33,228 results match your criteria neuroblastoma cell

BORIS/CTCFL expression activates the TGFβ signaling cascade and induces Drp1 mediated mitochondrial fission in neuroblastoma.

Free Radic Biol Med 2021 Sep 14. Epub 2021 Sep 14.

Department of Applied Biology, CSIR- Indian Institute of Chemical Technology (IICT), Tarnaka, Hyderabad, 50007, India. Electronic address:

The cancer-testis antigen CTCFL/BORIS (Brother of Regulator of Imprinted Sites) also known, as a paralog of CTCF -the "master weaver of the genome" is a key transcriptional regulator. Both CTCF and BORIS can bind to the same promoter sequence and recruit diverse proteins. BORIS is also known to be associated with actively translating ribosomes suggesting new roles of BORIS in gene expression. Read More

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September 2021

Thiolactomide: A New Homocysteine Thiolactone Derivative from sp. with Neuroprotective Activity.

J Microbiol Biotechnol 2021 Sep 15;31(1). Epub 2021 Sep 15.

Anticancer Agent Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju 28116, Korea.

A new homocysteine thiolactone derivative, thiolactomide (), was isolated along with a known compound, -acetyl homocysteine thiolactone (), from a culture extract of soil-derived sp. RK88-1441. The structures of these compounds were elucidated by detailed NMR and MS spectroscopic analyses with literature study. Read More

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September 2021

Pyridostigmine bromide, chlorpyrifos, and DEET combined Gulf War exposure insult depresses mitochondrial function in neuroblastoma cells.

J Biochem Mol Toxicol 2021 Sep 15:e22913. Epub 2021 Sep 15.

Laboratory of Molecular Biology, VA New Jersey Health Care System, Research & Development (Mailstop 15), East Orange, New Jersey, USA.

Gulf War Illness (GWI) is defined by the Centers for Disease Control and Prevention (CDC) as a multi-symptom illness having at least one symptom from two of three factors, which include: fatigue, mood-cognition problems, and musculoskeletal disorders. The cluster of long-term symptoms is unique to military personnel from coalition countries including United States, Australia, and the United Kingdom that served in Operation Desert Storm from 1990 to 1991. Reporting of these symptoms is much lower among soldiers deployed in other parts of the world like Bosnia during the same time period. Read More

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September 2021

An HDAC8-selective fluorescent probe for imaging in living tumor cell lines and tissue slices.

Org Biomol Chem 2021 Sep 16. Epub 2021 Sep 16.

School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, 210023, PR China.

Histone deacetylase 8 (HDAC8) has been used as a therapeutic target for many cancers as it is highly expressed in neuroblastoma cells and breast cancer cells. HDAC8-selective fluorescent probes need to be urgently developed. Herein, two novel fluorescent probes, namely and , based on the conjugation of 1,8-naphthalimide with a highly selective inhibitor of HDAC8 () were reported. Read More

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September 2021

Digitally Driven Aerosol Jet Printing to Enable Customisable Neuronal Guidance.

Front Cell Dev Biol 2021 30;9:722294. Epub 2021 Aug 30.

Faculty of Engineering and Physical Sciences, School of Mechanical Engineering, University of Leeds, Leeds, United Kingdom.

Digitally driven manufacturing technologies such as aerosol jet printing (AJP) can make a significant contribution to enabling new capabilities in the field of tissue engineering disease modeling and drug screening. AJP is an emerging non-contact and mask-less printing process which has distinct advantages over other patterning technologies as it offers versatile, high-resolution, direct-write deposition of a variety of materials on planar and non-planar surfaces. This research demonstrates the ability of AJP to print digitally controlled patterns that influence neuronal guidance. Read More

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Robotic Surgery in Pediatric Oncology: Lessons Learned from the First 100 Tumors-A Nationwide Experience.

Ann Surg Oncol 2021 Sep 14. Epub 2021 Sep 14.

Department of Pediatric Surgery and Urology, Hôpital Necker-Enfants Malades, Assistance Publique-Hôpitaux de Paris, Paris, France.

Background: While robotics has become commonplace in adult oncology, it remains rare in pediatric oncology due to the rarity of childhood cancers. We present the results of a large nationwide experience with robotic oncology, with the aim of providing practical and feasible guidelines for child selection.

Methods: This was a prospective analysis performed over a period of 4 years. Read More

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September 2021

The biguanide polyamine analog verlindamycin promotes differentiation in neuroblastoma via induction of antizyme.

Cancer Gene Ther 2021 Sep 14. Epub 2021 Sep 14.

