1,183,798 results match your criteria neurologic manifestations


Clinical, Immunological, and Genetic Features in 938 Patients with Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED): a Systematic Review.

Expert Rev Clin Immunol 2021 May 6. Epub 2021 May 6.

Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.

Background: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a rare inborn immune error associated with the autoimmune regulator () gene mutation. It is classically characterized by a triad of chronic mucocutaneous candidiasis (CMC), hypoparathyroidism (HP), and adrenal insufficiency (ADI).

Methods: Literature search was conducted in PubMed, Web of Science, and Scopus databases using related keywords, and included studies were systematically evaluated. Read More

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Anxiety-Related Adverse Event Clusters After Janssen COVID-19 Vaccination - Five U.S. Mass Vaccination Sites, April 2021.

MMWR Morb Mortal Wkly Rep 2021 May 7;70(18):685-688. Epub 2021 May 7.

CDC COVID-19 Response Team.

On April 7, 2021, after 5 weeks' use of the Janssen COVID-19 vaccine under the Food and Drug Administration (FDA) Emergency Use Authorization (EUA), CDC received reports of clusters of anxiety-related events after administration of Janssen COVID-19 vaccine from five mass vaccination sites, all in different states. To further investigate these cases, CDC interviewed vaccination site staff members to gather additional information about the reported events and vaccination site practices. Four of the five sites temporarily closed while an investigation took place. Read More

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Hyperammonemia Syndrome Associated with Ureaplasma spp. Infections in Immunocompromised Patients and Transplant Recipients: A Systematic Review and Meta-Analysis.

Clin Transplant 2021 May 4:e14334. Epub 2021 May 4.

College of Medicine, University of the Philippines Manila, Taft Ave, Manila, Philippines.

Background: Hyperammonemia syndrome (HS) is reported to occur in patients with Ureaplasma spp. infections. We performed a systematic review and meta-analysis of studies reporting HS in patients with Ureaplasma spp. Read More

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COVID-19 Related Acute Hemorrhagic Necrotizing Encephalitis: A Report of Two Cases and Literature Review.

Cureus 2021 Apr 1;13(4):e14236. Epub 2021 Apr 1.

Medicine/Neurological Intensive Care, Prisma Health Greenville Memorial Hospital, Greenville, USA.

Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus, has proven neurotropism and causes a multitude of neurologic manifestations. Acute hemorrhagic necrotizing encephalitis (AHNE), though rare, can be seen in patients with severe infection and is associated with devastating neurologic outcomes. The true prevalence of this syndrome is unknown due to underrecognition, difficulty in timely acquisition of neuroimaging, and high mortality in this subset of patients escaping detection. Read More

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A Systematic Review of Urban Navigation Systems for Visually Impaired People.

Sensors (Basel) 2021 Apr 29;21(9). Epub 2021 Apr 29.

School of Computer Science, Technological University Dublin, D07EWV4 Dublin, Ireland.

Blind and Visually impaired people (BVIP) face a range of practical difficulties when undertaking outdoor journeys as pedestrians. Over the past decade, a variety of assistive devices have been researched and developed to help BVIP navigate more safely and independently. In addition, research in overlapping domains are addressing the problem of automatic environment interpretation using computer vision and machine learning, particularly deep learning, approaches. Read More

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People Lifting Patterns-A Reference Dataset for Practitioners.

Sensors (Basel) 2021 Apr 30;21(9). Epub 2021 Apr 30.

R&D Center, Polish-Japanese Academy of Information Technology, 02-008 Warszawa, Poland.

Many health professionals do not use correct person transfer techniques in their daily practice. This results in damage to the paraspinal musculature over time, resulting in lower back pain and injuries. In this work, we propose an approach for the accurate multimodal measurement of people lifting and related motion patterns for ergonomic education regarding the application of correct patient transfer techniques. Read More

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Sensor Validation and Diagnostic Potential of Smartwatches in Movement Disorders.

Sensors (Basel) 2021 Apr 30;21(9). Epub 2021 Apr 30.

Institute of Geophysics, University of Münster, 48149 Münster, Germany.

Smartwatches provide technology-based assessments in Parkinson's Disease (PD). It is necessary to evaluate their reliability and accuracy in order to include those devices in an assessment. We present unique results for sensor validation and disease classification via machine learning (ML). Read More

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[Multidisciplinary pelvic floor team: 5 year experience.]

Arch Esp Urol 2021 May;74(4):383-388

Servicio de Urología. Hospital Galdakao-Usansolo. Galdakao. España.

