205 results match your criteria nests kidney


Clear cell clusters in the kidney: a rare finding that should not be misdiagnosed as renal cell carcinoma.

Virchows Arch 2021 Jan 14. Epub 2021 Jan 14.

Department of Pathology, Hospital POVISA, Vigo, Spain.

Clear cytoplasm is a major characteristic feature of most malignant renal neoplasms. Benign clear cells in the renal parenchyma, usually histiocytes, can occasionally be found, but they are infrequently of an epithelial nature. We report histological, immunohistochemical, ultrastructural, and cytogenomic features of clear epithelial cell clusters incidentally found in four kidney specimens. Read More

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January 2021

Renal angiomyoadenomatous tumor (RAT): a rare distinct entity with diagnostic challenges-a case report.

J Egypt Natl Canc Inst 2021 Jan 7;33(1). Epub 2021 Jan 7.

Department of Radiology, Goa Medical College, Bambolim, Goa, India.

Background: Renal angiomyoadenomatous tumor (RAT) is a recently described rare renal neoplasm with variations in the presentation, gross, and microscopic findings, and having a benign course and good prognosis. It is characterized microscopically by the admixture of three components-epithelial cells arranged in tubules and nests, angiomyomatous stroma, and capillary-sized interconnecting vascular channels in close association with the epithelial cell clusters. Microscopically, these tumors can be confused with clear cell carcinoma, papillary carcinoma, mixed epithelial and stromal tumors, and angiomyolipoma. Read More

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January 2021

ALK-rearranged renal cell carcinoma with a novel PLEKHA7-ALK translocation and metanephric adenoma-like morphology.

Virchows Arch 2020 Jun 28;476(6):921-929. Epub 2020 Jan 28.

Department of Pathology and Laboratory Medicine, Taipei Veterans General Hospital, No. 201, Section 2, Shipai Road, Taipei, 11217, Taiwan.

ALK-rearranged renal cell carcinoma is a provisional entity in the 2016 WHO Classification of Tumors of the Urinary System and Male Genital Organs. The reported fusion partners included VCL, TPM3, EML4, STRN, and HOOK1. Herein, we present a peculiar renal cell carcinoma morphologically resembling metanephric adenoma and harboring a novel PLEKHA7-ALK fusion. Read More

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PAX8 positivity in nested variant of urothelial carcinoma: a potential diagnostic pitfall.

Hum Pathol 2019 12 25;94:11-15. Epub 2019 Oct 25.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231; Departments of Urology and Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231. Electronic address:

Nested variant of urothelial carcinoma is a rare variant of urothelial carcinoma morphologically characterized by infiltrative nests of cytologically bland urothelial cells. It is widely recognized that nested variant of urothelial carcinoma can closely mimic von Brunn nests. However, nested variant of urothelial carcinoma with tubule formation can also resemble nephrogenic adenoma, where immunohistochemical positivity for PAX8 has been used to establish the diagnosis of nephrogenic adenoma. Read More

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December 2019

The influence of natural variation and organohalogenated contaminants on physiological parameters in white-tailed eagle (Haliaeetus albicilla) nestlings from Norway.

Environ Res 2019 10 15;177:108586. Epub 2019 Jul 15.

Department of Biology, Norwegian University of Science and Technology (NTNU), NO-7491, Trondheim, Norway. Electronic address:

Environmental exposure to organohalogenated contaminants (OHCs), even at low concentrations, may cause detrimental effects on the development and health of wild birds. The present study investigated if environmental exposure to OHCs may influence the variation of multiple physiological parameters in Norwegian white-tailed eagle (Haliaeetus albicilla) nestlings. Plasma and feather samples were obtained from 70 nestlings at two archipelagos in Norway in 2015 and 2016. Read More

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October 2019

PATHOLOGY OF LEATHERBACK SEA TURTLE () EMBRYOS AND HATCHLINGS FROM NESTS IN ST. KITTS, WEST INDIES (2015-16).

J Wildl Dis 2019 10 5;55(4):782-793. Epub 2019 Jun 5.

Center for Conservation Medicine and Ecosystem Health, Ross University School of Veterinary Medicine, Camps, St. Kitts, West Indies.

Sustained hatchling production is a priority for leatherback sea turtle () conservation. Yet the species is challenged by notoriously low hatch success, much lower than other species of sea turtles, and the result of a high rate of embryo mortality for which the causes are not understood. The aim of our study was to describe the pathology of embryos and dead-in-nest hatchlings, to help understand the basis for low hatch success in St. Read More

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October 2019

Succinate Dehydrogenase-Deficient Renal Cell Carcinoma.

