839 results match your criteria negative logarithm

Positive Relationship Between Precompetitive Sympathetic Predominance and Competitive Performance in Elite Extreme Sports Athletes.

Front Sports Act Living 2021 23;3:712439. Epub 2021 Aug 23.

NTT Communication Science Laboratories, Nippon Telegraph and Telephone Corporation, Atsugi, Japan.

Elite athletes achieve superior performance under high pressure in competitive situations. Although it is known that such situations affect the precompetitive activity of their autonomic nervous system (ANS), the relationship between precompetitive ANS activity and performance remains controversial. Especially in extreme sports, it has been shown that cardiac sympathetic tone occurs in athletes before competition attempts. Read More

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Time-Course Study of the Antibacterial Activity of an Amorphous SiOCH Coating Certified for Food Contact.

Antibiotics (Basel) 2021 Jul 23;10(8). Epub 2021 Jul 23.

Department of Life Sciences, University of Modena and Reggio Emilia, 41125 Modena, Italy.

One of the most-used food contact materials is stainless steel (AISI 304L or AISI 316L), owing to its high mechanical strength, cleanability, and corrosion resistance. However, due to the presence of minimal crevices, stainless-steel is subject to microbial contamination with consequent significant reverb on health and industry costs due to the lack of effective reliability of sanitizing agents and procedures. In this study, we evaluated the noncytotoxic effect of an amorphous SiOCH coating deposited on stainless-steel disks and performed a time-course evaluation for four Gram-negative bacteria and four Gram-positive bacteria. Read More

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Trends in Victorian burn injuries 2008-2017.

Burns 2021 Jul 7. Epub 2021 Jul 7.

School of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, Australia; Health Data Research UK, Swansea University Medical School, Swansea University, Swansea, SA2 8QA, United Kingdom. Electronic address:

Objectives: To describe incidence and characteristics of hospital presentations and deaths due to burn injury in the Australian state of Victoria from 2008 to 2017 and identify trends in incidence and patterns.

Methods: Three population-based datasets were used to ascertain burn-related hospital admissions, emergency department presentations, and deaths. These were the Victorian Admitted Episodes Dataset (VAED), Victorian Emergency Minimum Dataset (VEMD), and the Cause of Death-Unit Record File (COD-URF), respectively. Read More

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Elective neck irradiation in the management of esthesioneuroblastoma: a systematic review and meta-analysis.

Rhinology 2021 Jul 13. Epub 2021 Jul 13.

Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.

Background: There is no consensus about the optimal management of the neck in clinically node negative esthesioneuroblastoma (ENB). The aim of this study is to assess the impact of elective neck irradiation (ENI) in terms of regional disease control and survival.

Methods: The study was performed according to the PRISMA guidelines searching on Scopus, PubMed/MEDLINE, and Google Scholar databases. Read More

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In vivo kinetics of SARS-CoV-2 infection and its relationship with a person's infectiousness.

medRxiv 2021 Jun 30. Epub 2021 Jun 30.

The within-host viral kinetics of SARS-CoV-2 infection and how they relate to a person's infectiousness are not well understood. This limits our ability to quantify the impact of interventions on viral transmission. Here, we develop data-driven viral dynamic models of SARS-CoV-2 infection and estimate key within-host parameters such as the infected cell half-life and the within-host reproductive number. Read More

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Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy.

Kidney Int Rep 2021 Jun 3;6(6):1669-1676. Epub 2021 Mar 3.

Department of Renal Medicine, University College London, London, UK.

Introduction: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to glomerulonephritis. Primary MN has a strong male predominance, accounting for approximately 65% of cases; yet, currently associated genetic loci are all located on autosomes. Previous reports of familial MN have suggested the existence of a potential X-linked susceptibility locus. Read More

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Human U90926 orthologous long non-coding RNA as a novel biomarker for visual prognosis in herpes simplex virus type-1 induced acute retinal necrosis.

Sci Rep 2021 Jun 9;11(1):12164. Epub 2021 Jun 9.

Isotope Science Center, The University of Tokyo, Tokyo, Japan.

