375 results match your criteria negative gca

Limited utility of novel serological biomarkers in patients newly suspected of having giant cell arteritis.

Int J Rheum Dis 2021 Apr 13. Epub 2021 Apr 13.

Departments of Rheumatology, Nuclear Medicine and Anatomical Pathology, Royal North Shore Hospital, Sydney, NSW, Australia.

Aim: Diagnosing and monitoring vascular activity in giant cell arteritis (GCA) is difficult due to the paucity of specific serological biomarkers. We assessed the utility of 8 novel biomarkers in an inception cohort of newly suspected GCA patients.

Method: Consecutive patients were enrolled between May 2016 and December 2017. Read More

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[An update on giant cell arteritis].

Rev Med Chil 2020 Nov;148(11):1619-1629

Departamento de Radiología, Clínica Las Condes, Santiago, Chile.

Giant cell arteritis (GCA) is a primary granulomatous systemic vasculitis involving the aorta and its main branches that affects people aged over 50 years with a genetic predisposition. Its main phenotypes are cranial and extracranial involvement, with or without symptoms of polymyalgia rheumatica. These phenotypes can overlap. Read More

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November 2020

Vision loss in patients with giant cell arteritis treated with tocilizumab.

Arthritis Res Ther 2021 03 22;23(1):92. Epub 2021 Mar 22.

Department of Rheumatology, Immunology and Allergology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

Objectives: Giant cell arteritis (GCA) may lead to vision loss. To what extent tocilizumab (TCZ) is able to prevent vision loss is unknown. The aim was to analyze the occurrence of vision loss in a large GCA cohort treated with TCZ. Read More

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Correlation of Frontal Atrophy and CSF Tau Levels With Neuropsychiatric Symptoms in Patients With Cognitive Impairment: A Memory Clinic Experience.

Front Aging Neurosci 2021 5;13:595758. Epub 2021 Mar 5.

Unit of Behavioral Neurology, IRCCS Mondino Foundation, Pavia, Italy.

: Behavioral and psychological symptoms of dementia (BPSD) are a distressful condition. We aimed to investigate the BPSD distribution in subjects with cognitive impairment, and the potential correlations between BPSD and neurodegeneration in terms of cerebrospinal fluid (CSF) tau and brain atrophy. : One-hundred patients with mild cognitive impairment (MCI) or dementia (Alzheimer's disease, AD; Lewy-body disease, LBD; frontotemporal dementia, FTD; vascular dementia, VD) underwent a complete diagnostic workup, including 3T-MRI and/or CT and CSF. Read More

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Influence of different types of sterile cytoplasms (A3, A4, 9E) on the combining ability of CMS lines of sorghum.

Vavilovskii Zhurnal Genet Selektsii 2020 Oct;24(6):549-556

Agricultural Research Institute of the South-East Region of Russia, Saratov, Russia.

Investigation of the effect of the cytoplasm on the combining ability (CA) of lines with cytoplasmic male sterility (CMS) is of considerable interest in terms of understanding the genetic functions of the cytoplasm and for practical purposes to create hybrids with improved economically valuable traits. In order to investigate the effect of different types of sterile cytoplasm (A3, A4, 9E) on CA in sorghum, we studied the manifestation of a number of biological and agronomic traits in 54 F1 hybrid combinations obtained using iso-nuclear CMS lines with the nuclear genome of the line Zheltozernoye 10, differing only in the types of sterile cytoplasm (A3, A4 and 9E). Eighteen varieties and lines of grain sorghum developed at the Russian Research and Project-technological Institute of Sorghum and Maize were used as paternal parents. Read More

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October 2020

Associations among temporal and large artery abnormalities on vascular ultrasound in giant cell arteritis.

Scand J Rheumatol 2021 Mar 3:1-9. Epub 2021 Mar 3.

Harvard Medical Faculty, Harvard Medical School, Boston, MA, USA.

: Giant cell arteritis (GCA) can manifest in cranial and/or extracranial arteries. We investigated the distribution of affected arteries on vascular ultrasound (VUS) among patients with new-onset or prior-onset GCA.: We retrospectively studied patients with either new-onset or prior-onset GCA and an abnormal VUS, from 2013 to 2017. Read More

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Discordance Rate Among Bilateral Simultaneous and Sequential Temporal Artery Biopsies in Giant Cell Arteritis: Role of Frozen Sectioning Based on the Mayo Clinic Experience.

JAMA Ophthalmol 2021 Feb 18. Epub 2021 Feb 18.

Department of Neurology, Mayo Clinic College of Medicine & Science, Rochester, Minnesota.