Division of Clinical Studies, Institute of Cancer Research, London, UK.

Deregulated polyamine biosynthesis is emerging as a common feature of neuroblastoma and drugs targeting this metabolic pathway such as DFMO are in clinical and preclinical development. The polyamine analog verlindamycin inhibits the polyamine biosynthesis pathway enzymes SMOX and PAOX, as well as the histone demethylase LSD1. Based on our previous research in acute myeloid leukemia (AML), we reasoned verlindamycin may also unblock neuroblastoma differentiation when combined with all-trans-retinoic acid (ATRA). Read More

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September 2021

A new underlying mechanism for the neuroprotective effect of bosutinib: Reverting toxicity-induced PARylation in SIN1-mediated neurotoxicity.

J Biochem Mol Toxicol 2021 Sep 14:e22915. Epub 2021 Sep 14.

Department of Biotechnology, Graduate School of Natural and Applied Sciences, Ege University, Izmir, Turkey.

Increased levels of reactive oxygen and nitrogen species play an important role in the development and progression of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. The overproduction of these highly reactive chemical species leads to DNA damage and subsequent activation of the poly(ADP-ribose)polymerase (PARP) enzyme. Several studies have demonstrated the potential use of PARP inhibitors for neuroprotection. Read More

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September 2021

Acetonitrile adduct analysis of underivatised amino acids offers improved sensitivity for hydrophilic interaction liquid chromatography tandem mass-spectrometry.

J Chromatogr A 2021 Sep 3;1655:462530. Epub 2021 Sep 3.

School of Life Sciences, Faculty of Science, The University of Technology Sydney, Ultimo 2007, Australia. Electronic address:

LC-MS/MS method development for native amino acid detection can be problematic due to low ionisation efficiencies, in source fragmentation, potential for cluster ion formation and incorrect application of chromatography techniques. This has led to the majority of the scientific community derivatising amino acids for more sensitive analysis. Derivatisation has several benefits including reduced signal-to-noise ratios, more efficient ionisation, and a change in polarity, allowing the use of reverse phase chromatography. Read More

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September 2021

Design, Synthesis, and Biological Evaluation of Hybrid Glypromate Analogues Using 2-Azanorbornane as a Prolyl and Pipecolyl Surrogate.

ACS Chem Neurosci 2021 Sep 13. Epub 2021 Sep 13.

LAQV/REQUIMTE, Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.

Neurodegenerative disorders of the central nervous system are a class of heterogeneous pathologies affecting millions of people worldwide and represent a global health burden in developed and developing countries. Without restorative treatments currently available, research on neuroprotective drugs is considered a health priority. In this study, new analogues of the glycyl-l-prolyl-l-glutamic acid (Glypromate) neuropeptide were designed, synthesized, and biologically evaluated using (1,3,4)-2-azanorbornane-3-carboxylic acid as a hybrid construct of l-proline and l-pipecolic acid. Read More

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September 2021

Antitumor Effect of Saikosaponin A on Human Neuroblastoma Cells.

Biomed Res Int 2021 1;2021:5845554. Epub 2021 Sep 1.

Joint Program of Nanchang University and Queen Mary University of London, Nanchang 330006, China.

Objective: Neuroblastoma (NB) is a highly metastatic tumor in children that develops in the sympathetic nervous system and has a low curative rate. Saikosaponin A (SSA), an active ingredient isolated from the root of Radix Bupleuri, is a natural compound with various pharmacological activities and shows good application prospects in antitumors. This study investigated the antihuman NB activity of SSA and underlying mechanisms associated with its actions. Read More

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September 2021

LncRNA NEAT1 knockdown ameliorates MPP-induced cell injury through miR-519a-3p/SP1 axis in Parkinson's disease.

World Neurosurg 2021 Sep 8. Epub 2021 Sep 8.

Department of Neurology, 908 Hospital of PLA Joint Logistics Support Force, 330000, Nanchang, Jiangxi, China. Electronic address:

Background: Parkinson's disease (PD) is a neurodegenerative disease and is characterized by resting tremor, dementia, and gait disorder. Previous studies have indicated that long noncoding RNA (lncRNA) participates in the regulation of the pathogenesis of PD. The study aims to reveal the effects of lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) on 1-methyl-4-pehnyl-pyridine (MPP)-induced human neuroblastoma cell injury and underneath mechanism. Read More

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September 2021

A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors.

Oncogene 2021 Sep 10. Epub 2021 Sep 10.

Department of Molecular Medicine, University La Sapienza, 00161, Rome, Italy.

