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Awake epilepsy surgery in patients with focal cortical dysplasia.

World Neurosurg 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurosurgery, University Hospital "St. Ivan Rilski", Sofia, Bulgaria.

Background: Awake craniotomy (AC) and direct electrical stimulation (DES) emerged together with epilepsy surgery more than 80 years ago. The goal of our study was to evaluate the benefits of awake surgery in patients with drug-resistant epilepsy due to focal cortical dysplasia (FCD) affecting eloquent areas.

Methods: Our material included 95 patients with drug-resistant epilepsy and FCD, who were operated on between January 2009 and December 2018. Read More

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Hybrid Anterior Column Realignment - Pedicle Subtraction Osteotomy for Severe Rigid Sagittal Deformity.

World Neurosurg 2021 Apr 16. Epub 2021 Apr 16.

Department of Neurosurgery, Houston Methodist Hospital Neurological Institute 6560 Fannin Street Suite 802, Houston, TX USA 77030.

Objective: Recently, a hybrid anterior column realignment-pedicle subtraction osteotomy (ACR-PSO) approach has been conceived for patients with severe rigid sagittal deformity, the clinical and radiographic outcomes of which require further investigation compared to ACR only.

Methods: A single-center, retrospective chart review identified patients undergoing a combination of hyperlordotic lateral lumbar interbody grafting (ACR) and concurrent Schwab grade 3 three-column osteotomy and propensity-matched patients undergoing ACR only in the same timeframe. Anterior longitudinal ligament was directly released or partially sectioned in all patients. Read More

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Predictors of Medical Malpractice Outcomes After Spine Surgery: A Comprehensive Analysis From 2010 to 2019.

Clin Spine Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Orthopedic Surgery David Geffen School of Medicine, University of California, Los Angeles, CA.

Study Design: Retrospective review of spine surgery malpractice cases.

Objectives: The aim was to compare medical malpractice outcomes among different types of spine surgery and identify predictors of litigation outcomes.

Summary Of Background Data: Spine surgery is highly litigious in the United States with data suggesting favorable outcomes for defendant surgeons. Read More

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Spinal muscular atrophy: state of the art and new therapeutic strategies.

Neurol Sci 2021 Apr 19. Epub 2021 Apr 19.

Department of Child Neurology, University Policlinico Gemelli, Rome, Italy.

Spinal muscular atrophy (SMA) is a severe disorder of motor neurons and the most frequent cause of genetic mortality, due to respiratory complications. We are facing an exciting era with three available therapeutic options in a disease considered incurable for more than a century. However, the availability of effective approaches has raised up ethical, medical, and financial issues that are routinely faced by the SMA community. Read More

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Perioperative Complications in 255 Patients Who Underwent Lateral Anterior Lumbar Interbody Fusion (LaLIF) Surgery.

Eur Spine J 2021 Apr 19. Epub 2021 Apr 19.

Department of Spine Surgery, the First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan, 2nd Road, Guangzhou, 510080, Guangdong, China.

Purpose: To investigate the perioperative complications of lateral anterior lumbar interbody fusion (LaLIF) surgery.

Methods: The participants were patients who underwent LaLIF surgery for degenerative lumbar diseases between April 2016 and November 2020. The collected data were classified into intraoperative and early-stage postoperative (1 month) complications. Read More

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Propensity score-based analysis of long-term follow-up in patients supported with durable centrifugal left ventricular assist devices: the EUROMACS analysis.

Eur J Cardiothorac Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic.

Objectives: The HeartWare HVAD (HW) and the HeartMate3 (HM3) are presently the most commonly used continuous-flow left ventricular assist devices worldwide. We compared the outcomes of patients supported with either of these 2 devices based on data from the EUROMACS (European Registry for Patients with Mechanical Circulatory Support).

Methods: A retrospective analysis of the survival and complications profile in propensity score-matched adult patients enrolled in the EUROMACS between 01 January 2016 and 01 September 2020 and supported with either an HW or HM3. Read More

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Enterovirus-A71 exploits peripherin and Rac1 to invade the central nervous system.

EMBO Rep 2021 Apr 19:e51777. Epub 2021 Apr 19.

Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Enterovirus-A71 (EV-A71) has been associated with severe neurological forms of hand, foot, and mouth disease (HFMD). EV-A71 infects motor neurons at neuromuscular junctions (NMJs) to invade the central nervous system (CNS). Here, we investigate the role of peripherin (PRPH) during EV-A71 infection, a type III intermediate neurofilament involved in neurodegenerative conditions. Read More

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Extracorporeal Membrane Oxygenation Utilization in Blunt and Penetrating Traumatic Injuries: A Systematic Review.

Am Surg 2021 Apr 18:31348211011112. Epub 2021 Apr 18.

Department of Surgery, Division of Trauma and Surgical Critical Care, 14506Kendall Regional Medical Center, Miami, FL, USA.

Background: Extracorporeal membrane oxygenation (ECMO) has become an increasingly used treatment modality for severe respiratory insufficiency in trauma patients. Examining ECMO use specifically in blunt and penetrating traumas can aid in directing future protocols. We aim to evaluate the outcomes of ECMO use in both blunt and penetrating trauma patients through a systematic review of current literature. Read More

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Delayed post-traumatic Tension Hydropneumocephalus; a Case Report of Conservative Treatment.

Arch Acad Emerg Med 2021 27;9(1):e22. Epub 2021 Feb 27.

Emergency Department; Rajaei Hospital, Medical Faculty, Qazvin University of Medical Science, Qazvin, Iran.

Pneumocephalus refers to the presence of air in the cranial cavity. Trauma is the most common cause of acquired pneumocephalus. Tension pneumocephalus occurs when intracranial accumulation of air causes high pressure on the brain as compared to extracranial pressure. Read More

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February 2021

Hypophosphatasia: A Case of Two Patients With Spinal Cord Compression From Increase in Ligamentous Ossifications During Treatment.

JBMR Plus 2021 Apr 5;5(4):e10449. Epub 2021 Mar 5.

Centre de Rhumatologie du Centre Hospitalo-Universitaire de Toulouse [Rheumatology Center of Toulouse University Hospital] Toulouse France.

Treatment with asfotase alfa has transformed the prognosis of hypophosphatasia in children and improves the bone and muscle signs in adults. The doses used in adults are the same as in children, whereas bone remodeling is different between them. We report on the cases of two patients treated with 1 mg/kg/day of asfotase alfa who developed spinal cord compression from spinal ossifications during treatment. Read More

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Challenge for management without tracheostomy tube after laryngo-tracheal separation in children with neurological disorders.

Laryngoscope Investig Otolaryngol 2021 Apr 6;6(2):332-339. Epub 2021 Feb 6.

Department of General Pediatrics and Interdisciplinary medicine National Center for Child Health and Development Tokyo Japan.

Objectives: The present study analyzed surgical outcomes of laryngotracheal separation (LTS) in children with neurological disorders. The purpose of this study was to investigate respiratory impairment and severe complications after LTS in children, and identify the possibility of permanent tracheostomy without a tracheostomy tube as the safest respiratory management method.

Methods: Twenty-eight patients (male:female = 16:12) with neurological disorders (6 months to 32 years) who underwent LTS between January 2012 and April 2018 were reviewed. Read More

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Alterations of frontal-temporal gray matter volume associate with clinical measures of older adults with COVID-19.

Neurobiol Stress 2021 Apr 13:100326. Epub 2021 Apr 13.

Department of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, USA.

COVID-19, the infectious disease caused by the most recently discovered severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a global pandemic. It dramatically affects people's health and daily life. Neurological complications are increasingly documented for patients with COVID-19. Read More

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Interspinous Process (ISP) Devices in Comparison to the Use of Traditional Posterior Spinal Instrumentation.

Cureus 2021 Mar 14;13(3):e13886. Epub 2021 Mar 14.

Neurosurgery, Hoag Memorial Hospital, Newport Beach, USA.