Importance: Frozen section temporal artery biopsy (TAB) may prevent a contralateral biopsy from being performed.

Objective: To evaluate the sensitivity and specificity of TAB frozen vs permanent section pathology results for giant cell arteritis (GCA) and determine the discordance rate of bilateral TABs.

Design, Setting, And Participants: In this retrospective cohort study, medical records were reviewed from 795 patients 40 years or older who underwent TAB from January 1, 2010, to December 1, 2018, treated at a single tertiary care center with the ability to perform both frozen and permanent histologic sections. Read More

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February 2021

Comparison of 18- and 22-MHz probes for the ultrasonographic diagnosis of giant cell arteritis.

J Clin Ultrasound 2021 Feb 10. Epub 2021 Feb 10.

Vascular Medicine Department, Brest Teaching Hospital, Brest University, Brest, France.

Purpose: Little is known about the diagnostic concordance of images provided by ultrasound probes with emitting frequencies below or above 20 MHz for the diagnosis of giant cell arteritis (GCA).

Methods: We compared, using Cohen's kappa statistic, data obtained with an 18-MHz and a 22-MHz probe for the ultrasonographic evaluation of temporal arteries in 80 patients referred for suspected GCA.

Results: The halo sign was found in 25% of cases with the 18-MHz probe and in 35% with the 22-MHz probe. Read More

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February 2021

Evaluation of MR Visual Rating Scales in Major Forms of Dementia.

J Neurosci Rural Pract 2021 Jan 4;12(1):16-23. Epub 2020 Nov 4.

Department of Neurology, Lady Hardinge Medical College, Delhi, India.

 The aim of the study is to visually rate major forms of dementia using global cortical atrophy (GCA), medial temporal lobe atrophy (MTA), and Fazeka's scales and Koedam's score using magnetic resonance imaging (MRI). The purpose is to correlate the visual rating scales (VRS) with severity of dementia.  Thirty patients fulfilling DSM 5 (Diagnostic and Statistical Manual of Mental Disorders) criteria for Alzheimer's dementia (AD), vascular dementia (VaD), and frontotemporal dementia (FTD) underwent MRI brain. Read More

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January 2021

The Adequate Number of Histopathology Cross-sections of Temporal Artery Biopsy in Establishing the Diagnosis of Giant Cell Arteritis.

J Ophthalmic Vis Res 2021 Jan-Mar;16(1):77-83. Epub 2021 Jan 20.

Eye Research Center, The Five Senses Institute, Rassoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Purpose: To determine the appropriate number of histopathological cross-sections that are required for a conclusive diagnosis of giant cell arteritis (GCA).

Methods: In this cross-sectional study, the number of sections per slide for paraffin-embedded blocks for 100 randomly selected cases where GCA was suspected and those for negative temporal artery biopsies (TABs) were compared with the number of cross-sections per specimen for eight positive-TABs. All aforementioned examinations were conducted at our center from 2012 to 2016. Read More

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January 2021

Peripheral retinal arteriolar leakage in giant cell arteritis: a case report.

J Ophthalmic Inflamm Infect 2021 Jan 29;11(1). Epub 2021 Jan 29.

Division of Neuro-Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD, 21287, USA.

A 76-year old African American female with a history of arteritic ischemic optic neuropathy (AION) secondary to biopsy-proven giant cell arteritis (GCA) presented with unilateral vision loss in her contralateral eye despite high-dose oral steroid treatment. Dilated fundus examination revealed three cotton wool spots. Fluorescein angiography showed slowed arteriolar filling with late staining of small peripheral arteries, consistent with small vessel arteritis. Read More

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January 2021

First Report of Pectobacterium polaris Causing Soft Rot and Black Leg of Potato in Russia.

Plant Dis 2021 Jan 26. Epub 2021 Jan 26.

Рeoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation;

Blackleg and soft rot of potato (Solanum tuberosum) were monitored in the Central European part of Russia within a period of 2012- 2019. Symptoms included decay of tubers, blackening of stem vascular bundles, and partial yellowing of leaves. The disease causes serious potato yield losses in the field and storage. Read More

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January 2021

Comparative mitogenome analyses uncover mitogenome features and phylogenetic implications of the subfamily Cobitinae.

BMC Genomics 2021 Jan 14;22(1):50. Epub 2021 Jan 14.

State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, the Innovation Academy of Seed Design, Chinese Academy of Sciences, Wuhan, 430072, China.

