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Comprehensive immunohistochemical analysis of RET, BCAR1, and BCAR3 expression in patients with Luminal A and B breast cancer subtypes.

Breast Cancer Res Treat 2022 Jan 15. Epub 2022 Jan 15.

Discipline of Oncology, Department of Radiology and Oncology, Faculty of Medicine, University of São Paulo, São Paulo, 01246-903, Brazil.

Purpose: Breast cancer (BC) is considered a heterogeneous disease composed of distinct subtypes with diverse clinical outcomes. Luminal subtype tumors have the best prognosis, and patients benefit from endocrine therapy. However, resistance to endocrine therapies in BC is an obstacle to successful treatment, and novel biomarkers are needed to understand and overcome this mechanism. Read More

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January 2022

Central Venous-to-Arterial CO2 Difference-Assisted Goal-Directed Hemodynamic Management During Major Surgery-A Randomized Controlled Trial.

Anesth Analg 2022 Jan 13. Epub 2022 Jan 13.

From the Department of Anaesthesiology and Critical Care, All India Institute of Medical Sciences, Bhubaneswar, India.

Background: Different goals have guided goal-directed therapy (GDT). Protocols aiming for central venous-to-arterial carbon dioxide gap (DCO2) <6 mm Hg have improved organ function in septic shock. Evidence for use of DCO2 in the perioperative period is scarce. Read More

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January 2022

Optimal individualization of patient-oriented ovarian stimulation in Japanese assisted reproductive technology clinics, a review for unique setting with advanced-age patients.

J Obstet Gynaecol Res 2022 Jan 13. Epub 2022 Jan 13.

Department of Obstetrics and Gynecology, Saitama Medical University, Saitama, Japan.

Ovarian stimulation is a key issue in assisted reproductive technology (ART) treatment. ART practice in Japan is unique with various types of ovarian stimulation protocols, which may contribute to lower pregnancy rates compared to other countries. This review aims to clarify optimal individualized ovarian stimulation for improving the pregnancy rate per one oocyte retrieval cycle in Japan. Read More

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January 2022

Evaluation of State-Led Surveillance of Neonatal Abstinence Syndrome - Six U.S. States, 2018-2021.

MMWR Morb Mortal Wkly Rep 2022 Jan 14;71(2):37-42. Epub 2022 Jan 14.

Opioid use disorder (OUD) is a significant public health problem in the United States, which affects children as well as adults. During 2010-2017, maternal opioid-related diagnoses increased approximately 130%, from 3.5 to 8. Read More

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January 2022

Identifying the key factors of subsidiary supervision and management using an innovative hybrid architecture in a big data environment.

Financ Innov 2021 4;7(1):10. Epub 2021 Feb 4.

School of Accounting, Nanfang College of Sun Yat-Sen University, Guangzhou, China.

In a highly intertwined and connected business environment, globalized layout planning can be an effective way for enterprises to expand their market. Nevertheless, conflicts and contradictions always exist between parent and subsidiary enterprises; if they are in different countries, these conflicts can become especially problematic. Internal control systems for subsidiary supervision and management seem to be particularly important when aiming to align subsidiaries' decisions with parent enterprises' strategic intentions, and such systems undoubtedly involve numerous criteria/dimensions. Read More

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February 2021

[Framework for a Group Intervention Aiming at Coping with out-of-home Placement - Focus Groups in Residential Foster Homes].

Prax Kinderpsychol Kinderpsychiatr 2022 Jan;71(1):55-71

Universitätsklinikum Ulm Klinik für Kinder- und Jugendpsychiatrie/Psychotherapie Steinhövelstraße 3 89075 Ulm Deutschland.

Out-of-home placement is a critical life event for affected children and adolescents. We explored the potential content and conditions for a group intervention aiming at coping with this critical life event by the means of three focus groups with n = 13 participants. The participants reported feelings of guilt, uncertainty concerning their future, experiences of loss, and lack of confidence. Read More

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January 2022

A Capstone Laboratory theme investigating properties of non-steroidal anti-inflammatory drugs and their solubilization by cationic surfactant micelles.

Biochem Mol Biol Educ 2022 Jan 13. Epub 2022 Jan 13.

Pre-Medical Education Unit, Weill Cornell Medical College-Qatar, Doha, Qatar.

