81 results match your criteria neonatal fosfomycin

Amikacin Combined with Fosfomycin for Treatment of Neonatal Sepsis in the Setting of Highly Prevalent Antimicrobial Resistance.

Antimicrob Agents Chemother 2021 Jun 17;65(7):e0029321. Epub 2021 Jun 17.

Antimicrobial Pharmacodynamics and Therapeutics, University of Liverpool, Liverpool Health Partners, Liverpool, United Kingdom.

Antimicrobial resistance (particularly through extended-spectrum β-lactamase and aminoglycoside-modifying enzyme production) in neonatal sepsis is a global problem, particularly in low- and middle-income countries, with significant mortality rates. High rates of resistance are reported for the current WHO-recommended first-line antibiotic regimen for neonatal sepsis, i.e. Read More

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Colonization with multidrug-resistant Enterobacteriaceae among infants: an observational study in southern Sri Lanka.

Antimicrob Resist Infect Control 2021 04 30;10(1):72. Epub 2021 Apr 30.

Division of Infectious Diseases, Department of Medicine, Duke University School of Medicine, Durham, NC, USA.

Background: The timing of and risk factors for intestinal colonization with multidrug-resistant Enterobacteriaceae (MDRE) are still poorly understood in areas with high MDRE carriage. We determined the prevalence, timing, and risk factors associated with MDRE intestinal colonization among infants in southern Sri Lanka.

Methods: Women and their newborn children were enrolled within 48 h after delivery in southern Sri Lanka. Read More

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IV and oral fosfomycin pharmacokinetics in neonates with suspected clinical sepsis.

J Antimicrob Chemother 2021 Jun;76(7):1855-1864

Infection, Immunity and Inflammation, Great Ormond Street Institute of Child Health, University College London, London, UK.

Background: Fosfomycin has the potential to be re-purposed as part of a combination therapy to treat neonatal sepsis where resistance to current standard of care (SOC) is common. Limited data exist on neonatal fosfomycin pharmacokinetics and estimates of bioavailability and CSF/plasma ratio in this vulnerable population are lacking.

Objectives: To generate data informing the appropriate dosing of IV and oral fosfomycin in neonates using a population pharmacokinetic analysis of plasma and CSF data. Read More

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Antibiotic Resistance Patterns of Bacterial Isolates from Neonatal Sepsis Patients at University Hospital of Leipzig, Germany.

Antibiotics (Basel) 2021 Mar 19;10(3). Epub 2021 Mar 19.

Institute of Medical Microbiology and Epidemiology of Infectious Diseases, Faculty of Medicine, University of Leipzig, 04103 Leipzig, Germany.

Neonatal sepsis caused by resistant bacteria is a worldwide concern due to the associated high mortality and increased hospitals costs. Bacterial pathogens causing neonatal sepsis and their antibiotic resistance patterns vary among hospital settings and at different points in time. This study aimed to determine the antibiotic resistance patterns of pathogens causing neonatal sepsis and to assess trends in antibiotic resistance. Read More

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Characterization of Neonatal Infections by Gram-Negative Bacilli and Associated Risk Factors, Havana, Cuba.

Infect Dis Rep 2021 Mar 9;13(1):219-229. Epub 2021 Mar 9.

Tropical Medicine Institute "Pedro Kouri", Havana 11400, Cuba.

Infections represent an important problem in neonates because of the high mortality. An increase in neonatal infections has been found in Cuban hospitals in recent years. The aim of this study was to provide evidence on the clinical and microbiological behavior of Gram-negative bacilli that cause neonatal infections in hospitals of Havana, Cuba. Read More

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Prevalence of methicillin-sensitive, methicillin-resistant , and extended-spectrum beta-lactamase-producing in newborns: a cross-sectional study.

J Matern Fetal Neonatal Med 2020 Nov 18:1-12. Epub 2020 Nov 18.

Bavarian Health and Food Safety Authority, Munich/Oberschleißheim/Erlangen, Germany.

Background: The prevalence of antimicrobial-resistant bacteria and methicillin-sensitive (MSSA) in healthy newborns and the role of maternal transmission are scarcely discussed.

Objectives: The objective of this study was to evaluate the prevalence of MSSA, MRSA, and ESBL among healthy newborns. Additionally, mother-to-newborn transmission rates were investigated as well as antibiotic susceptibility of MSSA, MRSA, and ESBL isolates. Read More

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November 2020

Urinary Tract Infections among Indonesian Pregnant Women and Its Susceptibility Pattern.