MYCN drives aggressive behavior and refractoriness to chemotherapy, in several tumors. Since MYCN inactivation in clinical settings is not achievable, alternative vulnerabilities of MYCN-driven tumors need to be explored to identify more effective and less toxic therapies. We previously demonstrated that PARP inhibitors enhance MYCN-induced replication stress and promote mitotic catastrophe, counteracted by CHK1. Read More

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September 2021

Combining APR-246 and HDAC-Inhibitors: A Novel Targeted Treatment Option for Neuroblastoma.

Cancers (Basel) 2021 Sep 5;13(17). Epub 2021 Sep 5.

Hopp Children's Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany.

APR-246 (Eprenetapopt/PRIMA-1) is a very potent anti-cancer drug in clinical trials and was initially developed as a p53 refolding agent. As an alternative mode of action, the elevation of reactive oxygen species (ROS) has been proposed. Through an in silico analysis, we investigated the responses of approximately 800 cancer cell lines (50 entities; Cancer Therapeutics Response Portal, CTRP) to APR-246 treatment. Read More

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September 2021

Enhancement of Neuroblastoma NK-Cell-Mediated Lysis through NF-kB p65 Subunit-Induced Expression of FAS and PVR, the Loss of Which Is Associated with Poor Patient Outcome.

Cancers (Basel) 2021 Aug 29;13(17). Epub 2021 Aug 29.

Academic Department of Pediatrics (DPUO), Ospedale Pediatrico Bambino Gesù, IRCCS, 00165 Rome, Italy.

High-risk neuroblastoma (NB) is a rare childhood cancer whose aggressiveness is due to a variety of chromosomal genetic aberrations, including those conferring immune evasion. Indeed, NB cells adopt several molecular strategies to evade recognition by the immune system, including the downregulation of ligands for NK-cell-activating receptors. To date, while molecular strategies aimed at enhancing the expression of ligands for NKG2D- and DNAM-1-activating receptors have been explored, no evidence has been reported on the immunomodulatory mechanisms acting on the expression of death receptors such as Fas in NB cells. Read More

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Landscape of Bone Marrow Metastasis in Human Neuroblastoma Unraveled by Transcriptomics and Deep Multiplex Imaging.

Cancers (Basel) 2021 Aug 26;13(17). Epub 2021 Aug 26.

St. Anna Children's Cancer Research Institute (CCRI), 1090 Vienna, Austria.

While the bone marrow attracts tumor cells in many solid cancers leading to poor outcome in affected patients, comprehensive analyses of bone marrow metastases have not been performed on a single-cell level. We here set out to capture tumor heterogeneity and unravel microenvironmental changes in neuroblastoma, a solid cancer with bone marrow involvement. To this end, we employed a multi-omics data mining approach to define a multiplex imaging panel and developed DeepFLEX, a pipeline for subsequent multiplex image analysis, whereby we constructed a single-cell atlas of over 35,000 disseminated tumor cells (DTCs) and cells of their microenvironment in the metastatic bone marrow niche. Read More

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CD47-SIRPα Checkpoint Inhibition Enhances Neutrophil-Mediated Killing of Dinutuximab-Opsonized Neuroblastoma Cells.

Cancers (Basel) 2021 Aug 24;13(17). Epub 2021 Aug 24.

Sanquin Research and Landsteiner Laboratory, Department of Molecular Hematology, Amsterdam UMC, University of Amsterdam, 1066 CX Amsterdam, The Netherlands.

High-risk neuroblastoma, especially after recurrence, still has a very low survival rate. Immune checkpoint inhibitors targeting T cells have shown remarkable clinical efficacy in adult solid tumors, but their effects in pediatric cancers have been limited so far. On the other hand, targeting myeloid immune checkpoints, such as CD47-SIPRα, provide the opportunity to enhance antitumor effects of myeloid cells, including that of neutrophils, especially in the presence of cancer-opsonizing antibodies. Read More

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Peptides Derived from Angiogenin Regulate Cellular Copper Uptake.

Int J Mol Sci 2021 Sep 2;22(17). Epub 2021 Sep 2.

Department of Pharmacy, University of Pisa, via Bonanno Pisano 6, 56126 Pisa, Italy.

The angiogenin protein (ANG) is one of the most potent endogenous angiogenic factors. In this work we characterized by means of potentiometric, spectroscopic and voltammetric techniques, the copper complex species formed with peptide fragments derived from the N-terminal domain of the protein, encompassing the sequence 1-17 and having free amino, Ang1-17, or acetylated N-terminus group, AcAng1-17, so to explore the role of amino group in metal binding and cellular copper uptake. The obtained data show that amino group is the main copper anchoring site for Ang1-17. Read More

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September 2021

S1P Stimulates Erythropoietin Production in Mouse Renal Interstitial Fibroblasts by S1P and S1P Receptor Activation and HIF-2α Stabilization.

