97,263 results match your criteria nerve stimulation

Pathogenesis, Etiology and Treatment of Failed Back Surgery Syndrome.

Neurochirurgie 2021 Sep 17. Epub 2021 Sep 17.

Department of Orthopedic Surgery, School of Medicine, AJA University of Medical Science, Tehran, Iran. Electronic address:

Failed back surgery syndrome (FBSS) is associated with persistent lower back pain after and despite one or more surgical interventions. A number of factors underlie and maintain FBSS and successful management of pain chiefly depends on identifying them. Pharmacological, surgical, and non-surgical therapeutic measures are taken to treat the pain. Read More

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September 2021

Comparison between ultrasound-guided monopolar and bipolar pulsed radiofrequency treatment for refractory chronic cervical radicular pain: A randomized trial.

J Back Musculoskelet Rehabil 2021 Sep 13. Epub 2021 Sep 13.

Department of Rehabilitation Medicine, College of Medicine, Yeungnam University, Daegu, Korea.

Background: Many patients complain of chronic cervical radicular pain, and pulsed radiofrequency (PRF) is known to have a positive effect for alleviating neuropathic pain.

Objectives: In the present study, we used ultrasound (US) guidance and compared the effects of monopolar PRF with those of bipolar PRF in patients with chronic cervical radicular pain refractory to repeated transforaminal epidural steroid injections.

Methods: Sixty-six patients with chronic cervical radicular pain were included in this study. Read More

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September 2021

Intermittent Vagal Nerve Stimulation-Associated Vocal Fold Movement Impairment.

Ann Otol Rhinol Laryngol 2021 Sep 18:34894211047459. Epub 2021 Sep 18.

Pediatric Otolaryngology, Texas Children's Hospital, Houston, TX, USA.

Objectives: Implanted vagal nerve stimulators (VNS) are an accepted therapy for refractory seizures. However, VNS have been shown to affect vocal fold function, leading to voice complaints of hoarseness. We present a case of intermittent VNS-related vocal fold paralysis leading to dysphonia and dysphagia with aspiration in a pediatric patient. Read More

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September 2021

The effect of peripheral high-frequency electrical stimulation on the primary somatosensory cortex in pigs.

IBRO Neurosci Rep 2021 Dec 9;11:112-118. Epub 2021 Sep 9.

Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

This study implements the use of Danish Landrace pigs as subjects for the long-term potentiation (LTP)-like pain model. This is accomplished by analyzing changes in the primary somatosensory cortex (S1) in response to electrical stimulation on the ulnar nerve after applying high-frequency electrical stimulation (HFS) on the ulnar nerve. In this study, eight Danish Landrace pigs were electrically stimulated, through the ulnar nerve, to record the cortically evoked response in S1 by a 16-channel microelectrode array (MEA). Read More

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December 2021

Aligned fibrin/functionalized self-assembling peptide interpenetrating nanofiber hydrogel presenting multi-cues promotes peripheral nerve functional recovery.

Bioact Mater 2022 Feb 12;8:529-544. Epub 2021 Jun 12.

State Key Laboratory of New Ceramics and Fine Processing, Key Laboratory of Advanced Materials of Ministry of Education, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, PR China.

Nerve guidance conduits with hollow lumen fail to regenerate critical-sized peripheral nerve defects (15 mm in rats and 25 mm in humans), which can be improved by a beneficial intraluminal microenvironment. However, individual cues provided by intraluminal filling materials are inadequate to eliminate the functional gap between regenerated nerves and normal nerves. Herein, an aligned fibrin/functionalized self-assembling peptide (AFG/fSAP) interpenetrating nanofiber hydrogel that exerting synergistic topographical and biochemical cues for peripheral nerve regeneration is constructed via electrospinning and molecular self-assembly. Read More

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February 2022

Brain plasticity and vagus nerve stimulation.

Auton Neurosci 2021 Sep 7;236:102876. Epub 2021 Sep 7.

Institute for Neuromodulation and Neurotechnology, Department of Neurosurgery and Neurotechnology, University of Tuebingen, Tuebingen, Germany.

