3,269 results match your criteria neurodegeneration temporal

Assessment of Retinal Neurodegeneration and Choroidal Thickness in COVID-19 Patients Using Swept-Source OCT Technology.

Klin Monbl Augenheilkd 2021 Apr 14. Epub 2021 Apr 14.

Ophthalmology, Sisli Hamidiye Etfal Egitim ve Arastirma Hastanesi, Istanbul, Turkey.

Purpose: To analyze the central macular thickness (CMT), retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), and choroidal thickness (ChT) measurements in patients with coronavirus disease 2019 (COVID-19).

Methods: The study was conducted cross-sectionally 4 weeks after the completed treatment of COVID-19. The diagnosis of COVID-19 was based on the polymerase chain reaction test and/or clinical and radiological findings. Read More

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Ultrastructural maturation of the endbulb of Held active zones comparing wild-type and otoferlin-deficient mice.

iScience 2021 Apr 8;24(4):102282. Epub 2021 Mar 8.

Molecular Architecture of Synapses Group, Institute for Auditory Neuroscience, InnerEarLab and Center for Biostructural Imaging of Neurodegeneration, University Medical Center Göttingen, 37075 Göttingen, Germany.

Endbulbs of Held are located in the anteroventral cochlear nucleus and present the first central synapses of the auditory pathway. During development, endbulbs mature functionally to enable rapid and powerful synaptic transmission with high temporal precision. This process is accompanied by morphological changes of endbulb terminals. Read More

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Hybrid imaging in dementia: A semi-quantitative (F)-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging approach in clinical practice.

World J Nucl Med 2021 Jan-Mar;20(1):23-31. Epub 2020 Oct 2.

Department of Radiology, Stony Brook University Hospital, Stony Brook, NY, USA.

Neurodegenerative disorders may demonstrate typical lobar and regional patterns of volume loss with corresponding decreased glucose metabolism. In this retrospective study, we correlated semi-quantitative volumetric changes utilizing NeuroQuant morphometric analysis with decreased fluorodeoxyglucose (FDG) uptake age-matched calculated -scores utilizing F-FDG positron emission tomography/magnetic resonance imaging (PET/MRI). Eighty-nine patients (mean age 71. Read More

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October 2020

Neuroimaging Biomarkers of Chronic Traumatic Encephalopathy: Targets for the Academic Memory Disorders Clinic.

Neurotherapeutics 2021 Apr 13. Epub 2021 Apr 13.

Department of Neurology, Boston University Alzheimer's Disease Research Center, Boston University CTE Center, Boston University School of Medicine, 72 E Concord St, Suite B7800, MA, 02118, Boston, USA.

Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts, such as those from contact sports. The pathognomonic lesion for CTE is the perivascular accumulation of hyper-phosphorylated tau in neurons and other cell process at the depths of sulci. CTE cannot be diagnosed during life at this time, limiting research on risk factors, mechanisms, epidemiology, and treatment. Read More

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Quantification of different iron forms in the aceruloplasminemia brain to explore iron-related neurodegeneration.

Neuroimage Clin 2021 Apr 3;30:102657. Epub 2021 Apr 3.

Department of Internal Medicine, Center for Lysosomal and Metabolic Diseases, Porphyria Center Rotterdam, Erasmus University Medical Center, Erasmus MC, Rotterdam, the Netherlands.

Aims: Aceruloplasminemia is an ultra-rare neurodegenerative disorder associated with massive brain iron deposits, of which the molecular composition is unknown. We aimed to quantitatively determine the molecular iron forms in the aceruloplasminemia brain, and to illustrate their influence on iron-sensitive MRI metrics.

Methods: The inhomogeneous transverse relaxation rate (R*) and magnetic susceptibility obtained from 7 T MRI were combined with Electron Paramagnetic Resonance (EPR) and Superconducting Quantum Interference Device (SQUID) magnetometry. Read More

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The CD200R1 microglial inhibitory receptor as a therapeutic target in the MPTP model of Parkinson's disease.

J Neuroinflammation 2021 Apr 6;18(1):88. Epub 2021 Apr 6.

Department of Cerebral Ischemia and Neurodegeneration, Institut d'Investigacions Biomèdiques de Barcelona-Consejo Superior de Investigaciones Científicas (CSIC), Institut d'Investigacions Biomèdiques August-Pi i Sunyer (IDIBAPS), Barcelona, Spain.

