76,876 results match your criteria neonatal prognosis

Debate - Replacement of the Mitral Valve Under One Year of Age: Mechanical Valves Should Be Used.

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:44-56

Heart Institute and Department of Surgery, and the Division of Cardiothoracic Surgery, Department of Surgery, University of Cincinnati College of Medicine, Cincinnati, Ohio.

This article reviews the literature, focusing on publications from the third millennium and the results of mitral valve replacement in children younger than 1 year of age. Special consideration has been given to neonatal and infant valve replacement to provide insights into valve choice and technique. Mitral valve replacement is an important topic because it carries the highest mortality and poorer long-term prognosis than any other valve replacement in children. Read More

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January 2021

Hyperferritinemia: A Diagnostic Marker for Disseminated Neonatal Herpes Simplex Virus Infection?

Pediatr Ann 2021 Jun 1;50(6):e264-e267. Epub 2021 Jun 1.

Although the prognosis of neonatal herpes simplex virus (HSV) infection has improved with intravenous acyclovir, the morbidity and mortality of disseminated disease remains high. Transaminitis and thrombocytopenia have been reported to be sensitive markers of neonatal HSV disease; however, early diagnosis remains a challenge due to a lack of specific clinical and laboratory indicators for this disease process. Ferritin, an acute phase reactant known for its use in diagnosing hemophagocytic lymphohistiocytosis, has recently been reported as extremely elevated in neonates with disseminated HSV due to its high inflammatory nature. Read More

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Can we improve our ability to interpret category II fetal heart rate tracings using additional clinical parameters?

J Perinat Med 2021 Jun 9. Epub 2021 Jun 9.

Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Saba, Israel.

Objectives: This study examined predictive factors, in addition to Category II Fetal Herat Rate (FHR) monitoring that might imply fetal acidosis and risk of asphyxia.

Methods: This retrospective cohort study compared three groups of patients with Category II FHR monitoring indicating need for imminent delivery. Groups were divided based on fetal cord blood pH: pH≤7. Read More

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Early combined rehabilitation intervention to improve the short-term prognosis of premature infants.

BMC Pediatr 2021 Jun 9;21(1):269. Epub 2021 Jun 9.

Department of Neonatology, Sichuan Provincial Maternity and Child Health Care Hospital, No. 290 West Second Street, Shayan Road, Chengdu, 610031, Sichuan, China.

Background: To explore the clinical effect of early combined rehabilitation intervention on premature infants in the neonatal intensive care unit (NICU).

Methods: Premature infants with gestational ages less than 32 weeks or birth weights less than 1500 g were included in the present study.The participants were divided into the intervention group and control group. Read More

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J Gynecol Obstet Hum Reprod 2021 Jun 6:102178. Epub 2021 Jun 6.

Fetal Medicine Unit, Department of Obstetrics and Fetal Medicine, Necker-Enfants Malades Hospital, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; National Referral Centre for the Management of Complicated Monochorionic Pregnancies, Department of Obstetrics and Fetal Medicine, Necker-Enfants Malades Hospital, Université Paris Descartes, APHP, Paris, France.

Introduction: Pseudoamniotic Bands Syndrome (PABS) was described as iatrogenic complication from in utero procedure as fetoscopy.

Objective: The aim of our study was to identify the ultrasound findings in PABS diagnosed prenatally METHODS: First, we reported cases of PABS following fetoscopic surgery that were diagnosed prenatally in our institution. We collected all ultrasound data with fetal and neonatal issues. Read More

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Hypoglycemia and jaundice in newborns with pituitary stalk interruption syndrome.

Medicine (Baltimore) 2021 May;100(19):e25843

Department of Paediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan.

Abstract: Pituitary stalk interruption syndrome (PSIS) is a rare disease associated with either isolated growth hormone deficiency (GHD) or combined pituitary hormone deficiency (CPHD). In older children and adults, most patients experience short stature or hypogonadism. Neonatal PSIS is extremely rare and is difficult to recognize due to absence of dwarfism. Read More

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[Predictive value of lactate concentration combined with lactate clearance rate in the prognosis of neonatal septic shock].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):489-494

Department of Neonatal Intensive Care, Xi'an Children's Hospital, Xi'an Jiao Tong University, Xi'an 710003, China.

