801,519 results match your criteria nervous


Mechanism and Priority of Botulinum Neurotoxin A versus Sacral Neuromodulation for Refractory Overactive Bladder: A Review.

Urol Int 2021 Jun 15:1-6. Epub 2021 Jun 15.

First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Background: The treatment of common overactive bladder (OAB) has reached a consensus, but there is not a clear answer to the treatment of refractory OAB (ROAB). ROAB is defined as nonresponsive to treatment with behavioural and oral therapies. The disease can influence the physical and mental health of patients, cause poor quality of life, and create an urgent socio-economic burden. Read More

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Alcohol Consumption and Stroke Risk in Men: A Population-Based Cohort Study in Rural Tianjin, China.

Neuroepidemiology 2021 Jun 15:1-9. Epub 2021 Jun 15.

Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China.

Background: Although the protective effects of alcohol consumption against future cardiovascular disease have been published, the effects of alcohol on stroke risk remain controversial.

Method: We assessed the effects of alcohol consumption on stroke risk in a poorly educated, low-income population in rural China. Between 1991 and 2018, a population-based cohort study was conducted in rural Tianjin, China, to examine stroke risk. Read More

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Impact of Confinement in Patients under Long-Term Noninvasive Ventilation during the First Wave of the SARS-CoV-2 Pandemic: A Remarkable Resilience.

Respiration 2021 Jun 15:1-9. Epub 2021 Jun 15.

Division of Pulmonary Diseases, Geneva University Hospitals, Geneva, Switzerland.

Background: During the first wave of the SARS-CoV-2 pandemic in Switzerland, confinement was imposed to limit transmission and protect vulnerable persons. These measures may have had a negative impact on perceived quality of care and symptoms in patients with chronic disorders.

Objectives: To determine whether patients under long-term home noninvasive ventilation (LTHNIV) for chronic respiratory failure (CRF) were negatively affected by the 56-day confinement (March-April 2020). Read More

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A Comparison of Physical Activity Levels, Sleep Disrupting Behavior, and Stress/Affective Distress as Predictors of Sleep as Indexed by Actigraphy.

J Phys Act Health 2021 Jun 13:1-12. Epub 2021 Jun 13.

Background: Several behaviors have been reported to interfere with sleep in otherwise healthy adults, including low physical activity (PA) levels. However, few studies have compared low PA with the other behavioral risk factors of objective sleep impairment, despite the behavior tending to cooccur in highly stressed and affectively distressed individuals. Thus, the authors compared objective and subjective measures of PA and other potential sleep disrupting behaviors as predictors of objective sleep (sleep onset latency, actual sleep time, total sleep duration, awake time, and sleep efficacy) at baseline (T1) and 3 months later (T2). Read More

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Demystifying the spontaneous phenomena of motor hyperexcitability.

Clin Neurophysiol 2021 May 13;132(8):1830-1844. Epub 2021 May 13.

UK Dementia Research Institute, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK; King's College Hospital NHS Foundation Trust, Denmark Hill, London, UK.

Possessing a discrete functional repertoire, the anterior horn cell can be in one of two electrophysiological states: on or off. Usually under tight regulatory control by the central nervous system, a hierarchical network of these specialist neurons ensures muscular strength is coordinated, gradated and adaptable. However, spontaneous activation of these cells and their axons can result in abnormal muscular twitching. Read More

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Synthesis and evaluation of trypanocidal activity of derivatives of naturally occurring 2,5-diphenyloxazoles.

Bioorg Med Chem 2021 Jun 12;42:116253. Epub 2021 Jun 12.

Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan.

African trypanosomiasis is a zoonotic protozoan disease affecting the nervous system. Various natural products reportedly exhibit trypanocidal activity. Naturally occurring 2,5-diphenyloxazoles present in Oxytropis lanata, and their derivatives, were synthesized. Read More

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Significance of detecting postmortem serum IgE in frozen corpses for the diagnosis of anaphylaxis in forensic.