Infect Dis Obstet Gynecol 2020 21;2020:9681632. Epub 2020 Apr 21.

Faculty of Medicine Universitas Indonesia, Indonesia.

Pregnant women are usually at risk of urinary tract infections (UTIs) such as asymptomatic bacteriuria. In the current multidrug-resistance era, appropriate diagnosis and treatment should be provided to avoid complications in pregnant women in developing countries, which have limited facilities, such as Indonesia. The aim of this study was to evaluate in vitro susceptibility tests. Read More

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Prevalence of Virulence Genes and Antimicrobial Resistances in Associated with Neonatal Diarrhea, Postweaning Diarrhea, and Edema Disease in Pigs from Austria.

Antibiotics (Basel) 2020 Apr 24;9(4). Epub 2020 Apr 24.

University Clinic for Swine, University of Veterinary Medicine, 1210 Vienna, Austria.

Increasing numbers of multi-resistant from clinical specimens emphasize the importance of monitoring of their resistance profiles for proper treatment. Furthermore, knowledge on the presence of virulence associated genes in isolates from European swine stocks is scarce. Consequently, a total of 694 isolated between 2016 and 2018 from diarrheic piglets of Austrian swine herds were investigated. Read More

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Incidence and Antimicrobial Susceptibilities of in Pregnant Females, Ehime University Hospital.

Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi 2020 Apr;29(2):53-58

Department of Clinical Laboratory, Ehime University Hospital. Department of Infection Control Team, Ehime University Hospital.

Objective: usually colonizes the lower urogenital tract and has been occasionally associated with pelvic inflammatory disease, postpartum fever, preterm labor in pregnant females. The aim of this study was to investigate the incidence and antimicrobial susceptibilities of isolated from the urogenital tracts of pregnant females.

Methods: Specimens were obtained from the urogenital tract of pregnant females at Department of Obstetrics and Gynecology, Ehime University Hospital, between November 2014 and December 2017. Read More

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Potential of fosfomycin in treating multidrug-resistant infections in children.

J Paediatr Child Health 2020 Jun 15;56(6):864-872. Epub 2020 Apr 15.

Department of Infectious Diseases and Immunology, Sydney Children's Hospital, Sydney, New South Wales, Australia.

In an era of increasing antimicrobial resistance, there are limited treatment options available to treat multidrug-resistant organisms in paediatric patients. Fosfomycin is an antibiotic defined as 'critically important' by The World Health Organization due to its potential efficacy against multidrug-resistant bacteria and is increasingly cited in the international literature as a promising antimicrobial for combating sepsis in an era of increasing antimicrobial resistance. With broad-spectrum cover that includes both Gram-positive and Gram-negative organisms and both parenteral and oral formulations available, fosfomycin provides a promising treatment option for paediatric patients. Read More

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Antimicrobial resistance profiles and genes in uropathogenic Enterobacteriaceae in reproductive-age women in St. Petersburg, Russia: implication for treatment of pyelonephritis in pregnancy.

J Matern Fetal Neonatal Med 2020 Apr 14:1-3. Epub 2020 Apr 14.

Laboratory of Microbiology, D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, St. Petersburg, Russia.

Urinary tract infections (UTIs) are common in women, and during pregnancy can cause significant morbidity. Growing and greatly varying antimicrobial resistance (AMR) of Enterobacteriaceae, responsible for most UTIs, necessitates regular local AMR surveillance. In obstetric population, where beta-lactams are the mainstay for treatment of severe UTIs, particular focus should be placed on beta-lactam resistance. Read More

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Antibiotic resistance and virulence patterns of pathogenic Escherichia coli strains associated with acute gastroenteritis among children in Qatar.

BMC Microbiol 2020 03 6;20(1):54. Epub 2020 Mar 6.

Biomedical Research Center, Qatar University, P.O. Box 2713, Doha, Qatar.

Background: The treatment of Enterobacteriaceae family including diarrheagenic E. coli (DEC) has been increasingly complicated due to the emergence of resistant strains. Here we report on the phenotypic resistance profiles and ESBL genotype and virulence profiles of Enteroaggregative E. Read More

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Pan-genome diversification and recombination in Cronobacter sakazakii, an opportunistic pathogen in neonates, and insights to its xerotolerant lifestyle.

