7,276 results match your criteria neurodevelopmental outcome


Adolescent thalamic inhibition leads to long-lasting impairments in prefrontal cortex function.

Nat Neurosci 2022 May 19. Epub 2022 May 19.

Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Impaired cortical maturation is a postulated mechanism in the etiology of neurodevelopmental disorders, including schizophrenia. In the sensory cortex, activity relayed by the thalamus during a postnatal sensitive period is essential for proper cortical maturation. Whether thalamic activity also shapes prefrontal cortical maturation is unknown. Read More

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Predicting age and clinical risk from the neonatal connectome.

Neuroimage 2022 May 16:119319. Epub 2022 May 16.

Centre for the Developing Brain, School of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom; Department of Forensic and Neurodevelopmental Science, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom. Electronic address:

The development of perinatal brain connectivity underpins motor, cognitive and behavioural abilities in later life. Diffusion MRI allows the characterisation of subtle inter-individual differences in structural brain connectivity. Individual brain connectivity maps (connectomes) are by nature high in dimensionality and complex to interpret. Read More

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The Use of Lanreotide in the Treatment of Congenital Hyperinsulinism.

J Clin Endocrinol Metab 2022 May 19. Epub 2022 May 19.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA.

Context: Congenital hyperinsulinism (HI) results in severe, persistent hypoglycemia and is associated with high risk of neurodevelopmental deficits. Sixty percent of HI cases are unresponsive to diazoxide, the only FDA-approved drug. Somatostatin analogs are used off-label as second line treatment; the long-acting somatostatin analogue, lanreotide, has been used to treat HI over the past decade. Read More

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Pre- and postnatal brain magnetic resonance imaging in congenital cytomegalovirus infection: a case report and a review of the literature.

BMC Pediatr 2022 May 18;22(1):293. Epub 2022 May 18.

Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium.

Background: Congenital cytomegalovirus infection (cCMV) is the most common known viral cause of neurodevelopmental delay in children. The risk of severe cerebral abnormalities and neurological sequelae is greatest when the infection occurs during the first trimester of pregnancy. Pre- and postnatal imaging can provide additional information and may help in the prediction of early neurological outcome. Read More

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Early Detection of Neurodevelopmental Disorders of Toddlers and Postnatal Depression by Mobile Health App: Observational Cross-sectional Study.

JMIR Mhealth Uhealth 2022 May 16;10(5):e38181. Epub 2022 May 16.

Service de Pédopsychiatrie, Centre Hospitalier Universitaire de Nantes, Nantes, France.

Background: Delays in the diagnosis of neurodevelopmental disorders (NDDs) in toddlers and postnatal depression (PND) in mothers are major public health issues. In both cases, early intervention is crucial.

Objective: We aimed to assess if a mobile app named Malo can reduce delay in the recognition of NDD and PND. Read More

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Epilepsy in a cohort of children with Noonan syndrome and related disorders.

Eur J Pediatr 2022 May 16. Epub 2022 May 16.

Pediatric Genetics Unit, Department of Public Health and Pediatric Sciences, Università Degli Studi Di Torino, Turin, Italy.

Noonan syndrome (NS) and related disorders encompass a phenotypically heterogeneous group of conditions due to mutations in the Ras/Mitogen-activated protein kinase pathway. The main objective of this study was to assess the presence and characteristics of epilepsy in children and adolescents affected by NS and related disorders. The study included all the patients aged 5-21 years who had been diagnosed with NS or of one of three Noonan-like syndromes (i. Read More

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White Matter Injury in Preterm Infants: Pathogenesis and Potential Therapy From the Aspect of the Gut-Brain Axis.

Front Neurosci 2022 29;16:849372. Epub 2022 Apr 29.

Department of Neonatology, Children's Hospital of Chongqing Medical University, Chongqing, China.

Very preterm infants who survive are at high risk of white matter injury (WMI). With a greater understanding of the pathogenesis of WMI, the gut microbiota has recently drawn increasing attention in this field. This review tries to clarify the possible mechanisms behind the communication of the gut bacteria and the immature brain the gut-brain axis. Read More

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Feasibility and safety of intranasally administered mesenchymal stromal cells after perinatal arterial ischaemic stroke in the Netherlands (PASSIoN): a first-in-human, open-label intervention study.

Lancet Neurol 2022 Jun;21(6):528-536

Department of Neonatology, University Medical Center, Utrecht Brain Center and Wilhelmina Children's Hospital, Utrecht University, Utrecht, Netherlands. Electronic address:

Background: Perinatal arterial ischaemic stroke (PAIS) is an important cause of neurodevelopmental disabilities. In this first-in-human study, we aimed to assess the feasibility and safety of intranasally delivered bone marrow-derived allogeneic mesenchymal stromal cells (MSCs) to treat PAIS in neonates.