Research experience is becoming an increasingly crucial element of today's undergraduate science curriculum. In recent years, the establishment of the Course-Based Undergraduate Research Experience Network (CUREnet) has provided a framework for the development of courses aiming to cultivate students' proficiency in undergraduate research techniques while fostering scientific curiosity in a laboratory setting. Capstone Laboratory is one such course that was designed to provide second-year pre-medical students at Weill Cornell Medicine-Qatar with exposure to laboratory techniques to develop their repertoire of research skills. Read More

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January 2022

A method for identifying critical time windows of maternal air pollution exposures associated with low birth weight in offspring using massive geographic data.

Environ Sci Pollut Res Int 2022 Jan 13. Epub 2022 Jan 13.

Department of Geography, Texas Center for Geographic Information Science, Texas State University, San Marcos, TX, 78666, USA.

Associations between maternal exposures to air pollutants and low birth weight (LBW) in offspring varied when different exposure windows were considered. Methods used in previous studies lacked flexibility in delineating exposure windows and did not consider time periods before conception, which may restrict the discoveries of critical exposure windows. This study introduces a novel method to identify critical windows of maternal air pollution exposures associated with LBW in offspring using massive georeferenced data. Read More

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January 2022

Fragment Hotspot Mapping to Identify Selectivity-Determining Regions between Related Proteins.

J Chem Inf Model 2022 Jan 12. Epub 2022 Jan 12.

Centre for Medicines Discovery, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Headington, Oxford OX3 7DQ, U.K.

Selectivity is a crucial property in small molecule development. Binding site comparisons within a protein family are a key piece of information when aiming to modulate the selectivity profile of a compound. Binding site differences can be exploited to confer selectivity for a specific target, while shared areas can provide insights into polypharmacology. Read More

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January 2022

The use of topical nalbuphine in different concentrations to control pain after photorefractive keratectomy.

Int Ophthalmol 2022 Jan 12. Epub 2022 Jan 12.

Ophthalmology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Purpose: This is a randomized controlled study aiming to evaluate the safety and efficacy of two different concentrations of topical nalbuphine hydrochloride, when used to relieve pain in the first days following photorefractive keratectomy (PRK).

Methods: This is a prospective double blinded randomized clinical trial that included 189 patients who had PRK for correction of low and moderate refractive errors. Patients were randomly assigned to three groups according to the eye drops given to relieve pain in the first three postoperative days; the first group received topical nalbuphine with a concentration of 2 mg/ml (Group A = 64 patients), the second group received topical nalbuphine in a concentration of 1 mg/ml (Group B = 69 patients) and the third group received topical artificial tears only (Group C = 56 patients). Read More

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January 2022

Dietary Intake in the Lifelines Cohort Study: Baseline Results from the Flower Food Frequency Questionnaire among 59,982 Participants.

Nutrients 2021 Dec 23;14(1). Epub 2021 Dec 23.

Division of Human Nutrition and Health, Wageningen University & Research, 6700 AA Wageningen, The Netherlands.

The role of nutrition in health and disease is well established. However, more research on this topic is needed to fill gaps in our current knowledge. The Lifelines cohort study, a large Dutch prospective cohort study, was established as a resource for international researchers, aiming to obtain insight into the aetiology of healthy ageing. Read More

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December 2021

Latest evidence on the management of early-stage and locally advanced rectal cancer: a narrative review.

ANZ J Surg 2022 Jan 9. Epub 2022 Jan 9.

Department of Colorectal Surgery, Alfred Health, Melbourne, Victoria, Australia.

Rectal cancer is a challenging disease process to manage, with a rising incidence in young adults. Several clinical advances have been made in the past decade with regards to optimal treatment strategies in early-stage (T1-2, node negative tumours) and locally advanced cancers (T3-4 and/or nodal positivity) utilizing a multimodal approach of surgery, neoadjuvant chemoradiotherapy, and adjuvant chemotherapy, all aiming to optimize oncological outcomes, while minimizing associated morbidity. This narrative review aimed to summarize trial level evidence apropos the management of early and locally advanced rectal cancer. Read More

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January 2022

Recyclable Zr/Hf-Containing Acid-Base Bifunctional Catalysts for Hydrogen Transfer Upgrading of Biofuranics: A Review.

Front Chem 2021 21;9:812331. Epub 2021 Dec 21.

State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, State-Local Joint Laboratory for Comprehensive Utilization of Biomass, Center for Research and Development of Fine Chemicals, Guizhou University, Guiyang, China.

