23,718 results match your criteria nerve involvement

The Neuropathy In Hereditary Transthyretin Amyloidosis (Attrv): A Narrative Review.

J Peripher Nerv Syst 2021 May 7. Epub 2021 May 7.

Department of Neuroscience, Reproductive and Odontostomatological Science, University of Naples "Federico II", Naples, Italy.

Hereditary transthyretin amyloidosis (ATTRv) is a condition with adult-onset caused by mutation of transthyretin (TTR) gene and characterized by extracellular deposition of amyloid fibrils in tissue, expecially in peripheral nervous system (PNS) and heart. The PNS involvement lead to a rapidly progressive and disabling sensory-motor axonal neuropathy. Although awareness among neurologist raised in last years thank to new treatment options, ATTRv is frequently misdiagnosed and thus correct diagnosis can be delayed by several years. Read More

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Innervation of digital joints: an anatomical overview.

Surg Radiol Anat 2021 May 6. Epub 2021 May 6.

Department of Orthopedic Surgery, Rouen University Hospital, Rouen, France.

Introduction: The innervation of the digital joints as well as the anatomical relationships of the articular branches is present in this anatomical work to determine the technical feasibility of a selective and efficient denervation of the digital joints.

Materials And Methods: A study of 40 distal interphalangeal (DIP), 40 proximal interphalangeal (PIP), 50 metacarpophalangeal (MCP), 10 interphalangeal (IP) of the thumb, and 10 trapezo-metacarpophalangeal (TMC) joints was performed on ten hands. Under magnification and a proper surgical approach, we collected the course, the source origin, the number of articular nerve branches, and their caliber. Read More

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Obscure Involvement of MYC in Neurodegenerative Diseases and Neuronal Repair.

Mol Neurobiol 2021 May 5. Epub 2021 May 5.

Faculty of Special Education and Rehabilitation, University of Belgrade, Visokog Stevana 2, 11000, Belgrade, Serbia.

MYC is well known as a potent oncogene involved in regulating cell cycle and metabolism. Augmented MYC expression leads to cell cycle dysregulation, intense cell proliferation, and carcinogenesis. Surprisingly, its increased expression in neurons does not induce their proliferation, but leads to neuronal cell death and consequent development of a neurodegenerative phenotype. Read More

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Guillain-Barré syndrome in Local Eastern China: a study of 595 patients.

Eur J Neurol 2021 May 5. Epub 2021 May 5.

Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.

Background: To investigate geographical differences in clinical features of patients with Guillain-Barré syndrome (GBS) from local Eastern China and other areas.

Methods: A total of 595 patients fulfilling GBS and variants were included from two large hospitals located in Eastern China. Data collection included demographics, antecedent events, clinical presentation and signs, electrophysiological subtypes, treatment, complications during hospitalization, clinical severity at nadir and outcome at 12 months and were compared to the Southern China study and the Europe/Americas part of International GBS Outcome Study. Read More

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Monocentric study of 28 cases of chronic inflammatory demyelinating polyneuropathy: first Tunisian study.

Neurol Sci 2021 May 4. Epub 2021 May 4.

Department of Neurology, Military Hospital, Tunis, Tunisia.

Background: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a rare affection of the peripheral nervous system. Its diagnostic criteria have evolved since 1975. The aim of our work is to study the epidemiological, clinical, and paraclinical aspects of CIDP. Read More

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Nonabducent Cranial Neuropathies in Cerebral Venous Sinus Thrombosis: A Case Report and Literature Review.

Neurologist 2021 May 5;26(3):90-97. Epub 2021 May 5.

Department of Neurology, University of Florida College of Medicine, Gainesville, FL.

Introduction: Cerebral venous sinus thrombosis (CVST) can rarely present with cranial neuropathies other than abducent nerve palsy. The authors report a case and review the literature for nonabducent cranial neuropathies in CVST.