Leg Med (Tokyo) 2021 Jun 9;53:101930. Epub 2021 Jun 9.

Department of Forensic Medicine, Faculty of Basic Medical Sciences, Chongqing Medical University, Chongqing 400016, China. Electronic address:

The aim of this study was to detect the postmortem serum total IgE levels in frozen corpses and identify whether the death incident caused by an anaphylaxis in forensic medicine. Autopsy cases with pathological death (total, n = 106; 4-214 h postmortem) include cardiac disease (n = 15), pulmonary infection (n = 12), central nervous system disorder (n = 6), pulmonary emboliszn (n = 7), hapetic disease (n = 5), kidney disease (n = 6), enteric disease (n = 10), necrotizing pancreatitis (n = 7), diffuse peritonitis (n = 6), MODS (n = 6), toxicosis (n = 5:), anaphylactic shock (n = 7), bronchial asthma (n = 8) and other disease (n = 6) were examined. Results showed that there was no significant difference between serum IgE levels and ages, postmortem intervals (PMIs), gender as well as survival time. Read More

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Neuroimaging findings in rheumatologic disorders.

J Neurol Sci 2021 Jun 11;427:117531. Epub 2021 Jun 11.

University of Iowa Hospital and Clinics, Department of Radiology, USA. Electronic address:

Patients with rheumatological diseases may present with neurological manifestations of peripheral and/or central nervous system (CNS). Symptoms may be related to underlying rheumatological disease or CNS effects of immune-modulating drugs. Early diagnosis and therapy may help prevent serious complications. Read More

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Internet gaming disorder and comorbidities among campus-dwelling U.S. university students.

Psychiatry Res 2021 Jun 6;302:114043. Epub 2021 Jun 6.

Department of Psychiatry and Behavioral Sciences, Stanford University, CA, United States.

This study investigates the prevalence and associations of DSM-5 Internet Gaming Disorder (IGD) with sleep impairment, daytime functioning, psychiatric disorders, and health status among young adults living in student houses on the campus of an American university. A random sample of students living on the campus underwent phone interviews during the 2007 & 2015 academic years. The sample included 1,871 undergraduate and 1,113 graduate students (2,984 in total). Read More

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Tumefactive demyelination appearing as multiple cystic brain lesions.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurosurgery, St. Vincent's Hospital Melbourne, 41 Victoria Pde, Fitzroy, Victoria 3065, Australia.

Tumefactive demyelinating lesions (TDL) are a rare sequalae of idiopathic inflammatory demyelinating diseases (IIDD) of the central nervous system (CNS). Their propensity to mimic tumor and abscess poses a diagnostic challenge for the clinician. Our case depicts TDL causing right hand focal sensory seizures in an otherwise healthy 35-year-old female. Read More

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Interactive regulation of laryngeal cancer and neuroscience.

Biochim Biophys Acta Rev Cancer 2021 Jun 12;1876(1):188580. Epub 2021 Jun 12.

Department of Pathology, Harbin Medical University Cancer Hospital, Harbin 150081, China. Electronic address:

Nerve fibres are distributed throughout the body along with blood and lymphatic vessels. The intrinsic morphological characteristics of nerves and the general characteristics of secretions in the tumour microenvironment provide a solid theoretical basis for exploring how neuronal tissue can influence the progression of laryngeal cancer (LC). The central nervous system (CNS) and the peripheral nervous system (PNS) jointly control many aspects of cancer and have attracted widespread attention in the study of the progression, invasion and metastasis of tumour tissue banks. Read More

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Ethnomedicine and Neuropsychopharmacology in Mesoamerica.

J Ethnopharmacol 2021 Jun 12:114243. Epub 2021 Jun 12.

Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, 09042, Monserrato CA, Italy. Electronic address:

Ethnopharmacological Relevance: The burden of disease caused by mental and neurological disorders is increasing globally, to a disproportionate degree in Latin America. In contrast to the many psychoactive plants with a use history in Mesoamerican cultures, the translation to the wider population of knowledge around numerous botanicals used contemporarily by indigenous Mesoamerican societies to treat psychological and neurological disorders did not receive the same attention.

Material And Methods: We used the previously published Mesoamerican Medicinal Plant Database to extract species and associated botanical drugs used as treatments for illnesses associated with the nervous system by Mesoamerican cultures in Belize, Guatemala, and Mexico. Read More

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Possible involvement of agmatine in neuropharmacological actions of metformin in diabetic mice.

Eur J Pharmacol 2021 Jun 12:174255. Epub 2021 Jun 12.

Division of Neuroscience, Department of Pharmacology, Shrimati Kishoritai Bhoyar College of Pharmacy, New Kamptee, Nagpur, M.S, India, 441 002. Electronic address:

The risk of psychiatric and neurological disorders is significantly higher in patients with diabetes mellitus. Diabetic patients are more susceptible to depression, anxiety and memory impairment as compared with non-diabetic individuals. Metformin, a biguanide used for the management of type 2 diabetes mellitus (T2DM), promotes neurogenesis, enhances spatial memory function and protects the brain against oxidative imbalance beyond its effect on glucose metabolism. Read More

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The funny current in genetically modified mice.

Prog Biophys Mol Biol 2021 Jun 12. Epub 2021 Jun 12.

Institut de Génomique Fonctionnelle, Université de Montpellier, CNRS, INSERM, Montpellier, France; LabEx Ion Channels Science and Therapeutics (ICST), France. Electronic address:

Since its first description in 1979, the hyperpolarization-activated funny current (I) has been the object of intensive research aimed at understanding its role in cardiac pacemaker activity and its modulation by the sympathetic and parasympathetic branches of the autonomic nervous system. I was described in isolated tissue strips of the rabbit sinoatrial node using the double-electrode voltage-clamp technique. Since then, the rabbit has been the principal animal model for studying pacemaker activity and I for more than 20 years. Read More

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Chemoattractants driven and microglia based biomimetic nanoparticle treating TMZ-resistant glioblastoma multiforme.

J Control Release 2021 Jun 12;336:54-70. Epub 2021 Jun 12.

Department of Pharmaceutics, School of Pharmacy, Air Force Medical University, Xi'an 710032, China. Electronic address:

Currently, clinical treatment for temozolomide (TMZ)-resistant glioblastoma multiforme (GBM) is still a difficult problem. The aim of this paper is to set up a new GBM-targeted drug delivery system to treat TMZ-resistant GBM. Zoledronate (ZOL) not only induces apoptosis of TMZ-resistant GBM cells by down-regulation of farnesyl pyrophosphate synthetase (FPPS) but also increases the proportion of M1-type GBM associated macrophages (GAM). Read More

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Ligand gated receptor interactions: A key to the power of neuronal networks.

Biochem Pharmacol 2021 Jun 12;190:114653. Epub 2021 Jun 12.

HiQScreen Sàrl, 6 rte de Compois, 1222 Vésenaz, Geneva, Switzerland. Electronic address:

The discovery of the chemical synapse was a seminal finding in Neurobiology but the large body of microscopic interactions involved in synaptic transmission could hardly have been foreseen at the time of these first discoveries. Characterization of the molecular players at work at synapses and the increased granularity at which we can now analyze electrical and chemical signal processing that occur in even the simplest neuronal system are shining a new light on receptor interactions. The aim of this review is to discuss the complexity of some representative interactions between excitatory and inhibitory ligand-gated ion channels and/or G protein coupled receptors, as well as other key machinery that can impact neurotransmission and to explain how such mechanisms can be an important determinant of nervous system function. Read More

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Increase in brain L-lactate enhances fear memory in diabetic mice: involvement of glutamate neurons.