Introduction: Pelvic floor dysfunction (PFD) is expressed by many different symptoms that can affect pelvic floor organs. These symptoms can appear alone or associated. The involvement of different organs and the wide variety of symptoms we have to deal with, has become teamwork essential for diagnosis and treatment of PFD. Read More

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COVID-19 Presentation in Patients with Sickle Cell Disease: A Case Series.

Am J Case Rep 2021 May 4;22:e931758. Epub 2021 May 4.

Department of Internal Medicine, Division of Hematology, University of Texas Health Science Center, Houston, TX, USA.

BACKGROUND Certain health conditions have been proven to have an effect on the severity of COVID-19, the disease caused by SAR-COV-2. The list of identified comorbid conditions includes hematological diseases, with sickle cell disease (SCD) falling into this category. CASE REPORT This case series examines the history, presentation, and clinical course of 5 patients with SCD who tested positive for SAR-COV-2 during the spring and summer of 2020. Read More

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Tau phosphorylation and cochlear apoptosis cause hearing loss in 3×Tg-AD Mouse Model of Alzheimer's Disease.

Chin J Physiol 2021 Mar-Apr;64(2):61-71

School of Life Sciences, National Taiwan Normal University, Taipei, Taiwan.

Clinically typical dementia Alzheimer's disease (AD) is associated with abnormal auditory processing. However, possible molecular mechanisms responsible for the auditory pathology of AD patients are not known. According to our past research findings that the thresholds of auditory brainstem response, but not distortion product otoacoustic emissions, were significantly increased in AD mice from 9 months of age and thereafter. Read More

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The effect of sniffing Turkish coffee on olfactory disorders in COVID-19 patients: An experimental clinical study.

Ideggyogy Sz 2021 Mar;74(3-4):117-123

Adiyaman University, Medical Faculty, Department of Neurology, Adiyaman, Turkey.

Background And Purpose: The current study aimed to examine the effect of sniffing Turkish coffee on the sense of smell in COVID-19 patients.

Methods: This study utilized the experiment-control method. Data were collected using a patient and disease information form and the Connecticut Chemosensory Clinical Research Center (CCCRC) Test. Read More

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The visibility of the periventricular crossroads of pathways in preterm infants as a predictor of neurological outcome and occurrence of neonatal epileptic seizures.

Croat Med J 2021 Apr;62(2):165-172

Branka Bunoza, Department of Pediatrics, University Hospital Centre Zagreb, Kišpatićeva 12, 10 000 Zagreb, Croatia,

Aim: To evaluate the relationship between the neurological outcome, neonatal epileptic seizures, and signal-intensity visibility of the frontal and parietal periventricular crossroads of pathways on brain magnetic resonance imaging (MRI) in preterm infants at term-equivalent age.

Methods: The study enrolled 48 preterm infants born between 2012 and 2016. The signal-intensity characteristics of the frontal and parietal periventricular crossroads were evaluated and classified into four grades. Read More

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Anterior quadratus lumborum block for ambulatory laparoscopic cholecystectomy: a randomized controlled trial.

Croat Med J 2021 Apr;62(2):137-145

Ann-Chatrin Leonardsen, Østfold Hospital Trust, Postal box code 300, 1714 Grålum, Norway,

Aim: To explore the effects of an anterior quadratus lumborum block (QLB) on opioid consumption, pain, nausea, and vomiting (PONV) after ambulatory laparoscopic cholecystectomy.

Methods: This randomized controlled study recruited 70 patients scheduled for ambulatory laparoscopic cholecystectomy from January 2018 to March 2019. The participants were randomly allocated to one of the following groups: 1) anterior QLB (n=25) with preoperative ropivacaine 3. Read More

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Porphyria: awareness is the key to diagnosis!

Acta Clin Belg 2021 May 3:1-7. Epub 2021 May 3.

Department of General Internal Medicine, KU Leuven, Leuven, Belgium.

Porphyrias are disorders of the haem biosynthesis which are encountered infrequently and which often present themselves atypically as a combination of gastrointestinal, neurologic and/or dermatologic symptoms. Although they are primarily caused by enzyme defects, inheritance patterns are mostly not evident. Considering all of these characteristics, it is not surprising that there is a long delay between the onset of symptoms and the diagnosis of the disease, with as possible consequences impaired quality of life, irreversible neurologic damage and even death. Read More

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"Afferent and Efferent Neuro-Ophthalmic Complications of Coronavirus Disease 19".

J Neuroophthalmol 2021 Apr 24. Epub 2021 Apr 24.

Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, University of Iowa Carver College of Medicine, Iowa City, Iowa Department of Ophthalmology Department of Neurology, New York- Presbyterian Hospital, Weill Cornell Medical College, New York City, New York Department of Ophthalmology, Massachusetts Eye & Ear Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Purpose: To provide a summary of the neuro-ophthalmic manifestations of coronavirus disease 19 (COVID-19) documented in the literature thus far.