Methods: In this open-label intervention study in collaboration with all neonatal intensive care units in the Netherlands, we included neonates born at full term (≥36 weeks of gestation) with MRI-confirmed PAIS in the middle cerebral artery region. Read More

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Systemic Steroids in Preventing Bronchopulmonary Dysplasia (BPD): Neurodevelopmental Outcome According to the Risk of BPD in the EPICE Cohort.

Int J Environ Res Public Health 2022 May 5;19(9). Epub 2022 May 5.

ULR 2694-METRICS, Évaluation des Technologies de Santé et des Pratiques Médicales, University Lille, CHU Lille, F-59000 Lille, France.

Background: Postnatal steroids (PNS) have been used to prevent bronchopulmonary dysplasia (BPD) in preterm infants but have potential adverse effects on neurodevelopment. These effects might be modulated by their risk of BPD. We aimed to compare patients' neurodevelopment with PNS treatment according to their risk of BPD in a European cohort. Read More

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Neurodevelopmental Outcomes of Infants <29 Weeks' Gestation Born in Canada Between 2009 and 2016.

J Pediatr 2022 May 10. Epub 2022 May 10.

Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada.

Objective: To evaluate changes in mortality or significant neurodevelopmental impairment (sNDI) in children born <29 weeks' gestation in association with national quality improvement initiatives.

Methods: This longitudinal cohort study included children born at 22 to 28 weeks' gestation who were admitted to Canadian NICUs between 2009 and 2016. Primary outcome was a composite rate of death or significant NDI (Bayley-III scores <70, severe cerebral palsy, blindness, or deafness needing amplification) at 18 to 24 months corrected age. Read More

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Increase of Parkin and ATG5 plasmatic levels following perinatal hypoxic-ischemic encephalopathy.

Sci Rep 2022 May 12;12(1):7795. Epub 2022 May 12.

Department of Medical Sciences, Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Via Fossato di Mortara 70, 44121, Ferrara, Italy.

Brain injury at birth is an important cause of neurological and behavioral disorders. Hypoxic-ischemic encephalopathy (HIE) is a critical cerebral event occurring acutely or chronically at birth with high mortality and morbidity in newborns. Therapeutic strategies for the prevention of brain damage are still unknown, and the only medical intervention for newborns with moderate-to-severe HIE is therapeutic hypothermia (TH). Read More

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Vestibular and balance dysfunction in children with congenital CMV: a systematic review.

Arch Dis Child Fetal Neonatal Ed 2022 May 11. Epub 2022 May 11.

Academic Paediatrics, Royal Alexandra Children's Hospital, Brighton, UK.

Objective: This systematic review evaluates vestibular and balance dysfunction in children with congenital cytomegalovirus (cCMV), makes recommendations for clinical practice and informs future research priorities.

Design: MEDLINE, Embase, EMCARE, BMJ Best Practice, Cochrane Library, DynaMed Plus and UpToDate were searched from inception to 20 March 2021 and graded according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.

Patients: Children with cCMV diagnosed within 3 weeks of life from either blood, saliva and/or urine (using either PCR or culture). Read More

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Neonatal imitation, activation of the mirror neuron system and neurodevelopmental outcome of preterm infants.

Authors:
C Zores P Kuhn

Acta Paediatr 2022 May 11. Epub 2022 May 11.

CHU Strasbourg, Médecine et Réanimation du nouveau-né, Service de Pédiatrie 2, Pôle médico chirurgical Pédiatrique de Hautepierre, Avenue Molière, Strasbourg, France.

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Fruit and vegetable intake is inversely associated with severity of inattention in a pediatric population with ADHD symptoms: the MADDY Study.

Nutr Neurosci 2022 May 10:1-10. Epub 2022 May 10.

Department of Psychiatry & Behavioral Health, The Ohio State University, Columbus, OH, USA.

Objectives: Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with a U.S. pediatric prevalence of 8-10%. Read More

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The role of fingernail selenium in the association between arsenic, lead and mercury and child development in rural Vietnam: a cross-sectional analysis.

Br J Nutr 2022 May 10:1-23. Epub 2022 May 10.

Departments of Infectious Diseases, University of Melbourne, The Peter Doherty Institute of Infection and Immunity, Melbourne, VIC 3000, Australia.

Background: Arsenic, lead and mercury are common environmental contaminants in low- and middle-income countries. We investigated the association between child toxicant exposure and growth and development and determined if this association was mitigated by selenium concentration.