Background: It is suggested that neuroinflammation, in which activated microglial cells play a relevant role, contributes to the development of Parkinson's disease (PD). Consequently, the modulation of microglial activation is a potential therapeutic target to be taken into account to act against the dopaminergic neurodegeneration occurring in this neurological disorder. Several soluble and membrane-associated inhibitory mechanisms contribute to maintaining microglial cells in a quiescent/surveillant phenotype in physiological conditions. Read More

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Association between regional tau pathology and neuropsychiatric symptoms in aging and dementia due to Alzheimer's disease.

Alzheimers Dement (N Y) 2021 31;7(1):e12154. Epub 2021 Mar 31.

McGill University Research Centre for Studies in Aging Verdun Quebec Canada.

Background: Neuropsychiatric symptoms (NPS) are frequent in aging and Alzheimer's disease (AD). Here we study the relationship between NPS and AD pathologies in vivo.

Method: Two hundred and twenty-one individuals from the TRIAD cohort (143 cognitively unimpaired, 52 mild cognitive impairment, and 26 AD) underwent [F]MK6240-tau-positron emission tomography (PET), [F]AZD4694-amyloid-PET, magnetic resonance imaging, and neuropsychological evaluations. Read More

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Upper and Lower Motor Neuron Degenerations Are Somatotopically Related and Temporally Ordered in the Mouse Model of Amyotrophic Lateral Sclerosis.

Brain Sci 2021 Mar 13;11(3). Epub 2021 Mar 13.

Inserm UMR_S 1118, Centre de Recherche en Biomédecine de Strasbourg, Faculté de Médecine, Université de Strasbourg, 67 000 Strasbourg, France.

Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease arising from the combined degeneration of upper motor neurons (UMN) in the motor cortex, and lower motor neurons (LMN) in the brainstem and spinal cord. This dual impairment raises two major questions: (i) are the degenerations of these two neuronal populations somatotopically related? and if yes (ii), where does neurodegeneration start? If studies carried out on ALS patients clearly demonstrated the somatotopic relationship between UMN and LMN degenerations, their temporal relationship remained an unanswered question. In the present study, we took advantage of the well-described model of ALS to interrogate the somatotopic and temporal relationships between UMN and LMN degenerations in ALS. Read More

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Different miRNA Profiles in Plasma Derived Small and Large Extracellular Vesicles from Patients with Neurodegenerative Diseases.

Int J Mol Sci 2021 Mar 8;22(5). Epub 2021 Mar 8.

Genomic and post-Genomic Unit, IRCCS Mondino Foundation, 27100 Pavia, Italy.

Identifying biomarkers is essential for early diagnosis of neurodegenerative diseases (NDs). Large (LEVs) and small extracellular vesicles (SEVs) are extracellular vesicles (EVs) of different sizes and biological functions transported in blood and they may be valid biomarkers for NDs. The aim of our study was to investigate common and different miRNA signatures in plasma derived LEVs and SEVs of Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD) patients. Read More

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Longitudinal normative OCT retinal thickness data for wild-type mice, and characterization of changes in the 3×Tg-AD mice model of Alzheimer's disease.

Aging (Albany NY) 2021 Apr 2;13. Epub 2021 Apr 2.

University of Coimbra, Coimbra Institute for Biomedical Imaging and Translational Research (CIBIT), Institute for Nuclear Sciences Applied to Health (ICNAS), Coimbra, Portugal.

Mice are widely used as models for many diseases, including eye and neurodegenerative diseases. However, there is a lack of normative data for retinal thickness over time, especially at young ages. In this work, we present a normative thickness database from one to four-months-old, for nine layers/layer-aggregates, including the total retinal thickness, obtained from the segmentation of spectral-domain optical coherence tomography (SD-OCT) data from the C57BL6/129S mouse strain. Read More

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Iron Deficiency and Recovery in Yeast: A Quantitative Proteomics Approach.

J Proteome Res 2021 Apr 2. Epub 2021 Apr 2.

Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02155, United States.

Iron is an essential element for life, as it is critical for oxygen transport, cellular respiration, DNA synthesis, and metabolism. Disruptions in iron metabolism have been associated with several complex diseases like diabetes, cancer, infection susceptibility, neurodegeneration, and others; however, the molecular mechanisms linking iron metabolism with these diseases are not fully understood. A commonly used model to study iron deficiency (ID) is yeast, . Read More

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Fronto-temporal dementia risk gene has opposing effects in different lysosomal storage disorders.

Brain Commun 2021 16;3(1):fcaa200. Epub 2020 Nov 16.

Cellular Neuroscience, Neurodegeneration and Repair Program, Yale University School of Medicine, New Haven, CT, USA.

