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Acute and early life-stage toxicity of atrazine in sheepshead minnow (Cyprinodon variegatus).

Ecotoxicol Environ Saf 2021 May 8;218:112303. Epub 2021 May 8.

Department of Environment and Geography, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Given the limited data available for estuarine/marine fish species and potential risk of being exposed to the herbicide atrazine, additional toxicity data regarding sensitive life-stages are needed. As such, this work sought to characterize: 1) the acute larval toxicity, and 2) early life-stage toxicity of technical atrazine in the model marine species sheepshead minnow (Cyprinodon variegatus). Atrazine was observed to be slightly to moderately toxic towards C. Read More

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Mothers' voices and white noise on premature infants' physiological reactions in a neonatal intensive care unit: A multi-arm randomized controlled trial.

Int J Nurs Stud 2021 Mar 26;119:103934. Epub 2021 Mar 26.

Associate Professor, Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore. Electronic address:

Background: A few positive effects of mothers' voice on physiological outcomes have been studied and limited studies have focused on the level of cortisol. In addition, white noise has recently been found to be beneficial for human sleep, but studies in premature infants were limited and no study has compared the effects of mothers' voice and white noise on premature infants.

Objective: To examine the effects of mothers' voice and white noise on sleep-wake patterns, salivary cortisol levels, weight gain, heart rate, and oxygen saturation of premature infants in a neonatal intensive care unit (NICU). Read More

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Return to work after medial unicompartmental knee arthroplasty: A systematic review.

Knee 2021 May 7;30:254-266. Epub 2021 May 7.

Department of Orthopaedic Surgery, Tan Tock Seng Hospital, Singapore.

Introduction: This study aims to evaluate the current literature with regard to the average time to and overall rate of return to work (RTW) following medial unicompartmental knee arthroplasty (UKA).

Methods: A systematic search was conducted on MEDLINE (Ovid), Embase, Pubmed, CINAHL, Web of Science, Scopus, and the Cochrane Library to identify studies reporting RTW after UKA. Primary outcomes were the rate and time to RTW after UKA. Read More

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Vestibular Function in Older Adults With Cognitive Impairment: A Systematic Review.

Ear Hear 2021 Apr 22. Epub 2021 Apr 22.

1Department of Translational Neurosciences, University of Antwerp, Antwerp, Belgium 2Department of Otorhinolaryngology-Head and neck surgery, Antwerp University Hospital, Edegem, Belgium 3Department of Education, Health & Social Work, University College Ghent, Ghent, Belgium 4Department of Neurology, UZ Brussel and Center for Neurosciences (C4N), VUB, Brussels, Belgium 5Department of Biomedical Sciences and Institute Born-Bunge, University of Antwerp, Antwerp, Belgium 6Department of Neurology, Antwerp University Hospital, Edegem, Belgium.

Importance: Given the rising prevalence of patients with dementia and those at risk for it, early identification is prioritized. As vestibular dysfunction is associated with Alzheimer's disease (AD) and may contribute to its onset, vestibular assessment may yield an opportunity in early dementia screening.

Objective: This systematic review structures and compares the different raw outcome measures used to assess vestibular function while comparing older adults with preserved cognition to individuals with cognitive impairment, either suffering from mild cognitive impairment (MCI) or AD. Read More

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Patient and public involvement in care home research: Reflections on the how and why of involving patient and public involvement partners in qualitative data analysis and interpretation.

Health Expect 2021 May 11. Epub 2021 May 11.

Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.

Background: There is limited evidence for the impact of involving patients and the public (PPI) in health research. Descriptions of the PPI process are seldom included in publications, particularly data analysis, yet an understanding of processes and impacts of PPI is essential if its contribution to research is to be evaluated.

Objective: To describe the 'how' of PPI in qualitative data analysis and critically reflect on potential impact. Read More

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Vegetative traits can predict flowering quality in Phalaenopsis orchids despite large genotypic variation in response to light and temperature.

PLoS One 2021 11;16(5):e0251405. Epub 2021 May 11.

Horticulture and Product Physiology, Department of Plant Sciences, Wageningen University & Research, Wageningen, The Netherlands.

Phalaenopsis is an economically important horticultural ornamental, but its growth is slow and costly. The vegetative cultivation phase is long and required to ensure sufficient plant size. This is needed to develop high quality flowering plants. Read More

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NIS in non-thyroidal tissues and impact on thyroid cancer therapy.

Endocr Relat Cancer 2021 May 1. Epub 2021 May 1.

J Sipos, Endocrinology, The Ohio State University, Columbus, 43210, United States.

