Behav Brain Res 2021 Mar 31;408:113269. Epub 2021 Mar 31.
Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC, Australia; Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia; Department of Psychiatry, The University of Münster, Münster, Germany. Electronic address:
Background: We recently reported that tumor necrosis factor (TNF) signaling via the TNFR1 and TNFR2 receptors mediates the effects of long-term exercise on locomotion, cognition and anxiety, but not depressive-like behavior. We now investigated whether the TNF signaling via its receptors also mediates the effects of short-term exercise on cognition, anxiety and depressive-like behaviors.
Methods: Thirteen-month-old C57BL/6 (WT), TNF, TNFR1, and TNFR2 mice were provided with 4 weeks of voluntary wheel running followed by behavioral testing using an established behavioral battery. Read More