TMEM106B is a transmembrane protein localized to the endo-lysosomal compartment. Genome-wide association studies have identified as a risk modifier of Alzheimer's disease and frontotemporal lobar degeneration, especially with progranulin haploinsufficiency. We recently demonstrated that TMEM106B loss rescues progranulin null mouse phenotypes including lysosomal enzyme dysregulation, neurodegeneration and behavioural alterations. Read More

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November 2020

The Delayed Neuropathological Consequences of Traumatic Brain Injury in a Community-Based Sample.

Front Neurol 2021 16;12:624696. Epub 2021 Mar 16.

Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, United States.

The late neuropathological effects of traumatic brain injury have yet to be fully elucidated, particularly with respect to community-based cohorts. To contribute to this critical gap in knowledge, we designed a multimodal neuropathological study, integrating traditional and quantitative approaches to detect pathologic changes in 532 consecutive brain autopsies from participants in the Adult Changes in Thought (ACT) study. Diagnostic evaluation including assessment for chronic traumatic encephalopathy (CTE) and quantitative immunoassay-based methods were deployed to examine levels of pathological (hyperphosphorylated) tau (pTau) and amyloid (A) β in brains from ACT participants with ( = 107) and without ( = 425) history of remote TBI with loss of consciousness (w/LOC). Read More

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A Meta-Analysis of Brain DNA Methylation Across Sex, Age, and Alzheimer's Disease Points for Accelerated Epigenetic Aging in Neurodegeneration.

Front Aging Neurosci 2021 11;13:639428. Epub 2021 Mar 11.

Istituto di Ricovero e Cura a Carattere Scientifico Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.

Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation (DNAm) patterns. Age and sex, two major risk factors for AD, are also known to largely affect the epigenetic profiles in brain, but their contribution to AD-associated DNAm changes has been poorly investigated. In this study we considered publicly available DNAm datasets of four brain regions (temporal, frontal, entorhinal cortex, and cerebellum) from healthy adult subjects and AD patients, and performed a meta-analysis to identify sex-, age-, and AD-associated epigenetic profiles. Read More

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Regulation of nonsense-nediated mRNA decay in neural development and disease.

J Mol Cell Biol 2021 Mar 30. Epub 2021 Mar 30.

Department of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA.

Eukaryotes have evolved a variety of mRNA surveillance mechanisms to detect and degrade aberrant mRNAs with potential deleterious outcomes. Among them, nonsense-mediated mRNA decay (NMD) functions not only as a quality control mechanism targeting aberrant mRNAs containing a premature termination codon (PTC), but also as a post-transcriptional gene regulation mechanism targeting numerous physiological mRNAs. Despite its well-characterized molecular basis, the regulatory scope and biological functions of NMD at an organismal level are incompletely understood. Read More

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Recent Advances in Imaging of Preclinical, Sporadic, and Autosomal Dominant Alzheimer's Disease.

Rachel F Buckley

Neurotherapeutics 2021 Mar 29. Epub 2021 Mar 29.

Department of Neurology, Massachusetts General Hospital & Brigham and Women's, Harvard Medical School, Boston, MA, USA.

Observing Alzheimer's disease (AD) pathological changes in vivo with neuroimaging provides invaluable opportunities to understand and predict the course of disease. Neuroimaging AD biomarkers also allow for real-time tracking of disease-modifying treatment in clinical trials. With recent neuroimaging advances, along with the burgeoning availability of longitudinal neuroimaging data and big-data harmonization approaches, a more comprehensive evaluation of the disease has shed light on the topographical staging and temporal sequencing of the disease. Read More

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Contemporary Onset Of Atypical Chronic Inflammatory Demyelinating Polyradiculoneuropathy And Type 1 Diabetes In An Adolescent.

Diabet Med 2021 Mar 27:e14563. Epub 2021 Mar 27.

Unit of Pediatric Diabetology, Department of Mother and Child Healths, Sapienza University of Rome.

Chronic inflammatory demyelinating polyradiculoneuropathy is an autoimmune demyelinating disease of the peripheral nervous system causing axonal degeneration and presenting with a relapsing-remitting distal sensory-motor impairment and at least one out of four electrodiagnostic criteria including conduction block/temporal dispersion, prolonged minimal F wave latency, reduced nerve conduction velocity, prolonged distal latency (European Federation of Neurological Societies and the Peripheral Nerve Society criteria). Read More

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Flexibility as a marker of early cognitive decline in humanized apolipoprotein E ε4 (ApoE4) mice.

Neurobiol Aging 2021 Feb 5;102:129-138. Epub 2021 Feb 5.