Radioiodine (131I) has been used to ablate thyroid tissue not removed by surgery or to treat differentiated thyroid cancer that has metastasized to other parts of the body for the past 80 years. However, the Na+/I- symporter (NIS), which mediates active iodide uptake into thyroid follicular cells, is also expressed in several non-thyroidal tissues. This NIS expression permits 131I accumulation and radiation damage in these non-target tissues, which accounts for the adverse effects of radioiodine therapy. Read More

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How a Medication for Opioid Use Disorder Curriculum Translates into Experiences and Internal Medicine Residents' Understanding of Patients with Opioid Use Disorder.

Teach Learn Med 2021 May 11:1-8. Epub 2021 May 11.

VA HSRD Center for Health Information and Communication, Roudebush VAMC, Roudebush, Indiana, USA.

Problem: The number of people with an Opioid Use Disorder (OUD) continues to outpace access to associated medication. Ninety-six percent of states report higher rates of OUD than access to medications, and, despite being the standard of care, only 3% of physicians currently prescribe medication for opioid use disorder (MOUD). Prior studies have shown that decreasing barriers, such as a lack of knowledge about MOUD, increased physicians' willingness to prescribe. Read More

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Effect of an Internet-Delivered Stepped-Care Program vs In-Person Cognitive Behavioral Therapy on Obsessive-Compulsive Disorder Symptoms in Children and Adolescents: A Randomized Clinical Trial.

JAMA 2021 May;325(18):1863-1873

Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Solna, Sweden.

Importance: In most countries, young people with obsessive-compulsive disorder have limited access to specialist cognitive behavioral therapy (CBT), a first-line treatment.

Objective: To investigate whether internet-delivered CBT implemented in a stepped-care model is noninferior to in-person CBT for pediatric obsessive-compulsive disorder.

Design, Setting And Participants: A randomized clinical noninferiority trial conducted at 2 specialist child and adolescent mental health clinics in Sweden. Read More

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Breast cancer in Zimbabwe: patterns of care and correlates of adherence in a national referral hospital radiotherapy center cohort from 2014 to 2018.

Cancer Med 2021 May 10. Epub 2021 May 10.

Parirenyatwa Hospital Radiotherapy and Oncology Center, Harare, Zimbabwe.

Background: Breast cancer is the second most common cancer among women in Zimbabwe. Patients face socioeconomic barriers to accessing oncology care, including radiotherapy. We sought to understand patterns of care and adherence for women with breast cancer in sub-Saharan Africa (SSA) with radiotherapy access. Read More

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Clinical Manifestations of COVID-19.

Adv Exp Med Biol 2021 ;1318:179-196

Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third coronavirus causing an outbreak in the twenty-first century. It is related to a contagious coronavirus disease (COVID-19), which its high pace of spreading allowed it to lie to the whole world and be turned into a pandemic only a few months after the identification of the first case. Currently, the reverse transcription-polymerase chain reaction (RT-PCR) test of throat swap is the gold standard of diagnosis; however, several studies have reported false-negative results with non-ideal sensitivity. Read More

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January 2021

Skull base repair following endonasal pituitary and skull base tumour resection: a systematic review.

Pituitary 2021 May 10. Epub 2021 May 10.

Division of Neurosurgery, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.

Purpose: Postoperative cerebrospinal fluid rhinorrhoea (CSFR) remains a frequent complication of endonasal approaches to pituitary and skull base tumours. Watertight skull base reconstruction is important in preventing CSFR. We sought to systematically review the current literature of available skull base repair techniques. Read More

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Comprehensive mapping of neutralizing antibodies against SARS-CoV-2 variants induced by natural infection or vaccination.

medRxiv 2021 May 5. Epub 2021 May 5.

Background: Immunity after SARS-CoV-2 infection or vaccination has been threatened by recently emerged SARS-CoV-2 variants. A systematic summary of the landscape of neutralizing antibodies against emerging variants is needed.

Methods: We systematically searched PubMed, Embase, Web of Science, and 3 pre-print servers for studies that evaluated neutralizing antibodies titers induced by previous infection or vaccination against SARS-CoV-2 variants and comprehensively collected individual data. Read More

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Repetitiveness of the oral glucose tolerance test in children and adolescents.

World J Clin Pediatr 2021 May 9;10(3):29-39. Epub 2021 May 9.

Division of Paediatric Endocrinology and Diabetes, Department of Paediatrics, University of Patras School of Medicine, Patras 26504, Greece.

