168,116 results match your criteria nephrology


Ambulatory Blood Pressure in Kidney Transplant Recipients: More Questions than Answers.

Am J Nephrol 2021 Jul 26:1-3. Epub 2021 Jul 26.

Division of Nephrology & Hypertension, University of Minnesota, Minneapolis, Minnesota, USA.

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Diagnostic Performance of Office versus Ambulatory Blood Pressure in Kidney Transplant Recipients.

Am J Nephrol 2021 Jul 26:1-11. Epub 2021 Jul 26.

Clinic of Nephrology and Renal Transplantation, Laiko General Hospital, Medical School of Athens, National and Kapodistrian University, Athens, Greece.

Introduction: Hypertension is the most prominent risk factor in kidney transplant recipients (KTRs). No study so far assessed in parallel the prevalence, control, and phenotypes of blood pressure (BP) or the accuracy of currently recommended office BP diagnostic thresholds in diagnosing elevated ambulatory BP in KTRs.

Methods: 205 stable KTRs underwent office BP measurements and 24-h ambulatory BP monitoring (ABPM). Read More

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Contribution of miRNAs and lncRNAs in osteogenesis and related disorders.

Biomed Pharmacother 2021 Jul 23;142:111942. Epub 2021 Jul 23.

Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Non-coding RNAs have been found to regulate several developmental processes among them is osteogenesis. Although these transcripts have several distinct classes, two classes i.e. Read More

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LncRNA OIP5-AS1 reduces renal epithelial cell apoptosis in cisplatin-induced AKI by regulating the miR-144-5p/PKM2 axis.

Biomed J 2021 Jul 23. Epub 2021 Jul 23.

Department of SICU, the First Affiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, 450001, PR. China. Electronic address:

Background: The abnormal expression of long non-coding RNA (lncRNA) Opa-interacting protein 5 antisense RNA 1 (OIP5-AS1) has been observed in many human cancers and the underlying mechanisms have been well studied. However, the function of OIP5-AS1 in acute kidney injury (AKI) remains unclear.

Material And Methods: To explore the role of OIP5-AS1 in the progression of AKI, the cisplatin-induced AKI mouse and cell model were established. Read More

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Blocking AURKA with MK-5108 attenuates renal fibrosis in chronic kidney disease.

Biochim Biophys Acta Mol Basis Dis 2021 Jul 23:166227. Epub 2021 Jul 23.

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China; Jiangsu Key Laboratory of Pediatrics, Nanjing Medical University, Nanjing 210029, China; Nanjing Key Lab of Pediatrics, Children's Hospital of Nanjing Medical University, China. Electronic address:

Renal fibrosis, a common feature of chronic kidney disease (CKD), is characterized by excessive deposition of extracellular matrix (ECM) leading to scar formation in the renal parenchyma. Active epithelial-mesenchymal communication (EMC), and the proliferation and activation of fibroblasts are implicated in the causation of renal fibrosis. Aurora-A kinase (AURKA) is a serine/threonine kinase required for the process of mitosis. Read More

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Comment on skin biopsies for diagnosing intravascular lymphoma: a retrospective study of diagnostic accuracy.

J Am Acad Dermatol 2021 Jul 23. Epub 2021 Jul 23.

Department of Dermatology and Plastic Surgery, Akita University Graduate School of Medicine, Akita, Japan.

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Association of urinary calcium and phosphorus excretion with renal disease progression in type 2 diabetes.

Diabetes Res Clin Pract 2021 Jul 23:108981. Epub 2021 Jul 23.

Department of Nephrology, the First Affiliated Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China. Electronic address:

Objectives: Diabetes is associated with a high incidence of microvascular disease, including nephropathy. The current study aimed to investigate the association of urinary calcium and phosphorus excretion with chronic kidney disease (CKD) progression in type 2 diabetes mellitus.

Methods: A total of 159 T2DM patients with chronic kidney disease (CKD stage G1-G4) were retrospectively included. Read More

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Plasma and ascites pharmacokinetic of meropenem in patients with decompensated liver cirrhosis and spontaneous bacterial peritonitis.

J Hepatol 2021 Jul 23. Epub 2021 Jul 23.

Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover. Electronic address:

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Vitamin K and cardiovascular complications in CKD patients.

Kidney Int 2021 Jul 23. Epub 2021 Jul 23.

Division of Nephrology and Rheumatology, University Hospital, Rheinisch Westfälische Technische Hochschule (RWTH) Aachen, Germany. Electronic address:

Vitamin K, well known for its role in coagulation, encompasses two major subgroups: Vitamin K1 is exclusively synthesized by plants, whereas vitamin K2 mostly originates from bacterial synthesis. Vitamin K serves as a cofactor for the enzyme γ-glutamyl carboxylase, which carboxylates and thereby activates various vitamin K dependent proteins. Several vitamin K-dependent proteins are synthesized in bone but the role of vitamin K for bone health in CKD patients, in particular the prevention of osteoporosis is still not firmly established. Read More

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The disturbance and clinical significance of B cell and circulating follicular helper T cell subsets in children with primary nephrotic syndrome.