Sorbonne Université, CNRS, INSERM, Institut de Biologie Paris Seine (IBPS), Neurosciences Paris Seine (NPS), Cerebellum Navigation and Memory Team (CeZaMe), Paris, France. Electronic address:

To test the hypothesis that ApoE4 may be involved in cognitive deficits associated with aging, we investigated the impact of APOE4 status and aging on the flexibility and memory components of spatial learning in mice. Young adult (6 months) and middle-aged (14 months) ApoE4, ApoE3 and C57BL/6 male mice were tested for flexibility in an aquatic Y-maze, and for spatio-temporal memory acquisition in the Starmaze. Our results revealed a flexibility deficit of the 6-month-old ApoE4 mice compared to controls. Read More

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February 2021

Dissociating direct and indirect effects: a theoretical framework of how latent toxoplasmosis affects cognitive profile across the lifespan.

Neurobiol Aging 2021 Feb 11;102:119-128. Epub 2021 Feb 11.

Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Dresden, Germany; Biopsychology, Faculty of Psychology, TU Dresden, Dresden, Germany. Electronic address:

About one-third of the world's population has latent toxoplasmosis, which is typically most prevalent in old age due to its lifelong persistence. Most infected people do not reveal clinically relevant symptoms, but T. gondii might trigger cognitive changes in otherwise asymptomatic individuals. Read More

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February 2021

Early alterations of neurovascular unit in the retina in mouse models of tauopathy.

Acta Neuropathol Commun 2021 03 24;9(1):51. Epub 2021 Mar 24.

Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX, 77555-0144, USA.

The retina, as the only visually accessible tissue in the central nervous system, has attracted significant attention for evaluating it as a biomarker for neurodegenerative diseases. Yet, most of studies focus on characterizing the loss of retinal ganglion cells (RGCs) and degeneration of their axons. There is no integrated analysis addressing temporal alterations of different retinal cells in the neurovascular unit (NVU) in particular retinal vessels. Read More

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Progression of phosphorylated α-synuclein in Macaca fuscata.

Brain Pathol 2021 Mar 22:e12952. Epub 2021 Mar 22.

Dementia Research Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Prion-like spreading of abnormal proteins is proposed to occur in neurodegenerative diseases, and the progression of α-synuclein (α-syn) deposits has been reported in the brains of animal models injected with synthetic α-syn fibrils or pathological α-syn prepared from patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB). However, α-syn transmission in nonhuman primates, which are more similar to humans, has not been fully clarified. Here, we injected synthetic human α-syn fibrils into the left striatum of a macaque monkey (Macaca fuscata). Read More

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Correlation of Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment: A Memory Clinic Experience.

Front Aging Neurosci 2021 5;13:595758. Epub 2021 Mar 5.

Unit of Behavioral Neurology, IRCCS Mondino Foundation, Pavia, Italy.

: Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in terms of cerebrospinal fluid (CSF) tau and brain atrophy. : One-hundred patients with mild cognitive impairment (MCI) or dementia (Alzheimer's disease, AD; Lewy-body disease, LBD; frontotemporal dementia, FTD; vascular dementia, VD) underwent a complete diagnostic workup, including 3T-MRI and/or CT and CSF. Read More

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Evaluation of Retinal Neurodegeneration and Choroidal Thickness in Patients with Inactive Graves' Ophthalmopathy.

Klin Monbl Augenheilkd 2021 Mar 17. Epub 2021 Mar 17.

Ophthalmology, Samsun Gazi Community Hospital, Samsun, Turkey.

Purpose: The study was conducted for the assessment of the retinal nerve fiber layer, ganglion cell layer, and subfoveal choroidal thickness changes in patients with inactive Graves' ophthalmopathy (GO) using swept-source optical coherence tomography (SS-OCT) before the development of active GO findings.

Materials And Methods: The cross-sectional designed study consisted of patients with inactive Graves' ophthalmopathy (study group) and healthy subjects (control group). The thicknesses of the retinal ganglion cell layer, retinal nerve fiber layer, and subfoveal choroid (SFCT) were measured using SS-OCT with deep range imaging technology to compare these parameters between the study and control groups. Read More

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GABA Receptors in Neurodegeneration.

Curr Top Behav Neurosci 2021 Mar 17. Epub 2021 Mar 17.

Department of Bioscience and Chemistry, Biomolecular Research Centre, College of Health, Wellbeing and Life Sciences at Sheffield Hallam University, Sheffield, UK.

