89,633 results match your criteria neovascularization


Multimodal deep learning with feature level fusion for identification of choroidal neovascularization activity in age-related macular degeneration.

Acta Ophthalmol 2021 Jun 23. Epub 2021 Jun 23.

Department of Ophthalmology, College of Medicine, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

Purpose: This study aimed to determine the efficacy of a multimodal deep learning (DL) model using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) images for the assessment of choroidal neovascularization (CNV) in neovascular age-related macular degeneration (AMD).

Methods: This retrospective and cross-sectional study was performed at a multicentre, and the inclusion criteria were age >50 years and a diagnosis of typical neovascular AMD. The OCT and OCTA data for an internal data set and two external data sets were collected. Read More

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Peripheral Retinal Neovascularization in a Patient with Sarcoidosis and Cocaine-Associated Autoimmunity.

Case Rep Ophthalmol Med 2021 1;2021:9923260. Epub 2021 Jun 1.

Department of Ophthalmology, University Of Florida, USA.

A 63-year-old African-American female with history of sarcoidosis (lymph node biopsy proven) and cocaine abuse for 8 years was referred to us because of new floater. Her ocular history was unremarkable except for vague complaints of visual disturbance during a hospital admission in 2016. On presentation, her visual acuity was 20/400 in the right eye and 20/30 in the left eye. Read More

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Multicenter phase II study of apatinib single or combination therapy in HER2-negative breast cancer involving chest wall metastasis.

Chin J Cancer Res 2021 Apr;33(2):243-255

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Breast Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, China.

Objective: Breast cancer (BC) with chest wall metastasis (CWM) usually shows rich neovascularization. This trial explored the clinical effect of apatinib on human epidermal growth factor receptor 2 (HER2)-negative advanced BC involving CWM.

Methods: This trial involved four centers in China and was conducted from September 2016 to March 2020. Read More

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Modern diagnostic and therapeutic approaches in familial maculopathy with reference to North Carolina macular dystrophy.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2021 Jun 22. Epub 2021 Jun 22.

Department of Ophthalmology, University Hospital Hradec Kralove and Faculty of Medicine in Hradec Kralove, Charles University in Prague, Czech Republic.

Aims: We present a familial hereditary macular dystrophy, resembling North Carolina Macular Dystrophy. In members of a family, we describe the development of diagnostic-therapeutic approaches and their impact on the prognosis of those whose vision was affected.

Methods: The macular dystrophy of varying degrees of severity was diagnosed in 3 consecutive generations in different family members, both men and women. Read More

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Stem cell-seeded 3D-printed scaffolds combined with self-assembling peptides for bone defect repair.

Tissue Eng Part A 2021 Jun 22. Epub 2021 Jun 22.

Department of Spine Surgery, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou, China;

Bone defects caused by infection, tumor, trauma and so on remain difficult to treat clinically. Bone tissue engineering (BTE) has great application prospect in promoting bone defect repair. Polycaprolactone (PCL) is a commonly used material for creating BTE scaffolds. Read More

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An epigallocatechin-3-gallate formulation developed for endodontic use: a physicochemical and biological evaluation.

J Endod 2021 Jun 19. Epub 2021 Jun 19.

Department of Pediatric Dentistry, School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.

Introduction: Although epigallocatechin-3-gallate (EGCG) from green tea has been sucessfully used in the prevention and treatment of several infectious and immunoinflammatory diseases due to its proven anti-inflammatory, anti-oxidant, antimicrobial and anti-resorptive role, its use as an intracanal dressing has not been proposed. The aim of this study was to develop a formulation based on Epigallocatechin-3-gallate (EGCG) for endodontic use by assessing its physicochemical and biological properties.

Methods: Initially, physicochemical characterization of EGCG was performed by ultraviolet-visible (UV/Vis) and fluorescence spectroscopy to evaluate if the properties were maintained in acidic pH and time (1-6, 24 and 27 hours). Read More

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Video Vignette: laparoscopic approach of peritoneal carcinomatosis surgery guided by indocianine green: two cases in our center.

Colorectal Dis 2021 Jun 22. Epub 2021 Jun 22.

Hepatobiliar Unit, Hospital Regional Universitario de Malaga, Malaga, Spain.