Brain Res 2021 Jun 12:147560. Epub 2021 Jun 12.

Department of Pathophysiology and Therapeutics, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.

Previous reports suggest that diabetes mellitus is associated with psychiatric disorders, including depression and anxiety, but the mechanisms involved are unknown. We have reported that streptozotocin (STZ)-induced diabetic mice show enhancement of conditioned fear memory. To clarify the mechanisms through which diabetes affects conditioned fear memory, the present study investigated the role of L-lactate and glutamatergic function in enhancement of conditioned fear memory in diabetes. Read More

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Subspecialty Training of Neurology Residents and Junior Neurologists in the Baltic States.

Eur J Neurol 2021 Jun 15. Epub 2021 Jun 15.

Clinic of Neurology and Neurosurgery, Vilnius University, Vilnius, Lithuania.

Background: Neurology is a field of increasing subspecialization. There is no published data regarding the proportion of neurology subspecialists in the Baltic States. The aim of this cross-sectional study was to identify factors associated with neurology subspecialty choice, to examine possible differences between neurology residents' and junior neurologists' view of subspecialty, and to assess perceived subspecialty acquisition opportunities and subspecialty attractiveness. Read More

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The associations between smart device use and psychological distress among secondary and high school students in Kuwait.

PLoS One 2021 15;16(6):e0251479. Epub 2021 Jun 15.

Department of Physical Education, College of Basic Education, The Public Authority for Applied Education and Training, Kuwait.

Background: Smart devices (SDs) are widely used among adolescents. Numerous studies have recommended further research on this topic to find out the prevalence of SD overuse among school students and to what extent this is associated with psychological distress. The present study aimed to investigate the pattern of SD use among secondary and high school students in the state of Kuwait, as well as the possible associations with psychological problems, weight, physical activity, and school performance. Read More

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Describing the Mental Health State of Nurses in British Columbia: A Province-Wide Survey Study.

Healthc Policy 2021 May;16(4):31-45

Case and Contact Management, Pandemic Response, Island Health; Former Consultant, Former Executive Councillor of Occupational Health and Safety, British Columbia Nurses' Union, Burnaby, BC.

A cross-sectional province-wide survey study of 3,978 British Columbia (BC) nurses was conducted to explore the mental health state of the nursing workforce in BC. About one third of nurses reported depression and anxiety; about half reported symptoms of post-traumatic stress disorder and at least one third reported high levels of one or more dimensions of burnout. Mental health problems were about 1. Read More

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Organization of the central nervous system and innervation of cephalic sensory structures in the water bear Echiniscus testudo (Tardigrada: Heterotardigrada) revisited.

J Morphol 2021 Jun 15. Epub 2021 Jun 15.

Department of Zoology, Institute of Biology, Kassel, Germany.

The tardigrade brain has been the topic of several neuroanatomical studies, as it is key to understanding the evolution of the central nervous systems in Panarthropoda (Tardigrada + Onychophora + Arthropoda). The gross morphology of the brain seems to be well conserved across tardigrades despite often disparate morphologies of their heads and cephalic sensory structures. As such, the general shape of the brain and its major connections to the rest of the central nervous system have been mapped out already by early tardigradologists. Read More

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Associations Between Participation and Mental Health for Vulnerable Youth with Special Healthcare Needs.

Matern Child Health J 2021 Jun 15. Epub 2021 Jun 15.

Department of Disability and Human Development, University of Illinois at Chicago, 1640 W Roosevelt Road, Chicago, IL, 60608, USA.

Objectives: To understand the role of adverse child experiences and breadth of participation in the mental health outcomes of youth with special healthcare needs (YSHCN). Breadth of participation refers to the number of different activity contexts within which YSHCN participate.

Methods: The present, cross-sectional, study utilized the 2016 National Survey of Children's Health, a nationally representative survey of the physical and emotional health of children in the United States. Read More

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Impacts of OrX and cAMP-insensitive Orco to the insect olfactory heteromer activity.