Background: Data regarding the most suitable diagnostic method for the diagnosis of glucose impairment in asymptomatic children and adolescents are inconclusive. Furthermore, limited data are available on the reproducibility of the oral glucose tolerance test (OGTT) in children and adolescents who are obese (OB).

Aim: To investigate the usefulness of the OGTT as a screening method for glucose dysregulation in children and adolescents. Read More

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Anatomy of comorbidity complexity of COVID-19: the case of hospitalized South Korean patients.

Epidemiol Health 2021 May 7:e2021035. Epub 2021 May 7.

Department of Medicine, Division of Hematology & Oncology, University of Tennessee Health Science Center, TN, USA.

Objectives: We aimed to examine how comorbidities are associated with outcome (illness severity or death) in hospitalized COVID-19 patients.

Methods: We use data provided by Korea Disease Control & Prevention Agency, National Medical Center, which include the clinical and epidemiological patient data of all patients hospitalized with COVID-19, who were discharged on, or prior to, April 30, 2020, in South Korea. We conducted comorbidity network and multinomial logistic regression analyses to identify risk factors associated with the severity of and mortality from COVID-19 disease. Read More

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Evaluation of immunogenicity and protection mediated by Lawsonia intracellularis subunit vaccines.

Vet Immunol Immunopathol 2021 May 7;237:110256. Epub 2021 May 7.

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan, Canada. Electronic address:

Lawsonia intracellularis is an economically important bacterium that causes ileitis in pigs. Current vaccines for L. intracellularis do not allow for differentiation between infected and vaccinated animals (DIVA), which is beneficial for disease tracking and surveillance. Read More

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The impact of food insecurity on mental health in Africa: A systematic review.

Soc Sci Med 2021 Apr 20;278:113953. Epub 2021 Apr 20.

Department of Geography, Western University, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada; Environment Health and Hazards Lab, Western University, 1151 Richmond Street, London, Ontario, N6A 3K7, Canada.

In 2018, 676.1 million people in Africa (52.5% of the population) were moderately or severely food insecure. Read More

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Analysis of Medical Device Alerts Issued by the Portuguese Medicines Agency: Scoping the Purpose of New Regulatory Recommendations.

Acta Med Port 2021 Mar 1;34(3):201-208. Epub 2021 Mar 1.

Departamento de Sócio-Farmácia. Faculdade de Farmácia. Universidade de Lisboa. Lisboa. Portugal.

Introduction: Medical devices are healthcare technologies with a significantly growing market worldwide. This study aims to analyze medical device alerts issued by the Portuguese Medicines Agency, INFARMED, I.P. Read More

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Soft soled footwear has limited impact on toddler gait.

PLoS One 2021 10;16(5):e0251175. Epub 2021 May 10.

Department of Physiotherapy, Centre for Health, Exercise and Sports Medicine, School of Health Sciences, Faculty of Medicine Dentistry & Health Sciences, The University of Melbourne, Melbourne, Victoria, Australia.

The development of walking in young toddlers is an important motor milestone. Walking patterns can differ widely amongst toddlers, and are characterised by unique biomechanical strategies. This makes comparisons between newly walking toddler's and older children's walking difficult. Read More

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Insecticide resistance status and mechanisms in Aedes aegypti populations from Senegal.

PLoS Negl Trop Dis 2021 May 10;15(5):e0009393. Epub 2021 May 10.

Medical Zoology Pole, Institut Pasteur de Dakar, Dakar, Sénégal.

Aedes aegypti is the main epidemic vector of arboviruses in Africa. In Senegal, control activities are mainly limited to mitigation of epidemics, with limited information available for Ae. aegypti populations. Read More

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Dysregulation of microRNAs as the risk factor of lymph node metastasis in papillary thyroid carcinoma: systematic review.

Endokrynol Pol 2021 ;72(2):145-152

Department of Human and Medical Genetics, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Papillary thyroid carcinoma (PTC) has an excellent prognosis with a relatively low mortality rate, but a small portion of PTC patients suffer from an aggressive form of the disease. In such cases early detection of lymph node metastasis (LNM) is as paramount as it is problematic. The routine use of central neck lymph node dissection is not recommended. Read More

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January 2021

Resuscitative Effect of Centhaquine (Lyfaquin) in Hypovolemic Shock Patients: A Randomized, Multicentric, Controlled Trial.

Adv Ther 2021 May 10. Epub 2021 May 10.

Pharmazz India Private Limited, Greater Noida, India.