Methods: Toxicant concentrations in fingernail samples, anthropometry, and Bayley's Scales of Infant Development, 3rd edition (BSID) domains were assessed in 36-month-old children whose mothers had been part of a randomised controlled trial in rural Vietnam. Read More

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Risk factors in autism spectrum disorder: A Tunisian case-control study.

Saudi J Biol Sci 2022 Apr 4;29(4):2749-2755. Epub 2022 Jan 4.

Research Unit of Clinical and Molecular Biology, UR17ES29, Department of clinic biology A, Faculty of Pharmacy of Monastir, University of Monastir, Tunisia.

Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition that causes disability in social interaction, communication, and restrictive and repetitive behaviors. Common environmental factors like prenatal, perinatal, and/or postnatal factors play a key role in ASD etiologies. Moreover, specific metabolic disorders can be associated with ASD. Read More

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Neurodevelopmental outcomes of preterm infants with very low birth weight conceived with the assistance of in vitro fertilization.

Fertil Steril 2022 May 5. Epub 2022 May 5.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea. Electronic address:

Objective: To compare the neurodevelopmental outcomes at 18-24 months of corrected age between preterm (<32 weeks of gestational age) infants with very low birth weight (VLBW) conceived with and without the assistance of in vitro fertilization (IVF).

Design: Prospective cohort study.

Setting: Not applicable. Read More

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Effects of spike protein and toxin-like peptides found in COVID-19 patients on human 3D neuronal/glial model undergoing differentiation: Possible implications for SARS-CoV-2 impact on brain development.

Reprod Toxicol 2022 May 5;111:34-48. Epub 2022 May 5.

European Commission, Joint Research Centre (JRC), Geel, Belgium.

The possible neurodevelopmental consequences of SARS-CoV-2 infection are presently unknown. In utero exposure to SARS-CoV-2 has been hypothesized to affect the developing brain, possibly disrupting neurodevelopment of children. Spike protein interactors, such as ACE2, have been found expressed in the fetal brain, and could play a role in potential SARS-CoV-2 fetal brain pathogenesis. Read More

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National Trends in Survival and Short-term Outcomes of Periviable Births ≤24 weeks Gestation in the United States, 2009-2018.

Am J Perinatol 2022 May 6. Epub 2022 May 6.

Pediatrics / Neonatology, University of South Florida, Tampa, United States.

Objective Data from the academic medical centers in the US showing improvements in survival of periviable infants born at 22-24 weeks GA may not be nationally representative since a substantial proportion of preterm infants are cared for in community hospital-based neonatal intensive care units. Our objective was to examine the national trends in survival and other short-term outcomes among preterm infants born at ≤24 weeks' gestational age (GA) in the U.S from 2009 to 2018. Read More

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Parental Occupational Exposure and Neurodevelopmental Disorders in Offspring: a Systematic Review and Meta-analysis.

Curr Environ Health Rep 2022 May 6. Epub 2022 May 6.

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Purpose Of Review: Parental occupational exposures might be associated with neurodevelopmental disorders (NDDs) in offspring. We aimed to conduct a systematic review and meta-analysis to summarize and synthesize the current literature and to estimate the pooled magnitude of the underlying association(s) between parental occupational exposures and subsequent risk of NDDs.

Recent Findings: In the meta-analysis of 20 included studies, significant associations were found between parental occupational exposure to pesticides or solvents and the risk of attention deficit hyperactivity disorder in offspring. Read More

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To assess the magnitude of autism spectrum disorder in Jharkhand by M-CHAT-R as a screening tool.

J Family Med Prim Care 2022 Apr 18;11(4):1497-1501. Epub 2022 Mar 18.

Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India.

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder which is a clinically heterogenous condition with a wide range of etiological factors and causing significant public health burden. If diagnosed at an earlier age, early interventions can be started this leads to functional outcome of children with ASD with respect to social, behavior and occupational sphere. Therefore, early detection and intervention are widely recommended in these children. Read More

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The clinical effectiveness and cost effectiveness of clozapine for inpatients with severe borderline personality disorder (CALMED study): a randomised placebo-controlled trial.

Ther Adv Psychopharmacol 2022 29;12:20451253221090832. Epub 2022 Apr 29.

Department of Forensic Psychiatry, Nottinghamshire Healthcare NHS Foundation Trust, Nottingham, UK.

Background: Data from case series suggest that clozapine may benefit inpatients with borderline personality disorder (BPD), but randomised trials have not been conducted.

