Environ Toxicol 2020 Aug 24;35(8):895-905. Epub 2020 Apr 24.
Department of Biochemistry and Molecular Biology, School of Basic Medical and Biological Sciences, Soochow University, Suzhou, China.
Numerous studies have demonstrated the in vitro and in vivo neurotoxicity of nanoparticulate titanium dioxide (nano-TiO ), a mass-produced material for a large number of commercial and industrial applications. The mechanism of nano-TiO -induced inhibition of axonal development, however, is still unclear. In our study, primary cultured hippocampal neurons of 24-hour-old fetal Sprague-Dawley rats were exposed to 5, 15, or 30 μg/mL nano-TiO for 6, 12, and 24 hours, and the toxic effects of nano-TiO exposure on the axons development were detected and its molecular mechanism investigated. Read More