Arch Pathol Lab Med 2019 05 21;143(5):643-647. Epub 2018 Dec 21.

From the Department of Pathology, Chi Mei Medical Center, Tainan City, Taiwan.

Succinate dehydrogenase (SDH)-deficient renal cell carcinoma is a recently recognized distinct subtype of renal cell carcinoma in the 2016 World Health Organization classification. It is associated with gene germline mutations, which also cause paraganglioma/pheochromocytoma, gastrointestinal stromal tumor, and pituitary adenoma. The tumor most commonly presents in young adulthood. Read More

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Hydroxymethylnitrofurazone treatment in indeterminate form of chronic Chagas disease: Reduced intensity of tissue parasitism and inflammation-A histopathological study.

Int J Exp Pathol 2018 10 15;99(5):236-248. Epub 2018 Oct 15.

São Paulo State University (UNESP), School of Pharmaceutical Sciences, Department of Drugs and Medicines, Lapdesf - Laboratory of Research and Development of Drugs, Araraquara, São Paulo, Brazil.

Hydroxymethylnitrofurazone (NFOH) is a nitrofurazone prodrug effective in vivo during acute infections, and it has less hepatotoxicity effect than the standard drug benznidazole (BZN) which has been used during short- and long-term treatment. In the present study, we induced the indeterminate form of Chagas disease in mice with a Y strain of Trypanosoma cruzi and analysed the histopathological data about the effects of NFOH and BZN on different tissues, including the heart, skeletal muscle, liver, kidney, colon, spleen and brain. After infection, BALB/c mice were treated with NFOH (150 mg/kg) and BZN (60 mg/kg) for 60 days and then submitted to immunosuppression using dexamethasone (5 mg/kg) for 14 days. Read More

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October 2018

Somatic Mutations of TSC2 or MTOR Characterize a Morphologically Distinct Subset of Sporadic Renal Cell Carcinoma With Eosinophilic and Vacuolated Cytoplasm.

Am J Surg Pathol 2019 01;43(1):121-131

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

The differential diagnosis of renal cell neoplasms with solid or nested architecture and eosinophilic cytoplasm has become increasingly complex. Despite recent advances in classifying a number of entities exhibiting this morphology, some tumors remain in the unclassified category. Here we describe a morphologically distinct group of sporadic renal cell carcinoma (RCC) with predominantly nested architecture, eosinophilic, and remarkably vacuolated cytoplasm retrospectively identified from a cohort of previously unclassified tumors. Read More

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January 2019

Melanotic Xp11 translocation renal cancer: a report of a distinctive case and a review of the literature.

Diagn Pathol 2018 Aug 13;13(1):51. Epub 2018 Aug 13.

Department of Pathology, Shandong Cancer Hospital Affiliated to Shandong University, No. 440 Jiyan Road, Jinan, 250117, China.

Background: Melanotic Xp11 translocation renal cancer (TRC) is a newly described exceedingly rare tumor, and its characterization remains controversial. This study aimed to describe a case of distinctive melanotic Xp11 TRC and to elucidate its clinicopathological and molecular genetic features.

Case Presentation: A 44-year-old Chinese female presented with a left renal mass. Read More

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[Low-grade eosinophilic unclassified renal cell carcinoma, a recently proposed entity in the spectrum of eosinophilic renal cells tumors: Report of one case and discussion].

Ann Pathol 2018 Dec 1;38(6):395-400. Epub 2018 Aug 1.

Service d'anatomie et cytologie pathologiques, CHU Pontchaillou, 2, rue Henri-Le-Guilloux, 35000 Rennes, France.

Low-grade eosinophilic unclassified renal cell carcinoma is a rare kidney tumor recently described, not included in the WHO classification, which is very close to oncocytoma. It is unknown to most pathologists and clinicians. From a histopathological point of view, this tumor is composed of oncocytic cells arranged in a diffuse and solid pattern, without cell nests, that makes it possible to differentiate it from oncocytoma, and expresses cytokeratin 7 (CK7) heterogeneously. Read More

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December 2018

Eosinophilic solid and cystic renal cell carcinoma mimicking epithelioid angiomyolipoma: series of 4 primary tumors and 2 metastases.