The massive burning of a large amount of fossil energy has caused a lot of serious environmental issues (e.g., air pollution and climate change), urging people to efficiently explore and valorize sustainable alternatives. Read More

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December 2021

Analysis of glucose and xylose metabolism in new indigenous Meyerozyma caribbica strains isolated from corn residues.

World J Microbiol Biotechnol 2022 Jan 6;38(2):35. Epub 2022 Jan 6.

Laboratory of Biochemistry and Genetics, Campus Chapecó, Federal University of Fronteira Sul, Rodovia SC 484, Km 2, 89815-899, Bairro Fronteira Sul, Chapecó, SC, Brazil.

Aiming to broaden the base of knowledge about wild yeasts, four new indigenous strains were isolated from corn residues, and phylogenetic-tree assemblings on ITS and LSU regions indicated they belong to Meyerozyma caribbica. Yeasts were cultivated under full- and micro-aerobiosis, starting with low or high cell-density inoculum, in synthetic medium or corn hydrolysate containing glucose and/or xylose. Cells were able to assimilate both monosaccharides, albeit by different metabolic routes (fermentative or respiratory). Read More

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January 2022

Gender-affirming hormone therapy: An updated literature review with an eye on the future.

J Intern Med 2022 Jan 4. Epub 2022 Jan 4.

Department of Endocrinology, Ghent University Hospital, Ghent, 9000, Belgium.

In line with increasing numbers of transgender (trans) and gender non-binary people requesting hormone treatment, the body of available research is expanding. More clinical research groups are presenting data, and the numbers of participants in these studies are rising. Many previous review papers have focused on all available data, as these were scarce, but a more recent literature review is timely. Read More

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January 2022

Risk assessment, diagnosis, and treatment of cancer treatment-related adrenal insufficiency.

Expert Rev Endocrinol Metab 2022 Jan 3:1-13. Epub 2022 Jan 3.

Royal Adelaide Hospital, Endocrine and Metabolic Unit Adelaide, Adelaide, Australia.

Introduction: Adrenal insufficiency (AI) is an easily treatable, potentially life-threatening condition, which is increasingly recognized in malignancy. The recent introduction of immune checkpoint inhibitors, in particular, and increasing use of tyrosine kinase inhibitors have increased the frequency of AI in patients with malignancy. A review is therefore warranted to summarize current knowledge on the topic and guide safe clinical practices. Read More

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January 2022

Remote cognitive rehabilitation in patients post-cerebrovascular accident: an experience report.

Alzheimers Dement 2021 Dec;17 Suppl 12:e058382

Federal University of Juiz de Fora, Juiz de Fora, Brazil.

Background: Aiming to contribute to the reduction of cognitive impairment, as well as to improve the quality of life of patients affected by stroke, it was proposed to carry out a cognitive rehabilitation focused on attentional aspects (sustained, alternate, selective and divided attention). Due to the new Coronavirus pandemic and the need for social isolation, the rehabilitation was adapted to the remote model.

Methods: The rehabilitation was designed and carried out with six patients, coming from a public neurology outpatient service, who had suffered a stroke within a period of up to one year before the start of rehabilitation. Read More

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December 2021

The Effect of Ketogenic Diet on Inflammatory Arthritis and Cardiovascular Health in Rheumatic Conditions: A Mini Review.

Front Med (Lausanne) 2021 14;8:792846. Epub 2021 Dec 14.

Medicine and Rheumatology Unit, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Istituto Ortopedico Rizzoli, Bologna, Italy.

The principle of ketogenic diet (KD) is restriction of carbohydrates to a maximum of 5-10% of the total daily caloric intake, aiming at shifting body metabolism toward ketone bodies. Different studies suggested promising results of KD to help patients to lose weight, to reduce insulin requirements in diabetes, to supplement cancer protocols, to treat neurological conditions and to optimize control of metabolic and cardiovascular diseases. However, literature about the anti-inflammatory properties of KD in rheumatic diseases is still limited. Read More

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December 2021

Bixa orellana L. (Achiote, Annatto) as an antimicrobial agent: A scoping review of its efficiency and technological prospecting.

J Ethnopharmacol 2021 Dec 28;287:114961. Epub 2021 Dec 28.

