22 results match your criteria neem clear

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Clinical interventions for tungiasis (sand flea disease): a systematic review.

Lancet Infect Dis 2021 Jul 5. Epub 2021 Jul 5.

Faculty of Health, University of Canberra, Bruce, Canberra, ACT, Australia. Electronic address:

Tungiasis (sand flea disease) is an epidermal parasitic skin disease occurring in resource-limited communities. There is no standard treatment for tungiasis, and available treatment options are scarce. To our knowledge, this is the first systematic review aimed to assess randomised controlled trials (RCTs) investigating interventions for tungiasis. Read More

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The anti-cancer properties of neem () through its antioxidant activity in the liver; its pharmaceutics and toxic dosage forms; a literature review.

J Complement Integr Med 2021 May 10. Epub 2021 May 10.

Department of Physiology and Medical Physics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Objectives: The neem () have been used in herbal medicine for the treatment of multiple diseases, particularly cancer. The mechanism of anti-cancer properties of neem are far from clear. However, it is well accepted that anti-cancer effects of neem is mediated via its hepatic anti-oxidant activity. Read More

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Larvicidal Action of Cannabidiol Oil and Neem Oil against Three Stored Product Insect Pests: Effect on Survival Time and in Progeny.

Biology (Basel) 2020 Oct 1;9(10). Epub 2020 Oct 1.

Department of Pharmacy, University of Patras, 26504 Patras, Greece.

SStored product pests can be detrimental to agricultural produce. As much as chemical pesticides are effective control agents, they involve several environmental and health risks. Within the framework of studies on alternative pest management methods, interest has focused on a plethora of plants whose extracts have demonstrated promising action as insecticides. Read More

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October 2020

The Efficacy of Alternative, Environmentally Friendly Plant Protection Measures for Control of Fall Armyworm, , in Maize.

Insects 2020 Apr 10;11(4). Epub 2020 Apr 10.

CABI Europe-Switzerland, Rue des Grillons 1, CH-2800 Delémont, Switzerland.

The invasive fall armyworm (FAW) is threatening maize production and the livelihoods of millions of smallholder farmers in the newly invaded areas in Africa and Asia. To control this new key pest and to overcome health, environmental, and resistance problems related to the indiscriminate use of insecticides, effective and sustainable alternative pest control approaches are needed. Here, we report on field trials that tested maltodextrin, neem-based products, ash, and soil, as well as the locally produced alata samina soap, in the Upper West and Greater Accra regions, Ghana. Read More

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Toxicological screening and DNA sequencing detects contamination and adulteration in regulated herbal medicines and supplements for diet, weight loss and cardiovascular health.

J Pharm Biomed Anal 2019 Nov 23;176:112834. Epub 2019 Aug 23.

Medical, Molecular and Forensic Sciences, Murdoch University, South St, Murdoch, WA, 6150, Australia; Separation Science and Metabolomics Laboratory and the Advanced Mass Spectrometry Facility, Murdoch University, 90 South St, Murdoch, WA, 6150, Australia. Electronic address:

Use of herbal medicines and supplements by consumers to prevent or treat disease, particularly chronic conditions continues to grow, leading to increased awareness of the minimal regulation standards in many countries. Fraudulent, adulterated and contaminated herbal and traditional medicines and dietary supplements are a risk to consumer health, with adverse effects and events including overdose, drug-herb interactions and hospitalisation. The scope of the risk has been difficult to determine, prompting calls for new approaches, such as the combination of DNA metabarcoding and mass spectrometry used in this study. Read More

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November 2019

Branding Practices on Four Dairies in Kantale, Sri Lanka.

Animals (Basel) 2018 Aug 7;8(8). Epub 2018 Aug 7.

Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine and Animal Science, University of Peradeniya, Peradeniya 20400, Sri Lanka.