Hum Pathol 2018 10 6;80:65-75. Epub 2018 Jun 6.

Department of Pathology, University of Washington Medical Center, Seattle, WA 98105, USA. Electronic address:

Eosinophilic solid and cystic renal cell carcinoma (ESC-RCC) is a novel entity of rare tumors with rather unique morphology and immunohistochemical profile. Until recently these tumors were characterized by indolent behavior. Herein, we describe a series of six primary and metastatic ESC-RCCs morphologically and immunophenotypically mimicking epithelioid angiomyolipoma (eAML). Read More

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October 2018

NUTM1 Gene Fusions Characterize a Subset of Undifferentiated Soft Tissue and Visceral Tumors.

Am J Surg Pathol 2018 05;42(5):636-645

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY.

NUT midline carcinoma is an aggressive tumor that occurs mainly in the head and neck and, less frequently, the mediastinum and lung. Following identification of an index case of a NUTM1 fusion positive undifferentiated soft tissue tumor, we interrogated additional cases of primary undifferentiated soft tissue and visceral tumors for NUTM1 abnormalities. Targeted next-generation sequencing was performed on RNA extracted from formalin-fixed paraffin-embedded tissue, and results validated by fluorescence in situ hybridization using custom bacterial artificial chromosome probes. Read More

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Antitumor Memory T-Cells Become Functionally Mature from 30 to 100 days in a Mouse Model of Neoplasia.

Anticancer Res 2018 01;38(1):147-157

Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, U.S.A.

Background: Late metastases develop from cancer of the breast, prostate, lung, kidney and malignant melanomas. Memory T-cells have excellent potential to prevent this devastating development in the same way that they routinely prevent emergence of latent viruses.

Material And Methods: A peritoneal tumor mouse model of viral oncotherapy was used to generate therapeutic antitumor memory T-cells. Read More

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January 2018

Kidney carcinoid tumor: Histological, immunohistochemical and ultrastructural features.

Ultrastruct Pathol 2018 Jan-Feb;42(1):18-22. Epub 2017 Dec 1.

a Department of Pathology , Louisianan State University Health Science Center-Shreveport , Shreveport , LA , USA.

Primary carcinoid tumor of the kidney is uncommon. Only limited morphologic studies have been reported in the literature. In general, renal carcinoid tumor reveals typical morphological features as present in carcinoid tumors in the other organs, i. Read More

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Germ Cell Migration, Proliferation and Differentiation during Gonadal Morphogenesis in All-Female Japanese Flounder (Paralichthys Olivaceus).

Anat Rec (Hoboken) 2018 04 6;301(4):727-741. Epub 2018 Jan 6.

Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China.

In this study, all genetic female (XX) broods of Japanese flounder were produced artificially by mating the females with sex-reversed males. The proliferation and migration of primordial germ cells (PGCs), formation of ovary and oogenesis were described in detail. After hatching, around 20 individual PGCs migrated from the lateral to the dorsal of trunk region. Read More

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Occult Langerhans Cell Histiocytosis in Clear Cell Renal Cell Carcinoma.

Int J Surg Pathol 2018 Apr 11;26(2):194-196. Epub 2017 Oct 11.

1 Yeungnam University, Daegu, South Korea.

Langerhans cell histiocytosis is a rare disease that is characterized by a localized or systemic proliferation of Langerhans dendritic cells and a wide spectrum of clinical presentations. We experienced an unusual case of occult Langerhans cell histiocytosis associated with clear cell renal cell carcinoma. A 62-year-old man underwent a partial nephrectomy for left renal mass. Read More

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Renal angiomyoadenomatous tumour.

Turk J Urol 2017 Sep 3;43(3):378-382. Epub 2017 Aug 3.

Department of Urology, Government Medical College, Thrissur, Kerala, India.

Renal angiomyoadenomatous tumour is a newly described rare neoplasm. This tumour is characterised microscopically by admixture of three components- epithelial cells arranged in tubules and nests, angiomyomatous stroma and capillary sized interconnecting vascular channels in close association with the epithelial cell clusters. Microscopically it has wide range of differential diagnoses which include mixed epithelial and stromal tumour of kidney, angiomyolipoma and clear cell renal cell carcinoma with angiomyolipomatous/angiomyoadenomatous areas. Read More

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September 2017

Spontaneous nephroblastoma with striated muscle differentiation in an F344 rat.

J Toxicol Pathol 2017 Jul 24;30(3):231-234. Epub 2017 Mar 24.