Mol Biol Rep 2021 Jun 11. Epub 2021 Jun 11.

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Moscow, Russia.

Insect odorant receptors (ORs) have been suggested to function as ligand-gated cation channels, with OrX/Orco heteromers combining ionotropic and metabotropic activity. The latter is mediated by different G proteins and results in Orco self-activation by cyclic nucleotide binding. In this contribution, we co-express the odor-specific subunits DmOr49b and DmOr59b with either wild-type Orco or an Orco-PKC mutant lacking cAMP activation heterologously in mammalian cells. Read More

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The Impact of COVID-19 on HIV Self-Management, Affective Symptoms, and Stress in People Living with HIV in the United States.

AIDS Behav 2021 Jun 15. Epub 2021 Jun 15.

Indiana University School of Nursing, 600 Barnhill Dr., Indianapolis, IN, 46202, USA.

COVID-19 has the potential to detrimentally impact HIV self-management in people living with HIV (PLHIV). Effective HIV-self management is critically important in managing symptoms as well as viral suppression. We examined the impact of the COVID-19 pandemic on HIV self-management, social support, social isolation, depressive symptoms, anxiety, and stress in PLHIV. Read More

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Peer-to-Peer Support and Changes in Health and Well-being in Older Adults Over Time.

JAMA Netw Open 2021 Jun 1;4(6):e2112441. Epub 2021 Jun 1.

Department of Medicine and Population Health, University of Texas at Austin Dell Medical School, Austin.

Importance: Literature on peer-to-peer (P2P) programs suggests they improve health and well-being of older adults. Analysis from a previous study showed P2P to be associated with higher rates of hospitalization and no significant differences in rates of emergency department or urgent care visits; however, it is not known whether measures of health and well-being varied by group over time.

Objective: To compare the association between receiving P2P support and secondary outcomes (ie, health status, quality of life, and depressive and anxiety symptoms) with receiving standard community services (SCS) over time. Read More

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Chronic Pelvic Pain in Women: A Review.

JAMA 2021 Jun;325(23):2381-2391

Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles.

Importance: Chronic pelvic pain (CPP) is a challenging condition that affects an estimated 26% of the world's female population. Chronic pelvic pain accounts for 40% of laparoscopies and 12% of hysterectomies in the US annually even though the origin of CPP is not gynecologic in 80% of patients. Both patients and clinicians are often frustrated by a perceived lack of treatments. Read More

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Application of fluorescent dextrans to the brain surface under constant pressure reveals AQP4-independent solute uptake.

J Gen Physiol 2021 Aug 15;153(8). Epub 2021 Jun 15.

Departments of Medicine and Physiology, University of California San Francisco, San Francisco, CA.

Extracellular solutes in the central nervous system are exchanged between the interstitial fluid, the perivascular compartment, and the cerebrospinal fluid (CSF). The "glymphatic" mechanism proposes that the astrocyte water channel aquaporin-4 (AQP4) is a major determinant of solute transport between the CSF and the interstitial space; however, this is controversial in part because of wide variance in experimental data on interstitial uptake of cisternally injected solutes. Here, we investigated the determinants of solute uptake in brain parenchyma following cisternal injection and reexamined the role of AQP4 using a novel constant-pressure method. Read More

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Pythagorean Self-Awareness Intervention for Multiple Sclerosis Patients: A Quasi-Experimental Pragmatic Trial.

Arch Clin Neuropsychol 2021 Jun 15. Epub 2021 Jun 15.

1st Department of Neurology, Aeginition Hospital, Medical School, National Kapodistrian University of Athens, Athens, Greece.

Objective: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system affecting patients' well-being and quality of life. Pythagorean Self-Awareness Intervention (PSAI) is a novel non-pharmaceutical intervention with significant benefits both in MS and other chronic diseases. In this study, the longstanding effectiveness of PSAI was investigated. Read More

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