After damage to the central nervous system, caused by traumatic injury or ischemia, plasticity becomes critically important for functional recovery. When this inherent capacity to adapt is limited despite training, external stimulation may support this process. Vagus nerve stimulation (VNS) is an effective method to enhance the effect of motor rehabilitation training on functional recovery. Read More

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September 2021

Posterolateral trans dentate approach to anterior extensive extramedullary tumor of the cervical spine in a pediatric case: how I do it.

Acta Neurochir (Wien) 2021 Sep 18. Epub 2021 Sep 18.

Hospital Universitario Virgen del Rocio, Sevilla, Spain.

Background: Extramedullary anterior cervical canal tumors can be challenging lesions to reach. The posterolateral trans dentate approach offers an alternative route.

Method: Classic posterior laminoplasty is done to expose the medulla; the dentate ligament is identified as a fibrous structure running from the lateral pial surface of the medulla to the lateral dura between nerve roots spaces. Read More

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September 2021

Platinized graphene fiber electrodes uncover direct spleen-vagus communication.

Commun Biol 2021 09 17;4(1):1097. Epub 2021 Sep 17.

Biomedical Engineering and Biomedical Sciences, University of Houston, Health 2, 4849 Calhoun Rd., Room 6014, Houston, TX, 77204-6064, USA.

Neural interfacing nerve fascicles along the splenic neurovascular plexus (SNVP) is needed to better understand the spleen physiology, and for selective neuromodulation of this major organ. However, their small size and anatomical location have proven to be a significant challenge. Here, we use a reduced liquid crystalline graphene oxide (rGO) fiber coated with platinum (Pt) as a super-flexible suture-like electrode to interface multiple SNVP. Read More

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September 2021

An implantable restorative-neurostimulator for refractory mechanical chronic low back pain: a randomized sham-controlled clinical trial.

Pain 2021 Oct;162(10):2486-2498

Division of Pain Medicine, Brigham and Women's Hospital Harvard Medical School, Boston, MA, United States.

Abstract: Chronic low back pain can be caused by impaired control and degeneration of the multifidus muscles and consequent functional instability of the lumbar spine. Available treatment options have limited effectiveness and prognosis is unfavorable. We conducted an international randomized, double-blind, sham-controlled trial at 26 multidisciplinary centers to determine safety and efficacy of an implantable, restorative neurostimulator designed to restore multifidus neuromuscular control and facilitate relief of symptoms (clinicaltrials. Read More

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October 2021

Activation of vagovagal reflex prevents hepatic ischemia/reperfusion-induced lung injury via anti-inflammatory and antioxidant effects.

Exp Physiol 2021 Sep 17. Epub 2021 Sep 17.

Department of Cardiology, The First People's Hospital of Jingmen, Jingmen, 448000, China.

New Findings: What is the central question of this study? Does VNS have protective effects against both direct liver damage and distant lung injury in a hepatic ischemia/reperfusion rat model? What is the main finding and its importance? VNS provides the protective effects through anti-inflammation and anti-oxidative stress possibly achieved by the vagovagal reflex.

Abstract: Hepatic ischemia reperfusion (I/R) is not an isolated event; instead, it can result in remote organ dysfunction. The aim of this study was to investigate whether vagal nerve stimulation (VNS) can alleviate hepatic I/R-induced lung injury and to explore the underlying mechanism. Read More

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September 2021

Value of intraoperative monitoring of the trigeminal nerve in detection of a superiorly displaced facial nerve during surgery for large vestibular schwannomas.

Neurosurg Rev 2021 Sep 17. Epub 2021 Sep 17.

Department of Otorhinolaryngology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

The aim of this study was to investigate the role of trigeminal and facial nerve monitoring in the early identification of a superiorly (anterior and superior (AS)) displaced facial nerve. This prospective study included 24 patients operated for removal of large vestibular schwannomas (VS). The latencies of the electromyographic (EMG) events recorded from the trigeminal and facial nerve innervated muscles after mapping the superior surface of the tumor were analyzed. Read More

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September 2021

Neurological susceptibility to environmental exposures: pathophysiological mechanisms in neurodegeneration and multiple chemical sensitivity.

Rev Environ Health 2021 Sep 16. Epub 2021 Sep 16.

Family and Community Medicine, University of Toronto, Toronto, ON, Canada.