A systematic literature review was conducted on studies comparing interspinous process (ISP) devices to traditional methods of posterior spinal instrumentation (pedicle screw-rod construct), in terms of indications of use, complications, pain assessment, estimated blood loss, length of hospital stay, reoperation rates, and return to work. The objective was to analyze, evaluate and summarize the current published literature on the proposed efficacy and clinical and surgical long-term outcomes of the ISP device in comparison to the traditional posterior spinal instrumentation (pedicle screw-rod construct). The ISP device is a minimally invasive and less disruptive alternative to traditional methods of posterior spinal instrumentation (pedicle screw-rod construct). Read More

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Bell's Palsy as a Late Neurologic Manifestation of COVID-19 Infection.

Cureus 2021 Mar 14;13(3):e13881. Epub 2021 Mar 14.

Internal Medicine, Reading Hospital - Tower health, West Reading, USA.

Bell's palsy is acute peripheral facial nerve palsy; its cause is often unknown but it can be triggered by acute viral infection. Coronavirus disease 2019 (COVID-19) infection commonly presents with respiratory symptoms, but neurologic complications have been reported. A few studies have reported the occurrence of facial nerve palsy during the COVID-19 pandemic. Read More

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Severe Form of Bacterial Meningitis After Spine Surgery: A Case Report and Review of the Literature.

Cureus 2021 Mar 14;13(3):e13877. Epub 2021 Mar 14.

Orthopaedics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, IND.

Meningitis after spine surgery is a rare complication. In this report, we aim to discuss the case of a male patient who developed this rare condition after undergoing cervical spine surgery with devastating outcomes. We also engage in a review of the relevant literature. Read More

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Neurological Outcomes of Patients With Mycotic Aneurysms in Infective Endocarditis.

Neurohospitalist 2021 Jan 15;11(1):5-11. Epub 2020 Jun 15.

Division of Vascular Neurology, Department of Neurology, Columbia University Irving Medical Center, New York, NY, USA.

Background And Purpose: Mycotic aneurysms (MA) are rare neurovascular complications of infective endocarditis (IE). The natural history and outcomes of MA under contemporary medical therapy have not been well characterized. The purpose of this study is to describe treatments and outcomes of patients with ruptured and unruptured MA in IE, specifically in relation to medical versus surgical/endovascular treatment. Read More

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January 2021

Case Report: Successful Cerebral Revascularization and Cardiac Transplant in a 16-Year-Old Male With Syndromic -Related Moyamoya Angiopathy.

Front Neurol 2021 30;12:655303. Epub 2021 Mar 30.

Pediatric Cardiology Unit, Department of Pediatrics, Children's Hospital, Toulouse University Hospital, Toulouse, France.

deletions are associated with a rare familial moyamoya angiopathy with extracranial manifestations. We report the case of an adolescent male presenting with progressive and symptomatic moyamoya angiopathy and severe dilated cardiomyopathy caused by a hemizygous deletion of . He was treated for renovascular hypertension by left kidney homograft and right nephrectomy in infancy and had other syndromic features, including cryptorchidism, growth hormone deficiency, and facial dysmorphism. Read More

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Glycated Hemoglobin as a Marker for Predicting Outcomes of Patients With Stroke (Ischemic and Hemorrhagic): A Systematic Review and Meta-Analysis.

Yaya Bao Dadong Gu

Front Neurol 2021 31;12:642899. Epub 2021 Mar 31.

Department of Neurology, Zhuji Affiliated Hospital of Shaoxing University, Zhuji, China.

Glycated hemoglobin (HbA1c) has emerged as a useful biochemical marker reflecting the average glycemic control over the last 3 months, and the values are not affected by short-term transient changes in blood glucose levels. However, its prognostic value in the acute neurological conditions such as stroke is still not well-established. The present meta-analysis was conducted to assess the relationship of HbA1c with outcomes such as mortality, early neurological complications, and functional dependence in stroke patients. Read More

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Telemonitoring of Patients With Chronic Traumatic Brain Injury: A Pilot Study.

Front Neurol 2021 1;12:598777. Epub 2021 Apr 1.

Sant'Anna Institute, Crotone, Italy.

Telehealth systems have shown success in the remote management of several neurological disorders, but there is a paucity of evidence in disorders of consciousness (DOC). In this study, we explore the effectiveness of a new telemonitoring system, for monitoring Vegetative State (VS) and Minimally Conscious State (MCS) patients. This was a prospective, mono-center randomized controlled study. Read More

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