Introduction: Centhaquine (Lyfaquin) showed significant efficacy as a resuscitative agent in animal models of haemorrhagic shock. Its safety and tolerability were confirmed in healthy human volunteers. In this study, our primary objective was to determine the safety, and the secondary objective was to assess the efficacy of centhaquine in patients with hypovolemic shock. Read More

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Incremental Model Fit Assessment in the Case of Categorical Data: Tucker-Lewis Index for Item Response Theory Modeling.

Prev Sci 2021 May 10. Epub 2021 May 10.

Chung-Ang University, Seoul, Korea.

The Tucker-Lewis index (TLI; Tucker & Lewis, 1973), also known as the non-normed fit index (NNFI; Bentler & Bonett, 1980), is one of the numerous incremental fit indices widely used in linear mean and covariance structure modeling, particularly in exploratory factor analysis, tools popular in prevention research. It augments information provided by other indices such as the root-mean-square error of approximation (RMSEA). In this paper, we develop and examine an analogous index for categorical item level data modeled with item response theory (IRT). Read More

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Moral Distress and Resilience Associated with Cancer Care Priority Setting in a Resource Limited Context.

Oncologist 2021 May 10. Epub 2021 May 10.

Partners In Health/Inshuti Mu Buzima, Rwinkwavu, Rwanda.

Background: Moral distress and burnout are highly prevalent among oncology clinicians. Research is needed to better understand how resource constraints and systemic inequalities contribute to moral distress in order to develop effective mitigation strategies. Oncology providers in low- and middle-income countries (LMICs) are well positioned to provide insight into the moral experience of cancer care priority setting and expertise to guide solutions. Read More

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Prognostication in post-stroke aphasia: speech pathologists' clinical insights on formulating and delivering information about recovery.

Disabil Rehabil 2021 May 8:1-14. Epub 2021 May 8.

School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Australia.

Purpose: For people with post-stroke aphasia, "Will I get better?" is a question often asked, but one that is intellectually and emotionally demanding for speech pathologists to answer. Speech pathologists' formulation and delivery of aphasia prognoses is varied and there is limited evidence for optimising practice. We aimed to understand speech pathologists' clinical experiences, reasoning, and support needs in aphasia prognostication. Read More

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Antifungal Activity of Boric Acid, Triclosan and Zinc Oxide Against Different Clinically Relevant Candida Species.

Mycoses 2021 May 10. Epub 2021 May 10.

Departamento de Farmacia, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín, Colombia.

Background: The genus Candida includes about 200 different species, but only a few are able to produce disease in humans. The species responsible for the highest proportion of human infections is Candida albicans. However, in the last two decades there has been an increase in the proportion of infections caused by other Candida species, including C. Read More

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Complete mitochondrial genome of (Mediophyceae, Bacillariophyta).

Mitochondrial DNA B Resour 2021 Apr 26;6(4):1560-1562. Epub 2021 Apr 26.

CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.

is a species-rich genus with about 170 described species, many of which are harmful algal species with significant negative ecological impact. However, genome data of these species remain limited. In this study, the complete mitochondrial genome of (Hendey) Hasle 1973 was determined for the first time. Read More

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The effectiveness of axillary reverse mapping in preventing breast cancer-related lymphedema: a meta-analysis based on randomized controlled trials.

Gland Surg 2021 Apr;10(4):1447-1459

Department of Breast Disease, Henan Breast Cancer Center, The affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China.

Background: Here, we carried out an extensive meta-analysis to investigate the effectiveness of the use of axillary reverse mapping (ARM) during axillary lymph node dissection (ALND) in preventing breast cancer-related lymphedema (BCRL).

Methods: Database searches to identify relevant randomized controlled trials (RCTs) were performed of MEDLINE (PubMed), Web of Science, Embase, and the Cochrane Library. Eligible articles with a publication date from database establishment to December 2020 were retrieved by combining keywords including: "breast cancer", "breast carcinoma", "breast neoplasm", "axillary reverse mapping", "axillary lymph node dissection", "lymphatic arm drainage", and "lymphedema". Read More

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Omics analyses in peritoneal metastasis-utility in the management of peritoneal metastases from colorectal cancer and pseudomyxoma peritonei: a narrative review.

J Gastrointest Oncol 2021 Apr;12(Suppl 1):S191-S203

Department of Tumor Biology, Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.

High-throughput "-omics" analysis may provide a broader and deeper understanding of cancer biology to define prognostic and predictive biomarkers and identify novel therapy targets. In this review we provide an overview of studies where the peritoneal tumor component of peritoneal metastases from colorectal cancer (PM-CRC) and pseudomyxoma peritonei (PMP) were analyzed. Most of the available data was derived from DNA mutation analysis, but a brief review of findings from transcriptomic and protein expression analysis was also performed. Read More

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