Acute retinal necrosis (ARN) is a form of infectious uveitis caused by alpha herpesviruses, including herpes simplex virus type 1 (HSV-1). We previously found that the long non-coding RNA (lncRNA) U90926 is upregulated in murine retinal photoreceptor cells following HSV-1 infection, leading to host cell death. However, to date, an orthologous transcript has not been identified in humans. Read More

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Associations between peripheral blood microbiome and the risk of hypertension.

Am J Hypertens 2021 Jun 9. Epub 2021 Jun 9.

Department of Epidemiology and Statistics, School of Public Health, Medical College of Soochow University, Soochow, Jiangsu, China.

Background: Although previous studies have reported the gut microbiome is closely related to hypertension development, whether the change in blood microbiome is associated with the risk of hypertension remains unclear.

Methods: One hundred and fifty incident hypertension cases and 150 age (± 2 years) and gender (1:1) matched non-hypertension controls included in this nested case-control study were recruited from a prospective cohort study of "135". The composition of the blood microbiome was characterized using bacterial 16S ribosomal RNA gene sequencing. Read More

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Quantitative investigation of platelet aggregation under high shear force for anti-platelet aggregation in vitro tests.

Int J Artif Organs 2021 May 31:3913988211020765. Epub 2021 May 31.

National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan.

Blood pumps are often used for hemofiltration in patients with renal failure. To design effective centrifugal blood pumps for hemofiltration, it is important to suppress clogging caused by platelet aggregation. However, the optimal conditions for conducting anti-platelet aggregation tests in vitro have not yet been established. Read More

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Season-Long Heart-Rate Variability Tracking Reveals Autonomic Imbalance in American College Football Players.

Int J Sports Physiol Perform 2021 May 26:1-10. Epub 2021 May 26.

Purpose: To track cardiac-autonomic functioning, indexed by heart-rate variability, in American college football players throughout a competitive period.

Methods: Resting heart rate (RHR) and the natural logarithm root mean square of successive differences (LnRMSSD) were obtained throughout preseason and ∼3 times weekly leading up to the national championship among 8 linemen and 12 nonlinemen. Seated 1-minute recordings were performed via mobile device and standardized for time of day and proximity to training. Read More

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The relationship between body mass index and income: Using genetic variants from HUNT as instrumental variables.

Health Econ 2021 Aug 15;30(8):1933-1949. Epub 2021 May 15.

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Several studies have estimated effects of body mass index (BMI) on labour market outcomes, and these studies have mixed findings. A significant challenge has been to adequately control for omitted variables, selection, reverse causality, and measurement error. We examine the impact of BMI on income using genetic variants as instrumental variables for BMI. Read More

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Estimating safety performance functions for two-lane rural roads using an alternative functional form for traffic volume.

Accid Anal Prev 2021 Jul 8;157:106173. Epub 2021 May 8.

Department of Civil and Environmental Engineering, The Pennsylvania State University, 231 Sackett Building, University Park, PA, 16802, United States. Electronic address:

Statistical models of expected crash frequency are referred to as Safety Performance Functions (SPFs) in the first edition of the American Association of State Highway and Transportation Officials' Highway Safety Manual (HSM). The SPFs in the HSM specify expected annual crash frequencies as a function of various roadway and roadside features, with the most important predictor variable being traffic volume, which serves as a measure of vehicle exposure to crashes. Traffic volumes are typically measured using the average annual daily traffic and are incorporated into the SPFs using a natural logarithm transformation. Read More

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Predicting anionic surfactant toxicity to Daphnia magna in aquatic environment: a green approach for evaluation of EC values.

Environ Sci Pollut Res Int 2021 Sep 10;28(36):50731-50746. Epub 2021 May 10.

Department of Biostatistics and Epidemiology, School of Public Health, Shahid Sadoughi University of Medical Sciences, I. R, Yazd, Iran.

The median effective concentration (EC) is the concentration of a substance expected to produce a specific effect in 50% of the populations with a certain density under defined conditions. This parameter is expressed as an acute toxicity and is obtained via chemical toxicity testing. But, the laboratory work is time-consuming, expensive, and not eco-friendly. Read More

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September 2021

Comparison of Treatments for Cocaine Use Disorder Among Adults: A Systematic Review and Meta-analysis.

JAMA Netw Open 2021 May 3;4(5):e218049. Epub 2021 May 3.