Case Report: A 22-year-old woman with a history of oral contraceptive use developed right-sided headache, blurred vision, and dizziness for 4 days. Read More

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Ultrasound-guided erector spinae plane block in horses: a cadaver study.

Vet Anaesth Analg 2021 Mar 19. Epub 2021 Mar 19.

Department of Small Animal Clinical Science, University of Liverpool, Liverpool, UK; Department of Equine Clinical Science, University of Liverpool, Liverpool, UK.

Objectives: To describe dye distribution and spinal nerve involvement after a simulated erector spinae plane (ESP) block performed on fresh equine cadavers.

Study Design: Experimental cadaver study.

Animals: A group of 11 adult equine cadavers. Read More

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Neurological Manifestations of COVID-19 Associated Multi-system Inflammatory Syndrome in Children: A Systematic Review and Meta-analysis.

J Nepal Health Res Counc 2021 Apr 23;19(1):10-18. Epub 2021 Apr 23.

Department of Neurology, University Medicine Associates/ University Health System/ University of Texas Health, San Antonio, Texas, USA.

Background: Children comprise only 1-5% of COVID-19 cases. Recent studies have shown that COVID-19 associated multisystem inflammatory syndrome in children (MIS-C) can present with neurological signs and symptoms. In this systematic review and meta-analysis, we have reviewed neurological involvement in these patients. Read More

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Central Nervous System Involvement in Patients with Acute Myeloid Leukemia.

Turk J Med Sci 2021 May 2. Epub 2021 May 2.

Introduction: To evaluate the incidence, clinical features, risk factors, and prognosis of central nervous system (CNS) involvement in patients with acute myeloid leukemia (AML).

Methods: All AML patients who were admitted to Hacettepe University hospital between 2000 and 2021 were evaluated. The medical records of 548 AML cases were retrospectively analyzed. Read More

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Alzheimer's disease: An evolving understanding of noradrenergic involvement and the promising future of electroceutical therapies.

Cody Slater Qi Wang

Clin Transl Med 2021 Apr;11(4):e397

Department of Biomedical Engineering, Columbia University, New York, New York, USA.

Alzheimer's disease (AD) poses a significant global health concern over the next several decades. Multiple hypotheses have been put forth that attempt to explain the underlying pathophysiology of AD. Many of these are briefly reviewed here, but to-date no disease-altering therapy has been achieved. Read More

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Input of Sensory, Limbic, Basal Ganglia and Pallial/Cortical Information into the Ventral/Lateral Habenula: Functional Principles in Anuran Amphibians.

Brain Res 2021 Apr 27:147506. Epub 2021 Apr 27.

Institute for Zoology, University of Cologne, Zülpicher Str. 47b, 50674 Cologne, Germany.

The habenula - a phylogenetically old brain structure present in all vertebrates - is involved in pain processing, reproductive behaviors, sleep-wake cycles, stress responses, reward, and learning. We performed intra- and extracellular recordings of ventral habenula (VHb) neurons in the isolated brain of anurans and revealed similar cell and response properties to those reported for the lateral habenula of mammals. We identified tonic regular, tonic irregular, rhythmic firing, and silent VHb neurons. Read More

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Traumatic Rupture of the Flexor Carpi Ulnaris Muscle Belly in a Circus Rigger.

J Hand Surg Asian Pac Vol 2021 Jun;26(2):274-279

Department of Hand and Reconstructive Microsurgery, National University Health System, Singapore.

Closed traumatic rupture of forearm flexor muscles has been reported rarely. Previous reports have included ruptures of the flexor digitorum profundus, flexor digitorum superficialis, flexor pollicis longus, flexor carpi radialis, pronator quadratus and the palmaris longus. We report a patient with a closed traumatic rupture through the muscle belly of the flexor carpi ulnaris and summarise the published literature on ruptures involving the forearm flexor muscles. Read More

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Total Petrosectomy for the Total Resection of Sphenopetroclival Meningioma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2021 Apr 29. Epub 2021 Apr 29.