To investigate the predictive value of lactate concentration within 1 h after admission combined with lactate clearance rate (LC) at 6 h after fluid resuscitation in prognosis of neonatal septic shock. In this retrospective study, 58 newborns with septic shock admitted to the Neonatal Intensive Care Unit of Xi'an Children's Hospital,Xi'an Jiao Tong University from June 2016 to March 2020 were enrolled. According to the mortality within 60 days after admission,which was also set as the end point, the patients were divided into death group and survival group. Read More

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[Clinical and genetic studies on 76 patients with hydrocephalus caused by methylmalonic acidemia combined with homocysteinuria].

Zhonghua Er Ke Za Zhi 2021 Jun;59(6):459-465

Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.

To analyze the clinical features, genetic characteristics, treatment and follow-up results of patients with hydrocephalus caused by methylmalonic acidemia combined with homocysteinuria, and to discuss the optimal strategies for assessing and treating such patients. From January 1998 to December 2020, 76 patients with hydrocephalus due to methylmalonic acidemia combined with homocysteinuria in the Department of Pediatrics in 11 hospitals including Peking University First Hospital were diagnosed by biochemical, genetic analysis and brain imaging examination. The patients were divided into operation-group and non-operation-group according to whether they underwent ventriculoperitoneal shunt. Read More

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[Early clinical efficacy analysis of personalized three-dimensional printing talus prosthesis in the treatment of collapse talus necrosis].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):470-476

Orthopaedic Sports Medicine Center, the First Affiliated Hospital to Army Medical University, Chongqing 400038, China.

To examine the preliminary clinical efficacy of custom-made three-dimensional(3D) printed talus prosthesis in the treatment of collapse talus necrosis. The clinical data of 8 patients who received 3D printed custom-made talus prostheses replacement for severe collapsed necrosis of the talus at the Orthopaedic Sports Medical Center, the First Affiliated Hospital to Army Medical University were analyzed retrospectively.All patients were male,with an average age of 38. Read More

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Prenatal ultrasound measurements of mild congenital pulmonary airway malformation and long-term prognosis: A retrospective cohort study.

Int J Gynaecol Obstet 2021 Jun 8. Epub 2021 Jun 8.

Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China.

Objective: To investigate the relationship between mild congenital pulmonary airway malformation (CPAM) and its long-term prognosis in childhood and to explore whether surgery was necessary.

Methods: We conducted a retrospective cohort of mild CPAM fetuses diagnosed prenatally with available long-term outcomes in childhood from 2004 to 2016. The patients were divided into two groups according to the fetal CPAM-volume ratio (CVR) of less than 1. Read More

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Changes in amplitude-integrated electroencephalography, neuron-specific enolase, and S100B in neonates with brain injury induced by neonatal hyperbilirubinemia and their significance.

Brain Inj 2021 Jun 7:1-6. Epub 2021 Jun 7.

Department of Pediatrics, Xuzhou Central Hospital (Xuzhou Clinical School of Xuzhou Medical University), Xuzhou, China.

: To explore the changes in amplitude-integrated electroencephalography (aEEG), neuron-specific enolase (NSE), and S100B in neonates with brain injury induced by neonatal hyperbilirubinemia (NHB).: 67 neonates with brain injury induced by NHB admitted to our hospital from March 2016 to October 2018 were included in a brain injury group (BIG), and 82 neonates with NHB but without brain injury in our hospital during the same period were included in a non-BIG. The two groups were compared regarding the rates of normal and abnormal aEEG results. Read More

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Precision Medicine in Neonates: A Tailored Approach to Neonatal Brain Injury.

Front Pediatr 2021 19;9:634092. Epub 2021 May 19.

Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Despite advances in neonatal care to prevent neonatal brain injury and neurodevelopmental impairment, predicting long-term outcome in neonates at risk for brain injury remains difficult. Early prognosis is currently based on cranial ultrasound (CUS), MRI, EEG, NIRS, and/or general movements assessed at specific ages, and predicting outcome in an individual (precision medicine) is not yet possible. New algorithms based on large databases and machine learning applied to clinical, neuromonitoring, and neuroimaging data and genetic analysis and assays measuring multiple biomarkers (omics) can fulfill the needs of modern neonatology. Read More

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Role of age, gender and marital status in prognosis for adults with depression: An individual patient data meta-analysis.