Department of Neurosurgery, Stanford University, Stanford, California.

Importance: In the US and the United Kingdom, cocaine use is the second leading cause of illicit drug overdose death. Psychosocial treatments for cocaine use disorder are limited, and no pharmacotherapy is approved for use in the US or Europe.

Objective: To compare treatments for active cocaine use among adults. Read More

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Direct assessment of the acidity of individual surface hydroxyls.

Nature 2021 Apr 28;592(7856):722-725. Epub 2021 Apr 28.

Institute of Applied Physics, TU Wien, Vienna, Austria.

The state of deprotonation/protonation of surfaces has far-ranging implications in chemistry, from acid-base catalysis and the electrocatalytic and photocatalytic splitting of water, to the behaviour of minerals and biochemistry. An entity's acidity is described by its proton affinity and its acid dissociation constant pK (the negative logarithm of the equilibrium constant of the proton transfer reaction in solution). The acidity of individual sites is difficult to assess for solids, compared with molecules. Read More

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Skewness of local logarithmic exports.

Phys Rev E 2021 Mar;103(3-1):032314

School of Computational Sciences and Center for AI and Natural Sciences, Korea Institute for Advanced Study, Seoul 02455, Korea.

The distributions of trade values and relationships among countries and product categories reflect how countries select their trade partners and design export portfolios. Here we consider the exporter-importer network and the exporter-product network with links weighted by the logarithm of the corresponding export values each year from 1962 to 2018, and study how the weights of the outgoing links from each country are distributed. Such local logarithmic export distributions by destinations and products are found to follow approximately the Gaussian distribution across exporters and time, implying random assignment of export values on a logarithmic scale. Read More

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5-HT receptor- and M muscarinic acetylcholine receptor-mediated activation of Gα in postmortem dorsolateral prefrontal cortex of opiate addicts.

Pharmacol Rep 2021 Aug 9;73(4):1155-1163. Epub 2021 Apr 9.

Laboratory of Neuropharmacology, IUNICS/IdISPa, University of the Balearic Islands (UIB), Palma de Mallorca, Spain.

Background: Chronic exposure to opiates causes the development of tolerance and physical dependence as well as persistent brain neuroplasticity. Despite a wealth of postmortem human studies for opiate addicts, little direct information regarding the functional status of serotonergic and cholinergic receptor-mediated signaling pathways in the human brain of opiate addicts is yet available.

Methods: Functional activation of Gα proteins coupled to 5-HT and M type muscarinic acetylcholine receptor (mAChR) was assessed by using the method named [S]GTPγS binding/immunoprecipitation in frontal cortical membrane preparations from postmortem human brains obtained from opiate addicts and matched controls. Read More

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The COVID-19 Pandemic Has Had Negative Effects on Baseline Clinical Presentation and Outcomes of Patients with Newly Diagnosed Treatment-Naïve Exudative AMD.

J Clin Med 2021 Mar 18;10(6). Epub 2021 Mar 18.

Department of Ophthalmology, University Vita-Salute, IRCCS Ospedale San Raffaele, 20132 Milan, Italy.

Purpose: To investigate whether the coronavirus disease 2019 (COVID-19) pandemic-associated postponement in care had effects on the baseline clinical presentation of patients with newly diagnosed treatment-naïve exudative neovascular age-related macular degeneration (AMD).

Methods: We included the first 50 consecutive patients referred within the COVID-19 pandemic with a diagnosis of treatment-naïve exudative neovascular AMD. Two groups of fifty consecutive patients with newly diagnosed neovascular exudative AMD presenting in 2018 and 2019 (control periods) were also included for comparisons. Read More

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Protein interaction potential landscapes for yeast replicative aging.

Sci Rep 2021 Mar 30;11(1):7143. Epub 2021 Mar 30.

Department of Computer Science and Engineering, The University of Tennessee at Chattanooga, Chattanooga, TN, 37405, USA.

We proposed a novel interaction potential landscape approach to map the systems-level profile changes of gene networks during replicative aging in Saccharomyces cerevisiae. This approach enabled us to apply quasi-potentials, the negative logarithm of the probabilities, to calibrate the elevation of the interaction landscapes with young cells as a reference state. Our approach detected opposite landscape changes based on protein abundances from transcript levels, especially for intra-essential gene interactions. Read More

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Review and meta-analysis of add-on tranylcypromine with antipsychotic drugs for the treatment of schizophrenia with predominant negative symptoms: a restoration of evidence.