The World Health Organization lists air pollution as one of the top five risks for developing chronic non-communicable disease, joining tobacco use, harmful use of alcohol, unhealthy diets and physical inactivity. This review focuses on how host defense mechanisms against adverse airborne exposures relate to the probable interacting and overlapping pathophysiological features of neurodegeneration and multiple chemical sensitivity. Significant long-term airborne exposures can contribute to oxidative stress, systemic inflammation, transient receptor subfamily vanilloid 1 (TRPV1) and subfamily ankyrin 1 (TRPA1) upregulation and sensitization, with impacts on olfactory and trigeminal nerve function, and eventual loss of brain mass. Read More

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September 2021

Vagus nerve bundle stimulation using 1505-nm laser irradiation in an in-vivo rat model.

J Biophotonics 2021 Sep 16. Epub 2021 Sep 16.

Izmir Biomedicine and Genome Center, Izmir, Turkey.

Laser nerve stimulation using near-infrared laser irradiation has recently been studied in the peripheral nervous system as an alternative method to conventional electrical nerve stimulation. Bringing this method to the vagus nerve model could leverage this emerging stimulation approach to be tested in broader preclinical applications. Here, we report the capability of the laser nerve stimulation method on the rat vagus nerve bundle with a 1505-nm diode laser operated in continuous-wave mode. Read More

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September 2021

Short-, long-, and very long-term results of secondary anterior sphincteroplasty in 20 patients with obstetric injury.

Int J Colorectal Dis 2021 Sep 16. Epub 2021 Sep 16.

Department of Pediatric and Gastrointestinal Surgery, Oslo University Hospital, Ullevål, P. O. Box 4956, 0424, Nydalen, Oslo, Norway.

Purpose: More long-term follow-up studies beyond 10 years after secondary sphincteroplasty for obstetric damage are warranted. This prospective study aimed to compare reported data on incontinence and satisfaction in a cohort of such patients examined at short-, long-, and very long-term follow-up.

Methods: Twenty out of 33 obstetric patients (61%) operated with secondary anterior overlapping sphincteroplasty during February 1996 to April 2004 were evaluated preoperatively and at short-, long-, and very long-term follow-up. Read More

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September 2021

Application of patch stimulator for intraoperative neuromonitoring during thyroid surgery: maximizing surgeon's convenience.

Gland Surg 2021 Aug;10(8):2378-2385

Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.

Background: Intraoperative neuromonitoring (IONM) is frequently used in thyroid surgery to reduce recurrent laryngeal nerve (RLN) injury by providing the surgeon with real-time feedback on nerve stimulation during dissection. We applied a disposable adhesive patch electrode to a dissecting instrument to transfer electrical stimulation to the dissecting instrument for IONM during thyroid surgery. This study aimed to evaluate the feasibility of using the patch stimulator approach for IONM during thyroid surgery. Read More

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Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients.

Front Psychiatry 2021 30;12:678594. Epub 2021 Aug 30.

Department of Nursing, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.

Protracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and symptoms (including anxiety, irritability, mood instability, insomnia, and cravings), make alcohol abstinence difficult and increase the risk of relapse in recovering alcoholics. The goal of this study was to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on PAWS and plasma brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and leptin levels in patients with alcohol dependency. A total of 114 patients with alcohol dependence were randomly divided into two groups: the treatment group and the control group. Read More

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J Neurophysiol 2021 Sep 15. Epub 2021 Sep 15.

Department of Neuroscience and Physiology, Sahlgrenska Academy, grid.8761.8University of Gothenburg, Göteborg, Sweden.

The review surveys various aspects of the plasticity of nerve fibres, in particular the prolonged increase in their excitability evoked by polarization, focusing on a long-lasting increase in the excitability of myelinated afferent fibres traversing the dorsal columns of the spinal cord. We review the evidence that increased axonal excitability (i) follows epidurally applied direct current as well as relatively short (5 or 10 ms) current pulses and synaptically evoked intrinsic field potentials; (ii) critically depends on the polarization of branching regions of afferent fibres at the sites where they bifurcate and give off axon collaterals entering the spinal grey matter in conjunction with actions of extrasynaptic GABA membrane receptors; and (iii) shares the feature of being activity-independent with the short-lasting effects of polarization of peripheral nerve fibres. A comparison between the polarization evoked sustained increase in the excitability of dorsal column fibres and spinal motoneurons (plateau potentials) indicates the possibility that they are mediated by partly similar membrane channels (including non-inactivating type L Cav 1. Read More

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September 2021

[Detection of oropharyngeal sensory function in normal population].