BMC Microbiol 2019 12 27;19(1):306. Epub 2019 Dec 27.

Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH, 03824, USA.

Background: Cronobacter sakazakii is an emerging opportunistic bacterial pathogen known to cause neonatal and pediatric infections, including meningitis, necrotizing enterocolitis, and bacteremia. Multiple disease outbreaks of C. sakazakii have been documented in the past few decades, yet little is known of its genomic diversity, adaptation, and evolution. Read More

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December 2019

Systematic review of carbapenem-resistant Enterobacteriaceae causing neonatal sepsis in China.

Ann Clin Microbiol Antimicrob 2019 Nov 14;18(1):36. Epub 2019 Nov 14.

Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St. George's University of London, London, UK.

Background: Carbapenems are β-lactam antibiotics which are used to treat severe infections caused by multidrug resistant Enterobacteriacea. The recent emergence and rapid spread of Enterobacteriaceae resistant to carbapenems is a global concern. We undertook a systematic review of the antibiotic susceptibility and genotypic characteristics of carbapenem-resistant Enterobacteriaceae in Chinese neonates. Read More

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November 2019

Fosfomycin in the pediatric setting: Evidence and potential indications.

Rev Esp Quimioter 2019 May;32 Suppl 1:55-61

Fernando Baquero-Artigao, Servicio de Pediatría, Enfermedades Infecciosas y Patología Tropical. Hospital Universitario La Paz. Paseo de la Castellana, 261. 28046 Madrid. Spain.

To date, there has been little experience in using fosfomycin in children. However, its broad spectrum of action and excellent safety profile have renewed interest in this antibiotic, especially for treating infections by multidrug-resistant bacteria. The main indication for fosfomycin in pediatrics is currently community-acquired lower urinary tract infection. Read More

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In vitro susceptibility of urinary Escherichia coli isolates to first- and second-line empirically prescribed oral antimicrobials: CANWARD surveillance study results for Canadian outpatients, 2007-2016.

Int J Antimicrob Agents 2019 Jul 26;54(1):62-68. Epub 2019 Apr 26.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Escherichia coli isolates (n = 2035) from urine specimens of outpatients presenting to Canadian medical clinics and hospital emergency departments from 2007-2016 were collected as part of the CANWARD surveillance study. Isolate identification and antimicrobial susceptibility testing (AST) were performed at a central site (Health Sciences Centre, Winnipeg, Canada). AST of first- and second-line oral antimicrobial agents was performed using CLSI methods (M07, 11th ed, 2018); fosfomycin was tested by agar dilution and all other agents by broth microdilution. Read More

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The potential of fosfomycin for multi-drug resistant sepsis: an analysis of in vitro activity against invasive paediatric Gram-negative bacteria.

J Med Microbiol 2019 May 17;68(5):711-719. Epub 2019 Apr 17.

The University of Oxford, Nuffield Department of Clinical Medicine, Headington, Oxford, UK.

Purpose: Antimicrobial resistance (AMR) is of increasing global concern, threatening to undermine recent progress in reducing child and neonatal mortality. Repurposing older antimicrobials is a prominent strategy to combat multidrug-resistant sepsis. A potential agent is fosfomycin, however, there is scarce data regarding its in vitro activity and pharmacokinetics in the paediatric population. Read More

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Intravenous fosfomycin for the treatment of multidrug-resistant pathogens: what is the evidence on dosing regimens?

Expert Rev Anti Infect Ther 2019 03 4;17(3):201-210. Epub 2019 Feb 4.

g 3rd Department of Internal Medicine, SOTIRIA Hospital , National and Kapodistrian University of Athens , Athens , Greece.

Introduction: The intravenous (IV) formulation of fosfomycin has been re-introduced in clinical practice mainly to overcome treatment failures against multidrug-resistant (MDR) bacteria. Appropriate dosing schedules of the IV formulation have not yet been established. Areas covered: The mechanism of action and resistance development, commercial IV formulations, pharmacokinetic/pharmacodynamic (PK/PD) properties, IV dosing regimens for the treatment of MDR infections along with efficacy and safety issues were reviewed. Read More

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Incidence of multidrug resistance and extended-spectrum beta-lactamase expression in community-acquired urinary tract infection among different age groups of patients.