Curr Med Res Opin 2021 Jul 20;37(7):1233-1248. Epub 2021 May 20.

Clinic of Psychiatry, Psychotherapy and Psychosomatics, Danuvius Clinics, Pfaffenhofen an der Ilm, Germany.

Background: Treatment using add-on antidepressants with antipsychotic drugs in negative symptoms of schizophrenia has been reviewed recently in comprehensive meta-analyses. Tranylcypromine (TCP), an irreversible monoamine oxidase (MAO)-A/B inhibitor applied in treatment resistant depression, was not included because of strict requirements for quality of study design. To get a clear picture of available evidence for this resource in the treatment of schizophrenia, we conducted a review and meta-analysis of add-on TCP in the treatment of predominant negative symptoms of schizophrenia (negative schizophrenia). Read More

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A comparison of post vaccination hepatitis B surface antibody level on the large and appropriate for gestational age infants.

Clin Exp Vaccine Res 2021 Jan 31;10(1):47-51. Epub 2021 Jan 31.

Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.

Purpose: The aim of this study was to compare the hepatitis B surface antibody (HBs Ab) titer 1 month after the 4th dose of hepatitis B vaccine administration on the large and appropriate for gestational age infants.

Materials And Methods: This cross-sectional study was conducted on 7-month-old cases (n=132) divided into two groups of 2-4 kg (group 1: appropriate for gestational age, 63 cases) and >4 kg (group 2: large for gestational age, 69 cases), whom were vaccinated with a four-dose schedule of hepatitis B vaccine in 2016, Tehran, Iran.

Results: Mean birth weight of the groups was 2. Read More

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January 2021

Predisposing factors, microbiological features and outcomes of patients with clinical presumed concomitant microbial and herpes simplex keratitis.

Eye (Lond) 2021 Feb 19. Epub 2021 Feb 19.

The University of Sydney, Save Sight Institute, Discipline of Ophthalmology, Faculty of Medicine and Health, Sydney, NSW, Australia.

Background/objectives: To describe the predisposing factors, pathogens and outcomes in patients with clinical presumed concomitant microbial and herpes simplex keratitis (HSK) at Sydney Eye Hospital, Australia over a 5-year period.

Subjects/methods: A retrospective case review was conducted. Patients with clinical presumed concomitant microbial and HSK from 2012 to 2016 were identified from pathology and hospital coding databases. Read More

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February 2021

Cardiac ryanodine receptor calcium release deficiency syndrome.

Sci Transl Med 2021 02;13(579)

Department of Cardiology, Aarhus University Hospital, and Department of Clinical Medicine, Health, Aarhus University, Palle Juul-Jensens Blv 99, DK-8200 Aarhus N, Denmark.

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic polymorphic ventricular tachycardia, a condition characterized by prominent ventricular ectopy in response to catecholamine stress, which can be reproduced on exercise stress testing (EST). However, reports of sudden cardiac death (SCD) have emerged in EST-negative individuals who have loss-of-function (LOF) RyR2 mutations. The clinical relevance of RyR2 LOF mutations including their pathogenic mechanism, diagnosis, and treatment are all unknowns. Read More

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February 2021

Concentration Addition, Independent Action, and Quantitative Structure-Activity Relationships for Chemical Mixture Toxicities of the Disinfection By products of Haloacetic Acids on the Green Alga Raphidocelis subcapitata.

Environ Toxicol Chem 2021 May 31;40(5):1431-1442. Epub 2021 Mar 31.

College of Environmental Science and Engineering, Guilin University of Technology, Guilin, China.

The potential toxicity of haloacetic acids (HAAs), common disinfection by products (DBPs), has been widely studied; but their combined effects on freshwater green algae remain poorly understood. The present study was conducted to investigate the toxicological interactions of HAA mixtures in the green alga Raphidocelis subcapitata and predict the DBP mixture toxicities based on concentration addition, independent action, and quantitative structure-activity relationship (QSAR) models. The acute toxicities of 6 HAAs (iodoacetic acid [IAA], bromoacetic acid [BAA], chloroacetic acid [CAA], dichloroacetic acid [DCAA], trichloroacetic acid [TCAA], and tribromoacetic acid [TBAA]) and their 68 binary mixtures to the green algae were analyzed in 96-well microplates. Read More

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Association between county level cannabis dispensary counts and opioid related mortality rates in the United States: panel data study.