Int J Mol Sci 2021 Aug 31;22(17). Epub 2021 Aug 31.

Institute of Pharmacology, University of Bern, Inselspital, INO-F, CH-3010 Bern, Switzerland.

Erythropoietin (Epo) is the critical hormone for erythropoiesis. In adults, Epo is mainly produced by a subset of interstitial fibroblasts in the kidney, with minor amounts being produced in the liver and the brain. In this study, we used the immortalized renal interstitial fibroblast cell line FAIK F3-5 to investigate the ability of the bioactive sphingolipid sphingosine 1-phosphate (S1P) to stimulate Epo production and to reveal the mechanism involved. Read More

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Protective, Antioxidant and Antiproliferative Activity of Grapefruit IntegroPectin on SH-SY5Y Cells.

Int J Mol Sci 2021 Aug 29;22(17). Epub 2021 Aug 29.

Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università di Palermo, Corso Tukory 129, 90134 Palermo, Italy.

Tested in vitro on SH-SY5Y neuroblastoma cells, grapefruit IntegroPectin is a powerful protective, antioxidant and antiproliferative agent. The strong antioxidant properties of this new citrus pectin, and its ability to preserve mitochondrial membrane potential and morphology, severely impaired in neurodegenerative disorders, make it an attractive therapeutic and preventive agent for the treatment of oxidative stress-associated brain disorders. Similarly, the ability of this pectic polymer rich in RG-I regions, as well as in naringin, linalool, linalool oxide and limonene adsorbed at the outer surface, to inhibit cell proliferation or even kill, at high doses, neoplastic cells may have opened up new therapeutic strategies in cancer research. Read More

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Biosynthesis and Cytotoxic Properties of Ag, Au, and Bimetallic Nanoparticles Synthesized Using Callus Culture Extract.

Int J Mol Sci 2021 Aug 27;22(17). Epub 2021 Aug 27.

Federal Scientific Center of the East Asia Terrestrial Biodiversity, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russia.

The present study reports a green chemistry approach for the rapid and easy biological synthesis of silver (Ag), gold (Au), and bimetallic Ag/Au nanoparticles using the callus extract of as a reducing and capping agent. The biosynthesized nanoparticles were characterized with ultraviolet-visible (UV-Vis) spectroscopy, X-ray diffraction (XRD) analysis, and transmission electron microscopy (TEM). Our results showed the formation of crystalline metal nanostructures of both spherical and non-spherical shape. Read More

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In Vitro and In Vivo Effects of Nobiletin on DRG Neurite Elongation and Axon Growth after Sciatic Nerve Injury.

Int J Environ Res Public Health 2021 Aug 26;18(17). Epub 2021 Aug 26.

Laboratory of Veterinary Toxicology, College of Veterinary Medicine, Jeju National University, Jeju 63243, Korea.

Sciatic nerve injury (SNI) leads to sensory and motor dysfunctions. Nobiletin is a major component of polymethoxylated flavonoid extracted from citrus fruits. The role of nobiletin on sciatic nerve regeneration is still unclear. Read More

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Imidazopyridazine Acetylcholinesterase Inhibitors Display Potent Anti-Proliferative Effects in the Human Neuroblastoma Cell-Line, IMR-32.

Molecules 2021 Sep 1;26(17). Epub 2021 Sep 1.

Neuroinflammation Research Laboratory, Faculty of Life Sciences and Biotechnology, South Asian University, New Delhi 110021, India.

Imidazo[1,2-]pyridazine compounds are a new class of promising lead molecules to which we have incorporated polar nitro and amino moieties to increase the scope of their biological activity. Two of these substituted 3-nitro-6-amino-imidazo[1,2-]pyridazine compounds (5c and 5h) showed potent acetylcholinesterase (AChE) inhibitory activity (IC 40-50 nM), which we have previously reported. In this study, we wanted to test the biological efficacy of these compounds. Read More

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September 2021

Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice.

Molecules 2021 Aug 30;26(17). Epub 2021 Aug 30.

College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University_Seoul, 32 Dongguk-lo, Ilsandong-gu, Goyang-si 10326, Gyonggi-do, Korea.