Methods: Multicentre, double-blind, placebo-controlled trial. We aimed to recruit 222 inpatients with severe BPD aged 18 or over, who had failed to respond to other antipsychotic medications. Read More

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Impact of Seizure Recurrence on 1-Year Functional Outcome and Mortality in Patients With Poststroke Epilepsy.

Neurology 2022 May 4. Epub 2022 May 4.

Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan

Background And Objectives: The functional outcome and mortality of post-stroke epilepsy (PSE) patients have not been assessed in a prospective study. Previous reports have suggested that PSE patients may suffer from prolonged functional deterioration following a seizure. In the current study, we prospectively investigated the functional outcome and mortality of PSE patients and analyzed the impact of seizure recurrence on the outcomes. Read More

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Effects of maternal docosahexaenoic acid supplementation on brain development and neurodevelopmental outcomes of breastfed preterm neonates: protocol for a follow-up at preschool age of a randomised clinical trial (MOBYDIckPS).

BMJ Open 2022 May 4;12(5):e057482. Epub 2022 May 4.

Department of Pediatrics, CHU de Québec-Université Laval, Québec City, Québec, Canada.

Introduction: Docosahexaenoic acid (DHA), an omega-3 fatty acid, is important for brain development with possible implications in neurodevelopmental outcomes. In the two-arm, randomised, double-blind, placebo-controlled Maternal Omega-3 Supplementation to Reduce Bronchopulmonary Dysplasia in Very Preterm Infants trial, very preterm infants (<29 weeks' gestation) were supplemented in high doses of DHA or placebo until they reached 36 weeks' postmenstrual age. We propose a long-term neurodevelopmental follow-up of these children. Read More

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Social communication therapy for children at risk for neurodevelopmental difficulties: Protocol for a clinical trial.

Ann N Y Acad Sci 2022 May 4. Epub 2022 May 4.

Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil.

Exposure to adverse environments are risk factors for neurodevelopmental problems in childhood. Children exposed to such environments may benefit from interventions that target social communication abilities, since these are protective factors for healthy neurodevelopment. This randomized controlled trial will test the efficacy of Paediatric Autism Communication Therapy (PACT) in improving social communication development in young children at risk for neurodevelopmental difficulties living in poverty in Brazil. Read More

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SRF depletion in early life contributes to social interaction deficits in the adulthood.

Cell Mol Life Sci 2022 May 4;79(5):278. Epub 2022 May 4.

Laboratory of Neurobiology, Nencki-EMBL Partnership for Neural Plasticity and Brain Disorders - Braincity, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur Street, 02-093, Warsaw, Poland.

Alterations in social behavior are core symptoms of major developmental neuropsychiatric diseases such as autism spectrum disorders or schizophrenia. Hence, understanding their molecular and cellular underpinnings constitutes the major research task. Dysregulation of the global gene expression program in the developing brain leads to modifications in a number of neuronal connections, synaptic strength and shape, causing unbalanced neuronal plasticity, which may be important substrate in the pathogenesis of neurodevelopmental disorders, contributing to their clinical outcome. Read More

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Estimating the impact of child and early adolescent depression on subsequent educational attainment: secondary analysis of an existing data linkage.

Epidemiol Psychiatr Sci 2021 11 25;30:e76. Epub 2021 Nov 25.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Aims: Depression is thought to be associated with lower subsequent educational attainment during school. But, without longitudinal studies which take account of prior attainment and other potential confounders, estimates of the impact of clinically recognised depression in childhood and early adolescence are unknown. We investigated whether a clinical diagnosis of depression is associated with lower subsequent educational attainment, and whether the association is modified by gender, ethnicity and socioeconomic status. Read More

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November 2021

Long-term follow-up of complicated monochorionic twin pregnancies: Focus on neurodevelopment.

Best Pract Res Clin Obstet Gynaecol 2022 Mar 31. Epub 2022 Mar 31.

Willem-Alexander Children's Hospital, Department of Pediatrics, Division of Pediatric Psychology, Leiden University Medical Center, Leiden, the Netherlands.

Monochorionic twin pregnancies have an increased risk of morbidity and mortality. Due to the advancements in screening and treatment strategies, mortality rates have decreased. Improving survival rates demands a shift in scope toward long-term outcomes. Read More

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Neonatal morbidities and postnatal growth failure in very low birth weight, very preterm infants.

Acta Paediatr 2022 May 1. Epub 2022 May 1.

Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Aim: To assess postnatal growth in infants with and without major neonatal morbidities.

Methods: This study is based on analysis of data collected by the Israel Neonatal Network on VLBW infants (≤1500 g) born in Israel from 2009 to 2018. Postnatal growth was assessed in two 5 years epochs: 2009-2013 (n = 4583) and 2014-2018 (n = 4558). Read More

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