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Sphenopetroclival meningioma is a most formidable meningioma. Many patients have few preoperative deficits and surgery has the potential of severe neurological complications. Surgical treatment is challenging due to brainstem compression, the involvement of multiple cranial nerves and cerebral vessels. Read More

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Rare Clinical Presentation in a Case of Pediatric Guillain-Barré Syndrome and Rehabilitation Outcome.

J Neurosci Rural Pract 2021 Apr 13;12(2):435-437. Epub 2021 Apr 13.

Department of Neurology, National Institute of Mental Health & Neuro Sciences (NIMHANS), Bengaluru, Karnataka, India.

Nearly half of patients with Guillain-Barré syndrome (GBS) have cranial nerve involvement. Ocular muscle weakness or ophthalmoplegia occurs in ~10% of these patients. Patients presenting with bilateral ptosis, with or without ophthalmoplegia, is a rare finding. Read More

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Malignant peripheral nerve sheath tumor of the orbit: a case report and review of the literature.

Orbit 2021 Apr 29:1-5. Epub 2021 Apr 29.

Department of Ophthalmology and Visual Sciences, West Virginia University, Morgantown, West Virginia, USA.

Malignant peripheral nerve sheath tumor is a rare tumor which infrequently involves the orbit. They occur most often in the setting of neurofibromatosis 1 (NF1), and therefore the involvement of the orbit without a history of NF1 is even less common. Management of this tumor is fraught with a high rate of recurrences and metastases, with a high mortality rate. Read More

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Optimal Management of the Unilateral Recurrent Laryngeal Nerve Involvement in Patients with Thyroid Cancer.

Cancers (Basel) 2021 Apr 28;13(9). Epub 2021 Apr 28.

Department of Otolaryngology-Head and Neck Surgery, Graduate School of Medicine, Kumamoto University, Kumamoto 860-8555, Japan.

We aimed to determine the optimal management of recurrent laryngeal nerve (RLN) involvement in thyroid cancer. We enrolled 80 patients with unilateral RLN involvement in thyroid cancer between 2000 and 2016. Eleven patients with preoperatively functional vocal folds (VFs) underwent sharp tumor resection to preserve the RLN (shaving group). Read More

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Increased expression of Netrin-4 is associated with allodynia in a trigeminal neuropathic pain model rats by infraorbital nerve injury.

PLoS One 2021 29;16(4):e0251013. Epub 2021 Apr 29.

Department of Molecular Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

Neuropathic pain refers to pain caused by lesions or diseases of the somatosensory nervous system that is characteristically different from nociceptive pain. Moreover, neuropathic pain occurs in the maxillofacial region due to various factors and is treated using tricyclic antidepressants and nerve block therapy; however, some cases do not fully recover. Netrin is a secreted protein crucially involved in neural circuit formation during development, including cell migration, cell death, neurite formation, and synapse formation. Read More

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Maternal serum adipokines and inflammatory markers at late gestation and newborn weight in mothers with and without gestational diabetes mellitus.

Ginekol Pol 2021 Apr 29. Epub 2021 Apr 29.

Endocrine Research Unit, National Medical Center, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Objectives: Maternal obesity increases the risk of gestational diabetes mellitus (GDM) and is positively correlated with neonatal obesity increasing the risk of adiposity in both young and adult offspring. Maternal secreted factors from adipose tissue such as adipokines and inflammatory cytokines may regulate fetal growth. This study investigated associations between maternal adipokines and inflammatory markers at late gestation, and neonatal anthropometric characteristics in mothers with and without GDM. Read More

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Ocular manifestation of rickettsial disease in South Indian population.

Indian J Ophthalmol 2021 May;69(5):1167-1171

Prasad Netralaya, Udupi, Karnataka, India.