Hot-iron branding is illegal in Sri Lanka, but is still commonly used to identify dairy herds in extensive farming systems, which are primarily located in the country's Dry Zone. Despite the negative welfare implications of this practice, there is no written documentation of branding in this region. We observed branding on four smallholder farms in Kantale, Eastern Province to understand the welfare implications associated with the procedure and challenges limiting the uptake of more welfare-friendly alternatives, such as ear tagging. Read More

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Azadirachtin impact on mate choice, female sexual receptivity and male activity in Drosophila melanogaster (Diptera: Drosophilidae).

Pestic Biochem Physiol 2017 Nov 5;143:95-101. Epub 2017 Sep 5.

Laboratoire Evolution, Génomes, Comportement, Ecologie, UMR 9191, CNRS, IRD, Université Paris-Sud et Université Paris-Saclay, Avenue de la Terrasse, F- 91198 Gif-sur-Yvette, France.

Azadirachtin, a neem compound (Azadirachta indica) with medical and anti-insect properties, is one the most successful botanical pesticides in agricultural use. However, its controversial impact on non-targeted species and its mechanism of action need to be clarified. In addition, Azadirachtin impact on pre- and post-mating traits remains largely undocumented. Read More

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November 2017

Preimaginal exposure to azadirachtin affects food selection and digestive enzymes in adults of Drosophila melanogaster (Diptera: Drosophilidae).

Pestic Biochem Physiol 2017 Aug 3;140:58-64. Epub 2017 Jun 3.

Laboratory of Applied Animal Biology, Department of Biology, Faculty of Sciences, Badji Mokhtar University of Annaba, 23000 Annaba, Algeria.

Among the plant derived product, azadirachtin, a neem-based insecticide, is exceptional in having a broad range of bioactivity including toxicity, growth, development and reproduction effects, repellency and antifeedancy. If considerable progress on the physiological and biological activities and agricultural application of azadirachtin has been achieved, its exact mechanism of action remains uncertain. In this study, we aimed at assessing the lethal and sublethal behavioral and physiological effects of azadirachtin on Drosophila melanogaster Meigen, 1830 (Diptera: Drosophilidae) as biological model. Read More

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Canadian Arctic sea ice reconstructed from bromine in the Greenland NEEM ice core.

Sci Rep 2016 09 21;6:33925. Epub 2016 Sep 21.

Centre for Ice and Climate, Niels Bohr Institute, University of Copenhagen, Juliane Maries Vej 30, Copenhagen Ø 2100 Denmark.

Reconstructing the past variability of Arctic sea ice provides an essential context for recent multi-year sea ice decline, although few quantitative reconstructions cover the Holocene period prior to the earliest historical records 1,200 years ago. Photochemical recycling of bromine is observed over first-year, or seasonal, sea ice in so-called "bromine explosions" and we employ a 1-D chemistry transport model to quantify processes of bromine enrichment over first-year sea ice and depositional transport over multi-year sea ice and land ice. We report bromine enrichment in the Northwest Greenland Eemian NEEM ice core since the end of the Eemian interglacial 120,000 years ago, finding the maximum extension of first-year sea ice occurred approximately 9,000 years ago during the Holocene climate optimum, when Greenland temperatures were 2 to 3 °C above present values. Read More

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September 2016

Damage Patterns, Monitoring, and Management of Procontarinia mangiferae (Diptera: Cecidomyiidae) in Pakistan.

J Econ Entomol 2016 Dec;109(6):2446-2453

Montana State University, Western Triangle Ag Research Center, P. O. Box 656, Conrad, Montana, 59425

Since 2005, mango has been damaged by a group of new pests, the gall midges, in all mango-growing areas of Pakistan. Little is known about these pests in Pakistan. In this report, we present information on the occurrence, damage patterns, methods for monitoring, and management of Procontarinia mangiferae (Felt), a mango gall midge found in the country. Read More

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December 2016

Morphological alterations in salivary glands of Rhipicephalus sanguineus ticks (Acari: Ixodidae) exposed to neem seed oil with known azadirachtin concentration.

Micron 2016 Apr 19;83:19-31. Epub 2016 Jan 19.