Minimally invasive surgery associated with hyperthermic chemotherapy (HIPEC) laparoscopy has shown to be a safe procedure in case of local peritoneal metastasis(PM) . Preoperative staging systems available have low sensitivity in detecting PM smaller than 5mm. Some studies have shown the ability of indocyanine green (ICG)-fluorescence to light up PM. Read More

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Increased cytoplasmic expression of DLL4 is associated with favorable prognosis in colorectal cancer.

Future Oncol 2021 Jun 22. Epub 2021 Jun 22.

Oncopathology Research Center, Iran University of Medical Sciences, Tehran, 14496-14530, Iran.

DLL4 of the Notch pathway is a key regulator of VEGF expression, which mediates tumor neovascularization and stem cell self-renewal in colorectal cancer (CRC). The authors investigated the association of DLL4 expression with the clinicopathological characteristics and survival outcomes of CRC patients. DLL4 expression level was evaluated in 199 CRC samples using immunohistochemistry analysis of tissue microarrays. Read More

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Detection of Carotid Artery Stenosis with Intraplaque Hemorrhage and Neovascularization Using a Scanning Interferometer.

Nano Lett 2021 Jun 22. Epub 2021 Jun 22.

Division of Medical Physics, Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, United States.

Carotid artery stenosis (CAS) is a major cause of stroke or transient ischemic attack (TIA, mini-stroke) in the United States. Carotid endarterectomy (CEA), a surgical procedure, is used to treat CAS. According to the American Heart Association, 1 out of 5 patients underwent CEA inappropriately, which was most commonly due to apparent overestimation of stenosis severity, and half had uncertain indicators. Read More

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Treatment Landscape of Macular Disorders in Indian Patients with the Advent of Razumab™ (World's First Biosimilar Ranibizumab): A Comprehensive Review.

Ophthalmol Ther 2021 Jun 21. Epub 2021 Jun 21.

Medical Affairs, Intas Pharmaceuticals Limited, Ahmedabad, Gujarat, India.

Ranibizumab is approved for the treatment of several macular disorders, including wet age-related macular degeneration (wet AMD), diabetic macular edema (DME), retinal vein occlusion (RVO) and myopic choroidal neovascularization (mCNV), among others. The unaffordability of the innovator ranibizumab among patients from developing countries such as India led to the development of the world's first biosimilar ranibizumab, which is a cost-effective alternative that does not compromise efficacy and safety. Razumab™, developed and produced by Intas Pharmaceuticals Ltd. Read More

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Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization.

Front Cell Dev Biol 2021 2;9:686886. Epub 2021 Jun 2.

State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Platelet-derived growth factor-D (PDGF-D) is highly expressed in immune cells. However, the potential role of PDGF-D in immune system remains thus far unclear. Here, we reveal a novel function of PDGF-D in activating both classical and alternative complement pathways that markedly increase chemokine and cytokine responses to promote macrophage polarization. Read More

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Role of bevacizumab intraocular injection in the management of neovascular glaucoma.

Int J Ophthalmol 2021 18;14(6):855-859. Epub 2021 Jun 18.

Department of Ophthalmology, College of Medicine, University of Mutah, Karak 61710, Jordan.

Aim: To assess the long-term effects of intraocular bevacizumab (Avastin) injections as an adjunctive drug to manage patients with neovascular glaucoma (NVG).

Methods: A retrospective study was conducted consisting of 34 eyes with secondary NVG caused by proliferative diabetic retinopathy (=25), ischemic central retinal vein occlusion (=8), and retinal ischemia resulting from persistent detachment (=1) were managed by intraocular injections of bevacizumab (1.25 mg/0. Read More

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Multimodal Optical Imaging to Investigate Spatiotemporal Changes in Cerebrovascular Function in AUDA Treatment of Acute Ischemic Stroke.

Front Cell Neurosci 2021 3;15:655305. Epub 2021 Jun 3.

Department of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Administration of 12-(3-adamantan-1-yl-ureido)-dodecanoic acid (AUDA) has been demonstrated to alleviate infarction following ischemic stroke. Reportedly, the main effect of AUDA is exerting anti-inflammation and neovascularization via the inhibition of soluble epoxide hydrolase. However, the major contribution of this anti-inflammation and neovascularization effect in the acute phase of stroke is not completely elucidated. Read More

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Using optical coherence tomography angiography to guide myopic choroidal neovascularization treatment: a 3-year follow-up study.

