Endocrinology 2021 May 8. Epub 2021 May 8.
National Institute of Diabetes and Digestive and Kidney Diseases, Laboratory of Endocrinology and Receptor Biology, National Institutes of Health, Bethesda, Maryland.
Thyroid hormones exert pleiotropic, essential actions in mammalian, including human, development. These actions depend upon provision of thyroid hormones in the circulation but also to a remarkable extent upon deiodinase enzymes in target tissues that amplify or deplete the local concentration of the primary active form of the hormone T3 (3,5,3'-triiodothyronine), the high affinity ligand for thyroid hormone receptors. Genetic analyses in mice have revealed key roles for activating (DIO2) and inactivating (DIO3) deiodinases in cell differentiation fates and tissue maturation, ultimately promoting neonatal viability, growth, fertility, brain development and behavior, as well as metabolic, endocrine and sensory functions. Read More