Methods: The PubMed and Google Scholar databases were searched using the keywords: Neuro-Ophthalmology, COVID-19, SARS-CoV-2, coronavirus. A manual search through reference lists of relevant articles was also performed. Read More

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Peripartum management for women with opioid dependence.

Curr Opin Anaesthesiol 2021 Jun;34(3):226-232

Department of Psychiatry, University of Arkansas for Medical Sciences, Arkansas, USA.

Purpose Of Review: Opioid use disorder (OUD) in pregnancy has more than quadrupled in prevalence over the past two decades and continues to increase steadily every year. With no defined standard of care for the management of pain during the peripartum period, variability in treatment plans potentially leaves room for interrupted patient care, decreased patient satisfaction, and poorer outcomes. The impact of OUD and its management during the peripartum period has become more widely discussed over the past several years and is the focus of this review. Read More

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[Analysis on application value of Fu's subcutaneous needling for intercostal pain after surgery of osteoporotic thoracic vertebral compression fracture].

Zhen Ci Yan Jiu 2021 Apr;46(4):326-9

Department of Acupuncture and Moxibustion, Chinese Medicine Hospital of Gansu Province, Lanzhou 730000.

Objective: To observe the effect of Fu's subcutaneous needling therapy on pain degree, quality of life, serum 5-hydroxytryptamine (5-HT) and neuropeptide Y (NPY) in patients with intercostal pain after surgery for osteoporotic thoracic vertebral compression fracture (OVCF) and explore the application value of Fu's subcutaneous needling in treatment of post-operative intercostal pain.

Methods: A total of 60 patients with intercostal pain after OVCF surgery were divided into a medication group and a Fu's subcutaneous needling therapy group, with 30 cases in each group. In the medication group, zoledronic acid injection, salmon calcitonin injection, calcitonin D tablets and mecobalamin tablets were prescribed. Read More

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The Spectrum of Maculopathy in Mitochondrial DNA A3243G Mutation: A Case Series of Six Patients.

Klin Monbl Augenheilkd 2021 Apr 30;238(4):414-417. Epub 2021 Apr 30.

Ophthalmology, Jules Gonin Eye Hospital, Lausanne, Switzerland.

Background: The mitochondrial DNA (mtDNA) A3243G point mutation encompasses a heterogenous group of disorders including mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS), maternally inherited diabetes and deafness (MIDD), and, rarely, chronic progressive external ophthalmoplegia (CPEO). Regardless of the clinical phenotype, a specific retinopathy has been associated with the presence of this mitochondrial DNA mutation. We present six female patients exhibiting retinopathy of the A3243G point mutation at various stages. Read More

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Ischaemic bowel perforation secondary to a gravid uterus in a patient with treated inflammatory bowel disease and an ileoanal pouch: a case report.

Ann R Coll Surg Engl 2021 May;103(5):e151-e155

Musgrove Park Hospital, Taunton, UK.

The diagnosis of visceral perforation during pregnancy is often delayed and the management complex. A 32-year-old primigravid woman in her second trimester presented with abdominal pain and a pre-existing ileoanal pouch. Initial imaging was negative but later imaging was suggestive of serious pathology. Read More

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[Betahistine in vestibular disorders: current concepts and perspectives].

Vestn Otorinolaringol 2021 ;86(2):73-81

Federal Siberian Research Clinical Centre under the Federal Medical Biological Agency, Krasnoyarsk, Russia.

The goal of this paper is to review the pharmacological profile of betahistine and evidence for using it in the treatment of common vestibular disorders. Betahistine is a weak agonist for histamine H1 receptors and strong antagonist for histamine H3 receptors. It demonstrates the maximum benefit in different types of peripheral vertigo, especially in Meniere's disease. Read More

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[Chronic catarrhal laryngitis in singers].

Vestn Otorinolaringol 2021 ;86(2):33-37

L.I. Sverzhevskiy Research and Clinical Institute of Otorhinolaryngology of the Moscow Healthcare Department, Moscow, Russia.

The article deals with optimization of treatment policy for singers with chronic catarrhal laryngitis. The survey sample is 51 singers with chronic catarrhal laryngitis of the age from 29 to 54 and the length of time worked from 8 to 22 years. The following methods are used: anamnesis, microbiological investigation, voice evaluation according to Visual Analog Scale (VAS), microlaryngoscopy, videolaryngostroboscopy, voice acoustic analysis (MDVP Kay Pentax system), statistical processing of results. Read More

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[Strategies of hearing aids fitting for improving speech recognition in noisy environments].