X L Liu X Y Li W Xu

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Aug;56(8):830-836

Department of Otorhinolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.

To study the oropharyngeal sensory function by Current Perception Threshold(CPT) detection, to explore the detection method of oropharyngeal sensory function in normal population, and to analyze the possible influencing factors. Fifty-eight normal subjects were included prospectively in this study. Age, gender, body mass index (BMI) were collected. Read More

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Altered topological properties of brain functional networks in drug-resistant epilepsy patients with vagus nerve stimulators.

Seizure 2021 Sep 7;92:149-154. Epub 2021 Sep 7.

Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, No.45 Changchun Street, Xicheng District, Beijing, 100053, PR China. Electronic address:

Purpose: To explore abnormalities of topological properties in drug-resistant epilepsy (DRE) patients after vagus nerve stimulation (VNS) by analyzing brain functional networks using graph theory.

Methods: Fifteen patients and eight healthy controls (HC) were scanned separately with resting-state functional magnetic resonance imaging (rs-fMRI). Graph theoretical analyses were chosen to compare the global (small-world parameters [γ, λ, σ, Cp, and Lp], and network efficiency [Eg and Eloc]), and nodal (BC, DC, and NE) properties in preoperative patients (EPpre), postoperative patients (EPpost) and HC. Read More

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September 2021

The bi-directional role of the gut-brain axis in inflammatory and other gastrointestinal diseases.

Curr Opin Gastroenterol 2021 Sep 13. Epub 2021 Sep 13.

Monash University and Alfred Health, Melbourne, Australia.

Purpose Of Review: There is a growing body of evidence implicating the role of the gut-brain axis in a multitude of inflammatory and non-inflammatory gastrointestinal disorders. The interaction between the gut and the brain is bidirectional and its therapeutic manipulation is gaining traction as the new frontier in the management of gastrointestinal disorders. This review summarizes the recent literature on this subject and serves as a reference for future research directions. Read More

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September 2021

Pain Modulation Induced by Electronic Wrist-ankle Acupuncture: A Functional Near-infrared Spectroscopy Study.

Pain Pract 2021 Sep 14. Epub 2021 Sep 14.

Changhai Hospital, Naval Medical University, Shanghai, 200433, China.

Background: As a new technology, electronic wrist-ankle acupuncture (E-WAA) combines the advantages of wrist-ankle acupuncture and transcutaneous electrical nerve stimulation, but the analgesic effect and mechanism need to be clarified. The purpose of this study was to identify the pain modulation caused by electronic wrist-ankle acupuncture by evaluating the response of prefrontal cortex (PFC) from the perspective of neurophysiology.

Methods: 50 male volunteers (age 25. Read More

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September 2021

Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine.

Br J Pharmacol 2021 Sep 14. Epub 2021 Sep 14.

Blizard Institute and the National Centre for Bowel Research, Barts The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.

Background And Purpose: Gastric pacemaker cells (interstitial cells of Cajal; ICC) are believed to initiate myogenic (non-neuronal) contractions. These become damaged in gastroparesis, associated with dysrhythmic electrical activity and nausea. We utilised mouse isolated stomach to model myogenic contractions, investigate their origin and actions of ICC modulators. Read More

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September 2021

High-resolution computational modelling of the current flow in the outer ear during transcutaneous auricular Vagus Nerve Stimulation (taVNS).

Brain Stimul 2021 Sep 10. Epub 2021 Sep 10.

Department of Biomedical Engineering, The City College of New York, New York, NY, USA. Electronic address:

Background: Transcutaneous auricular Vagus Nerve Stimulation (taVNS) applies low-intensity electrical current to the ear with the intention of activating the auricular branch of the Vagus nerve. The sensitivity and selectivity of stimulation applied to the ear depends on current flow pattern produced by a given electrode montage (size and placement).