Immunol Lett 2021 Jul 23. Epub 2021 Jul 23.

Department of Nephrology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders; Chongqing Key Laboratory of Pediatrics. Electronic address:

The immunopathogenesis of primary nephrotic syndrome is unclear. Here, we examined the frequency, subsets and molecular function of circulating B cells and follicular helper T cells by flow cytometry and explored the correlation between certain subsets and clinical disease indices in new-onset patients, relapsing patients and healthy controls. We found an increase in the proportions of CD86 activated cells and CD19CD138 plasma cells in the patients at onset and patients in relapse. Read More

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KLF15 negatively regulates cardiac fibrosis by which SDF-1β attenuates cardiac fibrosis in type 2 diabetic mice.

Toxicol Appl Pharmacol 2021 Jul 23:115654. Epub 2021 Jul 23.

Cancer Center, The First Hospital of Jilin University, Changchun, Jilin 130021, China. Electronic address:

Diabetic cardiomyopathy (DCM) is a serious diabetic complication that lacks effective preventive or therapeutic approaches. Wild-type and Klf15 knockout (Klf15-KO) mice were fed with either high fat diet (HFD, 60% kcal from fat) or normal diet (ND, 10% kcal from fat) for 3 months and then injected with streptozotocin or vehicle, to induce type 2 diabetes (T2D). All T2D and age-matched control mice were treated with or without SDF-1β at 5 mg/kg body-weight twice a week and also continually received HFD or ND for 3 months. Read More

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Kidney damage from nonsteroidal anti-inflammatory drugs-Myth or truth? Review of selected literature.

Pharmacol Res Perspect 2021 Aug;9(4):e00817

Department of Pharmacokinetics and Monitored Therapy, Pomeranian Medical University, Szczecin, Poland.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely available drugs with anti-inflammatory and analgesic properties. Their mechanism of action is associated with the enzymes of the arachidonic acid cycle (cyclooxygenases: COX-1 and COX-2). The cyclooxygenase pathway results in the formation of prostanoids (prostaglandins [PGs], prostacyclins, and thromboxanes). Read More

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Recent Therapeutic Targets In Diabetic Nephropathy.

Int J Clin Pract 2021 Jul 26:e14650. Epub 2021 Jul 26.

Clinical Pharmacy Department, Faculty of Pharmacy, Beni-Suef University, Beni-Suef, Egypt.

Background: The prevalence of diabetes mellitus has been increased dramatically which in turn leads to complications including cardiovascular diseases, diabetic kidney disease, and substantially end stage renal disease.

Methods: We reviewed articles discussing the pathophysiology of diabetic nephropathy with new agents that may be useful in the management of the disease. We used PubMed, Scopus, Google Scholar, and the Open-access searching engines. Read More

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Efficacy and Safety of Corticosteroids in Acute Respiratory Distress Syndrome: An overview of Meta-analyses.

Int J Clin Pract 2021 Jul 26:e14645. Epub 2021 Jul 26.

Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India, 576104.

Background: Evidence-based recommendations on efficacy and safety of corticosteroids in acute respiratory distress syndrome (ARDS) remains a therapeutic challenge. Findings from several systematic reviews and meta-analyses are inconsistent. We aimed to assess the published meta-analyses through a systematic review approach and provide further insight into the current uncertainty. Read More

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Impact of hypoxia on the pathogenesis and therapy resistance in multiple myeloma.

Cancer Sci 2021 Jul 26. Epub 2021 Jul 26.

Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine, Akita, Japan.

Multiple myeloma (MM) is a refractory plasma cell tumor. In myeloma cells, the transcription factor IRF4, the master regulator of plasma cells, is aberrantly upregulated and plays an essential role in oncogenesis. IRF4 forms a positive feedback loop with MYC, leading to additional tumorigenic properties. Read More

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Therapeutic efficacy of direct oral anticoagulants and vitamin K antagonists for left ventricular thrombus: Systematic review and meta-analysis.

PLoS One 2021 26;16(7):e0255280. Epub 2021 Jul 26.

Department of Laboratory and Transfusion Medicine, University of Occupational and Environmental Health Hospital, Kitakyushu, Japan.

Background: Although several meta-analyses have compared efficacies of vitamin K antagonists (VKAs) and direct oral anticoagulants (DOACs) for treatment of left ventricular thrombus (LVT), those meta-analyses included no single-arm studies.