Graefes Arch Clin Exp Ophthalmol 2021 Jun 18. Epub 2021 Jun 18.

Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.

Purpose: To report the long-term changes of the size of myopic choroidal neovascularization (mCNV) using optical coherence tomography angiography (OCTA).

Methods: This was a retrospective, observational case study of eleven eyes in eleven patients with mCNV followed with OCTA for a minimum of 3 years. The flow area of mCNV on OCTA, the size of chorioretinal atrophy (CRA) and central choroidal thickness were analyzed. Read More

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Efficacy of Lamellar Keratoplasty with Acellular Porcine Corneal Stroma in Treatment for Infectious Central and Peripheral Corneal Ulcers.

Ther Clin Risk Manag 2021 10;17:623-634. Epub 2021 Jun 10.

Department of Ophthalmology, General Hospital of Northern Theater Command, Shenyang, People's Republic of China.

Background: The aim of this study was to investigate the efficacy of acellular porcine corneal stroma (APCS) transplantation in the treatment of infectious central and peripheral corneal ulcers.

Methods: A total of 45 patients with infectious corneal ulcers who had undergone lamellar keratoplasty using APCS grafts were included. Among these, 24 had lesions located near the pupil (infectious central corneal ulcer group) and 21 had lesions located in the limbus or around the cornea (infectious peripheral corneal ulcer group). Read More

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Cytokine and Chemokine Profile Changes in Patients with Neovascular Age-Related Macular Degeneration After Intravitreal Ranibizumab Injection for Choroidal Neovascularization.

Drug Des Devel Ther 2021 9;15:2457-2467. Epub 2021 Jun 9.

Department of Ophthalmology, Shanghai Tenth People's Hospital, Tongji University, Shanghai, 200072, People's Republic of China.

Objective: To investigate the concentrations of cytokine and chemokines profiling in aqueous humor for choroidal neovascularization (CNV) due to neovascular age-related macular degeneration (nAMD) before and during Intravitreal injection of ranibizumab (IVR) and its relation with the disease's active state.

Methods: The cytokine levels in aqueous humour were detected by the Bio-Plex 200 System and the Bio-Plex™ Human Cytokine Standard 27-Plex, Group I. Aqueous humour samples of experimental group were collected from 19 patients diagnosed nAMD at baseline and at 1 month after IVR. Read More

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Strontium-calcium phosphate hybrid cement with enhanced osteogenic and angiogenic properties for vascularised bone regeneration.

J Mater Chem B 2021 Jun 17. Epub 2021 Jun 17.

Institute of Orthopedics and Department of Orthopedics, The First Affiliated Hospital, Soochow University, No. 708 Renmin Road, Suzhou 215006, P. R. China and Center for Health Science and Engineering (CHSE), School of Materials Science and Engineering, Hebei University of Technology, No. 8 Guangrong Road, Tianjin 300130, P. R. China.

Vascularized bone tissue engineering is regarded as one of the optimal treatment options for large bone defects. The lack of angiogenic properties and unsatisfactory physicochemical performance restricts calcium phosphate cement (CPC) from application in vascularized bone tissue engineering. Our previous studies have developed a starch and BaSO4 incorporated calcium phosphate hybrid cement (CPHC) with improved mechanical strength and handling properties. Read More

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Vascularized Carotid Atherosclerotic Plaque Models for the Validation of Novel Methods of Quantifying Intra-Plaque Neovascularization.

J Am Soc Echocardiogr 2021 Jun 12. Epub 2021 Jun 12.

Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Canada;; Department of Medicine, Cardiovascular Imaging Network at Queen's (CINQ), Queen's University, Canada. Electronic address:

Background: Intraplaque neovascularization (IPN) in advanced lesions of the carotid artery has been linked to plaque progression and risk of rupture. Quantitative measurement of IPN may provide a more powerful tool for the detection of such "vulnerable" plaque than the current visual scoring grading method. The aim of this study was to develop a phantom platform of a neovascularized atherosclerotic plaque within a carotid artery to assess new methods of quantifying IPN. Read More