Vestn Otorinolaringol 2021 ;86(2):28-32

Pavlov State Medical University, St. Petersburg, Russia.

The Aim Of The Study: To assess speech recognition in users of mono- and binaural hearing aids (HA) with dynamic environment control system (DECS).

Material And Methods: 25 HA users with symmetrical bilateral moderate to severe sensorineural hearing loss and 10 individuals with normal hearing underwent speech audiometry in a free sound field by listening to an adaptive Russian matrix sentence test with a background noise. The testing was conducted for hearing impaired patients with one and two HA. Read More

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[Assessment of the population and subpopulation composition of lymphocytes and their relationship in patients with sensorineural hearing loss].

Vestn Otorinolaringol 2021 ;86(2):16-20

East-Siberian Institute of Medical and Ecological Research, Angarsk, Russia.

Study of the role of the phenotypic composition of lymphocytes, shifts in which can cause the development of various pathological processes, including sensorineural hearing loss, is an important area of modern research. Purpose of the study. To study the population and subpopulation composition of lymphocytes and their intercellular cooperation in persons with occupational sensorineural hearing loss. Read More

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[Mobile solutions in hearing assessment].

Vestn Otorinolaringol 2021 ;86(2):4-9

Samara State Medical University of the Ministry of Health of Russia, Samara, Russia.

Purpose Of The Study: To evaluate the effectiveness of the application of the web application "Automated system of primary hearing assessment" created by us for the diagnosis of hearing impairment in different age groups.

Material And Methods: With the help of this web application, 712 patients were examined in 3 age groups: group 1 - patients aged 18 to 44 years, 196 people (average age 25.6±2. Read More

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Cardiovascular, hematological and neurosensory impact of COVID-19 and variants.

Eur Rev Med Pharmacol Sci 2021 04;25(8):3350-3364

Cardiovascular Division, Pompidou Hospital, University of Paris, Paris, France.

Objective: The purpose of this article was to review our clinical experience with COVID-19 patients observed in the Cardiovascular Division of Pompidou Hospital (University of Paris, France) and the Department of Neurology of the Eastern Piedmont University (Novara, Italy), related to the impact on the cardiovascular, hematological, and neurologic systems and sense organs.

Patients And Methods: We sought to characterize cardiovascular, hematological, and neurosensory manifestations in patients with COVID-19 and variants. Special attention was given to initial signs and symptoms to facilitate early diagnosis and therapy. Read More

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Guillain-Barre Syndrome in a Patient With Asymptomatic Coronavirus Disease 2019 Infection and Major Depressive Disorder.

Cureus 2021 Mar 28;13(3):e14161. Epub 2021 Mar 28.

Psychiatry, St. Luke's University Hospital Network, Bethlehem, USA.

Coronavirus disease 2019 (COVID-19) has had a devastating effect on all aspects of society, including the economy, healthcare, and educational institutions. One underrecognized effect of the pandemic is the decline of mental health in our communities. Studies have shown that pandemic-related stress is associated with increased depression and anxiety. Read More

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Effect of painting intervention based on Mandala-self theory on mood and physiological state in patients in preoperative waiting room.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar;46(3):293-299

Xiangya Nursing School, Central South University, Changsha 410013.

Objectives: The waiting room for surgery is an area set up to improve the surgical turnover rate, but the waiting time for surgery is uncertain. Patients are prone to negative emotions that affect their physiological state during waiting time. This study aims to explore the effect of Mandala painting intervention based on Mandala-self theory on the emotion and physiological state of patients waiting before operation. Read More

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Neuro-Ophthalmology for Internists.

Med Clin North Am 2021 May;105(3):511-529

Department of Ophthalmology, University of Pennsylvania, 51 N 39th St, Philadelphia, PA 19104, USA.

Neuro-ophthalmology is the study of the neurologic underpinnings of vision and includes a fascinating variety of disorders that span the broad spectrum of ophthalmic and neurologic disease. This subspecialty relies heavily on accurate neuroanatomic localization and examination. This article discusses neuro-ophthalmic complaints that frequently present to the internist, including acute vision loss, double vision, and unequal pupils. Read More

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Age-Related Macular Degeneration.

Med Clin North Am 2021 May 2;105(3):473-491. Epub 2021 Apr 2.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, 645 North Michigan Avenue, Suite 440, Chicago, IL 60611, USA. Electronic address:

Age-related macular degeneration (AMD) is a leading cause of blindness. The main risk factor is advancing age, with the severity of vision loss ranging from mild to severe. There is a 25% risk of early AMD and 8% risk of late AMD in patients over the age of 75, with the number of cases expected to increase because of the aging population. Read More

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