Graduate Program in Biochemistry and Bioprospection, Federal University of Pelotas, Pelotas, RS, Brazil; Graduate Program in Dentistry, Federal University of Pelotas, Pelotas, RS, Brazil. Electronic address:

Ethnopharmacological Relevance: Bixa orellana L. is reported to have numerous applications in traditional medicine and pharmacological properties such as wound healing, analgesic, hemostatic, and antioxidant activities. Recently, the literature has shown scientific interest of its antimicrobial properties aiming the development of cost-effective phytotherapeutic agents. Read More

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December 2021

Chronic rejection after liver transplantation: Opening the Pandora's box.

World J Gastroenterol 2021 Dec;27(45):7771-7783

Hepatology Unit, University of Tor Vergata, Rome 00100, Italy.

Chronic rejection (CR) of liver allografts causes damage to intrahepatic vessels and bile ducts and may lead to graft failure after liver transplantation. Although its prevalence has declined steadily with the introduction of potent immunosuppressive therapy, CR still represents an important cause of graft injury, which might be irreversible, leading to graft loss requiring re-transplantation. To date, we still do not fully appreciate the mechanisms underlying this process. Read More

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December 2021

Differences between adults and adolescents in responding to hip and knee pattern feedback during gait.

Hum Mov Sci 2022 Feb 21;81:102915. Epub 2021 Dec 21.

Center for Mobility and Rehabilitation Engineering Research, Kessler Foundation, West Orange, NJ, United States of America; Children's Specialized Hospital Research Center, New Brunswick, NJ, United States of America; Department of Physical Medicine and Rehabilitation, Rutgers New Jersey Medical School, Newark, NJ, United States of America. Electronic address:

Visual feedback techniques have shown potential in interventions aiming to retrain deviated gait patterns. Understanding the abilities of different age groups to modify their gait is needed to optimize interventions. Twelve adults (6F, 6 M; 26. Read More

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February 2022

New Trends and Most Promising Therapeutic Strategies for Epilepsy Treatment.

Front Neurol 2021 7;12:753753. Epub 2021 Dec 7.

Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.

Despite the wide availability of novel anti-seizure medications (ASMs), 30% of patients with epilepsy retain persistent seizures with a significant burden in comorbidity and an increased risk of premature death. This review aims to discuss the therapeutic strategies, both pharmacological and non-, which are currently in the pipeline. PubMed, Scopus, and EMBASE databases were screened for experimental and clinical studies, meta-analysis, and structured reviews published between January 2018 and September 2021. Read More

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December 2021

Sulfonitrocarburizing of High-Speed Steel Cutting Tools: Kinetics and Performances.

Materials (Basel) 2021 Dec 16;14(24). Epub 2021 Dec 16.

Department of Metallic Materials Science, Physical Metallurgy, Faculty of Materials Science and Engineering, University POLITEHNICA of Bucharest, 060042 Bucharest, Romania.

The scholarly literature records information related to the performance increase of the cutting tools covered by the superficial layers formed "in situ" when applying thermochemical processing. In this context, information is frequently reported on the carbamide role in processes aiming carbon and nitrogen surface saturation. Sulfur, together with these elements adsorbed and diffused in the cutting tools superficial layers, undoubtedly ensures an increase of their operating sustainability. Read More

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December 2021

Predictors of successful discontinuation of antipsychotics and antidepressants.

Psychol Med 2021 Dec 23:1-11. Epub 2021 Dec 23.

Universität Hamburg, Hamburg, Germany.

Background: To offer support for patients who decide to discontinue antipsychotic and antidepressant medication, identifying which potentially modifiable factors correlate with discontinuation success is crucial. Here, we analyzed the predictive value of the professional support received, circumstances prior to discontinuation, a strategy of discontinuation, and use of functional and non-functional coping strategies during discontinuation on self-reported discontinuation success and on objective discontinuation.

Methods: Patients who had attempted discontinuing antipsychotics (AP) and/or antidepressants (AD) during the past 5 years (n = 316) completed an online survey including questions on subjective and objective discontinuation success, sociodemographic, clinical and medication-related factors, and scales to assess the putative predictors. Read More

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December 2021

Healthy sexuality development in adolescence: proposing a competency-based framework to inform programmes and research.

Sex Reprod Health Matters 2021 Dec;29(1):1996116

Senior Researcher, Rutgers, Utrecht, The Netherlands.