Laboratory of Veterinary Pathology, Osaka Prefecture University, Izumisano, Osaka 598-8531, Japan.

An eleven-month old male F344/DuCrj (F344) rat was found dead and had right kidney mass at necropsy. Histopathologically, the mass was composed of nests of neoplastic stellate cells. At the center of the nests, neoplastic epithelial cells formed a tubular structure. Read More

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Clear cell neuroendocrine tumor of the pancreas in von Hippel-Lindau disease: a case report and literature review.

Neuro Endocrinol Lett 2017 May;38(2):83-86

Department of Pathology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Republic of Korea.

Clear cell neuroendocrine tumor (NET) of the pancreas is found in von Hippel-Lindau (VHL) disease, multiple endocrine neoplasia type I (MEN I), and sporadic form. Clear cell NETs are often misdiagnosed as metastatic renal cell carcinoma. A 47-year-old woman with VHL was found to have a mass in the pancreatic tail and two masses in the right kidney with two cysts. Read More

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TFEB-amplified Renal Cell Carcinomas: An Aggressive Molecular Subset Demonstrating Variable Melanocytic Marker Expression and Morphologic Heterogeneity.

Am J Surg Pathol 2016 11;40(11):1484-1495

Departments of *Pathology †Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD ‡Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.

Renal cell carcinomas (RCCs) with the t(6;11)(p21;q12) chromosome translocation are low-grade RCC which often occur in young patients. They typically feature an unusual biphasic morphology characterized by nests of larger epithelioid cells surrounding intraluminal collections of smaller cells clustered around basement membrane material. The t(6;11)(p21;q12) translocation fuses the Alpha (MALAT1) gene with the TFEB transcription factor gene, resulting in upregulated expression of intact native TFEB that drives the aberrant expression of melanocytic markers which is a hallmark of this distinctive neoplasm. Read More

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November 2016

Metastatic Adenoid Cystic Carcinoma Mimicking Butterfly Glioblastoma: A Rare Presentation in the Splenium of the Corpus Callosum.

World Neurosurg 2016 Nov 10;95:621.e13-621.e19. Epub 2016 Aug 10.

Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA. Electronic address:

Background: Intracranial spread of an adenoid cystic carcinoma (ACC) of the parotid gland is rare, and metastatic ACC to the splenium of the corpus callosum mimicking butterfly glioblastoma (GBM) has not been reported previously. We report a rare case of metastasis to the splenium of the corpus callosum from ACC of the parotid gland.

Case Description: The tumor occupied the splenium and mimicked the presentation of a butterfly glioma. Read More

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November 2016

Simultaneous targeted activation of Notch1 and Vhl-disruption in the kidney proximal epithelial tubular cells in mice.

Sci Rep 2016 08 5;6:30739. Epub 2016 Aug 5.

Division of Translational Cancer Research, Department of Laboratory Medicine, Medicon Village, Building 404 A3, Scheelevägen 8, 404A3, 223 63 Lund, Sweden.

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancer, representing approximately 75% of all renal neoplasms. ccRCC is known to be strongly associated with silencing of the von Hippel Lindau (VHL) tumor suppressor gene, yet VHL deficiency alone does not seem to be sufficient to drive the oncogenic transformation of normal renal epithelium and induce renal tumorigenesis. We, and others, have previously suggested that constitutive activation of the Notch signaling pathway, alongside with VHL loss, contribute to the oncogenic features of ccRCC. Read More

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Inhibition of mTOR Signaling Pathway Delays Follicle Formation in Mice.

J Cell Physiol 2017 Mar 24;232(3):585-595. Epub 2016 Jun 24.

State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.

In mammalian ovaries, follicle assembly requires proper germ cell cyst breakdown and the invasion of somatic cells to encapsulate individual oocytes. Abnormalities in this process lead to a number of pathologies such as premature ovarian failure and infertility. As a conserved pathway regulating cell growth and metabolism in response to growth factors and nutrients, the roles of mTOR signaling in follicular development have been extensively studied in recent years. Read More

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Embryonic common snapping turtles (Chelydra serpentina) preferentially regulate intracellular tissue pH during acid-base challenges.

J Exp Biol 2016 07 18;219(Pt 13):1994-2002. Epub 2016 Apr 18.

Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4.