The pharmacokinetic (PK) change in a drug by co-administered herbal products can alter the efficacy and toxicity. In the circumstances that herb-drug combinations have been increasingly attempted to alleviate Alzheimer's disease (AD), the PK evaluation of herb-drug interaction (HDI) is necessary. The change in systemic exposure as well as target tissue distribution of the drug have been issued in HDIs. Read More

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Conductive conduit based on electrospun poly (l-lactide-co-D, l-lactide) nanofibers containing 4-aminopyridine-loaded molecularly imprinted poly (methacrylic acid) nanoparticles used for peripheral nerve regeneration.

Int J Biol Macromol 2021 Sep 7;190:499-507. Epub 2021 Sep 7.

Nano-Biopolymers Research Laboratory, School of Chemical Engineering, College of Engineering, University of Tehran, P. O. Box: 11155-4563, Tehran, Iran.

Using biocompatible polymer nanofibrous conduits with a controlled drug delivery have attracted much attention for peripheral nerve regeneration. This work was aimed at preparing electrospun poly (l-lactide-co-D, l-lactide) (PLDLLA) containing multi-walled carbon nanotubes (MWCNTs) and 4-aminopyridine (4-AP)-loaded molecularly imprinted nanoparticles (MIP) as well as evaluating their performance in in vitro and in vivo assessments. After synthesis of MIP based on poly (methacrylic acid) with imprinting factor of 1. Read More

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September 2021

Circ_0062166 aggravates cerebral ischemia-reperfusion injury through targeting miR-526b-5p/BCL2L13 axis.

Brain Inj 2021 Sep 8:1-9. Epub 2021 Sep 8.

Department of Neurology, Lianyungang Clinical Medical College of Nanjing Medical University, The First People's Hospital of Lianyungang City, Lianyungang, Jiangsu, China.

Background: Cerebral ischemia-reperfusion (CIR) injury is a severe disease, which may cause serious dysfunction of the brain. Most circular RNAs (circRNAs) have been demonstrated to play a significant role in CIR injury. However, a novel circRNA, circ_0062166 (circ_BCL2L13) has not been investigated for CIR injury. Read More

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September 2021

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors.

Nat Commun 2021 Sep 7;12(1):5309. Epub 2021 Sep 7.

Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.

Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one of the most important prognostic factors, with children less than 1 year old having favorable outcomes. Here we study single-cell and single-nuclei transcriptomes of neuroblastoma with different clinical risk groups and stages, including healthy adrenal gland. Read More

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September 2021

Metastatic olfactory neuroblastoma: A small round blue cell puzzle on fine-needle aspiration cytology.

Diagn Cytopathol 2021 Sep 7. Epub 2021 Sep 7.

Division of Anatomical Pathology, Tygerberg Hospital, National Health Laboratory Service, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Small round blue cell tumors (SRBCTs) are a heterogeneous group of malignant neoplasms that can be challenging to distinguish on fine-needle aspiration (FNA) cytology. Ancillary tests as well as clinico-radiological correlation are often required to make an accurate diagnosis. FNA is a low-cost, low-infrastructure test, making it a coveted diagnostic tool, especially in low-resource settings. Read More

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September 2021

Exosomal miR-214-3p as a potential novel biomarker for rhabdoid tumor of the kidney.

Pediatr Surg Int 2021 Sep 7. Epub 2021 Sep 7.

Department of Pediatric Surgery, Nihon University School of Medicine, 30-1 Oyaguchi-Kamicho, Itabashi, Tokyo, 173-8610, Japan.

Purpose: Rhabdoid tumor of the kidney (RTK) is a rare, highly aggressive pediatric renal tumor. No specific biomarkers are available for detection of RTK, and the initial differential diagnosis from other pediatric abdominal tumors, including neuroblastoma (NB), is difficult. Exosomal miRNAs are novel cancer biomarkers that can be detected in biological fluids. Read More

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September 2021

Combining Immunocytokine and Activated NK Cells as a Platform for Enhancing Graft-Versus-Tumor Effects Against GD2 Murine Neuroblastoma.

Front Immunol 2021 19;12:668307. Epub 2021 Aug 19.

Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI, United States.

Management for high-risk neuroblastoma (NBL) has included autologous hematopoietic stem cell transplant (HSCT) and anti-GD2 immunotherapy, but survival remains around 50%. The aim of this study was to determine if allogeneic HSCT could serve as a platform for inducing a graft-versus-tumor (GVT) effect against NBL with combination immunocytokine and NK cells in a murine model. Lethally irradiated C57BL/6 (B6) x A/J recipients were transplanted with B6 bone marrow on Day +0. Read More

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