Positive aspects of sexuality remain understudied among young people globally, and consensus is lacking on how to conceptualise different aspects of healthy adolescent sexuality development in order to guide programmes, research, and policy. We propose a conceptual framework that draws on theories and literature related to positive youth development, empowerment, human rights, gender, social-ecological and life-course perspectives. The framework highlights six key competencies for healthy adolescent sexuality development: (1) sexual literacy, (2) gender-equal attitudes, (3) respect for human rights and understanding consent, (4) critical reflection skills, (5) coping skills, and (6) interpersonal skills. Read More

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December 2021

Needle-free anesthesia: clinical efficacy of a mucoadhesive patch for atraumatic anesthesia in dental procedures.

Braz Oral Res 2021 17;35:e131. Epub 2021 Dec 17.

Universidade de São Paulo - USP, School of Dentistry of Ribeirao Preto, Department of Dental Materials and Prosthodontics, Ribeirão Preto, SP, Brazil.

This study showcases the clinical efficacy of mucoadhesive patches designed for the buccal delivery of lidocaine and prilocaine hydrochlorides (1:1, 30 mg/patch). Such patches were developed for needle-free pre-operative local anesthesia in dentistry, aiming at mitigating the use of infiltrative anesthesia for medium-complexity clinical procedures. The patches were manufactured encompassing drug-release, mucoadhesive and backing layers, all prepared through film casting using biocompatible materials. Read More

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December 2021

EEG Neurofeedback in the Treatment of Adults with Binge-Eating Disorder: a Randomized Controlled Pilot Study.

Neurotherapeutics 2021 Dec 20. Epub 2021 Dec 20.

Integrated Research and Treatment Center Adiposity Diseases, Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, University of Leipzig Medical Center, Leipzig, Germany.

Specific alterations in electroencephalography (EEG)-based brain activity have recently been linked to binge-eating disorder (BED), generating interest in treatment options targeting these neuronal processes. This randomized-controlled pilot study examined the effectiveness and feasibility of two EEG neurofeedback paradigms in the reduction of binge eating, eating disorder and general psychopathology, executive functioning, and EEG activity. Adults with BED and overweight (N = 39) were randomly assigned to either a food-specific EEG neurofeedback paradigm, aiming at reducing fronto-central beta activity and enhancing theta activity after viewing highly palatable food pictures, or a general EEG neurofeedback paradigm training the regulation of slow cortical potentials. Read More

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December 2021

Dissociation between red and white stimulus perception: A perimetric quantification of protanopic color vision deficiencies.

PLoS One 2021 20;16(12):e0260362. Epub 2021 Dec 20.

Competence Center Vision Research / Study course Ophthalmic Optics/Optometry, Aalen University of Applied Sciences, Aalen, Germany.

Significance: Horizontal visual field extension was assessed for red and white stimuli in subjects with protanopia using semi-automated kinetic perimetry. In contrast to a conventional anomaloscope, the "red/white dissociation ratio" (RWR) allows to describe protanopia numerically. For the majority of subjects with protanopia a restriction for faint red stimuli was found. Read More

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December 2021

Awareness, Prevention, Detection, and Therapy Applications for Depression and Anxiety in Serious Games for Children and Adolescents: Systematic Review.

JMIR Serious Games 2021 Dec 16;9(4):e30482. Epub 2021 Dec 16.

Department of Computer Engineering, University of Burgos, Burgos, Spain.

Background: Depression and anxiety in children and adolescents are major health problems worldwide. In recent years, serious games research has advanced in the development of tools to address these mental health conditions. However, there has not been an extensive analysis of these games, their tendencies, and capacities. Read More

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December 2021

[Quercetin for the treatment of prostate cancer: Progress in studies].

Zhonghua Nan Ke Xue 2021 Jul;27(7):654-658

Department of Urology, Honghe First People's Hospital, Honghe, Yunnan 661100, China.

Prostate cancer (PCa) is a common urinary malignancy, and advanced PCa has a poor prognosis and a high mortality. Drug therapies currently available for this malignancy often cause serious adverse reactions, and therefore new drugs with fewer adverse effects or the potential to reduce the adverse effects of traditional chemotherapeutic drugs are badly needed for the management of PCa. Quercetin, as a natural flavonoid, has been extensively studied in recent years for its anti-cancer effects, as in cell signal transduction, apoptosis promotion, anti-proliferation and -oxidation, and growth inhibition. Read More

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