Epidemiol Psychiatr Sci 2021 Jun 4;30:e42. Epub 2021 Jun 4.

Research Department of Clinical, Educational & Health Psychology, Centre for Outcomes Research and Effectiveness (CORE), University College London, 1-19 Torrington Place, LondonWC1E 7HB, UK.

Aims: To determine whether age, gender and marital status are associated with prognosis for adults with depression who sought treatment in primary care.

Methods: Medline, Embase, PsycINFO and Cochrane Central were searched from inception to 1st December 2020 for randomised controlled trials (RCTs) of adults seeking treatment for depression from their general practitioners, that used the Revised Clinical Interview Schedule so that there was uniformity in the measurement of clinical prognostic factors, and that reported on age, gender and marital status. Individual participant data were gathered from all nine eligible RCTs (N = 4864). Read More

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Screening of Congenital Hypothyroidism in North-East Romania. Benefits and Messages for Further Improvement.

Acta Endocrinol (Buchar) 2020 Oct-Dec;16(4):437-442

Department of Endocrinology, Iasi, Romania.

Background: If not diagnosed at birth, congenital hypothyroidism (CH) can cause deleterious, irreversible neurodevelopmental sequels. The importance of thyroid newborn screening (NBS) is therefore well established.

Objective: To evaluate the efficacy of NBS for CH in North-East Romania. Read More

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Atypical, severe hypertrophic cardiomyopathy in a newborn presenting Noonan syndrome harboring a recurrent heterozygous MRAS variant.

Am J Med Genet A 2021 Jun 3. Epub 2021 Jun 3.

Unidade de Genética, Instituto da Criança do Hospital das Clínicas da Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

Noonan syndrome (NS) is a Mendelian phenotype, member of a group of disorders sharing neurocardiofaciocutaneous involvement, known as RASopathies, caused by germline variants in genes coding for components of the RAS/MAPK signaling pathway. Recently, a novel gene of the RAS family (MRAS) was reported to be associated with NS in five children, all of them presenting, among the cardinal features of NS, the same cardiac finding, hypertrophic cardiomyopathy (HCM). We report on a 2-month-old infant boy also presenting this cardiac anomaly that evolved to a fatal outcome after a surgical myectomy. Read More

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An Update Review on Listeria Infection in Pregnancy.

Infect Drug Resist 2021 26;14:1967-1978. Epub 2021 May 26.

Department of Obstetrics, The First Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.

Listeria monocytogenes (LM) is an intracellular, aerobic and facultative anaerobic, Gram-positive bacterium, which is primarily transmitted to humans orally via food. LM could occur in asymptomatic pregnant women; however, fetal infection is a serious condition, entailing premature birth, abortion, sepsis, central nervous system (CNS) involvement, or even death. If a pregnant woman exhibits symptoms, the performance is almost like influenza, such as fever, headache, diarrhea, myalgia, or other digestive-related symptoms. Read More

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Is the First of the Two Born Saved? A Rare and Dramatic Case of Double Placental Damage from SARS-CoV-2.

Viruses 2021 05 26;13(6). Epub 2021 May 26.

Section of Pathology, Department of Emergency and Organ Transplantation (DETO), University of Bari "Aldo Moro", 70124 Bari, Italy.

The current coronavirus pandemic has affected, in a short time, various and different areas of medicine. Among these, the obstetric field has certainly been touched in full, and the knowledge of the mechanisms potentially responsible for placental damage from SARS-CoV-2 occupy a certain importance. Here we present here a rare case of dichorionic twins born at 30 weeks and 4 days of amenorrhea, one of whom died in the first few hours of life after placental damages potentially related to SARS-CoV-2. Read More

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Growth Factors Assessed during Kasai Procedure in Liver and Serum Are Not Predictive for the Postoperative Liver Deterioration in Infants with Biliary Atresia.

J Clin Med 2021 May 5;10(9). Epub 2021 May 5.

Department of Pediatric Pulmonology, Allergology and Neonatology, Hannover Medical School, Carl-Neuberg-Straße 1, 30625 Hannover, Germany.