BMJ 2021 01 27;372:m4957. Epub 2021 Jan 27.

School of Management, Yale University, 165 Whitney Avenue, New Haven, CT 06520, USA

Objective: To examine county level associations between the prevalence of medical and recreational cannabis stores (referred to as dispensaries) and opioid related mortality rates.

Design: Panel regression methods.

Setting: 812 counties in the United States in the 23 states that allowed legal forms of cannabis dispensaries to operate by the end of 2017. Read More

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January 2021

Affine Transformation of Negative Values for NMR Metabolomics Using the mrbin R Package.

Matthias S Klein

J Proteome Res 2021 02 8;20(2):1397-1404. Epub 2021 Jan 8.

Department of Food Science and Technology, The Ohio State University, 2015 Fyffe Road, Columbus, Ohio 43210, United States.

Data from untargeted metabolomics studies employing nuclear magnetic resonance (NMR) spectroscopy oftentimes contain negative values. These negative values hamper data processing and analysis algorithms and prevent the use of such data in multiomics integration settings. New methods to deal with such negative values are thus an urgent need in the metabolomics community. Read More

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February 2021

[Simulation and uncertainty analysis of natural regeneration for pine-oak forests.]

Ying Yong Sheng Tai Xue Bao 2020 Dec;31(12):4004-4016

College of Forestry, Northwest A&F University, Yangling 712100, Shaanxi, China.

The complexity and uncertainty of forest regeneration is crucial for predicting forest ecosystem dynamics. A natural regeneration model of pine-oak forests in Qinling Mountains was constructed with competition, climate and topography factors using Bayesian statistics and global sensitivity analysis (GSA). The alternative models were based on Poisson, negative binomial (NB), zero-inflated Poisson (ZIP), and zero-inflated negative binomial (ZINB) models. Read More

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December 2020

Prediction of aquatic toxicity of chemical mixtures by the QSAR approach using 2D structural descriptors.

J Hazard Mater 2021 04 22;408:124936. Epub 2020 Dec 22.

Drug Theoretics and Cheminformatics Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. Electronic address:

The rapid industrialization has led to the generation of various organic chemicals and multi-component mixtures which affect the environment adversely. Although organic chemicals are often exposed to the environment as a form of chemical mixtures rather than individual compounds, there is insufficient toxicity data available for the chemical mixtures due to the associated complexities. Most importantly, the nature of toxicity of mixtures is completely different from the individual chemicals, which makes the evaluation more difficult and challenging. Read More

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Relationship between morphological changes in the foveal avascular zone of the epiretinal membrane and postoperative visual function.

BMJ Open Ophthalmol 2020 17;5(1):e000636. Epub 2020 Dec 17.

Division of Ophthalmology and Visual Science, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan.

Objective: To investigate the relationship between the preoperative morphology of the foveal avascular zone (FAZ) and postoperative visual function in patients with idiopathic epiretinal membrane (ERM).

Methods And Analysis: This retrospective study enrolled 36 patients who underwent a unilateral internal limiting membrane peeling with vitrectomy for idiopathic ERM. We measured the area of superficial FAZ in the eyes with ERM and in the contralateral control eyes preoperatively and at 6 months postoperatively using optical coherence tomography (OCT) angiography. Read More

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December 2020

Expected Logarithm and Negative Integer Moments of a Noncentral -Distributed Random Variable.

Stefan M Moser

Entropy (Basel) 2020 Sep 19;22(9). Epub 2020 Sep 19.

Signal and Information Processing Lab, ETH Zürich, 8092 Zürich, Switzerland.

Closed-form expressions for the expected logarithm and for arbitrary negative integer moments of a noncentral χ2-distributed random variable are presented in the cases of both even and odd degrees of freedom. Moreover, some basic properties of these expectations are derived and tight upper and lower bounds on them are proposed. Read More

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September 2020