Objective: We compare different electrodes designs for taVNS considering both the predicted peak electric fields (sensitivity) and their spatial distribution (selectivity). Read More

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September 2021

Bronchoscopic Targeted Lung Denervation in Patients with Severe Asthma: Preliminary Findings.

Respiration 2021 Sep 1:1-6. Epub 2021 Sep 1.

Department of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

Treatment options for severe asthma are limited, particularly in those patients who do not meet criteria for biologicals. Targeted lung denervation (TLD) is the bronchoscopic ablation of the peribronchial vagal nerve trunks to reduce cholinergic stimulation of airway smooth muscle and submucosal glands. This report describes the experience of the first 2 asthma patients treated with TLD worldwide. Read More

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September 2021

Neuroimmune Circuits Activated by Vagus Nerve Stimulation.

Nephron 2021 Aug 17:1-5. Epub 2021 Aug 17.

Division of Nephrology and Center for Immunity, Inflammation, and Regenerative Medicine, University of Virginia, Charlottesville, Virginia, USA.

The interaction between the nervous system and the immune system has recently been well-recognized. Vagus nerve stimulation (VNS) presents potential as an anti-inflammatory therapy through activation of neuroimmune pathways. Detailed understanding of the neuroimmune pathways VNS evokes is critical in order to successfully use it in the clinic for the treatment of acute kidney injury, in which inflammation plays an important role. Read More

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Rufinamide (RUF) suppresses inflammation and maintains the integrity of the blood-brain barrier during kainic acid-induced brain damage.

Open Life Sci 2021 25;16(1):845-855. Epub 2021 Aug 25.

Department of Clinical Skills Training Center of ZhuJiang Hospital, ZhuJiang Hospital of Southern Medical University, Guangzhou 510282, China.

Rufinamide (RUF) is a structurally unique anti-epileptic drug, but its protective mechanism against brain injury remains unclear. In the present study, we validated how the RUF protected mice with kainic acid (KA)-induced neuronal damage. To achieve that, a mouse epilepsy model was established by KA intraperitoneal injection. Read More

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Left-sided vagus nerve stimulation improves cardiopulmonary resuscitation outcomes in rats as effectively as right-sided vagus nerve stimulation.

World J Emerg Med 2021 ;12(4):309-316

Department of Emergency Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Background: Our group previously reported that right-sided vagus nerve stimulation (RVNS) significantly improved outcomes after cardiopulmonary resuscitation (CPR) in a rat model of cardiac arrest (CA). However, whether left-sided vagus nerve stimulation (LVNS) could achieve the same effect as RVNS in CPR outcomes remains unknown.

Methods: A rat model of CA was established using modified percutaneous epicardial electrical stimulation to induce ventricular fibrillation (VF). Read More

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January 2021

The Future of Training and Practice in Neuromodulation: An Interventional Psychiatry Perspective.

Front Psychiatry 2021 27;12:734487. Epub 2021 Aug 27.

Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United States.

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Pain Relief Salvage with a Novel Minimally Invasive Posterior Sacroiliac Joint Fusion Device in Patients with Previously Implanted Pain Devices and Therapies.

J Pain Res 2021 2;14:2709-2715. Epub 2021 Sep 2.

Department of Anesthesiology, University of Kansas Medical Center, Kansas City, KS, USA.

Background: Sacroiliac joint (SIJ) pain is a common cause of low back pain, a problem experienced by two-thirds of adults in the United States population. Traditionally, the management of persistent SIJ-related pain has involved conservative therapies (physical therapy, topical medications, oral anti-inflammatory medications), interventional therapies (SIJ steroid injections or ablation), and surgery (SIJ fusion; open and lateral approach). Recent advancements in technology have paved the way for SIJ fusion via a posterior approach, which aims to minimize complications and enhance recovery. Read More

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September 2021

Epilepsy centers in China: Current status and ways forward.

Epilepsia 2021 Sep 12. Epub 2021 Sep 12.

Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Objective: China has the largest population of patients with epilepsy worldwide, which imposes a heavy burden on the public and health care systems. Several epidemiological surveys on epilepsy have been performed in China. Although these surveys grossly describe the prevalence and gap in treatment of epilepsy, the status of epilepsy centers is unclear. Read More

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September 2021