UNESP, Avenida 24 A, 1515, 13506-900 Rio Claro, SP, Brazil. Electronic address:

Neem (Azadirachta indica) has attracted the attention of researchers worldwide due to its repellent properties and recognized effects on the morphology and physiology of arthropods, including ticks. Therefore, this study aimed to demonstrate the effects of neem seed oil enriched with azadirachtin on salivary glands of Rhipicephalus sanguineus ticks, targets of great veterinary interest because of their ability to transmit pathogens to dogs. For this, R. Read More

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A COMPREHENSIVE STUDY ON APOPTOSIS INDUCTION BY AZADIRACHTIN IN Spodoptera frugiperda CULTURED CELL LINE Sf9.

Arch Insect Biochem Physiol 2015 Jul 1;89(3):153-68. Epub 2015 Apr 1.

Laboratory of Insect Toxicology, Key Laboratory of Natural Pesticide and Chemical Biology, Ministry of Education, South China Agricultural University, Guangzhou, People's Republic of China.

The induction of apoptosis by azadirachtin, a well-known botanical tetranortriterpenoid isolated from the neem tree (Azadirachta indica A. Juss) and other members of the Meliaceae, was investigated in Spodoptera frugiperda cultured cell line (Sf9). Morphological changes in Sf9 cells treated by various concentrations of azadirachtin were observed at different times under light microscopy. Read More

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Morphological effects of neem (Azadirachta indica A. Juss) seed oil with known azadirachtin concentrations on the oocytes of semi-engorged Rhipicephalus sanguineus ticks (Acari: Ixodidae).

Parasitol Res 2015 Feb 28;114(2):431-44. Epub 2014 Oct 28.

Departamento de Biologia, Universidade Estadual Paulista "Júlio de Mesquita Filho", Av. 24-A, 1515, Bela Vista, POBOX 199, 13.506-900, Rio Claro, São Paulo, Brazil.

The concern about the harmful effects caused by synthetic pesticides has led to the search for safe and ecological alternatives for pest control. In this context, the neem tree (Azadirachta indica) stands out due to its repellent properties and effects on various arthropods, including ticks. For this reason, this study aimed to demonstrate the potential of neem as a control method for Rhipicephalus sanguineus ticks, important vectors of diseases in the veterinary point of view. Read More

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February 2015

Novel-porous-Ag0 nanocomposite hydrogels via green process for advanced antibacterial applications.

J Biomed Mater Res A 2014 Dec 2;102(12):4616-24. Epub 2014 Apr 2.

Composites Research Group, Department of Mechanical Engineering, Durban University of Technology, Durban, South Africa.

Silver nanoparticles (NPs) antibacterial characteristics were depends on its particle stabilization, particles size and nucleation agent. In this study, we report on green process of porous silver nanocomposite hydrogels for advanced antibacterial applications. The porous poly(acrylamide) (PAM) hydrogels were developed employing sucrose as porogenator. Read More

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December 2014

To evaluate the antigingivitis and antipalque effect of an Azadirachta indica (neem) mouthrinse on plaque induced gingivitis: A double-blind, randomized, controlled trial.

J Indian Soc Periodontol 2011 Oct;15(4):398-401

Department of Periodontics, Institute of Dental Sciences, Bareilly, Uttar Pradesh, India.

Background: Azadirachta indica (neem), a Meliaceae family tree, has been used in India for several decades for the treatment of several diseases in medicine and dentistry. Neem has been considered to have antiseptic activity, but still its use for the treatment of gingivitis and periodontitis is not very clear. Hence, the purpose of the present study was to assess the efficacy of neem based mouth rinse regarding its antigingivitis effect. Read More

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October 2011

Neem leaf glycoprotein inhibits CD4+CD25+Foxp3+ Tregs to restrict murine tumor growth.

Immunotherapy 2011 Aug;3(8):949-69

Department of Immunoregulation & Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37 SP Mukherjee Road, Kolkata 700026, India.