The nests of embryonic turtles naturally experience elevated CO2 (hypercarbia), which leads to increased blood PCO2  and a respiratory acidosis, resulting in reduced blood pH [extracellular pH (pHe)]. Some fishes preferentially regulate tissue pH [intracellular pH (pHi)] against changes in pHe; this has been proposed to be associated with exceptional CO2 tolerance and has never been identified in amniotes. As embryonic turtles may be CO2 tolerant based on nesting strategy, we hypothesized that they preferentially regulate pHi, conferring tolerance to severe acute acid-base challenges. Read More

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Polyclonal Crypt Genesis and Development of Familial Small Intestinal Neuroendocrine Tumors.

Gastroenterology 2016 07 18;151(1):140-51. Epub 2016 Mar 18.

Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland. Electronic address:

Background & Aims: Small intestinal neuroendocrine tumors (SI-NETs) are serotonin-secreting well-differentiated neuroendocrine tumors believed to originate from enterochromaffin (EC) cells. Intestinal stem cell (ISC) are believed to contribute to the formation of SI-NETs, although little is known about tumor formation or development. We investigated the relationship between EC cells, ISCs, and SI-NETs. Read More

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Biphasic Squamoid Alveolar Renal Cell Carcinoma: A Distinctive Subtype of Papillary Renal Cell Carcinoma?

Am J Surg Pathol 2016 May;40(5):664-75

Departments of *Pathology ***Urology, Charles University, Medical Faculty and Charles University Hospital Plzen ∥∥Department of Pathology, Charles University, Medical Faculty and Charles University Hospital Hradec Kralove, Czech Republic †Department of Pathology, Bellvitge University Hospital, Bellvitge Biomedical Research Institute (IDIBELL) ‡Department of Pathology and Experimental Therapeutics, University of Barcelona School of Medicine ‡‡Department of Pathology, Consorci Sanitari Integral, Barcelona §Department of Pathology, Cruces University Hospital, Biocruces Research Institute, University of the Basque Country, Barakaldo, Spain ∥Department of Pathology, University of Trieste, Trieste, Italy ¶Department of Pathology, University Hospital Erlangen, Erlangen, Germany #Department of Pathology, The University of Kansas School of Medicine, Kansas City, KS **Department of Pathology, National University Health System, Singapore, Singapore ††Department of Pathology, Clinical Hospital Center Zagreb §§"Ljudevit Jurak" Pathology Department, Clinical Hospital Center "Sestre milosrdnice", Zagreb, Croatia ¶¶Department of Pathology, East University, Riga, Latvia ##Department of Pathology, Petrov's Research Institute of Oncology, St Petersburg, Russia.

Biphasic squamoid alveolar renal cell carcinoma (BSARCC) has been recently described as a distinct neoplasm. Twenty-one cases from 12 institutions were analyzed using routine histology, immunohistochemistry, array comparative genomic hybridization (aCGH) and fluorescence in situ hybridization. Tumors were removed from 11 male and 10 female patients, whose age ranged from 53 to 79 years. Read More

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Morpho-histology of head kidney of female catfish Heteropneustes fossilis: seasonal variations in melano-macrophage centers, melanin contents and effects of lipopolysaccharide and dexamethasone on melanins.

Fish Physiol Biochem 2016 Oct 16;42(5):1287-306. Epub 2016 Mar 16.

School of Biotechnology, Banaras Hindu University, Varanasi, 221005, India.

In the catfish Heteropneustes fossilis, the anterior kidney is a hemopoietic tissue which surrounds the adrenal homologues, interrenal (IR) and chromaffin tissues corresponding to the adrenal cortical and adrenal medulla of higher mammals. The IR tissue is arranged in cell cords around the posterior cardinal vein (PCV) and its tributaries and secretes corticosteroids. The chromaffin tissue is scattered singly or in nests of one or more cells around the epithelial lining of the PCV or blood capillaries within the IR tissue. Read More

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October 2016

Malignant renal epithelioid angiomyolipoma: A case report and review of the literature.

Oncol Lett 2016 Jan 30;11(1):95-98. Epub 2015 Oct 30.

Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, P.R. China.

Malignant renal epithelioid angiomyolipoma (EAML) is rare, and currently there is no malignant criteria for its pathological diagnosis. In the present study, the case of a patient who suffered malignant renal EAML and underwent nephrectomy is reported. The histological patterns of the tumor were composed of sheets or nests of large polygonal epithelioid cells and thick-walled blood vessels, with clear mitoses. Read More

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January 2016