Methods And Results: PubMed, Scopus, and the Cochrane Library databases were searched for articles investigating thrombus resolution, stroke, any thromboembolism, major bleeding, any bleeding, or all-cause death in LVT treated with VKAs or DOACs, and single-class meta-analyses were also included (PROSPERO database, CRD42021230849). Event rates were pooled using a random effects model. Read More

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Risk of Breakthrough SARS-CoV-2 Infections in Adult Transplant Recipients.

Transplantation 2021 Jul 23. Epub 2021 Jul 23.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Surgery, Houston Methodist Hospital, Houston, Texas, USA Department of Medicine, Division of Infectious Disease, University of Miami Miller School of Medicine, Miami, Florida, USA Department of Nephrology and Hypertension, Rabin Medical Center, Petah-Tikva, Israel Department of Medicine, Division of Infectious Diseases and International Health, University of Virginia School of Medicine, Charlottesville, Virginia, USA Transplant Institute, NYU Langone Health, New York, New York, USA Department of Internal Medicine, Division of Infectious Diseases, Virginia Commonwealth University Health, Richmond, Virginia, USA Department of Surgery, Columbia University College of Physicians & Surgeons, New York, New York, USA Department of Nephrology, Arterial Hypertension, Dialysis and Transplantation, University Clinical Hospital Centre Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia Department of Medicine, Division of Infectious Diseases, Duke University, Durham, North Carolina, USA Department of Medicine, Division of Infectious Diseases, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA Avera Medical Group Nephrology, Sioux Falls, South Dakota, USA Department of Transplant, Mayo Clinic, Jacksonville, Florida, USA Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Virginia Transplant Center at Henrico Doctors' Hospital, Henrico, Virginia, USA Department of Internal Medicine, Section of Infectious Diseases, Yale University School of Medicine, New Haven, Connecticut, USA Department of Medicine, Division of Infectious Diseases & Global Public Health, University of California San Diego, San Diego, California, USA Sorbonne Université, INSERM, Institut Pierre Louis d'Epidémiologie et de Santé publique (iPLESP), APHP, Hôpital Pitié-Salpêtrière, Paris, France.

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A Two-fold Approach to Polyoma Virus (BK) Nephropathy in Kidney Transplants: Distinguishing Direct Virus Effects From Cognate T-Cell-mediated Inflammation.

Transplantation 2021 Jul 6. Epub 2021 Jul 6.

Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada.

Background: BK nephropathy (BKN) in kidney transplants diagnosed by histology is challenging because it involves damage from both virus activity and cognate T cell-mediated inflammation, directed against alloantigens (rejection) and/or viral antigens. The present study of indication biopsies from the INTERCOMEX study measured viral VP2 mRNA to assess virus activity and a TCMR classifier to assess cognate T cell-mediated inflammation.

Methods: Biopsies were assessed by local standard-of-care histology and by genome-wide microarrays and Molecular Microscope(R) (MMDx) algorithms to detect rejection and injury. Read More

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Humoral Response of Renal Transplant Recipients to the BNT162b2 SARS-CoV-2 mRNA Vaccine Using Both RBD IgG and Neutralizing Antibodies.

Transplantation 2021 Jul 6. Epub 2021 Jul 6.

Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.

Background: Data about SARS-CoV-2 vaccines efficacy in renal transplant recipients (RTR) is lacking.

Methods: To reveal predictors for humoral response to BNT162b2 vaccine among RTR, patients were divided to positive (N=42) and negative (N=78) response groups based on receptor-binding domain (RBD) IgG >= 1.1 and neutralizing antibodies (NA) >= 16 dilution versus RBD IgG < 1. Read More

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The Clinical and Economic Benefit of CMV Matching in Kidney Transplant: A Decision Analysis.

Transplantation 2021 Jul 6. Epub 2021 Jul 6.

Division of Nephrology and Hypertension, Department of Medicine, VA Portland Health Care System, Portland, OR.

Background: The development of cytomegalovirus (CMV) infection after kidney transplant remains a significant cause of posttransplant morbidity, graft loss, and mortality. Despite appropriate antiviral therapy, recipients without previous CMV exposure can currently be allocated a kidney from a donor with previous CMV infection (D+R-) which carries the greatest risk of posttransplant CMV infection and associated complications. Preferential placement of CMV D- organs in negative recipients (R-) has been shown to reduce the risk of viral infection and associated complications. Read More

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Identification of novel Topoisomerase II alpha inhibitors by virtual screening, molecular docking and bioassay.

Chem Biol Drug Des 2021 Jul 26. Epub 2021 Jul 26.

Department of Anesthesiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250117, Shandong, China.

Breast cancer is one of the most common tumors and its treatment still leaves room for improvement. Topoisomerase II alpha is a potential target for the treatment of human diseases such as breast cancer. In this article, we attempted to discover a novel anti-cancer drug. Read More

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Molidustat for the treatment of anemia in Japanese patients undergoing peritoneal dialysis: A single-arm, open-label, phase 3 study.

