Biomater Sci 2021 Jun 21. Epub 2021 Jun 21.
CAS Key Laboratory of SSAC, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, P.R. China. and University of Chinese Academy of Sciences, Beijing, 100049, P.R. China and Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, P.R. China and CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
Hydrogel microfibers are widely applied in tissue engineering and regenerative medicine due to their tunable morphology, componential anisotropy, and good biocompatibility. Specifically, grooved microfibers with unique advantages can facilitate cell alignment for mimicking the microstructures of myobundles. Herein, a microfluidic spinning system is proposed for flexibly generating grooved microfibers relying on the volume change after ionic crosslinking of sodium alginate (NaA) with different concentrations. Read More