Background: Loaches of Cobitinae, widely distributed in Eurasian continent, have high economic, ornamental and scientific value. However, the phylogeny of Cobitinae fishes within genera or family level remains complex and controversial. Up to now, about 60 Cobitinae mitogenomes had been deposited in GenBank, but their integrated characteristics were not elaborated. Read More

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January 2021

High-resolution MRI demonstrates signal abnormalities of the 3rd cranial nerve in giant cell arteritis patients with 3rd cranial nerve impairment.

Eur Radiol 2021 Jan 13. Epub 2021 Jan 13.

Department of Neuroradiology, Foundation Adolphe de Rothschild Hospital, 29 rue Manin, 75019, Paris, France.

Objective: To determine the sensitivity and specificity of high-resolution (HR) MRI for detecting signal abnormalities of cranial nerves (CN) in giant cell arteritis (GCA) patients presenting with diplopia.

Methods: This IRB-approved retrospective single-center study included GCA patients who underwent 3-T HR MRI from December 2014 to January 2020. Two radiologists, blinded to all data, individually assessed for the presence of enhancement of the 3rd, 4th, and/or 6th CN on post-contrast HR imaging and high signal intensity on HR T2-WI, for signal abnormalities of extraocular muscles and the brainstem, and for inflammatory changes of the ophthalmic and extracranial arteries. Read More

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January 2021

The U.S. Veterans Health Administration national giant cell arteritis (GCA) database cohort: incident ophthalmic complications in biopsy-negative GCA patients.

Clin Rheumatol 2021 Jan 8. Epub 2021 Jan 8.

Division of Rheumatology, University of Washington, Seattle, WA, USA.

Introduction/objectives: This study aimed to identify the incidence of ophthalmic complications of giant cell arteritis (GCA) among subjects with negative temporal artery biopsy (TAB) and to determine if duration of prednisone exposure relative to GCA diagnosis was associated with ophthalmic complications in TAB-negative subjects.

Method: The U.S. Read More

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January 2021

Ultrasonographic Halo Score in giant cell arteritis: association with intimal hyperplasia and ischaemic sight loss.

Rheumatology (Oxford) 2020 Dec 23. Epub 2020 Dec 23.

Department of Rheumatology.

Objectives: We investigated the relationship between the ultrasonographic Halo Score and temporal artery biopsy (TAB) findings in GCA.

Methods: This is a prospective study including 90 patients suspected of having GCA. Ultrasonography of temporal/axillary arteries and a TAB were obtained in all patients at baseline. Read More

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December 2020

Prevalence of Newly Diagnosed Malignancies in Patients with Polymyalgia Rheumatica and Giant Cell Arteritis, Comparison of 18F-FDG PET/CT Scan with Chest X-ray and Abdominal Ultrasound: Data from a 40 Week Prospective, Exploratory, Single Centre Study.

J Clin Med 2020 Dec 4;9(12). Epub 2020 Dec 4.

Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, 5000 Odense, Denmark.

The aim of the study was to identify the prevalence of newly diagnosed malignancies in patients with polymyalgia rheumatica (PMR) and giant cell arteritis (GCA), with the aid of 18F-FDG PET/CT scan compared to conventional imaging techniques: Chest X-ray (CXR) and abdominal ultrasound (US). Secondarily, to examine the relative diagnostic accuracy of these two imaging modalities for the detection of cancer. Eighty consecutive patients with newly diagnosed PMR, GCA, or concomitant PMR and GCA, were included and followed up for 40 weeks. Read More

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December 2020

Prevalence and potentially prognostic value of C-circles associated with alternative lengthening of telomeres in canine appendicular osteosarcoma.

Vet Comp Oncol 2020 Nov 19. Epub 2020 Nov 19.

Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria.

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere maintenance mechanism (TMM) with high prevalence in human osteosarcomas but remains unknown in canine osteosarcomas. The aim of this study was to evaluate the prevalence of ALT by detection of extra-chromosomal circles of telomeric DNA and to assess clinical outcome in canine patients with spontaneous occurring appendicular osteosarcoma. Fifty dogs with histopathological confirmed osteosarcomas were included into this study. Read More

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November 2020

Assessing the Role of Gay Community Attachment, Stigma, and PrEP Stereotypes on Young Men Who Have Sex with Men's PrEP Uptake.

AIDS Behav 2020 Nov 19. Epub 2020 Nov 19.

Department of Family and Community Health, University of Pennsylvania School of Nursing, 418 Curie Boulevard 243L, Philadelphia, PA, 19104, USA.