Purpose: The aim of this work was to study the ocular manifestations and its management in spotted fever and typhus group of rickettsial disease.

Methods: A retrospective analysis of 50 patients with serologically confirmed Rickettsial disease. In all patients, relevant history, investigations and treatment details were collected and they underwent complete ophthalmic evaluation including measurement of best-corrected visual acuity, anterior segment examination and dilated fundus examination. Read More

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She's got nerve: roles of octopamine in insect female reproduction.

J Neurogenet 2021 Apr 28:1-22. Epub 2021 Apr 28.

Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.

The biogenic monoamine octopamine (OA) is a crucial regulator of invertebrate physiology and behavior. Since its discovery in the 1950s in octopus salivary glands, OA has been implicated in many biological processes among diverse invertebrate lineages. It can act as a neurotransmitter, neuromodulator and neurohormone in a variety of biological contexts, and can mediate processes including feeding, sleep, locomotion, flight, learning, memory, and aggression. Read More

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A cross-sectional study of the upper limb non-neurogenic physical findings in computer operators and their relation to pain and neurological findings.

Int J Occup Med Environ Health 2021 Apr 23. Epub 2021 Apr 23.

Hospital South West Jutland, Esbjerg, Denmark (Department of Occupational Medicine).

Objectives: The character of upper limb disorders in computer operators is subject to debate. While nerve involvement is suggested by the presence of pain, paresthesia and subjective weakness, these symptoms are mainly interpreted as related to pathologies outside the nervous system. Findings in a previous study involving computer operators indicated peripheral nerve afflictions with specific locations in symptomatic subjects. Read More

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Gradenigo's and Vernet's syndrome in an adult man with Candida mastoiditis.

BMJ Case Rep 2021 Apr 27;14(4). Epub 2021 Apr 27.

Neurology, Baylor College of Medicine, Houston, Texas, USA.

The authors report a case of fungal otitis media complicated by extension of the infection into adjacent structures causing apical petrositis and subsequently involvement of the jugular foramen in a 71-year-old diabetic man. First described in 1907, Gradenigo's syndrome is a serious but rare clinical triad of acute otitis media, unilateral pain in the distribution of cranial nerve V (trigeminal) and ipsilateral cranial nerve VI (abducens) palsy that commonly presents without all three features and is therefore often missed. In this report, our patient was initially misdiagnosed as having a diabetic cranial neuropathy, and later he developed Vernet's syndrome. Read More

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Neurological impact of eosinophilic granulomatosis with polyangiitis.

Acta Neurol Belg 2021 Apr 27. Epub 2021 Apr 27.

Neurology Department, Coimbra University Hospital Centre, Praceta Mota Pinto, 3000-075, Coimbra, Portugal.

Nervous system (NS) affection may occur in Eosinophilic Granulomatosis with Polyangiitis (EGPA), but its clinical manifestations and pathophysiology are rarely described. Our aims are to characterize central and peripheral NS (CNS/PNS) involvement and compare biological markers in EGPA patients with and without neurological manifestations. Retrospective observational study, including EGPA patients with and without neurological manifestations. Read More

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Sham Feeding Induced Gastric Acid Secretion in Patients with Caustic Induced Esophageal Stricture.

Dysphagia 2021 Apr 27. Epub 2021 Apr 27.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Caustic ingestion can lead to structural changes in the upper gastro-intestinal tract. However, there is limited data on the effect of caustic ingestion on gastric secretion. This study was planned to determine changes in gastric acid output after sham feeding in patients with caustic induced esophageal stricture and to compare it with healthy controls. Read More

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Effect of omalizumab treatment on peripheral nerves in patients with chronic spontaneous urticaria.

Cutan Ocul Toxicol 2021 Apr 26:1-5. Epub 2021 Apr 26.

Department of Dermatology, Adiyaman University Faculty of Medicine, Adiyaman, Turkey.