Ther Apher Dial 2021 Jul 26. Epub 2021 Jul 26.

Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo, Japan.

This 36-week, open-label, single-arm, phase 3 study investigated the safety and efficacy of molidustat in Japanese patients with renal anemia undergoing peritoneal dialysis. Molidustat was titrated every 4 weeks to maintain hemoglobin levels within the target range (≥11.0 to <13. Read More

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Pediatric KT in children up to 15 kg: A single-center experience.

Pediatr Transplant 2021 Jul 26:e14102. Epub 2021 Jul 26.

Urology, Hospital Universitario Austral, Pilar, Argentina.

Background: KT is the preferred treatment for ESRD in pediatrics. However, it may be challenging in those weighing ≤15 kg with potential complications that impact on morbidity and graft loss.

Methods: This retrospective review reports our experience in KT in children, weighing ≤15 kg, and the strategies to reduce morbidity and mortality. Read More

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Renal-limited ANCA-associated vasculitis during erlotinib treatment for lung carcinoma.

CEN Case Rep 2021 Jul 26. Epub 2021 Jul 26.

Division of Nephrology and Endocrinology, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) had clinical success in the treatment of non-small cell lung carcinoma (NSCLC). An effect of this drug on kidney has not been clarified and the occurrence of glomerulonephritis related to EGFR-TKI has rarely been reported. We present the case of a 71-year-old man with NSCLC who developed proteinuria and microscopic hematuria with the rise in a titer of MPO-ANCA, when 2 years and 3 months passed since the initiation of erlotinib, one of oral EGFR-TKI. Read More

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Rankings From US News and World Report Have Minimal Correlation With Kidney and Liver Transplant Recipient Survival Results From Retrospective Data.

Exp Clin Transplant 2021 Jul 26. Epub 2021 Jul 26.

From the University of Toledo Medical Center, Toledo, Ohio, USA.

Objectives: Increased demand for quality health care has led to lay-press ranking systems, such as the ranking from US News and World Report (US News). Their "Best Hospitals" publication advertises itself as the go-to resource for patients seeking care in a number of specialty areas. We sought to test the relationship between US News rankings and transplant outcomes. Read More

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The prognosis and risk factors of baseline high peritoneal transporters on patients with peritoneal dialysis.

J Cell Mol Med 2021 Jul 26. Epub 2021 Jul 26.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

The relationship between baseline high peritoneal solute transport rate (PSTR) and the prognosis of peritoneal dialysis (PD) patients remains unclear. The present study combined clinical data and basic experiments to investigate the impact of baseline PSTR and the underlying molecular mechanisms. A total of 204 incident CAPD patients from four PD centres in Shanghai between 1 January 2014 and 30 September 2020 were grouped based on a peritoneal equilibration test after the first month of dialysis. Read More

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The addition of adjunctive letermovir to valganciclovir for refractory cytomegalovirus viremia in kidney transplant recipients.

Transpl Infect Dis 2021 Jul 26. Epub 2021 Jul 26.

Department of Medicine, Division of Infectious Diseases, University of Wisconsin School of Medicine and Public Health, Madison, WI.

Purpose: Persistent viral replication resulting in ongoing cytomegalovirus (CMV) viremia despite adequate therapy, is difficult to manage and associated with negative outcomes. We report a case series of kidney transplant recipients receiving adjunctive letermovir in combination with valganciclovir for refractory CMV.

Methods: Adult patients receiving a kidney or kidney-pancreas transplant were included if they developed CMV viremia and initiated letermovir 480 mg daily as part of a dual therapy regimen with valganciclovir 900 mg twice daily between 9/1/2020 and 12/31/2020. Read More

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Response to steroid and immunosuppressive therapies may predict post-transplant recurrence of steroid-resistant nephrotic syndrome.

Pediatr Transplant 2021 Jul 26:e14103. Epub 2021 Jul 26.

Department of Pediatric Nephrology, Tokyo Women's Medical University, Tokyo, Japan.

Background: Recurrence of SRNS is a major challenge in KT. Several clinical factors, including initial steroid sensitivity, have been associated with increased post-transplant SRNS recurrence risk. However, conflicting data have been reported, possibly due to the heterogeneous pathophysiology of SRNS and the lack of genetic testing of SRNS patients. Read More

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Hypoxia-Inducible Factor-Prolyl Hydroxylase Inhibitors for the Treatment of Anemia in CKD: Additional Pieces of the Jigsaw Puzzle.

Authors:
Jay B Wish

Kidney Int Rep 2021 Jul 23;6(7):1751-1754. Epub 2021 Jun 23.

Indiana University School of Medicine, IU Health University Hospital, Division of Nephrology, Indianapolis, Indiana, USA.

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