Negative stereotypes about pre-exposure prophylaxis (PrEP) hinder PrEP uptake among young men who have sex with men (YMSM). Prior research suggests community homophobia may be linked to negative PrEP attitudes. Conversely, individuals with high gay community attachments (GCA) may have more access to credible PrEP information/resources. Read More

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November 2020

Temporal artery biopsy for suspected giant cell arteritis: a retrospective analysis.

Rheumatol Int 2020 Nov 6. Epub 2020 Nov 6.

Division of Rheumatology, Department of Internal Medicine, Eskişehir Osmangazi University, Eskişehir, 26480, Turkey.

Temporal artery biopsy (TAB) is one of the diagnostic criteria of giant cell arteritis (GCA) according to 1990 ACR criteria and remains a tool for diagnosis. Although clinicians perform TAB with an intent to confirm suspected GCA, some biopsies result in negative and some lead to non-GCA diagnoses. We aim to review the diagnoses after TAB biopsy performed for suspected GCA and also wanted to evaluate the diagnostic changes and concomitant diseases that develop over time. Read More

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November 2020

Standalone performance of artificial intelligence for upper GI neoplasia: a meta-analysis.

Gut 2020 Oct 30. Epub 2020 Oct 30.

CIDES/CINTESIS, Faculty of Medicine, University of Porto, Porto, Portugal

Objective: Artificial intelligence (AI) may reduce underdiagnosed or overlooked upper GI (UGI) neoplastic and preneoplastic conditions, due to subtle appearance and low disease prevalence. Only disease-specific AI performances have been reported, generating uncertainty on its clinical value.

Design: We searched PubMed, Embase and Scopus until July 2020, for studies on the diagnostic performance of AI in detection and characterisation of UGI lesions. Read More

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October 2020

Interval-valued intuitionistic fuzzy MADM method based on TOPSIS and grey correlation analysis.

Math Biosci Eng 2020 08;17(5):5584-5603

National Key Laboratory of Science and Technology on ATR, College of Electronic Science, National University of Defence Technology, Changsha 410000, China.

In this paper, we propose an interval-valued intuitionistic fuzzy Multi-Attribute Decision Making (MADM) method based on improved TOPSIS and Grey Correlation Analysis (GCA), in which the attribute values are interval-valued intuitionistic fuzzy numbers. So that we can deal with imprecise information in fuzzy and rough form in MADM problems by using interval-valued intuitionistic fuzzy numbers Firstly, the concept of interval intuitionistic fuzzy entropy is introduced to calculate the entropy weight of attributes. And the combined weight is calculated by combining the entropy weight with the subjective weight. Read More

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[Buschke-Lowenstein tumor of the penis].

Pan Afr Med J 2020 5;37:19. Epub 2020 Sep 5.

Service d'Urologie-A, Centre Hospitalo-Universitaire Ibn Sina, Faculté de Médecine et de Pharmacie, Université Mohammed V, 10000, Rabat, Maroc.

Buschke-Lowenstein (BLT) tumor or giant condyloma acuminatum (GCA) is a rare viral disease belonging to the group of verrucous carcinomas; the virus responsible is human papilloma virus (HPV) type 6 and 11 which is transmitted in humans by sexual contact. It is characterized by its extension within the surface layer and at depth, by its degenerative potential and by its recurrent nature after treatment. Therapy is based on surgery. Read More

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January 2021

Herpes Simplex Virus Entry by a Nonconventional Endocytic Pathway.

J Virol 2020 11 23;94(24). Epub 2020 Nov 23.

Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington, USA

Herpes simplex virus 1 (HSV-1) causes significant morbidity and mortality in humans worldwide. HSV-1 enters epithelial cells via an endocytosis mechanism that is low-pH dependent. However, the precise intracellular pathway has not been identified, including the compartment where fusion occurs. Read More

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November 2020

sp. nov. and sp. nov., Isolated from the Discovery Deep Brine-Seawater Interface in the Red Sea.

Microorganisms 2020 Sep 25;8(10). Epub 2020 Sep 25.

Red Sea Research Center, King Abdullah University of Science and Technology, Thuwal Jeddah 23955-6900, Saudi Arabia.

Two extremely halophilic archaeal strains, designated SB29 and SB3, were isolated from the brine-seawater interface of Discovery Deep in the Red Sea. Cells of both strains were pleomorphic (irregular polyhedrals, ovals, and rods) and stained Gram-negative; colonies were pigmented pink. The sequence similarity of the 16S rRNA gene of strain SB29 with that of its most closely related validly described species ( DSM 16227) and that of strain SB3 with its closest validly described relative ( ATCC 35960) was 98. Read More

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September 2020

Significance of inflammation restricted to adventitial/periadventitial tissue on temporal artery biopsy.