Background: The presence of Tregs in tumors is associated with compromised tumor-specific immune responses and has a clear negative impact on survival of cancer patients. Thus, downregulation of Tregs is considered as a promising cancer immunotherapeutic approach. We have reported previously that neem leaf glycoprotein (NLGP) prophylaxis restricts tumor growth in mice by immune activation. Read More

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Light and scanning electron microscopic investigations on MiteStop-treated poultry red mites.

Parasitol Res 2010 Jul 20;107(2):433-7. Epub 2010 Jun 20.

Department of Parasitology, Heinrich Heine University, 40225, Düsseldorf, Germany.

Recent studies of the neem seed product MiteStop showed that it has a good acaricidal effect against all developmental stages of the poultry red mite, Dermanyssus gallinae. In vitro tests proved an efficacy at direct contact, as well as by fumigant toxicity. Light and scanning electron microscopic (SEM) investigations showed no clear, morphologically visible signs of an effect caused by fumigant toxicity. Read More

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In vitro efficacy of ByeMite and Mite-Stop on developmental stages of the red chicken mite Dermanyssus gallinae.

Parasitol Res 2009 Oct 13;105(5):1469-71. Epub 2009 Aug 13.

Zoology Department, Faculty of Science, Cairo University, Giza, Egypt.

The present in vitro study shows the efficacy of two antimite products (ByeMite = phoxim, Mite-Stop = neem seed extract) against all developing stages of the important red chicken mite Dermanyssus gallinae (obtained at two farms in France and Germany). While permanent contact with the active compound led to an efficacy of 100% in the case of Mite-Stop on mites in both farms, there was only a 96.2% killing effect of ByeMite on the mites of the French farm. Read More

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October 2009

Neem seed extract shampoo, Wash Away Louse, an effective plant agent against Sarcoptes scabiei mites infesting dogs in Egypt.

Parasitol Res 2008 Dec 4;104(1):145-8. Epub 2008 Sep 4.

Zoology Department, Cairo University, Cairo, Egypt.

In the present study, the efficacy of water-free neem seed extract shampoo Wash Away Louse, provided by Alpha-Biocare GmbH, Düsseldorf (Germany), was investigated against Sarcoptes scabiei infesting dogs in Egypt. Ten naturally infested dogs were collected from different areas in the Nile delta. The occurrence of lesions, hair loss, and skin inflammation were regarded as signs of infestation and proved by detection of adult parasites and their developmental stages in scrapings of infested lesions. Read More

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December 2008

Effect of neem limonoids on lactate dehydrogenase (LDH) of the rice leaffolder, Cnaphalocrocis medinalis (Guenée) (Insecta: Lepidoptera: Pyralidae).

Chemosphere 2006 Mar 12;62(8):1388-93. Epub 2005 Sep 12.

Department of Environmental Engineering, Chonbuk National University, 664-14 1ga Duckjin-Dong Duckjin, Jeonju City, Chola buktho, Chonbuk 561 756, Republic of Korea.

Neem is derived from the neem tree Azadirachta indica A. Juss. (Meliaceae), and its primary insecticidal component is the tetranortriterpenoid azadirachtin and other limonoids. Read More

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Cytotoxicity of azadirachtin A in human glioblastoma cell lines.

Life Sci 2001 Jan;68(10):1153-60

Department of Radiation Oncology, Faculty of Medicine, University of Stellenbosch, Tygerberg, South Africa.

The neem toxin azadirachtin A exhibits selective toxicity on insects. Despite its well-proven efficacy, the mode of action of this toxin remains obscure. The toxicity on vertebrate cells compared to insect cells is also not well characterized. Read More

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January 2001

Plant immunomodulators for termination of unwanted pregnancy and for contraception and reproductive health.

Immunol Cell Biol 1997 Apr;75(2):190-2

Reproductive Health and Vaccinology Division, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.

Neem (Azadirachta indica) seed and leaf extracts have spermicidal, anti-microbial, anti-fungal and anti-viral properties. They are also immunomodulators that induce primarily a TH1 type response. These properties are being exploited to develop two different useful methods of fertility control. Read More

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