Chronic spontaneous urticaria (CSU) is characterised by itchy, red and raised lesions that appear as an attack without any cause and last for six weeks or longer. Omalizumab is a humanised monoclonal antibody that selectively binds to the Ce3 moiety of circulating IgE and is indicated for the treatment of resistant CSU. In this study, we aimed to investigate whether there was peripheral nervous system involvement in patients with chronic urticaria receiving omalizumab treatment. Read More

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[Clinical features and prognosis of patients with leptomeningeal metastases].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(16):1154-1159

Department of Neurology, Henan Provincial People's Hospital, Zhengzhou 450003, China.

To describe the clinical manifestations, neuroimaging, cerebrospinal fluid(CSF) cytology and prognosis of Leptomeningeal metastases(LM). The clinical manifestations, imaging features and CSF cytology of LM patients admitted to Henan Provincial People's Hospital from May 1, 2015 to May 31, 2020 were retrospectively analyzed. The overall survival (OS) was evaluated by the time from the diagnosis of LM to death. Read More

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Metastatic Paraganglioma of the Spine With Mutation: Case Report and Review of the Literature.

Int J Spine Surg 2021 Feb 20;14(s4):S37-S45. Epub 2021 Jan 20.

Department of Neurosurgery, Division of Endocrinology and Endocrine Tumor Program, Stanford University School of Medicine, Stanford, California.

Background: Paragangliomas (PGLs) are rare neuroendocrine tumors that can arise from any autonomic ganglion of the body. Most PGLs do not metastasize. Here, we present a rare case of metastatic PGL of the spine in a patient with a germline pathogenic succinate dehydrogenase subunit B () mutation. Read More

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February 2021

Cavernous internal carotid artery aneurysm presenting with ipsilateral oculomotor nerve palsy: A case report.

Radiol Case Rep 2021 Jun 6;16(6):1339-1342. Epub 2021 Apr 6.

Neuroradiology Consultant, King Abdulaziz Hospital, Makkah, Saudi Arabia.

The oculomotor nerve palsy is a rare neurological deficit, it is associated with numerous underlying pathologies. Including stroke, neoplasms, trauma, post-surgical inflammation, and microvascular damage from chronic disease. It can cause a set of neurological deficits, including diplopia from oculomotor nerve involvement, decreased visual acuity from optic neuropathy, facial hypoesthesia from involvement of the trigeminal nerve, and less frequently facial pain. Read More

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Giant intramuscular thigh lipoma: A case report and review of literature.

Int J Surg Case Rep 2021 Apr 14;82:105885. Epub 2021 Apr 14.

Tecnológico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Dr. Ignacio Morones Prieto O 3000, Monterrey, 64710, Mexico. Electronic address:

Introduction: Lipomas are the most common soft tissue tumor. Giant lipomas are defined by measuring at least 10 cm in diameter in one dimension or by a minimum of 1000 g. They often are asymptomatic; however, they can cause compression syndromes due to nerve damage and difficulties in walking. Read More

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Central involvement of 5-HT1A receptors in antinociception induced by photobiomodulation in animal model of neuropathic pain.

Lasers Med Sci 2021 Apr 22. Epub 2021 Apr 22.

Physiotherapy Department, Federal University of Alfenas (UNIFAL), Alfenas, Brazil.

This study aimed to investigate the central involvement of 5-HT1A receptors in the nociceptive behavior of mice submitted to the chronic constriction injury (CCI) of sciatic nerve and the subsequent application of photobiomodulation (PBM). Male mice (Swiss-albino) were submitted to CCI and subsequently received an infusion of WAY100635 (5-HT1A receptor antagonist) or intracerebroventricular saline (ICV), followed by infrared laser irradiation (808 nm), in continuous mode, with the power of 100 mW and a dose of 0 J/cm (control group) or 50 J/cm. The thermal hyperalgesia was evaluated by hot plate test, while mechanical allodynia was evaluated by von Frey filaments. Read More

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