Semin Arthritis Rheum 2020 10 17;50(5):1064-1072. Epub 2020 Jun 17.

University of Modena and Reggio Emilia, Modena, Italy; Rheumatology Unit, Department of Specialistic Medicine, Azienda USL-IRCCS di Reggio Emilia, Italy. Electronic address:

Objective: To evaluate the characteristics and significance of inflammation restricted (RI) to the adventitial and/or periadventitial tissue on temporal artery biopsy (TAB).

Methods: We studied a retrospective cohort of 80 patients with RI, extending our earlier series of 39 patients. For comparison purposes, we collected the same data from 254 patients with transmural inflammation (TMI) and 81 TAB-negative patients. Read More

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October 2020

Giant cell arteritis and its mimics: A comparison of three patient cohorts.

Semin Arthritis Rheum 2020 10 17;50(5):923-929. Epub 2020 Jun 17.

Department of Internal Medicine, Division of Rheumatology, Mayo Clinic Alix School of Medicine, Rochester, MN, USA.

Objective: To compare temporal artery biopsy (TAB)-positive giant cell arteritis (GCA) to TAB-negative GCA and patients with GCA mimics METHODS: PATIENTS DIAGNOSED WITH TAB-POSITIVE AND TAB-NEGATIVE GCA BETWEEN 1/1/1998 AND 12/31/2013 WERE: retrospectively identified. These two groups were compared to a cohort of patients with TAB performed between 1/1/2009 and 12/31/2010 in which the TAB was negative and alternative diagnosis was provided after a minimum of 6-months of follow-up. Baseline characteristics were compared between groups using chi-square and rank sum tests. Read More

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October 2020

Temporal Artery Biopsy in the Workup of Giant Cell Arteritis: Diagnostic Considerations in a Veterans Administration Cohort.

J Neuroophthalmol 2020 12;40(4):450-456

School of Medicine (LDS), Oregon Health & Science University, Portland, Oregon; Department of Biostatistics (BAMP-E), Oregon Health & Science University-Portland State University School of Public Health, Portland, Oregon; Division of Neuro-Ophthalmology (KMW), Casey Eye Institute, Oregon Health & Science University, Portland, Oregon; Department of Ophthalmology (KMW), VA Portland Health Care System, Portland, Oregon; and Department of Neurology (KMW), Oregon Health & Science University, Portland, Oregon.

Background: Giant cell arteritis (GCA) is the most common systemic vasculitis in the American population older than 50 years and is a sight-threatening and life-threatening disease. It is definitively diagnosed with a temporal artery biopsy. Although there are many studies focusing on the clinical presentation and laboratory values in diagnosing GCA in the general population, studies focusing on the veteran population are lacking. Read More

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December 2020

Full-field optical coherence tomography for the diagnosis of giant cell arteritis.

PLoS One 2020 31;15(8):e0234165. Epub 2020 Aug 31.

Department of Internal Medicine and Clinical Immunology, François Mitterrand Hospital, Dijon University Hospital, Dijon, Bourgogne-Franche-Comté, France.

Histopathological examination of temporal artery biopsy (TAB) remains the gold standard for the diagnosis of giant cell arteritis (GCA) but is associated with essential limitations that emphasize the need for an upgraded pathological process. This study pioneered the use of full-field optical coherence tomography (FF-OCT) for rapid and automated on-site pathological diagnosis of GCA. Sixteen TABs (12 negative and 4 positive for GCA) were selected according to major histopathological criteria of GCA following hematoxylin-eosin-saffron-staining for subsequent acquisition with FF-OCT to compare structural modifications of the artery cell wall and thickness of each tunica. Read More

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October 2020

Reporting frequency of radiology findings increases after introducing visual rating scales in the primary care diagnostic work up of subjective and mild cognitive impairment.

Eur Radiol 2021 Feb 26;31(2):666-673. Epub 2020 Aug 26.

Department of Imaging and Function, Skånes University Hospital, Lund, Sweden.

Objectives: Study the effect of introducing a template for radiological reporting of non-enhanced computed tomography (NECT) in the primary care diagnostic work up of cognitive impairment using visual rating scales (VRS).

Methods: Radiology reports were assessed regarding compliance with a contextual report template and the reporting of the parameters medial temporal lobe atrophy (MTA), white matter changes (WMC), global cortical atrophy (GCA), and width of lateral ventricles (WLV) using established VRS in two age-matched groups examined with NECT before (n = 111) and after (n = 125) the introduction of contextual reporting at our department. True positive rate (TPR) and true negative rate (TNR) before and after were compared. Read More

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February 2021