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Effects of Macrophage Regulation on Fat Grafting Survival: Improvement, Mechanisms, and Potential Application A Review.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Department of Cosmetic and Plastic Surgery, Oral and Maxillofacial Surgery, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Background: Autologous fat grafting has become a popular tool in plastic surgery to solve soft tissue defects and achieve skin rejuvenation, but the volume loss after transplantation remains a disturbing problem. In recent years, some new strategies have improved the outcome to some extent, but the fat graft retention is still far from ideal, so there remains a wide development prospect in this field. Macrophages are closely related to the local microenvironment and tissue regeneration, and their role in fat grafting has been increasingly highlighted. Read More

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Intraoperative three-dimensional fluorescein angiography-guided pars plana vitrectomy for branch retinal vein occlusion.

Retin Cases Brief Rep 2020 Nov 25. Epub 2020 Nov 25.

1Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine. 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Purpose: To show surgical results of the intraoperative three-dimensional fluorescein angiography (3D-FA)-guided pars plana vitrectomy (PPV) for branch retinal vein occlusion (BRVO) with vitreous hemorrhage (VH) and neovascularization elsewhere (NVE).

Methods: The NGENUITY 3D ® visualization system was used for the digital assisted vitrectomy (DAV). 3D-FA-guided PPV was performed in three patients with BRVO with VH and NVE. Read More

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November 2020

HIF-1α and HIF-2α redundantly promote retinal neovascularization in patients with ischemic retinal disease.

J Clin Invest 2021 Jun;131(12)

Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Therapies targeting VEGF have proven only modestly effective for the treatment of proliferative sickle cell retinopathy (PSR), the leading cause of blindness in patients with sickle cell disease. Here, we shift our attention upstream from the genes that promote retinal neovascularization (NV) to the transcription factors that regulate their expression. We demonstrated increased expression of HIF-1α and HIF-2α in the ischemic inner retina of PSR eyes. Read More

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Experimental-based validation of corneal lenticule banking in a health authority-licensed facility.

Tissue Eng Part A 2021 Jun 15. Epub 2021 Jun 15.

Singapore National Eye Centre, Cornea External Disease and Refractive, 11 Third Hospital Avenue, Level 8, Singapore, Singapore, 168751.

With the expected rise in patients undergoing refractive lenticule extraction worldwide, the amount of discarded corneal stromal lenticules will increase. Therefore, establishing a lenticule bank to collect, catalog, process, cryopreserve and distribute the lenticules (for future therapeutic needs) could be advantageous. Here, we validated the safety of lenticule banking, which involved the collection of human lenticules from our eye clinic, transportation of the lenticules to a Singapore Ministry of Health-licensed lenticule bank, processing and cryopreservation of the lenticules, which after 3 months or, a longer-term, 12 months, were retrieved and transported to our laboratory for implantation in rabbit corneas. Read More

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Intravitreal anti-VEGF use in France: a cross-sectional and longitudinal Nationwide observational study.

Acta Ophthalmol 2021 Jun 14. Epub 2021 Jun 14.

EPI-PHARE (French National Agency for Medicines and Health Products Safety (ANSM) and French National Health Insurance (CNAM)), Saint-Denis, France.

Purpose: To describe the sociodemographic, medical and management characteristics of patients using intravitreal (IVT) anti-vascular endothelial growth factors (VEGF) in France.

Methods: An observational study was conducted in patients treated with IVT ranibizumab or aflibercept, aged 18 years or older using the French National Health Insurance Databases covering 99% of the French population. Patients currently treated in 2018 were included in a cross-sectional approach to describe treatment history over the previous 6 years. Read More

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Predominantly Persistent Subretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials (CATT).

Ophthalmol Retina 2021 Jun 11. Epub 2021 Jun 11.

Department of Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Objective: To describe predominantly persistent subretinal fluid (SRF) in eyes receiving ranibizumab or bevacizumab for neovascular age-related macular degeneration and compare visual acuity (VA) to eyes with non-persistent SRF.

Design: Cohort within randomized clinical trial PARTICIPANTS: Comparison of Age-related Macular Degeneration Treatments Trials patients assigned to pro re nata (PRN) treatment.

Methods: Reading center graders evaluated optical coherence tomography scans at baseline and monthly follow-up visits for SRF. Read More

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Evaluation of the histological and biomechanical properties of poly-4-hydroxybutyrate scaffold for pelvic organ prolapse, compared with polypropylene mesh in a rabbit model.