GABA is the main inhibitory neurotransmitter in the mammalian central nervous system (CNS) and acts via metabotropic GABA receptors. Neurodegenerative diseases are a major burden and affect an ever increasing number of humans. The actual therapeutic drugs available are partially effective to slow down the progression of the diseases, but there is a clear need to improve pharmacological treatment thus find alternative drug targets and develop newer pharmaco-treatments. Read More

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Interval aerobic training improves bioenergetics state and mitochondrial dynamics of different brain regions in restraint stressed rats.

Mol Biol Rep 2021 Mar 15. Epub 2021 Mar 15.

Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Evidence has validated the prophylactic effects of exercising on different aspects of health. On the opposite side, immobilization may lead to various destructive effects causing neurodegeneration. Here, we investigated the association between exercising and mitochondrial quality for preventing the destructive effects of restraint stress in different rat brain regions. Read More

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Aging Alters Daily and Regional Calretinin Neuronal Expression in the Rat Non-image Forming Visual Thalamus.

Front Aging Neurosci 2021 24;13:613305. Epub 2021 Feb 24.

Laboratory of Neurochemical Studies, Department of Physiology, Biosciences Center, Federal University of Rio Grande do Norte, Natal, Brazil.

Aging affects the overall physiology, including the image-forming and non-image forming visual systems. Among the components of the latter, the thalamic retinorecipient inter-geniculate leaflet (IGL) and ventral lateral geniculate (vLGN) nucleus conveys light information to subcortical regions, adjusting visuomotor, and circadian functions. It is noteworthy that several visual related cells, such as neuronal subpopulations in the IGL and vLGN are neurochemically characterized by the presence of calcium binding proteins. Read More

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February 2021

Retinal nerve fibre layer and peripapillary vascular density by optical coherence tomography angiography in schizophrenia.

Clin Exp Optom 2021 Feb 25:1-7. Epub 2021 Feb 25.

Ankara Ulucanlar Eye Training and Research Hospital, Ankara, Turkey.

: Schizophrenia is a progressive disease. Analysis of retinal nerve fibre layer and peripapillary vascular density by optical coherence tomography angiography in schizophrenia patients may help to explain the pathophysiology of the disease.: Both macular and optic nerve microvascular structures can be visualised with optical coherence tomography angiography. Read More

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February 2021

Comparison of CSF neurofilament light chain, neurogranin, and tau to MRI markers.

Alzheimers Dement 2021 Mar 4. Epub 2021 Mar 4.

Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.

Introduction: We determined whether cerebrospinal fluid (CSF) neurofilament light (NfL), neurogranin (Ng), and total-tau (t-tau) differentially mapped to magnetic resonance imaging (MRI) measures of cortical thickness, microstructural integrity (corpus callosum and cingulum fractional anisotropy [FA]), and white matter hyperintensities (WMH).

Methods: Analyses included 536 non-demented Mayo Clinic Study of Aging participants with CSF NfL, Ng, t-tau, amyloid beta (Aβ)42 and longitudinal MRI scans. Linear mixed models assessed longitudinal associations between CSF markers and MRI changes. Read More

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Effect of intravitreal ranibizumab and aflibercept injections on retinal nerve fiber layer thickness.

Sci Rep 2021 Mar 3;11(1):5010. Epub 2021 Mar 3.

Department of Ophthalmology, Hangil Eye Hospital, #35 Bupyeong-daero, Bupyeong-gu, Incheon, 21388, Korea.

The purpose is to evaluate the effects of multiple intravitreal ranibizumab (IVR) and aflibercept (IVA) injections on peripapillary retinal nerve fiber layer (RNFL) thickness in patients with exudative age-related macular degeneration (AMD). This retrospective, observational, consecutive case series study enrolled patients newly diagnosed with monocular exudative AMD from January 2014 to October 2019 who were administered IVR or IVA injections. Normal fellow eyes were included as controls. Read More

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Envelope following responses predict speech-in-noise performance in normal-hearing listeners.

J Neurophysiol 2021 Apr 3;125(4):1213-1222. Epub 2021 Mar 3.

Eaton-Peabody Laboratories, Massachusetts Eye and Ear, Boston, Massachusetts.

Permanent threshold elevation after noise exposure or aging is caused by loss of sensory cells; however, animal studies show that hair cell loss is often preceded by degeneration of the synapses between sensory cells and auditory nerve fibers. Silencing these neurons is likely to degrade auditory processing and may contribute to difficulties understanding speech in noisy backgrounds. Reduction of suprathreshold ABR amplitudes can be used to quantify synaptopathy in inbred mice. Read More

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