Background: Biliary atresia (BA) is a neonatal cholangiopathy characterized by progressive destruction of the biliary system resulting in liver cirrhosis. Residual bile drainage can temporarily be achieved through Kasai portoenterostomy (KPE) and some children show long-term survival with their native liver. However, most children eventually require liver transplantation (LTX). Read More

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Long-term clinical and serological follow-up of paediatric patients infected by SARS-CoV-2.

Infez Med 2021 Jun;29(2):216-223

Department of Paediatrics, Infermi Hospital, ASLTO3, Turin, Italy; Department of Hygiene and Public Health, ASLTO3, Turin, Italy; Department of Diagnostics, ASLTO3, Turin, Italy.

Studies concerning Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection in paediatrics are limited to children mainly selected from hospitals, where patients with complications and co-morbidities are managed. We aimed to describe the course of the Coronavirus Disease 2019 (COVID-19) in a population of children enrolled by place of residence, from diagnosis to recovery, with a long-term clinical and serological follow-up. We identified patients aged <14 years old living in the Turin Health District 3 who had SARS-CoV-2 detected in at least one nasopharyngeal swab from 1st March to 1st June 2020. Read More

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Incidence de la COVID-19 sur les issues de grossesse: examen systématique et méta-analyse.

CMAJ 2021 05;193(22):E813-E822

Département d'obstétrique-gynécologie (Wei), Centre hospitalier universitaire Sainte-Justine; Centre de recherche du Centre hospitalier de l'Université de Montréal, Département de médecine sociale et préventive (Auger), École de santé publique, Université de Montréal; Bureau d'information et d'études en santé des populations (Wei, Bilodeau-Bertrand, Auger), Institut national de santé publique du Québec, Montréal, Qc; Centre de surveillance et de recherche appliquée (Liu), Agence de la santé publique du Canada, Ottawa, Ont.

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HIV-negative case of pulmonary infection with a mutation.

J Int Med Res 2021 May;49(5):3000605211016761

Department of Respiratory Disease, Thoracic Disease Centre, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.

is a rare dimorphic pathogenic fungus that can induce severe infections in human immunodeficiency virus (HIV)-infected patients. However, such infections have also been reported in non-HIV hosts. This current case report describes a very rare case of a pulmonary infection in an HIV-negative patient with a mutation in the tuberous sclerosis complex subunit 2 () gene. Read More

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Risk Factors for Mortality in Neonatal Gastric Perforation: A Retrospective Cohort Study.

Front Pediatr 2021 13;9:652139. Epub 2021 May 13.

Department of Neonatal Surgery, Children's Hospital of Chongqing Medical University, Chongqing, China.

Neonatal gastric perforation is a rare but life-threatening issue. The aim of this study was to describe the clinical characteristics and prognosis of patients with neonatal gastric perforation and identify predictive factors for poor prognosis. This was a retrospective cohort study of patients with neonatal gastric perforation treated in a tertiary pediatric public hospital between April 2009 and October 2020. Read More

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Severe Consumptive Coagulopathy in an Extremely-Low-Birth-Weight Infant with Intra-Abdominal Umbilical Vein Varix: A Case Report.

AJP Rep 2021 Mar 27;11(2):e76-e79. Epub 2021 May 27.

Department of Pediatrics, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan.

Recent studies have shown favorable outcomes for intra-abdominal umbilical vein varices (IUVVs) in term neonates who have no other complications. Little is known, however, about the prognosis of IUVVs in preterm neonates. We encountered a case of IUVV in an extremely low-birth-weight infant who developed severe consumptive coagulopathy after birth. Read More

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Kagami-Ogata Syndrome: Case Series and Review of Literature.

AJP Rep 2021 Mar 27;11(2):e65-e75. Epub 2021 May 27.

Department of Pediatrics, Division of Neonatal-Perinatal Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.

Kagami-Ogata syndrome (KOS) (OMIM #608149) is a genetic imprinting disorder affecting chromosome 14 that results in a characteristic phenotype consisting of typical facial features, skeletal abnormalities including rib abnormalities described as "coat hanger ribs," respiratory distress, abdominal wall defects, polyhydramnios, and developmental delay. First identified by Wang et al in 1991, over 80 cases of KOS have been reported in the literature. KOS, however, continues to remain a rare and potentially underdiagnosed disorder. Read More

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Association of High-Mobility Group Box 1 (HMGB1) Gene Polymorphisms with Susceptibility and Better Survival Prognosis in Chinese Han Neonatal Necrotizing Enterocolitis.