Int Urogynecol J 2021 Jun 14. Epub 2021 Jun 14.

Division of Female Pelvic Medicine and Reconstructive Surgery, Donald and Barbara Zucker School of Medicine at Northwell Health, Long Island, NY, USA.

Introduction And Hypothesis: Poly-4-hydroxybutyrate (P4HB) is a biopolymer produced by Escherichia coli K12 bacteria. P4HB is fully resorbed in vivo by 18-24 months post-implantation. The aim of this study is to evaluate P4HB in the rabbit abdomen and vagina to determine that the biomechanical and histological properties are similar to the standard polypropylene mesh. Read More

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[Contact endoscopy with narrow-band imaging for detection of perpendicular vascular changes in benign, dysplastic, and malignant lesions of the vocal folds].

HNO 2021 Jun 14. Epub 2021 Jun 14.

Universitätsklinik für Hals‑, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Medizinische Fakultät, Otto-von-Guericke-Universität, Leipziger Straße 44, 39120, Magdeburg, Deutschland.

Background: Perpendicular vascular changes (PVC) are markers of tumor-induced neoangiogenesis at the vocal folds. Contact endoscopy with narrow-band imaging (CE-NBI) allows a detailed analysis of such vascular changes.

Objective: This work intends to evaluate the potential of CE-NBI for diagnosis of benign, dysplastic, and malignant lesions of the vocal folds. Read More

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North Carolina Macular Dystrophy: Phenotypic Variability and Computational Analysis of Disease-Associated Noncoding Variants.

Invest Ophthalmol Vis Sci 2021 Jun;62(7):16

Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom.

Purpose: North Carolina macular dystrophy (NCMD) is an autosomal dominant, congenital disorder affecting the central retina. Here, we report clinical and genetic findings in three families segregating NCMD and use epigenomic datasets from human tissues to gain insights into the effect of NCMD-implicated variants.

Methods: Clinical assessment and genetic testing were performed. Read More

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Multifocal Evanescent White Dot Syndrome-like Phenotypes Associated with Inflammatory and Myopic Choroidal Neovascularization.

Ocul Immunol Inflamm 2021 Jun 14:1-8. Epub 2021 Jun 14.

Uveitis Service, Moorfields Eye Hospital NHS Foundation Trust, London, UK.

: To present the observation of multifocal evanescent white dot syndrome (MEWDS)-like phenotypes developing in association with the onset of choroidal neovascularization (CNV) in a series of patients.: Patients presenting to tertiary-care centers with MEWDS-like phenotypes and CNV were identified.: Five patients presented for the management of CNV in the context of previous diagnoses of punctate inner choroidopathy (PIC) and/or myopia. Read More

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Different Outcomes of Anti-VEGF Treatment for Neovascular AMD according to Neovascular Sutypes and Baseline Features: 2-Year Real-Life Clinical Outcomes.

Biomed Res Int 2021 24;2021:5516981. Epub 2021 May 24.

Department of Ophthalmology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy.

Purpose: To evaluate the effects of anti-VEGF treatment of neovascular age-related macular degeneration (nAMD) in a real-life clinical setting.

Methods: Study design is a retrospective case series. Naïve nAMD patients treated with intravitreal injection of aflibercept or ranibizumab were analyzed over a 24-month follow-up. Read More

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Tyrosine-Protein Phosphatase Non-receptor Type 9 (PTPN9) Negatively Regulates the Paracrine Vasoprotective Activity of Bone-Marrow Derived Pro-angiogenic Cells: Impact on Vascular Degeneration in Oxygen-Induced Retinopathy.

Front Cell Dev Biol 2021 28;9:679906. Epub 2021 May 28.

Department of Ophthalmology, Maisonneuve-Rosemont Hospital Research Center, University of Montréal, Montréal, QC, Canada.

Background And Aim: Insufficient post-ischemic neovascularization is an initial key step in the pathogenesis of Oxygen-Induced Retinopathy (OIR). During neovascularization, pro-angiogenic cells (PACs) are mobilized from the bone marrow and integrate into ischemic tissues to promote angiogenesis. However, the modulation of PAC paracrine activity during OIR and the specific mechanisms involved remain to be explored. Read More

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