Indian J Pharmacol 2018 Mar-Apr;50(2):69-74

Microbiology section, FMRRC, PCSIR Laboratories Complex Karachi, Karachi, Pakistan.

Objectives: Urinary tract infection (UTI) is a frequent disorder and depends on age and gender. Ineffective empiric treatment of UTI is common when associated with extended-spectrum beta-lactamase (ESBL)-producing and . The aim of the study was to investigate the prevalence of Gram-negative uropathogens of and in different age groups along with the identification of ESBL-producing uropathogens and antimicrobial susceptibility profiles. Read More

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December 2018

Recent Prescription Patterns for Children With Acute Infectious Diarrhea.

J Pediatr Gastroenterol Nutr 2019 01;68(1):13-16

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Background: This study investigated recent trends in antibiotic use and factors associated with antibiotic use among children with acute infectious diarrhea. We obtained records of outpatients aged under 18 years diagnosed with acute infectious diarrhea from the Japan Medical Data Center database during 2012-2015.

Objective: We investigated prescription patterns of antibiotics at their initial visit and evaluated factors associated with antibiotic usage using multivariable log-binomial regression models. Read More

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January 2019

Clinical and molecular epidemiologic characteristics of carbapenem-resistant Klebsiella pneumoniae infection/colonization among neonates in China.

J Hosp Infect 2018 Sep 12;100(1):21-28. Epub 2018 May 12.

The Clinical Microbiology Laboratory, Children's Hospital of Fudan University, Shanghai, China; Department of Nosocomial Infection Control, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

Background: The spread of carbapenem-resistant Klebsiella pneumoniae (CR-KPN) is a major concern, but data on CR-KPN infection/colonization in paediatric populations are limited.

Aim: To analyse epidemiologic and clinical characteristics, and therapeutic options for CR-KPN infections in neonates in China.

Methods: A retrospective study was performed at the Children's Hospital of Fudan University, including 88 neonates with CR-KPN admitted between November 2015 and October 2016. Read More

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September 2018

Antimicrobial susceptibility profiles of bacteria causing urinary tract infections in Mexico: Single-centre experience with 10 years of results.

J Glob Antimicrob Resist 2018 09 23;14:90-94. Epub 2018 Mar 23.

Graduate Studies Division, Faculty of Biological and Medical Sciences 'Dr Ignacio Chávez', Universidad Michoacana de San Nicolás de Hidalgo, Av. Rafael Carrillo, Bosque Cuauhtémoc, 58020, Morelia, Michoacán, Mexico. Electronic address:

Objectives: The aim of this retrospective study was to describe urinary tract infections (UTIs) diagnosed in a single centre in Mexico through 10 years of results, with a particular emphasis on the aetiology, patterns of antimicrobial susceptibility and incidence of extended-spectrum β-lactamase (ESBL)-producing strains.

Methods: This study involved all urine samples analysed during the period March 2007 to September 2017 in a single centre in Mexico. Isolated uropathogens were identified to species level using routine laboratory methods, and antimicrobial susceptibility was determined by the disk diffusion method. Read More

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September 2018

Comparison of reduced metagenome and 16S rRNA gene sequencing for determination of genetic diversity and mother-child overlap of the gut associated microbiota.

J Microbiol Methods 2018 06 1;149:44-52. Epub 2018 Mar 1.

Faculty of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway. Electronic address:

Use of the 16S rRNA gene in microbiota studies is limited by the lack of taxonomic and functional resolution. High resolution analyses are particularly important for understanding transmission and persistence of bacteria. The aim of our work was therefore to compare a novel reduced metagenome sequencing (RMS) approach with 16S rRNA gene sequencing to determine both the metagenome genetic diversity and the mother-to-child sharing of the microbiota in a cohort of 17 mother-child pairs. Read More

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Analysis of the spectrum and antibiotic resistance of uropathogens in outpatients at a tertiary hospital.

J Chemother 2018 May 5;30(3):145-149. Epub 2018 Jan 5.

a Department of Pharmacy, Southwest Hospital , Third Military Medical University , Chongqing , China.