Med Sci Monit 2021 May 31;27:e930015. Epub 2021 May 31.

Department of Gastroenterology, Weifang People's Hospital, Weifang, Shandong, China (mainland).

BACKGROUND High-mobility group box 1 (HMGB1) plays a crucial role in a variety of diseases, including neonatal necrotizing enterocolitis (NEC). The purpose of this study was to investigate the association of HMGB1 gene single-nucleotide polymorphisms (SNPs) with susceptibility and survival prognosis in Chinese Han neonates with NEC. MATERIAL AND METHODS The HMGB1 gene rs1360485, rs1045411, and rs2249825 site SNPs were genotyped in all participants. Read More

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Recommendations on the skills profile and standards of the neonatal transport system in Spain.

An Pediatr (Engl Ed) 2021 Jun 26;94(6):420.e1-420.e11. Epub 2021 May 26.

Servicio de Neonatología, Hospital Clínico Universitario de Santiago, IDIS, Universidad de Santiago de Compostela, Comisión de Estándares, Santiago de Compostela, Spain.

The first hours of life of a sick or premature newborn are crucial for its prognosis and therefore delivery should take place in a center prepared for that degree of complexity. When this condition is not met, the newborn must be transferred in an optimal and safe way to the center that can offer the necessary care. The training, staffing, organization and coordination of the neonatal transport team are essential to guarantee a safe transfer. Read More

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Vitamin B12 deficiency: case report and review of literature.

Pan Afr Med J 2021 4;38:237. Epub 2021 Mar 4.

Department of Pediatrics, Military Teaching Hospital Mohammed V, Faculty of Medicine and Pharmacy, University Mohammed V, Rabat, Morocco.

Vitamin B12 deficiency in early childhood is an important cause of neurodevelopmental delay and regression. Most of these cases occur in exclusively breast-fed infants of deficient mothers. Symptoms and signs of vitamin B12 deficiency appear between the ages of 2 to 12 months and include vomiting, lethargy, failure to thrive, hypotonia, and arrest or regression of developmental skills. Read More

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Experience with the management of anorectal malformations in Ibadan, Nigeria.

Pan Afr Med J 2021 24;38:214. Epub 2021 Feb 24.

Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Introduction: anorectal malformation is a multi-systemic birth defect of the distal gastrointestinal tract, the management of which is challenging to the surgeons, the patients and the parents. The presence of associated congenital malformations may worsen the outcome with consequent psychosocial effects on the patients and the parents. The characteristics of anorectal malformations with the challenges associated with their management and the outcomes are therefore presented here. Read More

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COVID-19 vaccination in pregnant and lactating diabetic women.

Nutr Metab Cardiovasc Dis 2021 Apr 24. Epub 2021 Apr 24.

Interassociative Diabetes and Pregnancy Study Group, Italian Association of Diabetologists (AMD), Italian Society of Diabetology (SID), Rome, Italy; Department of Clinical and Experimental Medicine, Endocrinology Section, University of Catania Medical School, Catania, Italy.

Aim: To discuss available information on the opportunity for pregnant women affected by diabetes/obesity to receive COVID-19 vaccine.

Data Synthesis: Pregnant women with SARS-CoV-2 (COVID-19) infection are at high risk for severe acute respiratory syndrome and adverse outcomes. Pregnant women with severe COVID-19 present increased rates of preterm delivery (<37 gestational weeks), cesarean delivery and neonatal admissions to the intensive care unit. Read More

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Identification of Novel Gene Signature Associated with Cell Glycolysis to Predict Survival in Hepatocellular Carcinoma Patients.

J Oncol 2021 6;2021:5564525. Epub 2021 May 6.

Department of Rehabilitation Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.

Purpose: As hepatocellular carcinoma (HCC) is a complex disease, it is hard to classify HCC with a specific biomarker. This study used data from TCGA to create a genetic signature for predicting the prognosis of HCC patients.

Methods: In a group of HCC patients ( = 424) from TCGA, mRNA profiling was carried out. Read More

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