The objective of this study was to analyse the distribution and antimicrobial resistance of bacterial uropathogens isolated from outpatients at Henan Provincial People's Hospital. A total of 1419 samples from 823 newly diagnosed and 596 recurrent UTI outpatients culture positive. Escherichia coli was the most common uropathogen. Read More

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A Novel IncA/C1 Group Conjugative Plasmid, Encoding VIM-1 Metallo-Beta-Lactamase, Mediates the Acquisition of Carbapenem Resistance in ST104 Isolates from Neonates in the Intensive Care Unit of V. Monaldi Hospital in Naples.

Front Microbiol 2017 3;8:2135. Epub 2017 Nov 3.

Department of Public Health, University of Naples 'Federico II', Naples, Italy.

The emergence of carbapenemase producing Enterobacteriaceae has raised major public health concern. The aim of this study was to investigate the molecular epidemiology and the mechanism of carbapenem resistance acquisition of multidrug-resistant isolates from 20 neonates in the neonatal intensive care unit (NICU) of the V. Monaldi Hospital in Naples, Italy, from April 2015 to March 2016. Read More

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November 2017

Rapid in situ imaging and whole genome sequencing of biofilm in neonatal feeding tubes: A clinical proof of concept.

Sci Rep 2017 11 21;7(1):15948. Epub 2017 Nov 21.

School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, NG11 8NS, UK.

The bacterial flora of nasogastric feeding tubes and faecal samples were analysed for a low-birth weight (725 g) neonate EGA 25 weeks in intensive care. Samples were collected at age 6 and 8 weeks of life. Optical coherence tomography (OCT) was used to visualise bacterial biofilms inside the nasogastric feeding tubes. Read More

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November 2017

Antimicrobial susceptibility of microorganisms that cause urinary tract infections in pediatric patients.

Enferm Infecc Microbiol Clin (Engl Ed) 2018 Aug - Sep;36(7):417-422. Epub 2017 Oct 7.

Servicio de Microbiología, Hospital Universitario Marqués de Valdecilla-IDIVAL, Santander, Spain.

Introduction: Cumulative susceptibility reports are a valuable tool for the empirical treatment of urinary tract infections, especially in the current context of increasing resistance rates. Our objective was to analyze the antimicrobial susceptibility of bacterial isolates in urine cultures of pediatric patients during a five-year period.

Methods: Retrospective study of urine cultures from 2011 to 2015. Read More

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Vigilance on use of drugs, herbal products, and food supplements during pregnancy: focus on fosfomycin.

J Matern Fetal Neonatal Med 2019 Jan 17;32(1):125-128. Epub 2017 Sep 17.

a Department of Biomedical and Dental Sciences and Morphofunctional Imaging , University of Messina , Messina , Italy.

Purpose: Urinary tract infection (UTI) is defined as a common bacterial infection that can lead to significant morbidity such as stricture, fistula, abscess formation, bacteremia, sepsis, pyelonephritis, and kidney dysfunction with a mortality rates reported of 1% in men and 3% in women because of development of pyelonephritis. UTIs are more common in women and the 33% of them require antimicrobials treatment for at least one episode by the age of 24 years. UTIs are the most common infections observed during pregnancy and up to 30% of mothers with not treated asymptomatic bacteriuria may develop acute pyelonephritis which consequently can be associated to adverse maternal and fetal outcomes. Read More

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January 2019

The Potential Role of Fosfomycin in Neonatal Sepsis Caused by Multidrug-Resistant Bacteria.

Drugs 2017 Jun;77(9):941-950

Paediatric Infectious Diseases Research Group, Institute of Infection and Immunity, St George's, University of London, Cranmer Terrace, London, SW17 0RE, UK.

The broad-spectrum activity of fosfomycin, including against multidrug-resistant (MDR) strains, has led to renewed interest in its use in recent years. Neonatal sepsis remains a substantial cause of morbidity and mortality at a global level, with evidence that MDR bacteria play an increasing role. The evidence for use of fosfomycin in neonatal subjects is limited. Read More

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Characteristics of carbapenemase-producing as a cause of neonatal infection in Shandong, China.

Exp Ther Med 2017 Mar 20;13(3):1117-1126. Epub 2017 Jan 20.

Department of Microbiology, Clinical Laboratory, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China.

The goal of the present study was to examine the characteristics of carbapenem-resistant as a cause of neonatal infection. A total of 37 carbapenem-resistant -positive newborns hospitalized in Shandong Provincial Hospital, China between April 2011 and October 2013 were examined. Antibiotic susceptibility testing was performed using the agar dilution method and the Etest. Read More

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